LOCUS       NM_007662               2843 bp    mRNA    linear   ROD 28-MAY-2024
DEFINITION  Mus musculus cadherin 15 (Cdh15), mRNA.
ACCESSION   NM_007662
VERSION     NM_007662.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2843)
  AUTHORS   Lin,Y.J., Kao,C.H., Hsiao,S.P. and Chen,S.L.
  TITLE     The cooperation of cis-elements during M-cadherin promoter
            activation
  JOURNAL   Biochem J 478 (4), 911-926 (2021)
   PUBMED   33527978
  REMARK    GeneRIF: The cooperation of cis-elements during M-cadherin promoter
            activation.
REFERENCE   2  (bases 1 to 2843)
  AUTHORS   Liang,Z.S., Cimino,I., Yalcin,B., Raghupathy,N., Vancollie,V.E.,
            Ibarra-Soria,X., Firth,H.V., Rimmington,D., Farooqi,I.S.,
            Lelliott,C.J., Munger,S.C., O'Rahilly,S., Ferguson-Smith,A.C.,
            Coll,A.P. and Logan,D.W.
  TITLE     Trappc9 deficiency causes parent-of-origin dependent microcephaly
            and obesity
  JOURNAL   PLoS Genet 16 (9), e1008916 (2020)
   PUBMED   32877400
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2843)
  AUTHORS   Matsubara,H., Shimizu,Y., Arai,M., Yamagata,A., Ito,S.,
            Imakiire,T., Tsunoda,M., Kumagai,H. and Oshima,N.
  TITLE     PEPITEM/Cadherin 15 Axis Inhibits T Lymphocyte Infiltration and
            Glomerulonephritis in a Mouse Model of Systemic Lupus Erythematosus
  JOURNAL   J Immunol 204 (8), 2043-2052 (2020)
   PUBMED   32169847
  REMARK    GeneRIF: PEPITEM/Cadherin 15 Axis Inhibits T Lymphocyte
            Infiltration and Glomerulonephritis in a Mouse Model of Systemic
            Lupus Erythematosus.
REFERENCE   4  (bases 1 to 2843)
  AUTHORS   Kann,A.P. and Krauss,R.S.
  TITLE     Multiplexed RNAscope and immunofluorescence on whole-mount skeletal
            myofibers and their associated stem cells
  JOURNAL   Development 146 (20) (2019)
   PUBMED   31519691
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2843)
  AUTHORS   Zheng,F. and Cai,Y.
  TITLE     Concurrent exercise improves insulin resistance and nonalcoholic
            fatty liver disease by upregulating PPAR-gamma and genes involved
            in the beta-oxidation of fatty acids in ApoE-KO mice fed a high-fat
            diet
  JOURNAL   Lipids Health Dis 18 (1), 6 (2019)
   PUBMED   30611282
  REMARK    GeneRIF: Concurrent exercise improves insulin resistance and
            nonalcoholic fatty liver disease by upregulating PPAR-gamma, CPT-1A
            and Mcad activities.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2843)
  AUTHORS   Patapoutian,A., Yoon,J.K., Miner,J.H., Wang,S., Stark,K. and
            Wold,B.
  TITLE     Disruption of the mouse MRF4 gene identifies multiple waves of
            myogenesis in the myotome
  JOURNAL   Development 121 (10), 3347-3358 (1995)
   PUBMED   7588068
REFERENCE   7  (bases 1 to 2843)
  AUTHORS   Cifuentes-Diaz,C., Nicolet,M., Alameddine,H., Goudou,D.,
            Dehaupas,M., Rieger,F. and Mege,R.M.
  TITLE     M-cadherin localization in developing adult and regenerating mouse
            skeletal muscle: possible involvement in secondary myogenesis
  JOURNAL   Mech Dev 50 (1), 85-97 (1995)
   PUBMED   7605754
REFERENCE   8  (bases 1 to 2843)
  AUTHORS   Kaupmann,K., Becker-Follmann,J., Scherer,G., Jockusch,H. and
            Starzinski-Powitz,A.
