LOCUS       NM_026560               1626 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus cell division cycle associated 8 (Cdca8), mRNA.
ACCESSION   NM_026560
VERSION     NM_026560.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1626)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1626)
  AUTHORS   Didier-Mathon,H., Stoupa,A., Kariyawasam,D., Yde,S.,
            Cochant-Priollet,B., Groussin,L., Sebag,F., Cagnard,N.,
            Nitschke,P., Luton,D., Polak,M. and Carre,A.
  TITLE     Borealin/CDCA8 deficiency alters thyroid development and results in
            papillary tumor-like structures
  JOURNAL   Front Endocrinol (Lausanne) 14, 1286747 (2023)
   PUBMED   37964961
  REMARK    GeneRIF: Borealin/CDCA8 deficiency alters thyroid development and
            results in papillary tumor-like structures.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1626)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1626)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1626)
  AUTHORS   Naiman,N., Fujioka,K., Fujino,M., Valerius,M.T., Potter,S.S.,
            McMahon,A.P. and Kobayashi,A.
  TITLE     Repression of Interstitial Identity in Nephron Progenitor Cells by
            Pax2 Establishes the Nephron-Interstitium Boundary during Kidney
            Development
  JOURNAL   Dev Cell 41 (4), 349-365 (2017)
   PUBMED   28535371
REFERENCE   6  (bases 1 to 1626)
  AUTHORS   Zhang,Q., Lin,G., Gu,Y., Peng,J., Nie,Z., Huang,Y. and Lu,G.
  TITLE     Borealin is differentially expressed in ES cells and is essential
            for the early development of embryonic cells
  JOURNAL   Mol Biol Rep 36 (3), 603-609 (2009)
   PUBMED   18311593
  REMARK    GeneRIF: Borealin plays a crucial role in the early mouse embryonic
            development
REFERENCE   7  (bases 1 to 1626)
  AUTHORS   Bourhis,E., Hymowitz,S.G. and Cochran,A.G.
  TITLE     The mitotic regulator Survivin binds as a monomer to its functional
            interactor Borealin
  JOURNAL   J Biol Chem 282 (48), 35018-35023 (2007)
   PUBMED   17881355
REFERENCE   8  (bases 1 to 1626)
  AUTHORS   Jeyaprakash,A.A., Klein,U.R., Lindner,D., Ebert,J., Nigg,E.A. and
            Conti,E.
  TITLE     Structure of a Survivin-Borealin-INCENP core complex reveals how
            chromosomal passengers travel together
  JOURNAL   Cell 131 (2), 271-285 (2007)
   PUBMED   17956729
REFERENCE   9  (bases 1 to 1626)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   10 (bases 1 to 1626)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY137168.1 and AK077717.1.
            
            On Apr 21, 2009 this sequence version replaced NM_026560.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY550907.1, AK076422.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164140, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                BY137168.1         1-76
            77-1626             AK077717.1         30-1579
FEATURES             Location/Qualifiers
     source          1..1626
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 57.93 cM"
     gene            1..1626
                     /gene="Cdca8"
                     /gene_synonym="4831429J16Rik; BOR; Borealin; D4Ertd421e;
                     DasraB; MESRGP"
                     /note="cell division cycle associated 8"
                     /db_xref="GeneID:52276"
                     /db_xref="MGI:MGI:1196274"
     exon            1..329
                     /gene="Cdca8"
                     /gene_synonym="4831429J16Rik; BOR; Borealin; D4Ertd421e;
                     DasraB; MESRGP"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..1105
                     /gene="Cdca8"
                     /gene_synonym="4831429J16Rik; BOR; Borealin; D4Ertd421e;
                     DasraB; MESRGP"
                     /note="embryonic stem cell-related; MESrg; cell division
                     cycle-associated protein 8"
                     /codon_start=1
                     /product="borealin"
                     /protein_id="NP_080836.3"
                     /db_xref="CCDS:CCDS18631.1"
                     /db_xref="GeneID:52276"
                     /db_xref="MGI:MGI:1196274"
                     /translation="MAPKKRSSRGTRTNTLRSRKLASFLKDFDREVQVRTKQIESDRQ
                     TLLKEVENLYNIEILRLPKALQGMKWLDYFALGGNKQALEEAAKADRDITEINNLTAE
                     AIQTPLKSVKKRKVIEVEESIKEEEEEEEEGGGGGGRTKKSHKNLRSAKVKRCLPSKK
                     RTQSIQGRGRSKRLSHDFVTPAMSRLEPSLVKPTPGMTPRFDSRVFKTPGLRTPAAKE
                     QVYNISINGSPLADSKEISLSVPIGGGASLRLLASDLQRIDIAQLNPEALGNIRKLSS
                     RLAQICSSIRTGR"
