LOCUS       NM_009866               5080 bp    mRNA    linear   ROD 08-AUG-2024
DEFINITION  Mus musculus cadherin 11 (Cdh11), transcript variant 1, mRNA.
ACCESSION   NM_009866
VERSION     NM_009866.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5080)
  AUTHORS   Huycke,T.R., Hakkinen,T.J., Miyazaki,H., Srivastava,V., Barruet,E.,
            McGinnis,C.S., Kalantari,A., Cornwall-Scoones,J., Vaka,D., Zhu,Q.,
            Jo,H., Oria,R., Weaver,V.M., DeGrado,W.F., Thomson,M.,
            Garikipati,K., Boffelli,D., Klein,O.D. and Gartner,Z.J.
  TITLE     Patterning and folding of intestinal villi by active mesenchymal
            dewetting
  JOURNAL   Cell 187 (12), 3072-3089 (2024)
   PUBMED   38781967
REFERENCE   2  (bases 1 to 5080)
  AUTHORS   Chavula,T., To,S., Smith,J., Pedroza,M., Nimri,J., Devaraj,S.,
            Wenderfer,S., Vogel,T.P. and Agarwal,S.K.
  TITLE     CADHERIN-11 regulation of myeloid phagocytes and autoimmune
            inflammation in murine lupus
  JOURNAL   J Autoimmun 145, 103197 (2024)
   PUBMED   38447248
  REMARK    GeneRIF: CADHERIN-11 regulation of myeloid phagocytes and
            autoimmune inflammation in murine lupus.
REFERENCE   3  (bases 1 to 5080)
  AUTHORS   Hou,M., Luo,F., Ding,Y., Bao,X., Chen,X., Liu,L. and Wu,M.
  TITLE     Let-7c-3p suppresses lens epithelial-mesenchymal transition by
            inhibiting cadherin-11 expression in fibrotic cataract
  JOURNAL   Mol Cell Biochem 479 (4), 743-759 (2024)
   PUBMED   37171723
  REMARK    GeneRIF: Let-7c-3p suppresses lens epithelial-mesenchymal
            transition by inhibiting cadherin-11 expression in fibrotic
            cataract.
REFERENCE   4  (bases 1 to 5080)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 5080)
  AUTHORS   Stavely,R., Hotta,R., Guyer,R.A., Picard,N., Rahman,A.A., Omer,M.,
            Soos,A., Szocs,E., Mueller,J., Goldstein,A.M. and Nagy,N.
  TITLE     A distinct transcriptome characterizes neural crest-derived cells
            at the migratory wavefront during enteric nervous system
            development
  JOURNAL   Development 150 (5) (2023)
   PUBMED   36779913
REFERENCE   6  (bases 1 to 5080)
  AUTHORS   Marie,P.J., Hay,E., Modrowski,D., Revollo,L., Mbalaviele,G. and
            Civitelli,R.
  TITLE     Cadherin-mediated cell-cell adhesion and signaling in the skeleton
  JOURNAL   Calcif Tissue Int 94 (1), 46-54 (2014)
   PUBMED   23657489
  REMARK    Review article
REFERENCE   7  (bases 1 to 5080)
  AUTHORS   Kimura,Y., Matsunami,H., Inoue,T., Shimamura,K., Uchida,N.,
            Ueno,T., Miyazaki,T. and Takeichi,M.
  TITLE     Cadherin-11 expressed in association with mesenchymal morphogenesis
            in the head, somite, and limb bud of early mouse embryos
  JOURNAL   Dev Biol 169 (1), 347-358 (1995)
   PUBMED   7750650
REFERENCE   8  (bases 1 to 5080)
  AUTHORS   Hoffmann,I. and Balling,R.
  TITLE     Cloning and expression analysis of a novel mesodermally expressed
            cadherin
  JOURNAL   Dev Biol 169 (1), 337-346 (1995)
   PUBMED   7750649
REFERENCE   9  (bases 1 to 5080)
  AUTHORS   Hoffman,I. and Balling,R.
  TITLE     Chromosomal localization of the murine cadherin-11
  JOURNAL   Mamm Genome 6 (4), 304 (1995)
   PUBMED   7613040
REFERENCE   10 (bases 1 to 5080)
  AUTHORS   Okazaki,M., Takeshita,S., Kawai,S., Kikuno,R., Tsujimura,A.,
            Kudo,A. and Amann,E.
