LOCUS       NM_019707               3913 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus cadherin 13 (Cdh13), mRNA.
ACCESSION   NM_019707
VERSION     NM_019707.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3913)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3913)
  AUTHORS   Kang,H.S., Grimm,S.A., Liao,X.H. and Jetten,A.M.
  TITLE     GLIS3 expression in the thyroid gland in relation to TSH signaling
            and regulation of gene expression
  JOURNAL   Cell Mol Life Sci 81 (1), 65 (2024)
   PUBMED   38281222
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3913)
  AUTHORS   Popov,V.S., Brodsky,I.B., Balatskaya,M.N., Balatskiy,A.V.,
            Ozhimalov,I.D., Kulebyakina,M.A., Semina,E.V., Arbatskiy,M.S.,
            Isakova,V.S., Klimovich,P.S., Sysoeva,V.Y., Kalinina,N.I.,
            Tkachuk,V.A. and Rubina,K.A.
  TITLE     T-Cadherin Deficiency Is Associated with Increased Blood Pressure
            after Physical Activity
  JOURNAL   Int J Mol Sci 24 (18), 14204 (2023)
   PUBMED   37762507
  REMARK    GeneRIF: T-Cadherin Deficiency Is Associated with Increased Blood
            Pressure after Physical Activity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3913)
  AUTHORS   Fukuoka,K., Mineo,R., Kita,S., Fukuda,S., Okita,T.,
            Kawada-Horitani,E., Iioka,M., Fujii,K., Kawada,K., Fujishima,Y.,
            Nishizawa,H., Maeda,N. and Shimomura,I.
  TITLE     ER stress decreases exosome production through
            adiponectin/T-cadherin-dependent and -independent pathways
  JOURNAL   J Biol Chem 299 (9), 105114 (2023)
   PUBMED   37524131
  REMARK    GeneRIF: ER stress decreases exosome production through
            adiponectin/T-cadherin-dependent and -independent pathways.
REFERENCE   5  (bases 1 to 3913)
  AUTHORS   Guo,Q., Wang,Y., Wang,Q., Qian,Y., Jiang,Y., Dong,X., Chen,H.,
            Chen,X., Liu,X., Yu,S., Zhu,J., Shan,S., Wu,B., Zhou,W. and Wang,H.
  TITLE     In the developing cerebral cortex: axonogenesis, synapse formation,
            and synaptic plasticity are regulated by SATB2 target genes
  JOURNAL   Pediatr Res 93 (6), 1519-1527 (2023)
   PUBMED   36028553
REFERENCE   6  (bases 1 to 3913)
  AUTHORS   Huang,Z.Y., Wu,Y., Hedrick,N. and Gutmann,D.H.
  TITLE     T-cadherin-mediated cell growth regulation involves G2 phase arrest
            and requires p21(CIP1/WAF1) expression
  JOURNAL   Mol Cell Biol 23 (2), 566-578 (2003)
   PUBMED   12509455
  REMARK    GeneRIF: T-cadherin has a role in growth regulation involving
            p21(CIP1/WAF1) expression and G2 arrest
REFERENCE   7  (bases 1 to 3913)
  AUTHORS   Zhou,S., Matsuyoshi,N., Liang,S.B., Takeuchi,T., Ohtsuki,Y. and
            Miyachi,Y.
  TITLE     Expression of T-cadherin in Basal keratinocytes of skin
  JOURNAL   J Invest Dermatol 118 (6), 1080-1084 (2002)
   PUBMED   12060406
  REMARK    GeneRIF: Expression of T-cadherin in Basal keratinocytes of skin.
REFERENCE   8  (bases 1 to 3913)
  AUTHORS   Takeuchi,T., Misaki,A., Liang,S.B., Tachibana,A., Hayashi,N.,
            Sonobe,H. and Ohtsuki,Y.
  TITLE     Expression of T-cadherin (CDH13, H-Cadherin) in human brain and its
            characteristics as a negative growth regulator of epidermal growth
            factor in neuroblastoma cells
  JOURNAL   J Neurochem 74 (4), 1489-1497 (2000)
   PUBMED   10737605
REFERENCE   9  (bases 1 to 3913)
  AUTHORS   Kido,M., Obata,S., Tanihara,H., Rochelle,J.M., Seldin,M.F.,
            Taketani,S. and Suzuki,S.T.
  TITLE     Molecular properties and chromosomal location of cadherin-8
  JOURNAL   Genomics 48 (2), 186-194 (1998)
   PUBMED   9521872
REFERENCE   10 (bases 1 to 3913)
  AUTHORS   Munro,S.B., Duclos,A.J., Jackson,A.R., Baines,M.G. and
            Blaschuk,O.W.
