LOCUS       NM_001008420            5666 bp    mRNA    linear   ROD 19-DEC-2022
DEFINITION  Mus musculus cadherin 12 (Cdh12), mRNA.
ACCESSION   NM_001008420 XM_139351
VERSION     NM_001008420.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5666)
  AUTHORS   Polanco J, Reyes-Vigil F, Weisberg SD, Dhimitruka I and Bruses JL.
  TITLE     Differential Spatiotemporal Expression of Type I and Type II
            Cadherins Associated With the Segmentation of the Central Nervous
            System and Formation of Brain Nuclei in the Developing Mouse
  JOURNAL   Front Mol Neurosci 14, 633719 (2021)
   PUBMED   33833667
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5666)
  AUTHORS   Vagnozzi AN, Garg K, Dewitz C, Moore MT, Cregg JM, Jeannotte L,
            Zampieri N, Landmesser LT and Philippidou P.
  TITLE     Phrenic-specific transcriptional programs shape respiratory motor
            output
  JOURNAL   Elife 9, e52859 (2020)
   PUBMED   31944180
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5666)
  AUTHORS   Narayanan R, Pham L, Kerimoglu C, Watanabe T, Castro Hernandez R,
            Sokpor G, Ulmke PA, Kiszka KA, Tonchev AB, Rosenbusch J, Seong RH,
            Teichmann U, Frahm J, Fischer A, Bonn S, Stoykova A, Staiger JF and
            Tuoc T.
  TITLE     Chromatin Remodeling BAF155 Subunit Regulates the Genesis of Basal
            Progenitors in Developing Cortex
  JOURNAL   iScience 4, 109-126 (2018)
   PUBMED   30240734
REFERENCE   4  (bases 1 to 5666)
  AUTHORS   Bibollet-Bahena O, Okafuji T, Hokamp K, Tear G and Mitchell KJ.
  TITLE     A dual-strategy expression screen for candidate connectivity labels
            in the developing thalamus
  JOURNAL   PLoS One 12 (5), e0177977 (2017)
   PUBMED   28558017
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5666)
  AUTHORS   Duan X, Krishnaswamy A, De la Huerta I and Sanes JR.
  TITLE     Type II cadherins guide assembly of a direction-selective retinal
            circuit
  JOURNAL   Cell 158 (4), 793-807 (2014)
   PUBMED   25126785
REFERENCE   6  (bases 1 to 5666)
  AUTHORS   Oeschger FM, Wang WZ, Lee S, Garcia-Moreno F, Goffinet AM, Arbones
            ML, Rakic S and Molnar Z.
  TITLE     Gene expression analysis of the embryonic subplate
  JOURNAL   Cereb Cortex 22 (6), 1343-1359 (2012)
   PUBMED   21862448
REFERENCE   7  (bases 1 to 5666)
  AUTHORS   Lefkovics K, Mayer M, Bercsenyi K, Szabo G and Lele Z.
  TITLE     Comparative analysis of type II classic cadherin mRNA distribution
            patterns in the developing and adult mouse somatosensory cortex and
            hippocampus suggests significant functional redundancy
  JOURNAL   J Comp Neurol 520 (7), 1387-1405 (2012)
   PUBMED   22102170
REFERENCE   8  (bases 1 to 5666)
  AUTHORS   Demireva EY, Shapiro LS, Jessell TM and Zampieri N.
  TITLE     Motor neuron position and topographic order imposed by beta- and
            gamma-catenin activities
  JOURNAL   Cell 147 (3), 641-652 (2011)
   PUBMED   22036570
REFERENCE   9  (bases 1 to 5666)
  AUTHORS   Mayer M, Bercsenyi K, Geczi K, Szabo G and Lele Z.