  TITLE     Molecular cloning and characterization of OB-cadherin, a new member
            of cadherin family expressed in osteoblasts
  JOURNAL   J Biol Chem 269 (16), 12092-12098 (1994)
   PUBMED   8163513
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC141869.5 and AC105256.7.
            
            On Feb 2, 2023 this sequence version replaced NM_009866.5.
            
            Summary: This gene encodes a type II classical cadherin and
            preproprotein that is proteolytically processed to generate a
            mature protein product. This protein product is an integral
            membrane protein that mediates calcium-dependent cell-cell
            adhesion, specifically in the context of bone development.
            Homozygous knockout mice for this gene exhibit impaired synovium
            development and reduced bone density. Multiple pseudogenes of this
            gene have been identified in the genome. [provided by RefSeq, Aug
            2015].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049652.1, BC046314.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-184               AC141869.5         17594-17777
            185-302             AC141869.5         82143-82260
            303-702             AC141869.5         122662-123061
            703-997             AC141869.5         128567-128861
            998-1117            AC141869.5         132501-132620
            1118-1285           AC141869.5         134508-134675
            1286-1473           AC141869.5         137882-138069
            1474-1727           AC141869.5         144231-144484
            1728-1864           AC105256.7         3531-3667
            1865-1998           AC105256.7         6359-6492
            1999-2116           AC105256.7         6710-6827
            2117-2368           AC105256.7         17111-17362
            2369-5080           AC105256.7         19480-22191
FEATURES             Location/Qualifiers
     source          1..5080
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 50.44 cM"
     gene            1..5080
                     /gene="Cdh11"
                     /gene_synonym="Cad11; OSF-4"
                     /note="cadherin 11"
                     /db_xref="GeneID:12552"
                     /db_xref="MGI:MGI:99217"
     exon            1..184
                     /gene="Cdh11"
                     /gene_synonym="Cad11; OSF-4"
                     /inference="alignment:Splign:2.1.0"
     exon            185..302
                     /gene="Cdh11"
                     /gene_synonym="Cad11; OSF-4"
                     /inference="alignment:Splign:2.1.0"
     exon            303..702
                     /gene="Cdh11"
                     /gene_synonym="Cad11; OSF-4"
                     /inference="alignment:Splign:2.1.0"
     exon            703..997
                     /gene="Cdh11"
                     /gene_synonym="Cad11; OSF-4"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1117
                     /gene="Cdh11"
                     /gene_synonym="Cad11; OSF-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1285
                     /gene="Cdh11"
                     /gene_synonym="Cad11; OSF-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1473
                     /gene="Cdh11"
                     /gene_synonym="Cad11; OSF-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1727
                     /gene="Cdh11"
                     /gene_synonym="Cad11; OSF-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1864
                     /gene="Cdh11"
                     /gene_synonym="Cad11; OSF-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..1998
                     /gene="Cdh11"
                     /gene_synonym="Cad11; OSF-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2116