  TITLE     The gene for the cell adhesion molecule M-cadherin maps to mouse
            chromosome 8 and human chromosome 16q24.1-qter and is near the
            E-cadherin (uvomorulin) locus in both species
  JOURNAL   Genomics 14 (2), 488-490 (1992)
   PUBMED   1427864
REFERENCE   9  (bases 1 to 2843)
  AUTHORS   Donalies,M., Cramer,M., Ringwald,M. and Starzinski-Powitz,A.
  TITLE     Expression of M-cadherin, a member of the cadherin multigene
            family, correlates with differentiation of skeletal muscle cells
  JOURNAL   Proc Natl Acad Sci U S A 88 (18), 8024-8028 (1991)
   PUBMED   1840697
REFERENCE   10 (bases 1 to 2843)
  AUTHORS   Hatta,M., Miyatani,S., Copeland,N.G., Gilbert,D.J., Jenkins,N.A.
            and Takeichi,M.
  TITLE     Genomic organization and chromosomal mapping of the mouse
            P-cadherin gene
  JOURNAL   Nucleic Acids Res 19 (16), 4437-4441 (1991)
   PUBMED   1886768
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC167359.4 and AC132287.3.
            
            On Dec 27, 2006 this sequence version replaced NM_007662.1.
            
            Summary: This gene encodes a member of the cadherin family of
            calcium-dependent glycoproteins that mediate cell adhesion and
            regulate many morphogenetic events during development. The encoded
            preproprotein is further processed to generate a mature protein.
            Based on the expression of this gene in skeletal muscle, satellite
            cells and cerebellum, it was postulated that the encoded protein
            may be important for muscle development and regeneration. Mice
            lacking the encoded protein appear normal and display no
            discernible defects in skeletal musculature. Multiple distinct
            genes of the cadherin family, including this gene, are found on
            chromosome 8. [provided by RefSeq, Nov 2015].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M74541.1, BC157978.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               AC167359.4         172689-172844
            157-312             AC132287.3         34029-34184
            313-468             AC132287.3         34887-35042
            469-613             AC132287.3         36765-36909
            614-774             AC132287.3         38365-38525
            775-903             AC132287.3         38984-39112
            904-1089            AC132287.3         39505-39690
            1090-1343           AC132287.3         40832-41085
            1344-1486           AC132287.3         41770-41912
            1487-1726           AC132287.3         42026-42265
            1727-1966           AC132287.3         42517-42756
            1967-2103           AC132287.3         42855-42991
            2104-2268           AC132287.3         43125-43289
            2269-2843           AC132287.3         44350-44924
FEATURES             Location/Qualifiers
     source          1..2843
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 71.99 cM"
     gene            1..2843
                     /gene="Cdh15"
                     /gene_synonym="Cdh14; Mcad"
                     /note="cadherin 15"
                     /db_xref="GeneID:12555"
                     /db_xref="MGI:MGI:106672"
     exon            1..156
                     /gene="Cdh15"
                     /gene_synonym="Cdh14; Mcad"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..2469
                     /gene="Cdh15"
                     /gene_synonym="Cdh14; Mcad"
                     /note="M-cadherin; cadherin-14; muscle cadherin"
                     /codon_start=1