  TITLE     Characterization of cadherins expressed by murine thymocytes
  JOURNAL   Cell Immunol 169 (2), 309-312 (1996)
   PUBMED   8620560
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM944611.1, AK048724.1,
            CX242668.1, CF735928.1, AV343697.2, AI550332.1 and BB075948.1.
            
            On Nov 7, 2015 this sequence version replaced NM_019707.4.
            
            Summary: This gene encodes a member of the cadherin family of
            calcium-dependent glycoproteins that mediate cell adhesion and
            regulate many morphogenetic events during development. The encoded
            preproprotein is further processed to generate a mature protein.
            This gene is highly expressed in the vasculature including
            endothelial cells, smooth muscle cells and pericytes, where the
            encoded protein binds to adiponectin and has been implicated in the
            modulation of angiogenesis. Multiple distinct genes of the cadherin
            family, including this gene, are found on chromosome 8. [provided
            by RefSeq, Nov 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK134649.1, SRR1660811.189232.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               BM944611.1         1-144
            145-2434            AK048724.1         1-2290
            2435-2746           CX242668.1         385-696
            2747-3194           CF735928.1         265-712
            3195-3731           AV343697.2         125-661
            3732-3910           AI550332.1         1-179               c
            3911-3913           BB075948.1         216-218
FEATURES             Location/Qualifiers
     source          1..3913
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 65.97 cM"
     gene            1..3913
                     /gene="Cdh13"
                     /gene_synonym="4932416G01Rik; Cdht; Tcad"
                     /note="cadherin 13"
                     /db_xref="GeneID:12554"
                     /db_xref="MGI:MGI:99551"
     exon            1..288
                     /gene="Cdh13"
                     /gene_synonym="4932416G01Rik; Cdht; Tcad"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..2388
                     /gene="Cdh13"
                     /gene_synonym="4932416G01Rik; Cdht; Tcad"
                     /EC_number="3.6.1.3"
                     /note="H-cadherin; heart cadherin; T-cadherin"
                     /codon_start=1
                     /product="cadherin-13 preproprotein"
                     /protein_id="NP_062681.2"
                     /db_xref="CCDS:CCDS52682.1"
                     /db_xref="GeneID:12554"
                     /db_xref="MGI:MGI:99551"
                     /translation="MQPRTPLTLCVLLSQVLLVTSADDLECTPGFQRKVLHIHQPAEF
                     IEDQPVLNLTFNDCKGNEKLHYEVSSPHFKVNSDGTLVALRNITAVGRTLFVHARTPH
                     AEDMAELVIVGGKDIQGSLQDIFKFARTSPVPRQKRSIVVSPILIPENQRQPFPRDVG
                     KVVDSDRPEGSKFRLTGKGVDQDPKGTFRINENTGSVSVTRTLDRETIATYQLYVETT
                     DASGKTLEGPVPLEVIVIDQNDNRPIFREGPYIGHVMEGSPTGTTVMRMTAFDADDPA
                     TDNALLRYNIRQQTPDKPSPNMFYIDPEKGDIVTVVSPALLDRETLENPKYELIIEAQ
                     DMAGLDVGLTGTATATIVIDDKNDHSPKFTKKEFQATVEEGAVGVIVNLTVEDKDDPT
                     TGAWRAAYTIINGNPGQSFEIHTNPQTNEGMLSVVKPLDYEISAFHTLLIKVENEDPL
                     VPDVSYGPSSTATVHITVLDVNEGPVFYPDPMMVTKQENISVGSVLLTVNATDPDSLQ
                     HQTIRYSIYKDPAGWLSINPINGTVDTTAVLDRESPFVHNSVYTALFLAIDSGNPPAT
                     GTGTLLITLEDINDNAPVIYPTVAEVCDDARNLSVVILGASDKDLHPNTDPFKFEIHK
                     QTVPDKVWKISKINNTHALVSLLQNLNKANYNLPIMVTDSGKPPMTNITDLRVQVCSC
                     KNSKVDCNGAGALHLSLSLLLLFSLLSLLSGL"
     exon            289..400
                     /gene="Cdh13"
                     /gene_synonym="4932416G01Rik; Cdht; Tcad"
