LOCUS       NM_009864               4447 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus cadherin 1 (Cdh1), mRNA.
ACCESSION   NM_009864
VERSION     NM_009864.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4447)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (bases 1 to 4447)
  AUTHORS   Scavuzzo,M.A., Szlachcic,W.J., Hill,M.C., Ziojla,N.M., Teaw,J.,
            Carlson,J.C., Tiessen,J., Chmielowiec,J., Martin,J.F. and
            Borowiak,M.
  TITLE     Pancreatic organogenesis mapped through space and time
  JOURNAL   Exp Mol Med 57 (1), 204-220 (2025)
   PUBMED   39779976
REFERENCE   3  (bases 1 to 4447)
  AUTHORS   Wu,M., Jia,G., Liu,Y., Lou,Y., Li,Y., Xia,M., Li,H. and Li,W.
  TITLE     PKM2 controls cochlear development through lactate-dependent
            transcriptional regulation
  JOURNAL   Proc Natl Acad Sci U S A 122 (2), e2410829122 (2025)
   PUBMED   39773029
REFERENCE   4  (bases 1 to 4447)
  AUTHORS   He,Y., Wang,H., Hong,T., Hu,L., Gao,C., Gao,L., Cui,Y., Tan,R.,
            Pu,D. and Wu,J.
  TITLE     HFM1 is essential for the germ cell intercellular bridge transport
            in primordial follicle formation in mice
  JOURNAL   Cell Mol Life Sci 82 (1), 28 (2024)
   PUBMED   39725823
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4447)
  AUTHORS   Weberling,A., Siriwardena,D., Penfold,C., Christodoulou,N.,
            Boroviak,T.E. and Zernicka-Goetz,M.
  TITLE     Primitive to visceral endoderm maturation is essential for mouse
            epiblast survival beyond implantation
  JOURNAL   iScience 28 (1), 111671 (2024)
   PUBMED   39868030
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4447)
  AUTHORS   Shimamura,K. and Takeichi,M.
  TITLE     Local and transient expression of E-cadherin involved in mouse
            embryonic brain morphogenesis
  JOURNAL   Development 116 (4), 1011-1019 (1992)
   PUBMED   1295725
REFERENCE   7  (bases 1 to 4447)
  AUTHORS   Kaupmann,K., Becker-Follmann,J., Scherer,G., Jockusch,H. and
            Starzinski-Powitz,A.
  TITLE     The gene for the cell adhesion molecule M-cadherin maps to mouse
            chromosome 8 and human chromosome 16q24.1-qter and is near the
            E-cadherin (uvomorulin) locus in both species
  JOURNAL   Genomics 14 (2), 488-490 (1992)
   PUBMED   1427864
REFERENCE   8  (bases 1 to 4447)
  AUTHORS   Sefton,M., Johnson,M.H. and Clayton,L.
  TITLE     Synthesis and phosphorylation of uvomorulin during mouse early
            development
  JOURNAL   Development 115 (1), 313-318 (1992)
   PUBMED   1638988
REFERENCE   9  (bases 1 to 4447)
  AUTHORS   Spitkovsky,D.D., Royer-Pokora,B., Delius,H., Kisseljov,F.,
            Jenkins,N.A., Gilbert,D.J., Copeland,N.G. and Royer,H.D.
  TITLE     Tissue restricted expression and chromosomal localization of the
            YB-1 gene encoding a 42 kD nuclear CCAAT binding protein
  JOURNAL   Nucleic Acids Res 20 (4), 797-803 (1992)
   PUBMED   1542575
REFERENCE   10 (bases 1 to 4447)
  AUTHORS   Dressler,G.R. and Douglass,E.C.
  TITLE     Pax-2 is a DNA-binding protein expressed in embryonic kidney and
            Wilms tumor
  JOURNAL   Proc Natl Acad Sci U S A 89 (4), 1179-1183 (1992)
   PUBMED   1311084
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CF898038.1, AK076369.1,
            AC132132.4, AC147500.6 and BP765198.1.