  TITLE     Expression of two type II cadherins, Cdh12 and Cdh22 in the
            developing and adult mouse brain
  JOURNAL   Gene Expr Patterns 10 (7-8), 351-360 (2010)
   PUBMED   20723620
  REMARK    GeneRIF: spatio-temporal mRNA distribution pattern of Cdh12 and
            Cdh22 during CNS development; demonstrate presence of Cdh12 and
            Cdh22 mRNA in both excitatory and inhibitory neurons in adult CNS
            including cerebellum, neocortex, hippocampus and subcortical nuclei
REFERENCE   10 (bases 1 to 5666)
  AUTHORS   Selig S, Lidov HG, Bruno SA, Segal MM and Kunkel LM.
  TITLE     Molecular characterization of Br-cadherin, a developmentally
            regulated, brain-specific cadherin
  JOURNAL   Proc Natl Acad Sci U S A 94 (6), 2398-2403 (1997)
   PUBMED   9122206
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC086655.1.
            
            [WARNING] On Jan 25, 2024 this sequence was replaced by
            NM_001008420.3.
            
            On Nov 15, 2007 this sequence version replaced NM_001008420.1.
            
            Summary: This gene encodes a member of the cadherin family of
            calcium-dependent glycoproteins that mediate cell adhesion and
            regulate many morphogenetic events during development. The encoded
            preproprotein is further processed to generate a mature protein.
            This gene is expressed in both the excitatory and inhibitory
            neurons in various areas of the adult central nervous system
            including the cerebellum, neocortex, hippocampus and in different
            subcortical nuclei. Multiple distinct genes of the cadherin family,
            including this gene, are found on chromosome 15. [provided by
            RefSeq, Nov 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086655.1, SRR9219382.164162.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3336              BC086655.1         1-3336
            3337-5666           BC086655.1         3338-5667
FEATURES             Location/Qualifiers
     source          1..5666
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 8.25 cM"
     gene            1..5666
                     /gene="Cdh12"
                     /gene_synonym="Cdhb"
                     /note="cadherin 12"
                     /db_xref="GeneID:215654"
                     /db_xref="MGI:MGI:109503"
     exon            1..28
                     /gene="Cdh12"
                     /gene_synonym="Cdhb"
                     /inference="alignment:Splign:2.1.0"
     exon            29..433
                     /gene="Cdh12"
                     /gene_synonym="Cdhb"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..2587
                     /gene="Cdh12"
                     /gene_synonym="Cdhb"
                     /note="Br-cadherin"
                     /codon_start=1
                     /product="cadherin-12 preproprotein"
                     /protein_id="NP_001008420.1"
                     /db_xref="CCDS:CCDS27396.1"
                     /db_xref="GeneID:215654"
                     /db_xref="MGI:MGI:109503"
                     /translation="MLTRNSLYLLLWILFDGGLLTPLQPQPQQTLATEPKENVIHLSG