     exon            330..458
                     /gene="Cdca8"
                     /gene_synonym="4831429J16Rik; BOR; Borealin; D4Ertd421e;
                     DasraB; MESRGP"
                     /inference="alignment:Splign:2.1.0"
     exon            459..499
                     /gene="Cdca8"
                     /gene_synonym="4831429J16Rik; BOR; Borealin; D4Ertd421e;
                     DasraB; MESRGP"
                     /inference="alignment:Splign:2.1.0"
     exon            500..572
                     /gene="Cdca8"
                     /gene_synonym="4831429J16Rik; BOR; Borealin; D4Ertd421e;
                     DasraB; MESRGP"
                     /inference="alignment:Splign:2.1.0"
     exon            573..688
                     /gene="Cdca8"
                     /gene_synonym="4831429J16Rik; BOR; Borealin; D4Ertd421e;
                     DasraB; MESRGP"
                     /inference="alignment:Splign:2.1.0"
     exon            689..753
                     /gene="Cdca8"
                     /gene_synonym="4831429J16Rik; BOR; Borealin; D4Ertd421e;
                     DasraB; MESRGP"
                     /inference="alignment:Splign:2.1.0"
     exon            754..846
                     /gene="Cdca8"
                     /gene_synonym="4831429J16Rik; BOR; Borealin; D4Ertd421e;
                     DasraB; MESRGP"
                     /inference="alignment:Splign:2.1.0"
     exon            847..973
                     /gene="Cdca8"
                     /gene_synonym="4831429J16Rik; BOR; Borealin; D4Ertd421e;
                     DasraB; MESRGP"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1060
                     /gene="Cdca8"
                     /gene_synonym="4831429J16Rik; BOR; Borealin; D4Ertd421e;
                     DasraB; MESRGP"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1626
                     /gene="Cdca8"
                     /gene_synonym="4831429J16Rik; BOR; Borealin; D4Ertd421e;
                     DasraB; MESRGP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1596..1601
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdca8"
                     /gene_synonym="4831429J16Rik; BOR; Borealin; D4Ertd421e;
                     DasraB; MESRGP"
                     /note="hexamer: AATAAA"
     polyA_site      1623
                     /gene="Cdca8"
                     /gene_synonym="4831429J16Rik; BOR; Borealin; D4Ertd421e;
                     DasraB; MESRGP"
                     /note="major polyA site"
ORIGIN      
        1 tgtgcccgtt gagtttgaat tgggtggcgg ttaaccgagg agccgcccgt cccttagttg
       61 gagctgtgag ggttcctcag actgtgtttt gggacctgca ggtaggtttc ggcagagttc
      121 tggaaaccta gactccaacg actgaacttt ctcagctctc cgaccgctca caccctctcc
      181 ccgtctcagt cgcggagccg gctgcttggc ccctcgctcg acgcagccag gcgccatggc
      241 tcccaagaaa cgcagcagcc gcggaaccag gaccaacacg ctgcggagcc ggaagctcgc
      301 ctccttcctg aaggacttcg accgcgaggt gcaagttcga accaagcaaa ttgagtccga
      361 cagacagacc ctcctcaagg aggtggaaaa tctgtacaac atcgagatcc ttcggctccc
      421 caaggcgctg caagggatga agtggcttga ctacttcgcc ctaggaggaa acaagcaggc
      481 cctggaagag gcagcaaaag ctgatcgaga catcacagaa ataaacaatt taacagctga
      541 agctattcag acacctttga aatctgttaa aaagcgaaag gtaatcgagg tggaggaatc
      601 gataaaggaa gaagaagaag aggaagaaga aggaggagga ggaggaggaa gaacaaaaaa
      661 gagccataag aatcttcgat ctgcaaaagt caaaagatgc cttccatcca agaagagaac
      721 ccagtccata caaggaagag gcagaagtaa aaggttaagc catgactttg tgacgccagc
      781 tatgagcagg ctggagccgt ctctggtgaa accaacccca ggcatgacac ctaggtttga
      841 ctcccgggtc ttcaagactc cagggctacg cactccagca gccaaagagc aagtttacaa
      901 catctccatc aacggcagcc ctctcgcaga cagcaaagag atctccctca gtgtgcccat
      961 aggtggcggt gcgagcttgc ggttattggc cagtgacttg caaaggattg atattgctca
     1021 gctgaatcca gaggctctgg gaaacattag aaagctctcg agccgcctcg cccagatctg
     1081 cagcagcata cggacgggcc gatgagagga caacaggaca cacagtggca gcagggactg
     1141 tggtagcaga gtgcacacat ctgtccttct tctgtggggt ccttcactgc caacacctgc
     1201 aacggtgctt tgtctctctg acagctatgg tgtcttgctg cacacttcta gttagtggga
     1261 attttagacg gggaacacag ggctagtcag ggcctttgtg tgcttggtgt ggagtgactg
     1321 agaaccgtct atggttcaag gtcccactgg ggataaactg cttagagcac tgtcctagag
     1381 ggcaagtgta gccttcgcct ccgggcccag gcaggctatg cagtcagcag tagggtctgt
     1441 gctccatgcg ggtccaggcg cacggctctc ctattctgtt gtcatttgtg ccctctatgg
     1501 gcaggtgtgt ttcaagttgg ttttctgttg ctgaggcttt catacacatc agttaccatc
     1561 tcagctgatt tgtctactga aagcttgctg ttttcaataa atcttagttt gccatggttt
     1621 taagtc
//
