LOCUS       NM_025866               2387 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus cell division cycle associated 7 (Cdca7), transcript
            variant 1, mRNA.
ACCESSION   NM_025866
VERSION     NM_025866.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2387)
  AUTHORS   Vukic,M., Chouaref,J., Della Chiara,V., Dogan,S., Ratner,F.,
            Hogenboom,J.Z.M., Epp,T.A., Chawengsaksophak,K., Vonk,K.K.D.,
            Breukel,C., Ariyurek,Y., San Leon Granado,D., Kloet,S.L. and
            Daxinger,L.
  TITLE     CDCA7-associated global aberrant DNA hypomethylation translates to
            localized, tissue-specific transcriptional responses
  JOURNAL   Sci Adv 10 (6), eadk3384 (2024)
   PUBMED   38335290
  REMARK    GeneRIF: CDCA7-associated global aberrant DNA hypomethylation
            translates to localized, tissue-specific transcriptional responses.
REFERENCE   2  (bases 1 to 2387)
  AUTHORS   Wen,Y., Su,Z., Wang,Z., Yang,L., Liu,G., Shang,Z., Duan,Y., Du,H.,
            Li,Z., You,Y., Li,X., Yang,Z. and Zhang,Z.
  TITLE     Transcription Factor VAX1 Regulates the Regional Specification of
            the Subpallium Through Repressing Gsx2
  JOURNAL   Mol Neurobiol 58 (8), 3729-3744 (2021)
   PUBMED   33821423
REFERENCE   3  (bases 1 to 2387)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2387)
  AUTHORS   Hardikar,S., Ying,Z., Zeng,Y., Zhao,H., Liu,B., Veland,N.,
            McBride,K., Cheng,X. and Chen,T.
  TITLE     The ZBTB24-CDCA7 axis regulates HELLS enrichment at centromeric
            satellite repeats to facilitate DNA methylation
  JOURNAL   Protein Cell 11 (3), 214-218 (2020)
   PUBMED   31970665
  REMARK    GeneRIF: The ZBTB24-CDCA7 axis regulates HELLS enrichment at
            centromeric satellite repeats to facilitate DNA methylation.
REFERENCE   5  (bases 1 to 2387)
  AUTHORS   Ren,R., Hardikar,S., Horton,J.R., Lu,Y., Zeng,Y., Singh,A.K.,
            Lin,K., Coletta,L.D., Shen,J., Lin Kong,C.S., Hashimoto,H.,
            Zhang,X., Chen,T. and Cheng,X.
  TITLE     Structural basis of specific DNA binding by the transcription
            factor ZBTB24
  JOURNAL   Nucleic Acids Res 47 (16), 8388-8398 (2019)
   PUBMED   31226215
  REMARK    GeneRIF: The results demonstrated that the C382Y and C407G
            mutations in mouse ZBTB24 abolish specific DNA binding and fail to
            induce Cdca7 expression, modeling the events in
            immunodeficiency-centromeric instability-facial anomalies syndrome
            in humans.
REFERENCE   6  (bases 1 to 2387)
  AUTHORS   Goto,Y., Hayashi,R., Muramatsu,T., Ogawa,H., Eguchi,I., Oshida,Y.,
            Ohtani,K. and Yoshida,K.
  TITLE     JPO1/CDCA7, a novel transcription factor E2F1-induced protein,
            possesses intrinsic transcriptional regulator activity
  JOURNAL   Biochim Biophys Acta 1759 (1-2), 60-68 (2006)
   PUBMED   16580749
REFERENCE   7  (bases 1 to 2387)
  AUTHORS   Osthus,R.C., Karim,B., Prescott,J.E., Smith,B.D., McDevitt,M.,
            Huso,D.L. and Dang,C.V.
  TITLE     The Myc target gene JPO1/CDCA7 is frequently overexpressed in human
            tumors and has limited transforming activity in vivo
  JOURNAL   Cancer Res 65 (13), 5620-5627 (2005)
   PUBMED   15994934
REFERENCE   8  (bases 1 to 2387)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   9  (bases 1 to 2387)
  AUTHORS   Kagami,Y. and Furuichi,T.