                     RRSHFQRVKRGWVWNQFFVLEEYMGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAGTVF
                     TIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKF
                     LDGPYVASVPEMSPVGAYVLQVKATDADDPTYGNSARVVYSILQGQPYFSIDPKTGVI
                     RTALPNMDREVKEQYQVLIQAKDMGGQLGGLAGTTVVNITLTDVNDNPPRFPKSIFHL
                     KVPESSPVGSAIGRIRAVDPDFGKNAEIEYNIVPGDGGNLFDIVTDEDTQEGIIKLKK
                     PLDFETKKAYTFKVEASNLHLDHRFHSAGPFKDTATVKISVLDVDEPPVFSKPLYTME
                     VYEDTPVGTIIGAVTAQDLDVGSSAVRYFIDWKSDGESYFTIDGTEGTIATNELLDRE
                     NMAQYNFSIIASKVSNPLLTSKVNILINVLDVNEFPPEISVPYETAVCENAKPGQIIQ
                     IVGAVDRDLSPAGQQFSFRLAPEAVIKPNFTVHDFRNNTAGIETRRNGYSRRQQELYF
                     LPIVIEDSSYPVQSSTNTMTIRVCRCDSDGTILSCNVEAIFLPVGLSTGALIAILLCM
                     VILLAIVVLYVALRRQRKKDTLMTSKEDIRDNVIHYDDEGGGEEDTQAFDIGALRNPK
                     VIEENKIRRDIKPDSLCLSRQRPQVEDNTDIRDFIHRRLQENDADPAAPPYDSLATYA
                     YEGNGSVAESLSSIDSLTTEADQDYDYLSDWGPRFKVLADMFGEEESYNPDNVT"
     exon            434..728
                     /gene="Cdh12"
                     /gene_synonym="Cdhb"
                     /inference="alignment:Splign:2.1.0"
     exon            729..848
                     /gene="Cdh12"
                     /gene_synonym="Cdhb"
                     /inference="alignment:Splign:2.1.0"
     exon            849..1016
                     /gene="Cdh12"
                     /gene_synonym="Cdhb"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1204
                     /gene="Cdh12"
                     /gene_synonym="Cdhb"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1458
                     /gene="Cdh12"
                     /gene_synonym="Cdhb"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1595
                     /gene="Cdh12"
                     /gene_synonym="Cdhb"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1717
                     /gene="Cdh12"
                     /gene_synonym="Cdhb"
                     /inference="alignment:Splign:2.1.0"
     exon            1718..1835
                     /gene="Cdh12"
                     /gene_synonym="Cdhb"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..2087
                     /gene="Cdh12"
                     /gene_synonym="Cdhb"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..5639
                     /gene="Cdh12"
                     /gene_synonym="Cdhb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttgatcacc gagagtattt caattaaggt ctccttagat ggaatgtcat aaaccagaaa
       61 cttccaaagc atcaatgtgt gaattcctgt ccctgcacta aaccagaaag cccagcgatc
      121 agacacctca accctggatc ccacgactct acattaaata ctggagtatt tattactctt
      181 ctgtaggaga aagcctttgc caatgcttac aaggaactct ttatacctgc ttctctggat
      241 cctgtttgat ggaggtctcc taacaccact tcagccacag ccccaacaga ctttagccac
      301 agaaccaaaa gaaaatgtta tccacctttc ggggagacga tcccatttcc aacgagttaa
      361 acgtggctgg gtatggaatc agttttttgt gctggaagag tacatgggct ccgaacctca
      421 atatgtgggg aagctgcatt cggacttgga taaaggagag ggcactgtta aatacacgct
      481 ctccggagat ggtgctggca ctgtttttac aattgatgaa actacaggag acattcatgc
      541 aataagaagc ctggatagag aagaaaaacc tttctacact cttcgtgctc aggcagtgga