                     /inference="alignment:Splign:2.1.0"
     exon            401..609
                     /gene="Cdh13"
                     /gene_synonym="4932416G01Rik; Cdht; Tcad"
                     /inference="alignment:Splign:2.1.0"
     exon            610..726
                     /gene="Cdh13"
                     /gene_synonym="4932416G01Rik; Cdht; Tcad"
                     /inference="alignment:Splign:2.1.0"
     exon            727..879
                     /gene="Cdh13"
                     /gene_synonym="4932416G01Rik; Cdht; Tcad"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1024
                     /gene="Cdh13"
                     /gene_synonym="4932416G01Rik; Cdht; Tcad"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1203
                     /gene="Cdh13"
                     /gene_synonym="4932416G01Rik; Cdht; Tcad"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1344
                     /gene="Cdh13"
                     /gene_synonym="4932416G01Rik; Cdht; Tcad"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1527
                     /gene="Cdh13"
                     /gene_synonym="4932416G01Rik; Cdht; Tcad"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1781
                     /gene="Cdh13"
                     /gene_synonym="4932416G01Rik; Cdht; Tcad"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1924
                     /gene="Cdh13"
                     /gene_synonym="4932416G01Rik; Cdht; Tcad"
                     /inference="alignment:Splign:2.1.0"
     exon            1925..2158
                     /gene="Cdh13"
                     /gene_synonym="4932416G01Rik; Cdht; Tcad"
                     /inference="alignment:Splign:2.1.0"
     exon            2159..2380
                     /gene="Cdh13"
                     /gene_synonym="4932416G01Rik; Cdht; Tcad"
                     /inference="alignment:Splign:2.1.0"
     exon            2381..3913
                     /gene="Cdh13"
                     /gene_synonym="4932416G01Rik; Cdht; Tcad"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3437..3442
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdh13"
                     /gene_synonym="4932416G01Rik; Cdht; Tcad"
                     /note="hexamer: AATAAA"
     polyA_site      3456
                     /gene="Cdh13"
                     /gene_synonym="4932416G01Rik; Cdht; Tcad"
                     /note="major polyA site"
     regulatory      3887..3892
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdh13"
                     /gene_synonym="4932416G01Rik; Cdht; Tcad"
                     /note="hexamer: AATAAA"
     polyA_site      3911
                     /gene="Cdh13"
                     /gene_synonym="4932416G01Rik; Cdht; Tcad"
ORIGIN      
        1 ctcgccccta tctgccatgc aaaacgaggg agcgttatga aggaatccgt cttgtaaagc
       61 cattggtcct ggtcatcagc cgctacccaa tgctttcgcg atgctgccgc tgatctattt
      121 gggaagttgg ctggctggcg aggcagagcc tctcctcaaa ggctggctcc cacggaaaat
      181 atgctcagtg cagccgcgtg tgtgaatgca aacgccgcca ggcgcttctt ctagtcgggc
      241 aagatgcagc cgagaactcc gctcaccctg tgcgtcctgc tgtcccaggt gctcctggtc
      301 acgtctgcag atgatctgga gtgcacccct ggattccagc ggaaagtgtt acacatccac
      361 cagcctgccg aattcatcga ggaccagcct gtcctaaact tgaccttcaa tgactgcaag
      421 ggcaacgaga agctgcacta cgaggtctca agcccacact tcaaggtgaa cagcgacggc
      481 accttagtgg ctctcaggaa catcactgcg gtgggcagga ccctgtttgt ccatgcgagg
      541 actcctcatg ctgaagacat ggcagaactc gtgattgtcg ggggcaaaga catccagggc
      601 tccttgcagg atatctttaa atttgcaagg acatctcctg tcccaagaca aaagaggtcc
      661 attgtggtgt cccccatctt gatcccagag aaccagagac agcccttccc cagagatgtc
      721 ggcaaggtag tcgatagcga cagacccgaa gggtccaagt tccggctcac cgggaaggga
      781 gtggatcaag accctaaagg aactttcaga atcaatgaga acacaggcag tgtctccgtg