  TITLE     Investigation of differentially expressed genes during the
            development of mouse cerebellum
  JOURNAL   Brain Res Gene Expr Patterns 1 (1), 39-59 (2001)
   PUBMED   15018818
REFERENCE   10 (bases 1 to 2387)
  AUTHORS   Morelli,L., Lusignan,Y. and Lemieux,S.
  TITLE     Heterogeneity of natural killer cell subsets in NK-1.1+ and NK-1.1-
            inbred mouse strains and their progeny
  JOURNAL   Cell Immunol 141 (1), 148-160 (1992)
   PUBMED   1555248
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845274.17.
            
            On Mar 21, 2023 this sequence version replaced NM_025866.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066169.1, AK167734.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               AL845274.17        60228-60343
            117-239             AL845274.17        62938-63060
            240-497             AL845274.17        65723-65980
            498-581             AL845274.17        66461-66544
            582-788             AL845274.17        67387-67593
            789-926             AL845274.17        67911-68048
            927-1076            AL845274.17        68631-68780
            1077-1213           AL845274.17        69208-69344
            1214-2387           AL845274.17        69752-70925
FEATURES             Location/Qualifiers
     source          1..2387
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 43.35 cM"
     gene            1..2387
                     /gene="Cdca7"
                     /gene_synonym="2310021G01Rik; JPO1"
                     /note="cell division cycle associated 7"
                     /db_xref="GeneID:66953"
                     /db_xref="MGI:MGI:1914203"
     exon            1..116
                     /gene="Cdca7"
                     /gene_synonym="2310021G01Rik; JPO1"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1244
                     /gene="Cdca7"
                     /gene_synonym="2310021G01Rik; JPO1"
                     /note="isoform a is encoded by transcript variant 1; cell
                     division cycle-associated protein 7; c-Myc target JPO1"
                     /codon_start=1
                     /product="cell division cycle-associated protein 7 isoform
                     a"
                     /protein_id="NP_080142.1"
                     /db_xref="CCDS:CCDS16121.1"
                     /db_xref="GeneID:66953"
                     /db_xref="MGI:MGI:1914203"
                     /translation="MEARRARQKALKVKNLKDVRYMKLISMETSSSSDDSCDSFASDN
                     FANTRLQLNREGCRTRSQCRHSGPLRVAMKFPARNTRRAASKKAAPPKPSESSANDSH
                     SDSEEEEEEEEEEDGMNFLEKRALNIKQNKAMLAKLMSELESFPGLFSGRHSLPGHRA
                     KDSKSPRRRTFPGVATRRNPERRTRPLTRSRSRILGSLGALPTEEEEEEEEEEEDKYM
                     LVRQRKSMDSYMNDDDVPRSRRPGSMTLPHIIRPVEEVTEEEIRNICSNSREKIYNRS
                     LGSTCHQCRQKTTDTKTNCRNPDCWGIRGQFCGPCLRNRYGEEVKDALLDPNWHCPPC
                     RGICNCSFCRQRDGRCATGVLVYLAKYHGFGNVHAYLKSLKQEFEMQA"
     exon            117..239
                     /gene="Cdca7"
                     /gene_synonym="2310021G01Rik; JPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            240..497
                     /gene="Cdca7"
                     /gene_synonym="2310021G01Rik; JPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            498..581
                     /gene="Cdca7"
                     /gene_synonym="2310021G01Rik; JPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            582..788
                     /gene="Cdca7"
                     /gene_synonym="2310021G01Rik; JPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            789..926
                     /gene="Cdca7"
                     /gene_synonym="2310021G01Rik; JPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1076