      601 catagaaacc aggaagccac tggagcctga atcagagttc atcattaaag tgcaggatat
      661 taatgacaat gaaccaaagt ttttggatgg accttatgtt gctagtgttc cagaaatgtc
      721 tcctgtgggt gcgtatgtgc tgcaggtgaa ggccacagat gcagacgatc ctacctatgg
      781 gaacagtgcc agagttgttt acagcatcct tcaggggcaa ccttatttct ctattgatcc
      841 caaaacaggt gtcattagaa cagcattgcc aaacatggac agagaagtca aagagcagta
      901 ccaggtcctc attcaagcga aagacatggg aggacagctc ggaggacttg ctggaactac
      961 agttgtcaac atcaccctta ctgatgtcaa tgacaaccca cctcgcttcc caaaaagcat
     1021 cttccatctg aaagttcccg agtcttcccc tgttggctca gctattggaa gaataagagc
     1081 agtagatcct gattttggaa aaaatgcaga aattgaatac aacattgtcc caggagatgg
     1141 gggaaatttg tttgacattg tcacagatga ggatacacaa gaaggaatca tcaaattgaa
     1201 aaagccttta gattttgaaa ccaagaaggc atatactttt aaagtagagg cctccaacct
     1261 tcaccttgac caccgctttc actctgctgg gccatttaag gatactgcta cagtaaaaat
     1321 cagcgtgctg gatgtggatg agccaccagt gttcagcaaa ccactgtaca ccatggaggt
     1381 ttatgaagac actcctgtgg ggaccatcat cggagctgtc acagcacaag accttgatgt
     1441 gggcagtagt gctgttaggt acttcataga ttggaagagt gatggggaga gctactttac
     1501 aatagatgga acggaaggaa ccatcgccac taatgaatta ctagacagag agaacatggc
     1561 gcagtataat ttctccataa ttgcaagtaa agttagtaac ccattattaa ctagcaaagt
     1621 taacatacta attaatgtcc tagatgtcaa tgaatttcct ccagaaatat ctgtgccata
     1681 tgagacagct gtatgtgaga atgccaagcc aggacagata attcagatag ttggtgctgt
     1741 agaccgagat ctctcacctg ctgggcagca attctccttt agattagcac cagaggctgt
     1801 catcaaacca aattttacag tccatgactt cagaaacaac acagctggaa tcgaaacccg
     1861 aagaaatggc tatagccgca ggcagcagga gttgtatttc cttcccattg taatagaaga
     1921 cagcagttat cctgtccaga gcagcacgaa tacaatgact attcgtgttt gtaggtgtga
     1981 ctcagatggg accatcctgt cttgcaacgt ggaagcaatt tttctacctg taggactcag
     2041 cactggagct ttgattgcaa tcctactatg catggttata ctcttagcta ttgttgtgct
     2101 gtatgtagca ctgaggaggc agaggaagaa agacaccctt atgacctcta aagaagacat
     2161 cagagacaat gtcatccatt atgacgatga aggaggtggg gaggaggaca cccaggcctt
     2221 tgacatcggg gctctgagaa atcccaaggt gatcgaagag aacaaaattc gcagggatat
     2281 aaaaccagac tccctctgtt tatctcgtca aagaccacaa gtggaagaca acacagacat
     2341 aagggatttt attcaccgaa ggctacagga aaatgacgca gacccagcgg ctccaccata
     2401 cgattccttg gccacttatg cgtatgaggg gaatggctca gtggcagaat cactcagctc
     2461 catagactct ctcaccacag aagccgacca ggactatgac tatctatcag actggggacc
     2521 ccgctttaag gtcttggcag acatgtttgg agaagaagag agttacaacc ccgacaatgt
     2581 tacctagggg aaaaggaaag gctgatacac atctagagga gaaagttttg acaaaaataa
     2641 cacagataaa acacaatcac acacatacac acacacacac acacacacac acacactccc
     2701 agattttgca ggacaagact ttttttgatt atccagcttc taacaagttg ctctatttat
     2761 catattgtca ttttggttta ttatgtaggc acaaggtaaa tcctatgata tgtacttgct
     2821 ttgttttgtt ttgttatttc agaaacacac tgagacgagc tcaggcctat taaatgcaat
     2881 tcactgacat gacaacctag aatgaagata gctatgtggc gtcacggtgg aagagtgtat
     2941 gatttttctt aattccacta aagtgcctat tgaaactctt atccttatag tggtgttcat
     3001 aacactccgc tgtggtggct tgtcaggagt cgaaaataag gaggaagaaa gcagacagtg
     3061 tctctacgtc aagaagcaat agtgacatgc tgactctcag ttcttttaag aacagagaat