                     /product="cadherin-15 preproprotein"
                     /protein_id="NP_031688.2"
                     /db_xref="CCDS:CCDS22746.1"
                     /db_xref="GeneID:12555"
                     /db_xref="MGI:MGI:106672"
                     /translation="MGSALLLALGLLAQSLGLSWAVPEPKPSTLYPWRRASAPGRVRR
                     AWVIPPISVSENHKRLPYPLVQIKSDKQQLGSVIYSIQGPGVDEEPRNVFSIDKFTGR
                     VYLNATLDREKTDRFRLRAFALDLGGSTLEDPTDLEIVVVDQNDNRPAFLQDVFRGRI
                     LEGAIPGTFVTRAEATDADDPETDNAALRFSILEQGSPEFFSIDEHTGEIRTVQVGLD
                     REVVAVYNLTLQVADMSGDGLTATASAIISIDDINDNAPEFTKDEFFMEAAEAVSGVD
                     VGRLEVEDKDLPGSPNWVARFTILEGDPDGQFKIYTDPKTNEGVLSVVKPLDYESREQ
                     YELRVSVQNEAPLQAAAPRARRGQTRVSVWVQDTNEAPVFPENPLRTSIAEGAPPGTS
                     VATFSARDPDTEQLQRISYSKDYDPEDWLQVDGATGRIQTQRVLSPASPFLKDGWYRA
                     IILALDNAIPPSTATGTLSIEILEVNDHAPALALPPSGSLCSEPDQGPGLLLGATDED
                     LPPHGAPFHFQLNPRVPDLGRNWSVSQINVSHARLRLRHQVSEGLHRLSLLLQDSGEP
                     PQQREQTLNVTVCRCGSDGTCLPGAAALRGGGVGVSLGALVIVLASTVVLLVLILLAA
                     LRTRFRGHSRGKSLLHGLQEDLRDNILNYDEQGGGEEDQDAYDINQLRHPVEPRATSR
                     SLGRPPLRRDAPFSYVPQPHRVLPTSPSDIANFISDGLEAADSDPSVPPYDTALIYDY
                     EGDGSVAGTLSSILSSLGDEDQDYDYLRDWGPRFARLADMYGHQ"
     exon            157..312
                     /gene="Cdh15"
                     /gene_synonym="Cdh14; Mcad"
                     /inference="alignment:Splign:2.1.0"
     exon            313..468
                     /gene="Cdh15"
                     /gene_synonym="Cdh14; Mcad"
                     /inference="alignment:Splign:2.1.0"
     exon            469..613
                     /gene="Cdh15"
                     /gene_synonym="Cdh14; Mcad"
                     /inference="alignment:Splign:2.1.0"
     exon            614..774
                     /gene="Cdh15"
                     /gene_synonym="Cdh14; Mcad"
                     /inference="alignment:Splign:2.1.0"
     exon            775..903
                     /gene="Cdh15"
                     /gene_synonym="Cdh14; Mcad"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1089
                     /gene="Cdh15"
                     /gene_synonym="Cdh14; Mcad"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1343
                     /gene="Cdh15"
                     /gene_synonym="Cdh14; Mcad"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1486
                     /gene="Cdh15"
                     /gene_synonym="Cdh14; Mcad"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1726
                     /gene="Cdh15"
                     /gene_synonym="Cdh14; Mcad"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1966
                     /gene="Cdh15"
                     /gene_synonym="Cdh14; Mcad"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..2103
                     /gene="Cdh15"
                     /gene_synonym="Cdh14; Mcad"
                     /inference="alignment:Splign:2.1.0"
     exon            2104..2268
                     /gene="Cdh15"
                     /gene_synonym="Cdh14; Mcad"
                     /inference="alignment:Splign:2.1.0"
     exon            2269..2843
                     /gene="Cdh15"
                     /gene_synonym="Cdh14; Mcad"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2818..2823
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdh15"
                     /gene_synonym="Cdh14; Mcad"
                     /note="hexamer: ATTAAA"
     polyA_site      2841
                     /gene="Cdh15"
                     /gene_synonym="Cdh14; Mcad"
