LOCUS       NM_133974               3849 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Mus musculus CUB domain containing protein 1 (Cdcp1), mRNA.
ACCESSION   NM_133974
VERSION     NM_133974.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3849)
  AUTHORS   Chen,R., Fan,R., Chen,F., Govindasamy,N., Brinkmann,H.,
            Stehling,M., Adams,R.H., Jeong,H.W. and Bedzhov,I.
  TITLE     Analyzing embryo dormancy at single-cell resolution reveals dynamic
            transcriptional responses and activation of integrin-Yap/Taz
            prosurvival signaling
  JOURNAL   Cell Stem Cell 31 (9), 1262-1279 (2024)
   PUBMED   39047740
REFERENCE   2  (bases 1 to 3849)
  AUTHORS   Saponaro,M., Flottmann,S., Eckstein,M., Hommerding,O., Klumper,N.,
            Corvino,D., Hosni,S., Schmidt,A., Monig,N., Schmidt,D.,
            Ellinger,J., Toma,M., Kristiansen,G., Bald,T., Alimonti,A.,
            Ritter,M., Holzel,M. and Alajati,A.
  TITLE     CDCP1 expression is frequently increased in aggressive urothelial
            carcinoma and promotes urothelial tumor progression
  JOURNAL   Sci Rep 13 (1), 73 (2023)
   PUBMED   36593286
  REMARK    GeneRIF: CDCP1 expression is frequently increased in aggressive
            urothelial carcinoma and promotes urothelial tumor progression.
            Erratum:[Sci Rep. 2023 Feb 17;13(1):2838. doi:
            10.1038/s41598-023-28942-0. PMID: 36801926]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3849)
  AUTHORS   Zhang,L., Borjini,N., Lun,Y., Parab,S., Asonye,G., Singh,R.,
            Bell,B.A., Bonilha,V.L., Ivanov,A., Fox,D.A., Caspi,R.R. and Lin,F.
  TITLE     CDCP1 regulates retinal pigmented epithelial barrier integrity for
            the development of experimental autoimmune uveitis
  JOURNAL   JCI Insight 7 (18), e157038 (2022)
   PUBMED   35951427
  REMARK    GeneRIF: CDCP1 regulates retinal pigmented epithelial barrier
            integrity for the development of experimental autoimmune uveitis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3849)
  AUTHORS   Govindasamy,N., Long,H., Jeong,H.W., Raman,R., Ozcifci,B.,
            Probst,S., Arnold,S.J., Riehemann,K., Ranga,A., Adams,R.H.,
            Trappmann,B. and Bedzhov,I.
  TITLE     3D biomimetic platform reveals the first interactions of the embryo
            and the maternal blood vessels
  JOURNAL   Dev Cell 56 (23), 3276-3287 (2021)
   PUBMED   34741805
REFERENCE   5  (bases 1 to 3849)
  AUTHORS   Lun,Y., Borjini,N., Miura,N.N., Ohno,N., Singer,N.G. and Lin,F.
  TITLE     CDCP1 on Dendritic Cells Contributes to the Development of a Model
            of Kawasaki Disease
  JOURNAL   J Immunol 206 (12), 2819-2827 (2021)
   PUBMED   34099547
  REMARK    GeneRIF: CDCP1 on Dendritic Cells Contributes to the Development of
            a Model of Kawasaki Disease.
REFERENCE   6  (bases 1 to 3849)
  AUTHORS   Casar,B., He,Y., Iconomou,M., Hooper,J.D., Quigley,J.P. and
            Deryugina,E.I.
  TITLE     Blocking of CDCP1 cleavage in vivo prevents Akt-dependent survival
            and inhibits metastatic colonization through PARP1-mediated
            apoptosis of cancer cells
  JOURNAL   Oncogene 31 (35), 3924-3938 (2012)
   PUBMED   22179830
  REMARK    GeneRIF: established mechanism for initiation of CDCP1-mediated
            signaling; demonstrated that processing of surface CDCP1 by
            extracellular serine proteases is prerequisite for CDCP1-dependent
            survival of cancer cells during metastasis; preventing cleavage of
            CDCP1 abrogated survival signaling associated with CDCP1 and
            induced PARP1 cleavage and PARP1-mediated apoptosis
REFERENCE   7  (bases 1 to 3849)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   8  (bases 1 to 3849)
  AUTHORS   Siva,A.C., Wild,M.A., Kirkland,R.E., Nolan,M.J., Lin,B.,
            Maruyama,T., Yantiri-Wernimont,F., Frederickson,S., Bowdish,K.S.
            and Xin,H.
  TITLE     Targeting CUB domain-containing protein 1 with a monoclonal
            antibody inhibits metastasis in a prostate cancer model
  JOURNAL   Cancer Res 68 (10), 3759-3766 (2008)
   PUBMED   18483259
  REMARK    GeneRIF: CDCP1 may have a role in neoplasm metastasis; targeting it
            with a monoclonal antibody inhibits metastasis in a prostate cancer
            model
REFERENCE   9  (bases 1 to 3849)
  AUTHORS   Sherwood,R.I., Jitianu,C., Cleaver,O., Shaywitz,D.A., Lamenzo,J.O.,
            Chen,A.E., Golub,T.R. and Melton,D.A.
