LOCUS       NM_007663               3025 bp    mRNA    linear   ROD 11-OCT-2024
DEFINITION  Mus musculus cadherin 16 (Cdh16), transcript variant 1, mRNA.
ACCESSION   NM_007663
VERSION     NM_007663.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3025)
  AUTHORS   Kang,H.S., Grimm,S.A., Liao,X.H. and Jetten,A.M.
  TITLE     GLIS3 expression in the thyroid gland in relation to TSH signaling
            and regulation of gene expression
  JOURNAL   Cell Mol Life Sci 81 (1), 65 (2024)
   PUBMED   38281222
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3025)
  AUTHORS   Liang,X., Aranyi,T., Zhou,J., Guan,Y., Hu,H., Liu,H. and Susztak,K.
  TITLE     Tet2- and Tet3- Mediated Cytosine Hydroxymethylation in Six2
            Progenitor Cells in Mice Is Critical for Nephron Progenitor
            Differentiation and Nephron Endowment
  JOURNAL   J Am Soc Nephrol 34 (4), 572-589 (2023)
   PUBMED   36522157
REFERENCE   3  (bases 1 to 3025)
  AUTHORS   Tian,M., Zhang,L., Zhang,M., Qiao,L., Xu,B., Li,C., Liu,S.,
            Song,Y., Wei,Z., Wang,Y. and Wang,H.
  TITLE     JLP/Foxk1/N-cadherin axis fosters a partial epithelial-mesenchymal
            transition state in epithelial tubular cells
  JOURNAL   iScience 26 (4), 106396 (2023)
   PUBMED   37013185
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3025)
  AUTHORS   Zhang,J., Chen,J., Lu,Y., Yang,Y., Chen,W., Shen,B., Hu,J., Jia,P.,
            Xu,S., Shi,Y., Ning,Y., Wang,J., Fang,Y., Zhao,S., Li,Y., Dai,Y.,
            Zhang,X., Xiang,M., Tian,Y., Liu,Z., Song,N. and Ding,X.
  TITLE     TWIK-related acid-sensitive K+ channel 2 promotes renal fibrosis by
            inducing cell-cycle arrest
  JOURNAL   iScience 25 (12), 105620 (2022)
   PUBMED   36465115
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3025)
  AUTHORS   Thomson,R.B., Dynia,D.W., Burlein,S., Thomson,B.R., Booth,C.J.,
            Knauf,F., Wang,T. and Aronson,P.S.
  TITLE     Deletion of Cdh16 Ksp-cadherin leads to a developmental delay in
            the ability to maximally concentrate urine in mouse
  JOURNAL   Am J Physiol Renal Physiol 320 (6), F1106-F1122 (2021)
   PUBMED   33938239
  REMARK    GeneRIF: Deletion of Cdh16 Ksp-cadherin leads to a developmental
            delay in the ability to maximally concentrate urine in mouse.
REFERENCE   6  (bases 1 to 3025)
  AUTHORS   Shao,X., Somlo,S. and Igarashi,P.
  TITLE     Epithelial-specific Cre/lox recombination in the developing kidney
            and genitourinary tract
  JOURNAL   J Am Soc Nephrol 13 (7), 1837-1846 (2002)
   PUBMED   12089379
REFERENCE   7  (bases 1 to 3025)
  AUTHORS   Whyte,D.A., Li,C., Thomson,R.B., Nix,S.L., Zanjani,R., Karp,S.L.,
            Aronson,P.S. and Igarashi,P.
  TITLE     Ksp-cadherin gene promoter. I. Characterization and renal
            epithelial cell-specific activity
  JOURNAL   Am J Physiol 277 (4), F587-F598 (1999)
   PUBMED   10516284
REFERENCE   8  (bases 1 to 3025)
  AUTHORS   Wertz,K. and Herrmann,B.G.
  TITLE     Kidney-specific cadherin (cdh16) is expressed in embryonic kidney,
            lung, and sex ducts
  JOURNAL   Mech Dev 84 (1-2), 185-188 (1999)
   PUBMED   10473139
REFERENCE   9  (bases 1 to 3025)
  AUTHORS   Thomson,R.B., Ward,D.C., Quaggin,S.E., Igarashi,P., Muckler,Z.E.
            and Aronson,P.S.
  TITLE     cDNA cloning and chromosomal localization of the human and mouse
            isoforms of Ksp-cadherin
  JOURNAL   Genomics 51 (3), 445-451 (1998)
   PUBMED   9721215
REFERENCE   10 (bases 1 to 3025)
  AUTHORS   Thomson,R.B., Igarashi,P., Biemesderfer,D., Kim,R., Abu-Alfa,A.,
            Soleimani,M. and Aronson,P.S.
  TITLE     Isolation and cDNA cloning of Ksp-cadherin, a novel kidney-specific
            member of the cadherin multigene family
  JOURNAL   J Biol Chem 270 (29), 17594-17601 (1995)
   PUBMED   7615566
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK164546.1 and AJ609635.1.