                     /note="major polyA site"
ORIGIN      
        1 cttgcgctgt cactcagccc aatgctctca gcgtgggggt agaagaagca ccaccgcccg
       61 ttccaccggc cgcccagtcg gccacttgtc ctcggctctt ccgccactgc ctcaatgggt
      121 tctgctctgc tcctcgccct cgggctgctt gcccagagcc ttggcctgtc ctgggcagtc
      181 cctgagccca aacccagcac cctgtacccc tggcgccggg catcagcccc aggccgtgtg
      241 cggagagcct gggtcatccc acccattagt gtgtctgaga accacaaacg cctcccctac
      301 ccacttgtgc agatcaagtc tgacaaacag cagctaggca gtgtcatcta cagcatccag
      361 ggtcccggag tggatgagga gccccgaaat gtcttctcca tcgacaagtt caccgggagg
      421 gtgtacctca atgccacgct ggaccgcgag aagacggacc gcttcaggct aagggccttt
      481 gccttggact tgggtggctc taccctggag gaccccacgg acctggagat cgttgtggtg
      541 gatcaaaatg acaaccggcc agccttccta caggatgtgt tcagaggccg catcctggag
      601 ggtgccatcc caggcacctt cgtcaccagg gctgaggcca cagatgccga cgacccagag
      661 acagacaatg cagccctcag gttctccatc ctggagcagg gcagccctga gttcttcagc
      721 atcgacgagc acacgggaga gatccgcacg gtgcaagtgg ggctggaccg tgaggtggtg
      781 gctgtgtata atctgacctt gcaagtggca gacatgtcgg gagacggact cactgccaca
      841 gcctcggcca tcatctccat agatgacatc aacgacaatg cccccgagtt caccaaggat
      901 gagttcttta tggaggctgc agaggctgtc agtggagtgg acgtgggacg gctcgaggtg
      961 gaagacaagg acctgcctgg ttcccccaac tgggtggcca ggttcaccat ccttgaaggt
     1021 gatcctgatg ggcagttcaa gatctacaca gaccctaaga ccaatgaagg tgtgctgtcc
     1081 gtggtcaagc ccctggacta tgagagccgt gagcagtatg agctcagagt gtctgtacaa
     1141 aacgaggccc cgctgcaggc agctgcccct cgggctcggc ggggccagac cagggtcagc
     1201 gtgtgggttc aggacaccaa cgaagctcca gtgtttccag agaacccact gaggacgagc
     1261 atagctgaag gagccccccc aggcacctct gtggccacct tctctgccag agaccctgac
     1321 acagaacagc tgcagagaat cagctactcc aaagactacg acccagaaga ctggctgcaa
     1381 gtggacgggg ccacaggcag gatccagacc cagcgagtgc tgagccctgc ttcacccttt
     1441 ttgaaggacg gctggtacag agccatcatc ctagccctgg acaatgccat tcctcctagc
     1501 acagccacag gcaccctgtc catcgagatc ctagaagtca acgaccatgc ccctgcactg
     1561 gctcttcctc catctggcag cctgtgcagt gaaccagacc agggccctgg cctcctcttg
     1621 ggtgccacgg atgaggacct gcccccacac ggggcccctt tccacttcca gctgaacccc
     1681 agagtaccag atctgggccg gaactggagc gtcagccaga ttaacgtgag ccatgcacgc
     1741 ttgcggctcc gacatcaggt ctccgagggc ctgcatcgcc tgagcctgct actccaggac
     1801 tctggggagc caccccagca gcgagagcaa acgctgaacg tcaccgtgtg tcgctgtggg
     1861 tcggatggca cttgcctgcc cggggctgcc gcgcttcgag gaggaggtgt aggcgtcagc
     1921 ttgggggcac tggtcattgt gctggccagc accgtggtct tactagttct catcctgctt
     1981 gccgcgctcc gcacacggtt ccgggggcat tcccggggca agagtctgtt gcatggccta
     2041 caagaggacc ttcgggacaa catccttaac tatgatgagc aaggaggcgg ggaggaggac
     2101 caggatgcgt acgacataaa ccagctgcgc cacccagtgg agccgagggc cacaagtcgc
     2161 tctttgggca ggccacccct gcgcagggat gcccccttca gctatgtgcc acagccacat
     2221 cgagtgcttc ccaccagccc atctgacatt gccaacttca tcagtgatgg cttggaggct
     2281 gcggacagcg accccagcgt gcctccctac gacacagctc tcatctatga ctacgaggga
     2341 gatggctctg tggcagggac gctgagctcc attctgtcca gcctgggaga tgaagaccag
     2401 gactatgact acctccggga ctggggaccc cgctttgctc ggctggcgga catgtatgga
     2461 catcagtgag agccagggcc aagggcagat gtgctgtgtg gatacgccca cttggcccaa
     2521 ctaaggggct ctctcttggg atgtgcaccc agaaatccta tgagggtcaa cagcatggcc
     2581 catccttggc tccatggcag ataaactcaa ggaggtcatc tctgtgaggt ccaagagagg
     2641 actgagtcag gagtggtggg agaatctgga gcatggacta ggcagctaga gggagcactg
     2701 tcctggcaga gtgcagaagc cacccttagt cgccctgcta gggctcatcc catctttgat
     2761 tcccagttgt gactcttgcc tctgtatgaa aagcaggcgt ctaaagagtg gatttcaatt
     2821 aaaagcatac tatttggtgg atc
//