      841 acacggaccc tggacagaga aacgatcgct acttatcaac tgtatgtgga aaccacggat
      901 gccagtggca aaactctgga agggccagtg cctctggaag tcattgtgat tgaccagaac
      961 gacaacagac ccatcttccg ggaaggccct tacatcggcc atgtcatgga agggtcaccc
     1021 acagggacca cggtgatgcg gatgacagcg tttgatgcag atgacccggc tactgacaat
     1081 gctctcctga ggtacaacat ccgtcagcag acgcctgaca agccatctcc taacatgttc
     1141 tacatcgatc ccgagaaagg agacattgtc accgtggtgt cacctgcgct gctggaccgg
     1201 gagactctgg aaaaccccaa gtatgaactg atcatcgaag ctcaagatat ggcaggattg
     1261 gatgtcggac tgacaggcac agccacagcc accatcgtga tcgatgacaa aaatgatcac
     1321 tcaccaaaat tcaccaagaa agagtttcaa gccacagtgg aggagggagc tgtgggggtc
     1381 attgtcaact tgacagtgga agacaaagac gaccctacca caggagcctg gagggctgca
     1441 tacaccatca tcaatggaaa tcctgggcag agcttcgaga tccacaccaa cccacagacc
     1501 aacgagggca tgctctctgt ggtcaagccc ctggactatg agatctctgc ctttcacacc
     1561 ctgctgatca aagtggagaa tgaggaccca ctggtacccg acgtctccta tggccccagc
     1621 tccacggcaa ctgtccacat cacagtcctg gatgtcaacg agggaccagt cttctacccg
     1681 gaccccatga tggtgactaa acaggagaac atctctgtgg gcagtgtgct gctgacagtg
     1741 aatgccacag acccagactc cctgcaacat caaactatca ggtactctat ctacaaggac
     1801 ccagcaggct ggctgagtat caaccccatc aatggaacgg tggacaccac agctgtgttg
     1861 gaccgggagt ccccattcgt ccacaacagt gtgtacacgg ccctgttcct ggccatcgac
     1921 agtggcaacc ctcctgcaac tggcaccggg actctgctga taaccctaga ggacattaat
     1981 gacaacgctc ctgtcattta cccaactgtg gctgaggtct gcgatgatgc cagaaacctc
     2041 agcgtggtca ttctgggggc ttcggacaag gaccttcacc ccaacacaga ccccttcaag
     2101 tttgagattc ataaacagac agtccctgat aaagtctgga agatctccaa aatcaacaac
     2161 acccacgccc tcgtgagcct tcttcagaat ctgaacaagg caaactacaa cctgcccatc
     2221 atggtgacag attcagggaa gccacccatg acgaacatca cggacctcag ggtgcaggtg
     2281 tgctcttgca agaactccaa agtggactgc aacggggctg gggccctgca cctcagcctc
     2341 agcttgctgc tgctcttctc tctcctcagc ttattgtcag gtctgtgaga acgacacgcc
     2401 tgaagcttga ctcccaagtt gccatagcaa caggaaaaag aaaaaaaaaa aaacaggaaa
     2461 aaaaaaaagt ctatccaaat ctgaagattg ccgtttacag ctctcaaact tcacaaccag
     2521 gcctcaactg cccctcaccc tccgttttct ttgcagtttc atttaatctg tacctcacca
     2581 attgacagca tcttcctgcc tcctttgatt aatggaaccc tctggatttg ccctgaatgt
     2641 ttaaagatca tgcgtgtcac tggaccttag ggagcaggaa caatgactac tttttctgat
     2701 gtgtccacat gttgctagcc agtgctccgc ccacgcatct gtgtggtggg ttcctatctg
     2761 tccctgtatg ggtatctgtc tgtgtataga cccagtattt gtgtagaaga ctgcaggaga
     2821 tacctgcttt ggagatggtt agacagagga tgtggacgct cagacagctc cgccctccag
     2881 tcaaggtcag tccagtaagc tgtctgtcac tcacgtgtat agcaagggcc tgctcagtct
     2941 aaacactgaa tgctgaccaa ccagctaggc aggtccagag gttgggggtg ggggaagggc
     3001 aaggggaaga agtcttctct gcttagtagg actgccacca cgccccagta ccaccagatg
     3061 ccatggcttg atgtccttat gcccaagagt ggagcaaggc atcttgccat cagaggctaa
     3121 gggctgaact attctcccat gggcaagtct gccactgtac caccccagac ccacagtcct
     3181 atggtccttg tggtgacaca gatcatggtg gtggccctct ccctcctcgg tgtatgtaca
     3241 agtacaaatg tcatcatggt gtacctatga ggagaccaac agcaccatct tgtatgcaca
     3301 tctattaccc acacatgtac acacgcatta cgcatatccg caccgtttgt ttcctatata
     3361 caggcataaa atagagtaag cccaggtagt ttttcaagta cccttccgtg tgactaccgt
     3421 tgttcgcaaa gctgagaata aaaaagttgt tcattatgtc tggaaaggaa ttcagttttg
     3481 tcctgtgagc atgtcaggtt aagaagaaca tcacggctcc cactagggta accttcccat
     3541 tgacaaaccg taaatgaacc atcaaagctc acaccaaaat gttttctaag gaatgaagat
     3601 agtgccggcc tggggcttca gagcccagca ggagctaggg taaggtaagg taagtgtctt
     3661 ggtatatttt aatgctgtgg cttactaaag gtttcaaccc cacacacagt ggcacaaaca
     3721 tgctttctac tgcagtctgt gtcgccccgt gcttttgagt ttgccttccg ccaccagtag
     3781 ggtcatatgt cgtctgttgt agtgagatta cgtaggcaga gatccacacg ctgctcttcg
     3841 cttctgtttt ggaccataca gaatgcagag attttttttt cattaaaata aatgggtatc
     3901 agtggttaaa act
//