  TITLE     Prospective isolation and global gene expression analysis of
            definitive and visceral endoderm
  JOURNAL   Dev Biol 304 (2), 541-555 (2007)
   PUBMED   17328885
REFERENCE   10 (bases 1 to 3849)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC134248.3.
            
            On Nov 17, 2006 this sequence version replaced NM_133974.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085253.1, AK087108.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-211               AC134248.3         156647-156857       c
            212-421             AC134248.3         130740-130949       c
            422-784             AC134248.3         125872-126234       c
            785-1153            AC134248.3         124276-124644       c
            1154-1375           AC134248.3         122984-123205       c
            1376-1756           AC134248.3         120804-121184       c
            1757-2122           AC134248.3         118507-118872       c
            2123-2207           AC134248.3         116554-116638       c
            2208-3849           AC134248.3         113104-114745       c
FEATURES             Location/Qualifiers
     source          1..3849
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 73.92 cM"
     gene            1..3849
                     /gene="Cdcp1"
                     /gene_synonym="9030022E12Rik; E030027H19Rik"
                     /note="CUB domain containing protein 1"
                     /db_xref="GeneID:109332"
                     /db_xref="MGI:MGI:2442010"
     exon            1..211
                     /gene="Cdcp1"
                     /gene_synonym="9030022E12Rik; E030027H19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            212..421
                     /gene="Cdcp1"
                     /gene_synonym="9030022E12Rik; E030027H19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            422..784
                     /gene="Cdcp1"
                     /gene_synonym="9030022E12Rik; E030027H19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            785..1153
                     /gene="Cdcp1"
                     /gene_synonym="9030022E12Rik; E030027H19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1375
                     /gene="Cdcp1"
                     /gene_synonym="9030022E12Rik; E030027H19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1756
                     /gene="Cdcp1"
                     /gene_synonym="9030022E12Rik; E030027H19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..2122
                     /gene="Cdcp1"
                     /gene_synonym="9030022E12Rik; E030027H19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2123..2207
                     /gene="Cdcp1"
                     /gene_synonym="9030022E12Rik; E030027H19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2208..3849
                     /gene="Cdcp1"
                     /gene_synonym="9030022E12Rik; E030027H19Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcctgcgcg caggtgagcg gcggggcagg gcggggcgca gctgcgtttc ggtgcctagg
       61 cgccaccgag gccactcgca gacacaggcc acagtcgtgc cctagggaga ccgaggcgcc
      121 ccccgagtca tggcccactc ggcctgcggg ttctcagtcg cactgctggg ggccctgctg
      181 ctgggcacag cacgcctgct gcgcgggaca gaagcatctg agattgctct gccccagaga
      241 agtggcgtca cagtgagcat caagctgggg aacccagccc ttcctgtgaa aatctgctac
      301 atcgtcatgt ctagacagca tataaccgag ttgattatca gacctggaga aagaaagtct
      361 tttaccttta gctgcagcaa tccagagaag cactttgtct tgaagatcga gaagaatatt
      421 gactgcatgt caggcccgtg tccttttggg gaggttcatc ttcagccatc cacatcagag
      481 ctacccatcc tcaacagaac cttcatctgg gatgttagag ctcataagag cattggcttg
      541 gagctgcagt tcgcaacccc tcgactgagg cagattggac caggcgagag ctgtgcagac
      601 ggggtgactc actccatcag tggccatata gatgccactg aggtcagaat tgggaccttc
      661 tgcagtaatg gcaccgtgtc ccggatcaag atgcaagagg gtgtgaaaat ggccttacac