                     /gene="Cdca7"
                     /gene_synonym="2310021G01Rik; JPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1213
                     /gene="Cdca7"
                     /gene_synonym="2310021G01Rik; JPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..2387
                     /gene="Cdca7"
                     /gene_synonym="2310021G01Rik; JPO1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2367..2372
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdca7"
                     /gene_synonym="2310021G01Rik; JPO1"
                     /note="hexamer: AATAAA"
     polyA_site      2387
                     /gene="Cdca7"
                     /gene_synonym="2310021G01Rik; JPO1"
                     /note="major polyA site"
ORIGIN      
        1 gcctctgtcc cggagctcgg gttgttcggg ctctgagtgc tggtgtgttc cgacgaacta
       61 tccccgttcc gagtgcctgg gtacccgccg ccaacatgga ggctcgccgc gcgcggcaaa
      121 aggctctcaa agtaaagaac ttaaaggatg tcagatatat gaagttgatt tccatggaga
      181 catcgtcctc ctccgatgac agttgtgaca gctttgcttc tgataatttt gcaaacacaa
      241 gactgcagtt gaacagggaa ggctgcagga cccgaagtca gtgccggcac tccgggcctc
      301 tcagggtagc aatgaagttt ccggcacgaa atacccggag ggcggccagc aaaaaagcag
      361 cgcccccaaa gccctctgag agctctgcaa acgattccca ctctgactct gaagaagaag
      421 aagaagaaga agaagaagaa gatggcatga actttctgga gaagagagcc ttaaatataa
      481 agcagaacaa agcaatgctt gcaaaactca tgtcagaatt agaaagcttc cctggcttgt
      541 tctctggacg acattccctc ccaggccaca gagccaaaga ttcaaagtcg cctagacgac
      601 gcacattccc aggtgtggct accagaagga acccggaacg gagaactcga cctcttacca
      661 ggtcaaggtc ccggatcctg ggctccttgg gtgccctgcc caccgaggaa gaggaggagg
      721 aagaggagga ggaagaggat aagtacatgc tggtgagaca gaggaagtcc atggacagct
      781 acatgaacga cgatgatgtg cccagaagtc ggaggcctgg atccatgacc cttccgcata
      841 taatccgacc agtagaagaa gtcacagagg aagagattag gaacatctgc agcaactcga
      901 gagagaagat ttataaccgc tctctgggtt ctacatgtca tcagtgtcgc cagaaaacca
      961 ctgacaccaa aaccaactgc cgaaacccag actgctgggg catccggggc caattctgtg
     1021 gtccctgcct tcgaaaccgc tatggcgagg aggtcaagga cgctctgctg gatccgaatt
     1081 ggcactgccc accttgtcga ggaatttgca actgcagctt ctgccgccag cgtgatgggc
     1141 ggtgcgccac tggagtcctg gtgtatctgg caaagtatca tggcttcggg aacgtccatg
     1201 cttacttgaa aagtctgaag caggaatttg aaatgcaagc gtagagcctg aagattgtct
     1261 gcccgccttc ggcctctgaa ggctctcttg ttctcgacgt tgtgttgatg ggaacccgag
     1321 taagaatctc ggccatccgt ctgccttaga acttggtcgc gttgatctcg tatctcacac
     1381 ttgtttctga agcatcatga aaggcatgct actccttaca tttcagcgat atgtagtgtc
     1441 tcagagcttg ccccggcccc accttgtagc ctccctggtc ttttgccacc acttagattc
     1501 tgagctatct ttaactggca gcttgagaat ttgtgtgatc aggacatacc caagcacttt
     1561 ggggtacagt agtattgtga agcaacggtt gtgatgaatc acagagaaga gccccttaac
     1621 ttgtttacac agaatcaacg cacatagttt agtgtctagt gtttatattg gctaatgttt
     1681 taaatggaaa gggccaaggc acaaagggcc ggaaaccatg aggaagaatt aggtagttgt
     1741 tgtaaactgg agtatggcca cattggatgg ctttctggag gaatacatct ctggggtgct
     1801 gtgctcagtg tacgtcttgt cacagctgac actgttgctg ctgtcatctg gcctacccag
     1861 tcacccaaag gtttgtggga acttggtacc ataattacta aaaattgctg tagaaaaggt
     1921 gttctgggaa attaaagatg atagctcagc agcgggttga tctgaaacct tggtgttctg
     1981 cttcaggaac ttaaccttaa taatgtcact ttagatcctg gcagtttcct aaagaggtaa
     2041 ccctgggggt tgtgtccagg gtttctatat atttaggttt taaacacttt tggaatgatg
     2101 ggaagtggcc ttttagagat gggtagcttt gaacctctct gccagtgtag tttatgggtg
     2161 ggtgcctgaa gtcaccctcc ctcccctttc cctacaggtg ggtcattcag tactggtgac
     2221 gaagtgactg agtccctcac ctgtgtagcc tgtcagctgt gcctactctg tactctgtct
     2281 gtggtgctca gttggatctt gaatcattca gtgtaaatac agctttttgc tctgtaatgc
     2341 ttttatacaa aggtttttat tttaataata aaacattttg ttctaac
//
