LOCUS       NM_001316758            3194 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus cadherin 10 (Cdh10), transcript variant 2, mRNA.
ACCESSION   NM_001316758 XM_006520099
VERSION     NM_001316758.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3194)
  AUTHORS   Bessa,P., Newman,A.G., Yan,K., Schaub,T., Dannenberg,R., Lajko,D.,
            Eilenberger,J., Brunet,T., Textoris-Taube,K., Kemmler,E., Deng,P.,
            Banerjee,P., Ravindran,E., Preissner,R., Rosario,M. and
            Tarabykin,V.
  TITLE     Semaphorin heterodimerization in cis regulates membrane targeting
            and neocortical wiring
  JOURNAL   Nat Commun 15 (1), 7059 (2024)
   PUBMED   39152101
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3194)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3194)
  AUTHORS   Polanco,J., Reyes-Vigil,F., Weisberg,S.D., Dhimitruka,I. and
            Bruses,J.L.
  TITLE     Differential Spatiotemporal Expression of Type I and Type II
            Cadherins Associated With the Segmentation of the Central Nervous
            System and Formation of Brain Nuclei in the Developing Mouse
  JOURNAL   Front Mol Neurosci 14, 633719 (2021)
   PUBMED   33833667
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3194)
  AUTHORS   Vagnozzi,A.N., Garg,K., Dewitz,C., Moore,M.T., Cregg,J.M.,
            Jeannotte,L., Zampieri,N., Landmesser,L.T. and Philippidou,P.
  TITLE     Phrenic-specific transcriptional programs shape respiratory motor
            output
  JOURNAL   Elife 9, e52859 (2020)
   PUBMED   31944180
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3194)
  AUTHORS   Narayanan,R., Pham,L., Kerimoglu,C., Watanabe,T., Castro
            Hernandez,R., Sokpor,G., Ulmke,P.A., Kiszka,K.A., Tonchev,A.B.,
            Rosenbusch,J., Seong,R.H., Teichmann,U., Frahm,J., Fischer,A.,
            Bonn,S., Stoykova,A., Staiger,J.F. and Tuoc,T.
  TITLE     Chromatin Remodeling BAF155 Subunit Regulates the Genesis of Basal
            Progenitors in Developing Cortex
  JOURNAL   iScience 4, 109-126 (2018)
   PUBMED   30240734
REFERENCE   6  (bases 1 to 3194)
  AUTHORS   Chen,B., Schaevitz,L.R. and McConnell,S.K.
  TITLE     Fezl regulates the differentiation and axon targeting of layer 5
            subcortical projection neurons in cerebral cortex
  JOURNAL   Proc Natl Acad Sci U S A 102 (47), 17184-17189 (2005)
   PUBMED   16284245
REFERENCE   7  (bases 1 to 3194)
  AUTHORS   Williams,M.J., Lowrie,M.B., Bennett,J.P., Firth,J.A. and Clark,P.
  TITLE     Cadherin-10 is a novel blood-brain barrier adhesion molecule in
            human and mouse
  JOURNAL   Brain Res 1058 (1-2), 62-72 (2005)
   PUBMED   16181616
  REMARK    GeneRIF: This demonstration of a distinctive expression pattern of
            cadherin-10 suggests that it has a pivotal role in the development
            and maintenance of brain barriers.
REFERENCE   8  (bases 1 to 3194)
  AUTHORS   Kido,M., Obata,S., Tanihara,H., Rochelle,J.M., Seldin,M.F.,
            Taketani,S. and Suzuki,S.T.
  TITLE     Molecular properties and chromosomal location of cadherin-8
  JOURNAL   Genomics 48 (2), 186-194 (1998)
   PUBMED   9521872
REFERENCE   9  (bases 1 to 3194)
  AUTHORS   Munro,S.B. and Blaschuk,O.W.