      721 ctgccctggt tccaccgcag gaacgtctca ggcttcagta ttgcaaatcg gtcatctatc
      781 aaacgcctgt gcatcatcga gtcagtattt gagggtgaag gctcagcaac tctgatgtca
      841 gccaactacc caggaggctt ccctgaagat gagcttatga cctggcagtt tgttgtcccc
      901 gcacacctaa gggccagtgt ctccttcctc aacttcaatg tctccaactg tgagaggaag
      961 gaggaacgcg ttgaatacta tatcccaggc tccaccacca acccagaggt gttcaggctg
     1021 gaggacaagc agccaggaaa catggctggg aacttcaacc tctccctgca aggctgcgac
     1081 caggatgccc agagcccagg aatccttcgg cttcagttcc aggtcctggt ccaacgtcca
     1141 caggatgaaa gcaataaaac ctacatggtg gacctgagtc gtgagcgaac catgtcgctc
     1201 accatagagc cacggccagt aaaacatggc cgcaggtttg ttcctgggtg cttcgtgtgt
     1261 ctagagtctc ggacttgtag taccaatgtc accctgacag ctggctccat acacaagatt
     1321 tccttcctgt gcgatgactt gacacgcctg tgggtgaatg tggagaaaac cctaagttgc
     1381 ctggaccacc gctactgcta taggcagtcc ttcaaactgc aggtgcctga ctatatcctc
     1441 cagctgcctg tacagctgca tgacttctcc tggaagctac tggtgcccaa ggacaagctc
     1501 agccttatgc tggtgccagg ccagaagctg cagcagcata cgcaagagag gccttgtaac
     1561 accagcttcg ggtaccacgt gaccagcacc acccctggcc aggacctgta ctttggttcc
     1621 ttctgctcag gaggctccat cgagaagatc caggtgaagc aaaatagctc ggtgacactg
     1681 agagcctatg ctcccagctt tcaacaagaa gtctccaagc aaggcctgat agtgtcctat
     1741 acaccgtatt tcaaagagga aggcatcttc acggtgaccc cagacacaaa aaacaaggtc
     1801 tacctaagat cacccaactg ggaccgtggc ctgcctgccc tctcctcagt gtcttggaac
     1861 atcagtgtgc ctagcaacca agtggcttgt ctgaccgtct tgaaagagcg ttctggcttg
     1921 gcctgccagt cagggcgtgc attcatgatc atccaggagc agcagtcccg ggcagaggag
     1981 atcttcagct tggaggagga agtcctgcct aagccaagtt tccaccatca cagcttctgg
     2041 gttaacatct ccaattgcag ccccatgaat ggcaagcagc tagatttgct cttctgggtg
     2101 actcttaccc cgaggactgt agatttggct gtcgtcattg gtgcagcagg aggtggagct
     2161 ctgctgctgt ttgccctggt actcatcatc tgcttcgtga aaaagaagaa gaaggtggat
     2221 aagggtcctg ctgtgggtat ctataatggc aatgtcaata cccagatgcc ccagacccaa
     2281 aagttcccga aagggcgaaa agacaatgac tcccatgtgt atgctgtcat cgaagacacc
     2341 atggtgtatg ggcacttgct gcaggactcg ggtggatcct tcatccaacc agaggtggac
     2401 acctaccggc ccttccaggg ccccatggga gactgccctc ccaccccacc ccctctattc
     2461 tccaggaccc caactgcaaa gttcactgca gaggagctgg ctcctagtag ccctcctgag
     2521 tctgagagtg aaccttacac tttctcgcat cccaacaagg gggagattgg tgttagggag
     2581 actgacatcc ccttactcca tacccaagga ccagtggaga ctgaagagta acttggcccc
     2641 attccaaaga ctttgctgag atgcatggca ccagacattg agacatgaag aactgtccca
     2701 tcaagaagtc agagggaagc ccaatcagct agaaggaaga gtagcttttg caaggtgcca
     2761 tcaaatcttg atcttctggt ggactgcttc cagtgatggg caaatcatga cttctatgag
     2821 gatgccatcc taaagctcag gccttcctga actcgggttg tgttgaggct ggccacaggg
     2881 acagaagaga gacacggtcc acccagacaa gactacaatg agccctggag ttctggattc
     2941 ccgatgacga gcagagactt ggatgattcc caggagctcc acttgaggtc tctgctctca
     3001 ctggagacct atggatgaaa atggcaatgt gcttttttta aaattagttg tagtagtagt
     3061 agtagtagta gtagtagtag tagtagtatt tatttggtgg ccctgtatgt tttaaaaaag
     3121 ttggatgtgg agctgagggt gtagccaagt tggtagaatg cttgcccaac gtgtgcaaag
     3181 ctctgggctc catcctgcat aaaagcaggc aggatggtgc acacctgtag tctcgggaag
     3241 atcagaattt caagtcacca tcaagtatgc agtgaattga aggccccctg gtctgtgtaa
     3301 ggtcctcttg agaacacgca cagctctttt gacccctgtg gtaacggctc gtgctaactg
     3361 gtttggacag ctgtgctttg gtttttgtag acctctagat aaatgtacac ctgcggggaa
     3421 ggtgagaacc cagccagaag agtatctgca tgtatgtatc tcttactcaa taaggggttt
     3481 cccaatcctc cttgactgcc tatagctgtc ccactgcaga atttatcaca gatctcctcg
     3541 tcccctactc ctaaaaataa gagaaagttc cttgagctgc cttgtgtggt atgtggctct
     3601 cccacctgca gcaatacttt gacatgtaaa cagaaaattg agaataactt gatcccttaa
     3661 aaatatataa atataggcag tgttggtaca tgcctttaat tccagaactt gggagacaga
     3721 ggcaggcata tcctggtgag tttgaggcca atctggacta tatagtgagt tctaggacag
     3781 ccagggctac acacagaaat ccagctacac agagaaaccc tttcttgata aaacaaaaca
     3841 aaacaacaa
//