     3121 gcttcccaaa ctctatcttc ttatacagca aagcttttcc ttttgtaaat tgcaaactaa
     3181 aacagaaagg cttttccaat cctttcagaa actgggataa atgagacatt actaaattcc
     3241 atatgtaagt tatgatttct aagagtgatg cttaagtcat agcattcatt catgtgaaag
     3301 atgttaatta aggtgttagt ttttccaaaa aaaaaagaaa aaacaaataa aattatactg
     3361 aaggaaataa aaagaatccc tctttataaa gagaggcctc ggggctcaaa ttccaacatc
     3421 aaataaatat cggtttgttt aattctatgc tggtatatgg acattggttt taacaagtca
     3481 ttaaataagt taagctttca gtgatagatt aaaatttcag cttgtgtttc tactgaagtt
     3541 tctgaaagga aataaattat taatttaaac atgagaaaat tcaacattgt cattctcaga
     3601 gtttctatct agtggttctt tgatgaatga ttcaaacaaa atgcatatca aatactgtaa
     3661 tttataacaa gtatatatgc ttgttctata ctactgaaca ataagtcagg gacttcaaaa
     3721 ataaaaccaa tgactaaaat cccaaaggga acaaaacttc aatgccgggc agctgattca
     3781 ctttctctag tgatgcggat tttatcatta tgaactcagt tattgtatca gcccagagtc
     3841 acctcttcat tatctcatct acaaatatcc tcatgtaaat tactccttgt aactcttcag
     3901 ataaaatgtc tccactttat cgaaatgtct aagtgatgat ataattcatg actatattag
     3961 taataaacat tgttcacatc aattcaatag gaattataca tcatttagac attcacagga
     4021 tacaacaaat gcaaatttac cataaagtaa tatctattct taacaatgta gttggaataa
     4081 cgaacaactt ctacctatga acacgttgga aaaaattaaa gttaaagagc tgtgaatcac
     4141 atatcactaa tgtctaattt tataataaat ttctgtgact atcattatta tttgtgcggc
     4201 tatagagata aaactcacac actatggaat ctaagaaatt tacaaaatta gacaacttaa
     4261 ttttaggcat attctaaaat gcatatttta aattatttac ggtatagaaa tattacccct
     4321 tgtttctatg ttcaccattt ttagactctt tttctccatt ttggaatggg agattcaatt
     4381 tttgttttca gtcatcactc catacctctc ttgttccaat tttcatgtaa taaacaaatg
     4441 tatttagtac tttacatttg agaaaaatca cttataattg ccatgctaga gaagaaaaat
     4501 taatgacttg tttcttattt cattatgtac agataatgtc ttcttgaaga agaccacaca
     4561 ctattaagac ctgattcttg tcaaaaacta ttacactttg tatcttgaca agaaataaaa
     4621 taaccttctc atgaagttgc tagcagaagc catgataacc tagagatttg agaggctgat
     4681 gattttaaac cacatgacta tgaagatagt aaaatatgca atgtgtggct cttagttctc
     4741 atcacactca tatctttgta ataccctaca ttacttcatc agctcaaaac aaatgttcac
     4801 agacaaagtg aataacaaca gtttatttcc tcagctctga tggcaggttt cctcttacca
     4861 tcttctcctg gtagtggaga acattacctt ttctttccca cttcttctca tttctgtgct
     4921 tatttctgtt tctcttctca taaggacgat cttcatatta gagcagcatc tacccacagg
     4981 tcctctgttt gccttgttta ataataaagg ccttaccacc aagtcctatt tggtttggta
     5041 ctaccgcatg tggattcatg caatcccaat ctcaatatat taacagtgtt tattttctaa
     5101 atagcatttt agttacaaca atcaatgaaa gaaacataaa caagcagaat gataaaagta
     5161 atatatgatg tggaaaggag atcctttggt gcttataatt agaggaacta tggtatcttt
     5221 taggctactg aaaggactta gcccagtatt tcaatgcctg taataccttg ggaagttttt
     5281 ttgttgttgt tgttcataaa acaggtgttg accttcattc aagcattaag caatataaaa
     5341 atatttaaaa tttgtatgaa tgattttagc tatatacaaa cagcaatttt gttattggcg
     5401 tgcatgtcta tctttataga gatacatatg tacatgtata tatataaaac ttatatgttg
     5461 ccttcaatgc tactcaaaga agtgtatagt cagcatccaa aagtgaagca gtgttgattg
     5521 atgtactaaa gataatctgt gtgttttgaa ccattccccc ctttgactga aaacttccta
     5581 tggatcaaat tacttggcct tcattctttt attttcttta gtaaaaccag tttcctataa
     5641 aaaaaaaaaa aaaaaaaaaa aaaaaa
//