  TITLE     A comprehensive survey of the cadherins expressed in the testes of
            fetal, immature, and adult mice utilizing the polymerase chain
            reaction
  JOURNAL   Biol Reprod 55 (4), 822-827 (1996)
   PUBMED   8879495
REFERENCE   10 (bases 1 to 3194)
  AUTHORS   Munro,S.B., Duclos,A.J., Jackson,A.R., Baines,M.G. and
            Blaschuk,O.W.
  TITLE     Characterization of cadherins expressed by murine thymocytes
  JOURNAL   Cell Immunol 169 (2), 309-312 (1996)
   PUBMED   8620560
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC121768.2, BB649070.1,
            AK138606.1 and BC052056.1.
            
            On Oct 24, 2015 this sequence version replaced XM_006520099.2.
            
            Summary: This gene encodes a member of the cadherin family of
            calcium-dependent glycoproteins that mediate cell adhesion and
            regulate many morphogenetic events during development. The encoded
            preproprotein is further processed to generate a mature protein.
            This gene is expressed in the blood-brain barrier and retinal
            endothelia suggesting a role in the development and maintenance of
            brain barrier. Alternative splicing results in multiple transcript
            variants. Multiple distinct genes of the cadherin family, including
            this gene, are found on chromosome 15. [provided by RefSeq, Oct
            2015].
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Both variants 1 and 2 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF183946.1, ERR3363660.2789505.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AC121768.2         41724-41736
            14-141              BB649070.1         3-130
            142-3174            AK138606.1         375-3407
            3175-3194           BC052056.1         3114-3133
FEATURES             Location/Qualifiers
     source          1..3194
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 8.2 cM"
     gene            1..3194
                     /gene="Cdh10"
                     /gene_synonym="A830016G23Rik; C030003B10Rik;
                     C030011H18Rik"
                     /note="cadherin 10"
                     /db_xref="GeneID:320873"
                     /db_xref="MGI:MGI:107436"
     exon            1..141
                     /gene="Cdh10"
                     /gene_synonym="A830016G23Rik; C030003B10Rik;
                     C030011H18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            142..486
                     /gene="Cdh10"
                     /gene_synonym="A830016G23Rik; C030003B10Rik;
                     C030011H18Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..2622
                     /gene="Cdh10"
                     /gene_synonym="A830016G23Rik; C030003B10Rik;
                     C030011H18Rik"
                     /note="T2-cadherin"
                     /codon_start=1
                     /product="cadherin-10 preproprotein"
                     /protein_id="NP_001303687.1"
                     /db_xref="CCDS:CCDS37047.1"
                     /db_xref="GeneID:320873"
                     /db_xref="MGI:MGI:107436"
                     /translation="MTIYQFLRLFVLWACLPHFCCPELTFRRTPGIQQMTAESRAPRS
                     DGKILHRQKRGWMWNQFFLLEEYTGSDYQYVGKLHSDQDKGDGSLKYILSGDGAGTLF
                     IIDEKTGDIHATRRIDREEKAFYTLRAQAINRRTLRPVEPESEFVIKIHDINDNEPTF
                     PEEIYTASVPEMSVVGTSVVQVTATDADDPSYGNSARVIYSILQGQPYFSVEPETGII
                     RTALPNMNRENKEQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQNTIHL
                     RVLESSPVGTAVGSVKATDADTGKNAEVDYRIIDGDGTDMFDIITEKDTQEGIITVKK
                     PLDYENRRLYTLKVEAENTHVDPRFYYLGPFKDTTIVKISIEDVDEPPVFSRSSYLFE
                     VHEDIEVGTIIGTVMARDPDSTSSPIRFTLDRHTDLDRIFNIHSGNGSLYTSKPLDRE
                     LSQWHNLTVIAAEINNPKETTRVSVFVRILDVNDNAPQFAVFYDTFVCENARPGQLIQ
                     TISAVDKDDPLGGQKFFFSLAAVNPNFTVQDNEDNTARILTRKNGFNRHEISTYLLPV
                     VISDNDYPIQSSTGTLTIRVCACDSQGNMQSCSAEALLLPAGLSTGALIAILLCIIIL
                     LVIVVLFAALKRQRKKEPLILSKEDIRDNIVSYNDEGGGEEDTQAFDIGTLRNPAAIE
                     EKKLRRDIIPETLFIPRRTPTAPDNTDVRDFINERLKEHDLDPTAPPYDSLATYAYEG
                     NDSVAESLSSLESGTTEGDQNYDYLREWGPRFNKLAEMYGGGESDKDA"
     exon            487..781
                     /gene="Cdh10"
                     /gene_synonym="A830016G23Rik; C030003B10Rik;
                     C030011H18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            782..901
                     /gene="Cdh10"
                     /gene_synonym="A830016G23Rik; C030003B10Rik;
                     C030011H18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1069
                     /gene="Cdh10"
                     /gene_synonym="A830016G23Rik; C030003B10Rik;
                     C030011H18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1257
                     /gene="Cdh10"
                     /gene_synonym="A830016G23Rik; C030003B10Rik;
                     C030011H18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1511
                     /gene="Cdh10"
                     /gene_synonym="A830016G23Rik; C030003B10Rik;
                     C030011H18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1648
                     /gene="Cdh10"
                     /gene_synonym="A830016G23Rik; C030003B10Rik;
                     C030011H18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1770
                     /gene="Cdh10"
                     /gene_synonym="A830016G23Rik; C030003B10Rik;
                     C030011H18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1879
                     /gene="Cdh10"
                     /gene_synonym="A830016G23Rik; C030003B10Rik;
                     C030011H18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..2131
                     /gene="Cdh10"
                     /gene_synonym="A830016G23Rik; C030003B10Rik;
                     C030011H18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2132..3176
                     /gene="Cdh10"
                     /gene_synonym="A830016G23Rik; C030003B10Rik;
                     C030011H18Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3155..3160
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdh10"
                     /gene_synonym="A830016G23Rik; C030003B10Rik;
                     C030011H18Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3176
                     /gene="Cdh10"
                     /gene_synonym="A830016G23Rik; C030003B10Rik;
                     C030011H18Rik"
                     /note="major polyA site"
ORIGIN      
        1 gaaagcttga gttagaccga agtagaatca gggagagaaa aataacagca gaaaacaaac
       61 agaaaggggg acagggggac aggctcttca gggttatttg gctggaacca acttccgttt
      121 tccagaagct gatgaaacaa gctcttggga atatgtccat agcactgatg aagtgctgga
      181 agccagttga gatctaatac cataaacagg actacttttt catcacctac actggaattt
      241 ttcaagaagt aaactatgac aatctatcag ttcctgagac tgtttgttct ctgggcatgc
      301 ctgccccact tctgctgtcc agaattaacg ttcagaagga ctcctgggat tcagcaaatg