            
            On Nov 22, 2011 this sequence version replaced NM_007663.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ609635.1, AF016271.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               AK164546.1         2-134
            134-3025            AJ609635.1         1-2892
FEATURES             Location/Qualifiers
     source          1..3025
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.04 cM"
     gene            1..3025
                     /gene="Cdh16"
                     /note="cadherin 16"
                     /db_xref="GeneID:12556"
                     /db_xref="MGI:MGI:106671"
     exon            1..249
                     /gene="Cdh16"
                     /inference="alignment:Splign:2.1.0"
     exon            250..307
                     /gene="Cdh16"
                     /inference="alignment:Splign:2.1.0"
     CDS             263..2755
                     /gene="Cdh16"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; kidney-specific cadherin; KSP-cadherin"
                     /codon_start=1
                     /product="cadherin-16 isoform 1 precursor"
                     /protein_id="NP_031689.1"
                     /db_xref="CCDS:CCDS22583.1"
                     /db_xref="GeneID:12556"
                     /db_xref="MGI:MGI:106671"
                     /translation="MISARPWLLYLSVIQAFTTEAQPAESLHTEVPENYGGNFPFYIL
                     KLPLPLGRDEGHIVLSGDSNTADQNTFAVDTDSGFLVATRTLDREEKAEYQLQVTLES
                     EDGRILWGPQLVTVHVKDENDQVPQFSQAIYRAQLSQGTRPGVPFLFLEASDGDAPGT
                     ANSDLRFHILSQSPPQPLPDMFQLDPHLGALALSPSGSTSLDHALEETYQLLVQVKDM
                     GDQPSGHQAIATVEISIVENSWAPLEPVHLAENLKVVYPHSIAQVHWSGGDVHYQLES
                     QPPGPFDVDTEGMLHVTMELDREAQAEYQLQVRAQNSHGEDYAEPLELQVVVMDENDN
                     APVCSPHDPTVNIPELSPPGTEIARLSAEDLDAPGSPNSHIVYQLLSPEPEEGAENKA
                     FELDPTSGSVTLGTAPLHAGQSILLQVLAVDLAGSESGLSSTCEVTVMVTDVNNHAPE
                     FINSQIGPVTLPEDVKPGALVATLMATDADLEPAFRLMDFAIEEGDPEGIFDLSWEPD
                     SDHVQLRLRKNLSYEAAPDHKVVVVVSNIEELVGPGPGPAATATVTILVERVVAPLKL
                     DQESYETSIPVSTPAGSLLLTIQPSDPMSRTLRFSLVNDSEGWLCIKEVSGEVHTAQS
                     LQGAQPGDTYTVLVEAQDTDKPGLSTSATVVIHFLKASPVPALTLSAGPSRHLCTPRQ
                     DYGVVVSGVSEDPDLANRNGPYSFALGPNPTVQRDWRLQPLNDSHAYLTLALHWVEPG
                     EYMVPVVVHHDTHMWQLQVKVIVCRCNVEGQCMRKVGRMKGMPTKLSAVGVLLGTLAA
                     IGFILILVFTHLALARKDLDQPADSVPLKAAV"
     exon            308..397
                     /gene="Cdh16"
                     /inference="alignment:Splign:2.1.0"
     exon            398..553
                     /gene="Cdh16"
                     /inference="alignment:Splign:2.1.0"
     exon            554..692
                     /gene="Cdh16"
                     /inference="alignment:Splign:2.1.0"
     exon            693..851
                     /gene="Cdh16"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1048
                     /gene="Cdh16"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1171
                     /gene="Cdh16"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1322
                     /gene="Cdh16"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1550
                     /gene="Cdh16"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1627
                     /gene="Cdh16"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1816
                     /gene="Cdh16"
                     /inference="alignment:Splign:2.1.0"
     exon            1817..2058
                     /gene="Cdh16"
                     /inference="alignment:Splign:2.1.0"
     exon            2059..2192
                     /gene="Cdh16"
                     /inference="alignment:Splign:2.1.0"
     exon            2193..2435
                     /gene="Cdh16"
                     /inference="alignment:Splign:2.1.0"
     exon            2436..2543
                     /gene="Cdh16"
                     /inference="alignment:Splign:2.1.0"
     exon            2544..2660
                     /gene="Cdh16"
                     /inference="alignment:Splign:2.1.0"
     exon            2661..3004