            
            On Oct 22, 2015 this sequence version replaced NM_009864.2.
            
            Summary: This gene encodes E-cadherin, a calcium-dependent cell
            adhesion molecule that functions in the establishment and
            maintenance of epithelial cell morphology during embryongenesis and
            adulthood. The encoded preproprotein undergoes proteolytic
            processing to generate a mature protein. Targeted mutations
            disrupting binding of calcium to the encoded protein in mice cause
            death in utero due to failed blastocyst and trophectoderm
            formation. This gene is located adjacent to a related cadherin gene
            on chromosome 8. [provided by RefSeq, Oct 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK076369.1, X06115.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                CF898038.1         1-18
            19-1141             AK076369.1         2-1124
            1142-1585           AK076369.1         1126-1569
            1586-1586           AC132132.4         190224-190224
            1587-2469           AK076369.1         1571-2453
            2470-2470           AC132132.4         195524-195524
            2471-4055           AK076369.1         2455-4039
            4056-4056           AC147500.6         169299-169299       c
            4057-4431           AK076369.1         4041-4415
            4432-4447           BP765198.1         27-42               c
FEATURES             Location/Qualifiers
     source          1..4447
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.18 cM"
     gene            1..4447
                     /gene="Cdh1"
                     /gene_synonym="ARC-1; E-cad; Ecad; L-CAM; Um; UVO"
                     /note="cadherin 1"
                     /db_xref="GeneID:12550"
                     /db_xref="MGI:MGI:88354"
     exon            1..193
                     /gene="Cdh1"
                     /gene_synonym="ARC-1; E-cad; Ecad; L-CAM; Um; UVO"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..2800
                     /gene="Cdh1"
                     /gene_synonym="ARC-1; E-cad; Ecad; L-CAM; Um; UVO"
                     /note="uvomorulin; E-cadherin; epithelial cadherin"
                     /codon_start=1
                     /product="cadherin-1 preproprotein"
                     /protein_id="NP_033994.1"
                     /db_xref="CCDS:CCDS22638.1"
                     /db_xref="GeneID:12550"
                     /db_xref="MGI:MGI:88354"
                     /translation="MGARCRSFSALLLLLQVSSWLCQELEPESCSPGFSSEVYTFPVP
                     ERHLERGHVLGRVRFEGCTGRPRTAFFSEDSRFKVATDGTITVKRHLKLHKLETSFLV
                     RARDSSHRELSTKVTLKSMGHHHHRHHHRDPASESNPELLMFPSVYPGLRRQKRDWVI
                     PPISCPENEKGEFPKNLVQIKSNRDKETKVFYSITGQGADKPPVGVFIIERETGWLKV
                     TQPLDREAIAKYILYSHAVSSNGEAVEDPMEIVITVTDQNDNRPEFTQPVFEGFVAEG
                     AVPGTSVMKVSATDADDDVNTYNAAIAYTIVSQDPELPHKNMFTVNRDTGVISVLTSG
                     LDRESYPTYTLVVQAADLQGEGLSTTAKAVITVKDINDNAPVFNPSTYQGQVPENEVN