                     /gene="Cdh11"
                     /gene_synonym="Cad11; OSF-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2368
                     /gene="Cdh11"
                     /gene_synonym="Cad11; OSF-4"
                     /inference="alignment:Splign:2.1.0"
     exon            2369..5080
                     /gene="Cdh11"
                     /gene_synonym="Cad11; OSF-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3673..3678
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdh11"
                     /gene_synonym="Cad11; OSF-4"
                     /note="hexamer: AATAAA"
     polyA_site      3696
                     /gene="Cdh11"
                     /gene_synonym="Cad11; OSF-4"
                     /note="major polyA site"
     regulatory      5062..5067
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdh11"
                     /gene_synonym="Cad11; OSF-4"
                     /note="hexamer: AATAAA"
     polyA_site      5080
                     /gene="Cdh11"
                     /gene_synonym="Cad11; OSF-4"
                     /note="major polyA site"
ORIGIN      
        1 attccgcggc cgccgccagc tgaggggagc gtcgcgggcc gaggagcaga tgccgcgggg
       61 gccgctcgca gccgccgccg acttgtgaat gggactcgga ccggggcccg ggctgacacc
      121 gctgcgctcg ccccgtgcca gggacagccg gccaggaggt cgtgtccacc cgcaacggcc
      181 ccagaaatta ctgtgctttg tggccctttg aagacattca gttctgttat ttattgaatg
      241 accaatcaga tgggtggagc atgttatagg aattggcagc aggtatccaa tgggtgaaga
      301 agaagctgac tgcggaggtg accaaccctg gcgtgatgtc ctcagtgagt gaagatattc
      361 cattccagag gaggtctact tgacacatct gggaggccgc catccgaaag aaagccactc
      421 tgttggtgta gggagtgaca gctgcattct cctgtgccta ctgcataacc aaaaatgaag
      481 gagaactact gtttacaagc tgccctggtg tgcctgagca tgctatacca cagccaggcg
      541 tttgctctgg agcgacgaag ccacctgcat ccctctttcc atggacacca tgagaagggc
      601 aaggaggggc aggtgctgca acgctccaag agaggctggg tctggaacca attctttgtg
      661 atagaagagt acaccgggcc tgaccctgtg ctggtgggca ggcttcattc tgacattgac
      721 tccggtgatg ggaacattaa atacattctc tcaggtgaag gagcgggaac catttttgtg
      781 attgatgaca aatcagggaa cattcatgcc accaagacat tggaccgaga ggagagagcc
      841 cagtacacac tgatggctca ggcggtggac agggacacca acagaccact ggagccacct
      901 tcagaattca ttgttaaggt ccaggacatt aatgacaacc ctccagagtt tctgcatgaa
      961 atctatcatg ccaatgtgcc tgagaggtcc aatgtgggaa catcagttat ccaagtgaca
     1021 gcctctgatg cagatgatcc cacctatgga aatagtgcca agttagtgta tagcatcctt
     1081 gaaggacaac cctatttctc ggtggaggcc caaacaggta tcatcaggac agcccttccc
     1141 aatatggaca gagaagccaa ggaggagtac cacgtggtga tccaggccaa ggacatgggt
     1201 ggacacatgg gtggactctc agggacaacc aaagtgacga tcactctgac tgatgtcaac
     1261 gacaacccac caaagtttcc acagagcgtg taccagatgt ctgtatcaga agcagctgtc
     1321 ccgggggagg aagtaggaag ggtgaaggct aaagacccag acattggaga aaatggctta
     1381 gtcacataca atatcgttga tggagacggc atagaactgt ttgaaattac aacagactat
     1441 gaaacacagg atggtgtggt gaagctgaaa aagcctgtag attttgaaac caaaagagct
     1501 tatagcttga agatagaggc cgccaatgtt cacattgatc cgaagttcat cagcaatgga
     1561 cctttcaagg acactgtgac cgtcaagatt tcagtagaag atgccgatga gcctcccatg
     1621 ttcttggccc caagttatat ccatgaagtt caagaaaatg cagctgctgg cactgtggtt
     1681 gggagagtac atgccaaaga cccagatgct gccaacagcc caataaggta ttcaattgat
     1741 cgtcatactg acctcgacag gtttttcacg attaatccag aagatggttt tattaaaact
     1801 acgaaacctc tagataggga agaaactgcc tggctcaaca tctctgtctt cgcagcagaa
     1861 attcacaaca gacatcagga aaccaaagtc ccagtggcca tcagggtcct ggatgtcaat
     1921 gacaatgctc ctaagtttgc tgccccttat gaaggtttta tctgtgagag cgatcacccc
     1981 aaggcactct ccaaccagcc aatagttaca gttagtgcag atgaccagga cgacacagcc
     2041 aatggaccaa gatttatctt cagcctaccc cctgaaatca tgcacaaccc aaacttcaca