                     /gene="Cdh16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2969..2974
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdh16"
                     /note="hexamer: AATAAA"
     polyA_site      3004
                     /gene="Cdh16"
                     /note="major polyA site"
ORIGIN      
        1 agtcacggat gctgagcaga tctggctctc caaagtcaat aagtaacttg gggggactag
       61 gcggggccag gcctgctcct gtgggccccg gtggcatttt ccactcctga gcaagcacgg
      121 ccagaccgcc tacctgctca agtgtccacc ttgcctcgcc ccacctaagc caaatttgcc
      181 agagctccct gaagaaggat tcctttctcc tggaaactgg accaagggag aggctttggg
      241 catctgaagg tctgccttga ccatgatctc tgcccggccg tggctacttt acctctctgt
      301 tattcaggct ttcaccactg aggcccagcc tgcagaaagc ctgcacacag aagtccctga
      361 aaactatggt ggaaatttcc ctttttacat actcaagcta ccactacccc tggggagaga
      421 tgaaggccac attgtcctat caggagactc aaacacggca gatcaaaaca cctttgctgt
      481 ggacacagac tctggctttc tagtggcgac aaggaccctg gaccgggaag agaaagcaga
      541 ataccaacta caggtcacct tggagtctga ggatggacgt atcttgtggg gtccacagct
      601 tgtgactgtg catgtgaaag atgagaatga ccaggtaccc caattctccc aggccatcta
      661 cagagctcag ctgagccagg gcaccaggcc tggggtcccc ttcctcttcc ttgaggcttc
      721 tgatggggat gcaccaggca cagctaactc cgaccttcgc ttccacattc tgagccagtc
      781 cccacctcag cctttaccag acatgttcca gctggaccct cacctagggg ctctggctct
      841 tagtcccagt ggaagcacca gcctagacca tgcccttgaa gagacttacc agctattggt
      901 acaggtcaag gacatgggtg accagccttc aggccaccag gctattgcaa ctgtagagat
      961 ctccatagta gagaacagct gggcacccct agagcctgtt cacctggcag agaatctcaa
     1021 agttgtgtac ccacacagca ttgcccaggt gcactggagt ggaggagacg tgcactacca
     1081 gctggagagc cagcctccag gacccttcga tgtggataca gaggggatgc tccatgttac
     1141 catggagctg gaccgggagg cccaggctga gtaccagctc caagtccgag ctcagaattc
     1201 ccatggtgag gactacgcag aacccctgga gttgcaggtg gtggtgatgg atgaaaacga
     1261 caatgcacct gtctgctccc cacatgaccc aacagtcaac atccctgagc tcagcccccc
     1321 aggaactgaa atagccaggc tctcagcaga ggatttggat gcccctgggt cacccaattc
     1381 ccacattgta tatcagttgt tgagccctga gcctgaggag ggggctgaaa acaaagcctt
     1441 cgagttagat ccgacctcag gcagtgtaac actgggaact gccccactcc atgctggcca
     1501 gagtatcctg cttcaggtgc tggctgttga cctagcagga tcagagagtg gcctcagcag
     1561 cacatgtgag gtgacagtca tggtgacaga cgtcaacaac catgcccctg agttcatcaa
     1621 ttcccagatt gggcctgtaa ctcttcctga ggatgtaaaa cctggggctc tggtggcaac
     1681 actcatggcc actgatgctg accttgaacc tgccttccgc cttatggact ttgccattga
     1741 agaaggagac ccagaaggga tctttgacct gtcctgggag ccagactccg accatgtcca
     1801 gctcagactc cggaagaacc tcagctatga ggcagctcct gatcacaagg tggtggtggt
     1861 cgtgagtaac atagaagaac tggtgggccc aggcccaggc cctgcagcca cagccacagt
     1921 gactatacta gtggagaggg tggttgctcc cctcaagttg gaccaggaga gctatgagac
     1981 cagcatccca gtcagcaccc cagctggctc cctcctgctg accatccagc cctcagaccc
     2041 catgagcaga accctcaggt tctccctggt caatgactca gagggctggc tctgtatcaa
     2101 ggaggtgtct ggggaggtac acacagccca gtccctgcag ggtgcccagc ctggagacac
     2161 atacacagtg cttgtggagg cccaagacac agataagcca ggactgagca cttctgccac
     2221 tgttgtgatc cacttcctga aggcctctcc tgtcccagca ttgactctgt ctgctgggcc
     2281 cagccgacac ctctgtacac cccgccaaga ctacggtgta gttgtgagtg gggtcagtga
     2341 ggaccctgac ctagccaaca ggaatggtcc ctacagcttt gctctcggtc ccaatcccac
     2401 tgtgcagcgg gattggcgcc tccagcctct caacgattcc cacgcctacc tcaccttggc
     2461 attgcattgg gtagagcctg gtgaatacat ggtacctgtg gttgtccacc atgataccca
     2521 tatgtggcaa ctccaggtca aagtgattgt gtgtcgctgc aacgtggaag gccaatgtat
     2581 gcgcaaggtg ggtcgcatga agggaatgcc cacgaaactg tcagcggtgg gtgtcctctt
     2641 gggcaccctg gcagcgatag gcttcattct cattcttgtg ttcacgcacc tggccctggc
     2701 aaggaaggac ctggatcagc cagcagacag cgtgcctctg aaggcagcgg tgtgaatgat
     2761 ccaagcagcc ccagctggga ggttggcccc agctccctct gaactcactg agaaaggacc
     2821 cagtacccaa gatgcactgg ggaccaagac agagtaaaag cccttcacct tgttggagtg
     2881 aagacattat cacaggcatg tccccaaagc ctgagcacct actttatggg atgaccatgg
     2941 gaacactcca aatggcagct ctttgtccaa taaaggctca gagagctaga ctggaccctg
     3001 taaaaaaaaa aaaaaaaaaa aaaaa
//