      361 actgcagaat cccgtgcccc aaggagtgat ggtaaaatcc ttcaccgtca aaaacgtggc
      421 tggatgtgga atcagttttt cttgctggaa gaatatactg gatctgatta tcaatatgta
      481 ggcaagcttc attcagacca agataaagga gatggatcgc tcaaatatat tttgtctgga
      541 gacggagctg gtactctttt tattattgat gagaaaacag gtgatattca tgccacaaga
      601 agaattgata gagaagaaaa ggccttttat actctacgtg cacaagctat taacagaaga
      661 actctgaggc cagtagaacc agagtcagaa tttgtgatca aaatccatga tatcaatgac
      721 aatgagccta cattcccaga agaaatttat acagccagtg ttcctgaaat gtctgttgta
      781 ggtacttctg tggtgcaagt cacagctaca gatgccgatg acccttccta tggaaacagc
      841 gccagagtca tttacagcat ccttcaaggg cagccttatt tctctgtgga accagaaaca
      901 ggtatcatca gaacagctct gccaaatatg aaccgagaga acaaagaaca gtaccaggtg
      961 gttattcaag ccaaggatat gggcggccag atggggggtt tgtctggaac caccacagtg
     1021 aacatcactc tgacagatgt caacgacaat ccacctcgct tcccccagaa caccatccat
     1081 ctcagagttc ttgaatcctc tccagttggc acagctgtgg gaagtgtaaa agccactgat
     1141 gctgacacgg ggaaaaatgc tgaagtggat taccgcatta ttgatggaga tggcacggat
     1201 atgtttgaca ttataactga gaaggacaca caggaaggca tcatcactgt gaaaaagcca
     1261 cttgactatg agaaccgaag actatatact ctgaaggtgg aggcagaaaa cacccatgtg
     1321 gatccacgtt tttattatct agggccattc aaagatacta caattgtgaa aatctccata
     1381 gaagacgtgg acgagcctcc tgttttcagt cgatcctcct atctgtttga ggttcatgag
     1441 gatattgaag taggcacaat cattggtact gtaatggcaa gagatcctga ttctacatcc
     1501 agtcccatca gatttacatt ggatcgccat actgaccttg acaggatctt taacattcat
     1561 tctggaaatg gatcgcttta tacatcaaag ccacttgatc gtgaattatc tcaatggcac
     1621 aatcttaccg ttatagctgc tgagatcaat aatcctaaag agacaactcg tgtgtctgtt
     1681 tttgtgagga ttttggatgt taatgacaac gctccacaat ttgctgtgtt ttatgacaca
     1741 tttgtatgtg aaaatgccag accaggacag ctgatacaga ccataagtgc agttgacaaa
     1801 gatgacccct taggtggaca gaagtttttc ttcagtttgg ctgctgtgaa tccgaacttt
     1861 acagtacaag ataatgaaga caacactgct agaattttaa caagaaagaa tggcttcaac
     1921 cgtcatgaaa taagcaccta tctactgccg gtggtgatat cggataacga ctacccaatt
     1981 cagagcagca ctggcaccct gacgatccgt gtgtgcgcct gtgacagcca aggcaacatg
     2041 cagtcctgta gtgctgaagc cctgctcctc cccgctggcc tcagcactgg cgccttgatc
     2101 gccattctcc tctgcatcat tattctgctg gttatagtag tcctctttgc agccctcaaa
     2161 aggcaacgga agaaagagcc tctgattcta tccaaggagg acatcagaga caacatcgtg
     2221 agctataacg acgaaggtgg tggagaggag gacacccagg cctttgatat aggaaccctg
     2281 aggaaccctg cagctatcga ggagaaaaag ctccggcgag atataattcc tgaaacgtta
     2341 tttatacccc ggaggactcc taccgcccca gataacaccg atgtccggga tttcattaac
     2401 gagcgactca aagagcatga cctggacccc actgcgcctc cctacgactc actggctacc
     2461 tacgcctacg aaggaaacga ctccgtggcc gaatctctga gctctttaga atcaggtacc
     2521 actgaaggag accaaaacta cgattacctc cgagaatggg gacctcggtt taataaacta
     2581 gcagaaatgt acggtggtgg cgagagcgac aaagatgctt agcctggcgc ctgtgttatg
     2641 ttcaacgaga taaagttaac tttgcggaca ctgtctccac ttcacaatat ttgatattca
     2701 ggagaaattt ttttcctgcc actcagcaca cgtttcccac ttatttctta atttgttcat
     2761 taatgatatt aattctttcc tgtagggtgt ctcatggaat atatacgaca ttttatttaa
     2821 tcacttccaa gagccaaagc tatggaaatt caatgttgtc catcttagta aataaaagag
     2881 acctgagcag gatagttctc ccttaagcaa cctcacgaac aagccgcttc tgttagatac
     2941 acgtcttgct cttgcaaatg aagctttgat aagacgaaga aaacactgaa gatgtatcct
     3001 gttctgtaca ttaagtttaa agaaaaaaat gtacatgtgg tgttagttgg tgtgatatgc
     3061 agcctggtat acaagcattt gtgcaatttc atttcatcaa attctatctg ctaatgtttt
     3121 atatttatat ttttgtattt atttttaaaa aaaaaataaa ccagttttta caactaaaaa
     3181 aaaaaaaaaa aaaa
//