     2101 gtaagagaca acagagataa cactgcagga gtatatgccc gacgtggagg gttcagtcgg
     2161 cagaagcagg acttctacct cctgcccatt gtgatcagtg atggtggcat tccacctatg
     2221 agtagcacca ataccctcac tatcaaagtc tgtggctgtg atgtgaatgg ggcactgttg
     2281 tcctgtaacg ctgaagccta catcctgaat gccggtctga gcactggggc actgatcgcc
     2341 atccttgcct gcatcgtcat tcttctggtc atcgttgtgc tgtttgttac cctgaggagg
     2401 caaaagaaag aaccactcat tgtatttgaa gaggaggatg tccgtgagaa catcataacc
     2461 tatgatgatg aagggggtgg tgaggaagac actgaagcct tcgacatagc caccctgcag
     2521 aatcctgacg gcatcaatgg atttatccct cgcaaagata tcaaacctga gtatcagtat
     2581 atgcctagac ctgggctgcg accagcaccc aacagtgtgg atgtggacga cttcatcaac
     2641 acaagaatac aggaggcaga taatgatccc acagcccctc cctatgactc catccaaatc
     2701 tatggttatg agggccgggg ttccgtggct gggtccctga gctccttgga gtctgccacg
     2761 acagactcag acctggacta cgactatcta cagaactggg gacctcgttt taagaaactg
     2821 gcagacttgt atggctccaa agacactttt gatgatgact cttaacaata atgttacaaa
     2881 tttggcctta agaactgtgt ctggcattct caagaatcta gaagatgtgt aaacaggtat
     2941 ttttttaaat caaggaaagg ctcatttaaa acaagcagag ttttacagag aggaaacatt
     3001 taataaaact gcaaggacat caaagtggaa aatactgtga agtacctttt cccacttaaa
     3061 aagcaaatat tgaagttgtt tatcaacttc agtagaaaaa aaaaaaccac ttggcacaca
     3121 aaatatttaa atgaaggaga agtccacggt gaacttacaa tgaagggaaa tcgtctatgt
     3181 gttaagaaca tctaagtctc tcttatttta ttttttaatt tgtcaaagaa gcttccacaa
     3241 aattagaaag gacaacagtt ctgagctgta atttcgcctt aaactatgga cactctatct
     3301 gtagtgcgtt tttaaacttg aaatatataa tatccagcca gcttaaaccc atacaatgta
     3361 tgtacaatac aatgtacaat tatgtctctt gagcatcaat cttgttactg ctgattcttg
     3421 taaatctttt tgcttctact ttcatcctaa actaatacgt gccagatata actgtcttgt
     3481 ttcagtgagg agcaccctat ttctatgtca tttttaatgt atctatttgt acaattttaa
     3541 agttcttatt ttagtataca tacaaatatc agtattctga catgtacgaa aatgttacag
     3601 catcacactt atattttatg aacattgtac tgttgcttta atatgagctt caatataaga
     3661 agcaaccttt gaaataaaaa aaagattctt ttttaattct gggtttgatt cttaacattg
     3721 aaaaaaaata agggtttcta atgatccatt tatattccta atttaattgt gatctttaat
     3781 aaccctattt atgatctgtt gtagtctgct gctctcattg tttatttaaa tcaaatatgt
     3841 ttgagttttt ttaaagataa gattctgtaa cttcatgtaa atgatttttt gtatgttctg
     3901 gcttttcctg gagtatatct tctaaagaag gacattagag atctagacta gcctatgatt
     3961 agcctatgat tttacaatat gttatatatt atgcatttaa cctgtgaact catagttatg
     4021 agagacaaat tcatgaggac tgccagacct ctcgatgttc tagatataga cttgatgccc
     4081 tgccttgagc attgtggagt tgaaggggtg cagagtcaaa gccaactctg gttttcctta
     4141 tgtaattttt attaggataa agactgactg acagttgaaa gttctcattt ttgtcctcct
     4201 gtaattttat tttgtcttca aacaatataa aatttcaagt cttaatgaga gaaagggcaa
     4261 ttcactctcc aacctttatt atagaagatg ctttgggcca tgtactctca atgagatcag
     4321 ggatgatgct gaacattgat gattgatgcc atttgatctg tgataatgcc acagtcatct
     4381 gcagttgcct ctagtttcct gggaattgga acttctgtga aggacctttc acttgtacaa
     4441 cggaccaaag gtccagacaa agcaatactt gggaagacat cacacagagt cacactgcaa
     4501 acacttcccc tccttttctt gaaacacagg gcacaaacaa tttttttctc ttggattatg
     4561 gaaaattttg attttttttt actatattgt gattatttca tgagacctta tatactgttt
     4621 ttttatgatg cactccctcc cagttcactt tgcattgaca tcaaatcagt tgactaattc
     4681 aatgggagaa acttagtcga cattgacact tgagagtctt tgatcccagg aaggaatgtg
     4741 tattctcagt acttgcataa ttgcaggtta cgtttatttt atagataggc tttgtaatcc
     4801 aaagaatatt ttgctaggtt catgctgatc tccaattgaa tttaaaatta ctgaataact
     4861 caaaaggaaa atgaacctca ctctgctgta agtcccctca ccatcaatat gatcctttta
     4921 cttatatagg aatgtagtca gaatacagtt gacaacttct tttcttttcc attttttctt
     4981 tctttgtttc tttttctttt ctttttcttt ttttttactt taagtatctt aatgtttgta
     5041 gaatcctctt agaagctcgg aaataaaatg tctttcccaa
//