                     ARIATLKVTDDDAPNTPAWKAVYTVVNDPDQQFVVVTDPTTNDGILKTAKGLDFEAKQ
                     QYILHVRVENEEPFEGSLVPSTATVTVDVVDVNEAPIFMPAERRVEVPEDFGVGQEIT
                     SYTAREPDTFMDQKITYRIWRDTANWLEINPETGAIFTRAEMDREDAEHVKNSTYVAL
                     IIATDDGSPIATGTGTLLLVLLDVNDNAPIPEPRNMQFCQRNPQPHIITILDPDLPPN
                     TSPFTAELTHGASVNWTIEYNDAAQESLILQPRKDLEIGEYKIHLKLADNQNKDQVTT
                     LDVHVCDCEGTVNNCMKAGIVAAGLQVPAILGILGGILALLILILLLLLFLRRRTVVK
                     EPLLPPDDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARPEVTRNDVAPTLMSVPQ
                     YRPRPANPDEIGNFIDENLKAADSDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESD
                     QDQDYDYLNEWGNRFKKLADMYGGGEDD"
     exon            194..314
                     /gene="Cdh1"
                     /gene_synonym="ARC-1; E-cad; Ecad; L-CAM; Um; UVO"
                     /inference="alignment:Splign:2.1.0"
     exon            315..538
                     /gene="Cdh1"
                     /gene_synonym="ARC-1; E-cad; Ecad; L-CAM; Um; UVO"
                     /inference="alignment:Splign:2.1.0"
     exon            539..682
                     /gene="Cdh1"
                     /gene_synonym="ARC-1; E-cad; Ecad; L-CAM; Um; UVO"
                     /inference="alignment:Splign:2.1.0"
     exon            683..838
                     /gene="Cdh1"
                     /gene_synonym="ARC-1; E-cad; Ecad; L-CAM; Um; UVO"
                     /inference="alignment:Splign:2.1.0"
     exon            839..983
                     /gene="Cdh1"
                     /gene_synonym="ARC-1; E-cad; Ecad; L-CAM; Um; UVO"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1159
                     /gene="Cdh1"
                     /gene_synonym="ARC-1; E-cad; Ecad; L-CAM; Um; UVO"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1288
                     /gene="Cdh1"
                     /gene_synonym="ARC-1; E-cad; Ecad; L-CAM; Um; UVO"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1471
                     /gene="Cdh1"
                     /gene_synonym="ARC-1; E-cad; Ecad; L-CAM; Um; UVO"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1716
                     /gene="Cdh1"
                     /gene_synonym="ARC-1; E-cad; Ecad; L-CAM; Um; UVO"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1862
                     /gene="Cdh1"
                     /gene_synonym="ARC-1; E-cad; Ecad; L-CAM; Um; UVO"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..2087
                     /gene="Cdh1"
                     /gene_synonym="ARC-1; E-cad; Ecad; L-CAM; Um; UVO"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2315
                     /gene="Cdh1"
                     /gene_synonym="ARC-1; E-cad; Ecad; L-CAM; Um; UVO"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2446
                     /gene="Cdh1"
                     /gene_synonym="ARC-1; E-cad; Ecad; L-CAM; Um; UVO"
                     /inference="alignment:Splign:2.1.0"
     exon            2447..2590
                     /gene="Cdh1"
                     /gene_synonym="ARC-1; E-cad; Ecad; L-CAM; Um; UVO"
                     /inference="alignment:Splign:2.1.0"
     exon            2591..4432
                     /gene="Cdh1"
                     /gene_synonym="ARC-1; E-cad; Ecad; L-CAM; Um; UVO"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4409..4414
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdh1"
                     /gene_synonym="ARC-1; E-cad; Ecad; L-CAM; Um; UVO"
                     /note="hexamer: ATTAAA"
     polyA_site      4431
                     /gene="Cdh1"
                     /gene_synonym="ARC-1; E-cad; Ecad; L-CAM; Um; UVO"
                     /note="major polyA site"
ORIGIN      
        1 gcagcctctg cgctgctcac tggtgtggga gccgcggcgc actactgagt tcccaagaac
       61 ttctgctaga ctcctgcccg gcctaacccg gccctgcccg accgcacccg agctcagtgt
      121 ttgctcggcg tctgccgggt ccgccatggg agcccggtgc cgcagctttt ccgcgctcct
      181 gctcctgctg caggtctcct catggctttg ccaggagctg gagcctgagt cctgcagtcc
      241 cggcttcagt tccgaggtct acaccttccc ggtgccggag aggcacctgg agagaggcca
      301 tgtcctgggc agagtgagat ttgaaggatg cactggccgg ccaaggacag ccttcttttc
      361 ggaagactcc cgattcaaag tggcgacaga cggcaccatc acagtgaagc ggcatctaaa
      421 gctccacaag ctggagacca gtttcctcgt ccgcgcccgg gactccagtc atagggagct
      481 gtctaccaaa gtgacgctga agtccatggg gcaccaccat caccggcacc accaccgcga
      541 ccctgcctct gaatccaacc cagagctgct catgtttccc agcgtgtacc caggtctcag
      601 aagacagaaa cgagactggg tcatccctcc catcagctgc cccgaaaatg aaaagggcga
      661 atttccaaag aacctggttc agatcaaatc caacagggac aaagaaacaa aggttttcta
      721 cagcatcacc ggccaaggag ctgacaaacc ccccgttggc gttttcatca ttgagaggga
      781 gacaggctgg ctgaaagtga cacagcctct ggatagagaa gccattgcca agtacatcct
      841 ctattctcat gccgtgtcat caaatgggga agcggtggag gatcccatgg agatagtgat
      901 cacagtgaca gatcagaatg acaacaggcc agagtttacc cagccggtct ttgagggatt
      961 cgttgcagaa ggcgctgttc caggaacctc cgtgatgaag gtctcagcca ccgatgcaga
     1021 cgatgacgtc aacacctaca acgctgccat cgcctacacc atcgtcagcc aggatcctga
     1081 gctgcctcac aaaaacatgt tcactgtcaa tagggacacc ggggtcatca gtgtgctcac
     1141 ctctgggctg gaccgagaga gttaccctac atacactctg gtggttcagg ctgctgacct
     1201 tcaaggtgaa ggcttgagca caacagccaa ggctgtgatc actgtcaagg atattaatga
     1261 caacgctcct gtcttcaacc caagcacgta tcagggtcaa gtgcctgaga atgaggtcaa
     1321 tgcccggatc gccacactca aagtgaccga tgatgatgcc cccaacactc cggcgtggaa
     1381 agctgtgtac accgtagtca acgatcctga ccagcagttc gttgttgtca cagaccccac
     1441 gaccaatgat ggcattttga aaacagccaa gggcttggat tttgaggcca agcagcaata
     1501 catccttcat gtgagagtgg agaacgagga accctttgag gggtctcttg tcccttccac
     1561 agccactgtc actgtggacg tggtagacgt gaatgaagcc cccatcttta tgcctgcgga
     1621 gaggagagtc gaagtgcccg aagactttgg tgtgggtcag gaaatcacat cttataccgc
     1681 tcgagagccg gacacgttca tggatcagaa gatcacgtat cggatttgga gggacactgc
     1741 caactggctg gagattaacc cagagactgg tgccattttc acgcgcgctg agatggacag
     1801 agaagacgct gagcatgtga agaacagcac atatgtagct ctcatcatcg ccacagatga
     1861 tggttcaccc attgccactg gcacgggcac tcttctcctg gtcctgttag acgtcaatga
     1921 caacgctccc atcccagaac ctcgaaacat gcagttctgc cagaggaacc cacagcctca
     1981 tatcatcacc atcttggatc cagaccttcc ccccaacacg tcccccttta ctgctgagct
     2041 aacccatggg gccagcgtca actggaccat tgagtataat gacgcagctc aagaatctct
     2101 cattttgcaa ccaagaaagg acttagagat tggcgaatac aaaatccatc tcaagctcgc
     2161 ggataaccag aacaaagacc aggtgaccac gttggacgtc catgtgtgtg actgtgaagg
     2221 gacggtcaac aactgcatga aggcgggaat cgtggcagca ggattgcaag ttcctgccat
     2281 cctcggaatc cttggaggga tcctcgccct gctgattctg atcctgctgc tcctactgtt
     2341 tctacggagg agaacggtgg tcaaagagcc cctgctgcca ccagatgatg atacccggga
     2401 caatgtgtat tactatgatg aagaaggagg tggagaagaa gaccaggact ttgatttgag
     2461 ccagctgcac aggggcctgg atgcccgacc ggaagtgact cgaaatgatg tggctcccac
     2521 cctcatgagc gtgccccagt atcgtccccg tcctgccaat cctgatgaaa ttggaaactt
     2581 catcgatgaa aacctgaagg cagccgacag cgaccccacg gcaccccctt acgactctct
     2641 gttggtgttc gattacgagg gcagtggttc tgaagccgct agcctgagct cactgaactc
     2701 ctctgagtcg gatcaggacc aggactacga ttatctgaac gagtggggca accgattcaa
     2761 gaagctggcg gacatgtacg gcggtggtga ggacgactag gggactagca agtctccccc
     2821 gtgtggcacc atgggagatg cagaataatt atatcagtgg tctttcagct ccttccctga
     2881 gtgtgtagaa gagagactga tctgagaagt gtgcagattg catagtggtc tcactctccc
     2941 tactggactg tctgtgttag gatggttttc actgattgtt gaaatctttt tttatttttt
     3001 atttttacag tgctgagata taaactgtgc ctttttttgt ttgtttgttt ctgtttttgt
     3061 tcttttgagc tatgatctgc cccagacaca acagccccaa gcccctcaca cctcactaat
     3121 tttttacatt gtgtacttgc cctcaattac catgtttgct gtattctaat agtcactcat
     3181 gttcctgaat tctgttgccc tgcccaggtg atattctagg atgcagaaat gcctgggccc
     3241 ttttatggtg agagacaggt atcttggtgt gggtgcaact gcgctggata gtgtgtgtgt
     3301 tcccaagatc tttcgtggta ttccctctcc acctccagag aactcattta cagtggcatt
     3361 ccttgttcgg ctatgtgtct ggggcagaac aaaaaaaagg gaccactatg catgctgcac
     3421 acgtctcaga ttcttaggta cacacctgat tcttaggtgc atgccatagt gggatatgtt
     3481 gctttgatca gaacctgcag ggaggttttc gggcaccact taagtttctt ggcgtttctt
     3541 tcaaaccaaa actaaagaat ggttgttctc tgagagagac tggagtgcca ccaccaaaga
     3601 cagaggagag aaaaggagag aaaccaaact tggggacagc aacatcagcg aacccggcta
     3661 gttggcacac cgatggtgag ggtacacagg cggtgagacc tatcccacaa gatttctgga
     3721 agactaggct tatctcaacc aatgttttct ggctggaatc tttgtccatg tattcctgaa
     3781 gcccaggaaa tgcacccctc caatgcctgc tcttgatggt agctacagaa aatgctggcc
     3841 gatttaaacc caagttgccc agttctgagt agaaaactga gactatgctg tgtgtggcgg
     3901 cgcgcacctt taagcccagc actcaggagg cagaggcagt cagatctccc tgagttcgag
     3961 gccaacctgg tatatatagt atagtaagcg aattctagga cagccagggc tacacagaga
     4021 aaccctgtct ctgcaaacca aaagagaaaa ctgagaatat tacaaattgt gcattttctc
     4081 aggaagcagg aagagaacat tctaacggga aaaaggagac aagacctttg agagttttca
     4141 ttcaaaatgc aaatctcagc tttttgataa ccactggaaa gaattttatt gaaagttctg
     4201 tacttaccta actttggaag aaaatgatga ccacaatcaa ctgtgagaac tgttgatttc
     4261 tctgtagttt aatcatgtaa tgttgctaga gtgacctttg tatgtagttt gagtgtatgt
     4321 gtgtgggtgc tgataatttt gtattttgtg gggggtggaa aaggtaagcc attgaaaccg
     4381 ttctctaaga tgcattttta tgaattttat taaagagttt tgttaaactg ttaaaaaaaa
     4441 aaaaaaa
//
