LOCUS       NM_001359234            2114 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus cell division cycle associated 4 (Cdca4), transcript
            variant 2, mRNA.
ACCESSION   NM_001359234
VERSION     NM_001359234.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2114)
  AUTHORS   Tan,J., Chen,F., Wang,J., Li,J., Ouyang,B., Li,X., Li,Y., Zhang,W.
            and Jiang,Y.
  TITLE     ALKBH5 promotes the development of lung adenocarcinoma by
            regulating the polarization of M2 macrophages through CDCA4
  JOURNAL   Gene 895, 147975 (2024)
   PUBMED   37949419
  REMARK    GeneRIF: ALKBH5 promotes the development of lung adenocarcinoma by
            regulating the polarization of M2 macrophages through CDCA4.
REFERENCE   2  (bases 1 to 2114)
  AUTHORS   Peng,Y., Zhao,S., Song,L., Wang,M. and Jiao,K.
  TITLE     Sertad1 encodes a novel transcriptional co-activator of SMAD1 in
            mouse embryonic hearts
  JOURNAL   Biochem Biophys Res Commun 441 (4), 751-756 (2013)
   PUBMED   24211589
REFERENCE   3  (bases 1 to 2114)
  AUTHORS   Bennetts,J.S., Fowles,L.F., Berkman,J.L., van Bueren,K.L.,
            Richman,J.M., Simpson,F. and Wicking,C.
  TITLE     Evolutionary conservation and murine embryonic expression of the
            gene encoding the SERTA domain-containing protein CDCA4 (HEPP)
  JOURNAL   Gene 374, 153-165 (2006)
   PUBMED   16546331
  REMARK    GeneRIF: The evolutionary conservation and murine embryonic
            expression of the gene encoding the SERTA domain-containing protein
            Cdca4 was studied.
REFERENCE   4  (bases 1 to 2114)
  AUTHORS   Watanabe-Fukunaga,R., Iida,S., Shimizu,Y., Nagata,S. and
            Fukunaga,R.
  TITLE     SEI family of nuclear factors regulates p53-dependent
            transcriptional activation
  JOURNAL   Genes Cells 10 (8), 851-860 (2005)
   PUBMED   16098148
REFERENCE   5  (bases 1 to 2114)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   6  (bases 1 to 2114)
  AUTHORS   Abdullah,J.M., Jing,X., Spassov,D.S., Nachtman,R.G. and Jurecic,R.
  TITLE     Cloning and characterization of Hepp, a novel gene expressed
            preferentially in hematopoietic progenitors and mature blood cells
  JOURNAL   Blood Cells Mol Dis 27 (3), 667-676 (2001)
   PUBMED   11482882
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY199153.1, AK010535.1 and AF322238.1.
            
            Transcript Variant: This variant (2) represents the shortest
            transcript. All variants encode the same protein.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-216               BY199153.1         2-217
            217-2092            AK010535.1         109-1984
            2093-2114           AF322238.1         2061-2082
FEATURES             Location/Qualifiers
     source          1..2114
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 61.2 cM"
     gene            1..2114
                     /gene="Cdca4"
                     /gene_synonym="2410018C03Rik; HEPP; SEI-3"
                     /note="cell division cycle associated 4"
                     /db_xref="GeneID:71963"
                     /db_xref="MGI:MGI:1919213"
     exon            1..216
                     /gene="Cdca4"
                     /gene_synonym="2410018C03Rik; HEPP; SEI-3"
                     /inference="alignment:Splign:2.1.0"
     exon            217..2100
                     /gene="Cdca4"
                     /gene_synonym="2410018C03Rik; HEPP; SEI-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             223..936
                     /gene="Cdca4"
                     /gene_synonym="2410018C03Rik; HEPP; SEI-3"
                     /note="hematopoietic progenitor protein"
                     /codon_start=1
                     /product="cell division cycle-associated protein 4"
                     /protein_id="NP_001346163.1"
                     /db_xref="CCDS:CCDS26198.1"
                     /db_xref="GeneID:71963"
                     /db_xref="MGI:MGI:1919213"
                     /translation="MFARGLKRKYGDQEEGVEGFGTVPSYSLQRQSLLDMSLVKLQLC
                     HMLVEPNLCRSVLIANTVRQIQEEMSQDGVWHGMAPQNVDRAPVERLVSTEILCRTVR
                     GAEEEHPAPELEDAPLQNSVSELPIVGSAPGQRNPQSSLWEMDSPQENRGSFQKSLDQ
                     IFETLENKNSSSVEELFSDVDSSYYDLDTVLTGMMSGTKSSLCNGLEGFAAATPPPSS
                     TCKSDLAELDHVVEILVET"
     regulatory      2077..2082
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdca4"
                     /gene_synonym="2410018C03Rik; HEPP; SEI-3"
                     /note="hexamer: ATTAAA"
     polyA_site      2095
                     /gene="Cdca4"
                     /gene_synonym="2410018C03Rik; HEPP; SEI-3"
                     /note="major polyA site"
ORIGIN      
        1 gggaacgggg gcggggcggc ccagcgcgcg agcctaacgg ctgaggccga agcgcgggag
       61 acgcggccgg cgaggctccg ccttgcgtgg gtttgaacaa agctccaccc cgcacgccac
      121 caatcggcgc tcgtgcggcg gcgccatggc gaccctttgt gggcgctgac cgatccgggt
      181 gcccgaagga gtggcggggt ctgccttgcg gcgccggaca ggatgtttgc tagagggctg
      241 aagaggaaat atggtgacca ggaagaagga gtagagggtt ttggcactgt cccttcctat
      301 agcctgcagc gacagtcact cctggacatg tcccttgtca agctccagct ctgtcacatg
      361 ctagtggagc ccaatctctg ccgctcggtc ctcatcgcca acacagtccg gcagatccag
      421 gaggaaatga gccaggatgg tgtgtggcat gggatggcac cccagaatgt agatcgggca
      481 ccagttgaac gcctggtgtc cacagagatc ctgtgtcgta cagtgagggg agctgaggaa
      541 gagcaccctg ctcctgaact ggaagatgct cccttgcaaa actcggtttc cgagctcccc
      601 atcgttggct cagcaccagg gcaaaggaac cctcagagca gcctctggga gatggacagc
      661 ccacaagaaa acaggggaag ctttcagaag tcactggacc agatatttga gaccctggag
      721 aacaaaaact ccagttcagt ggaggaactc ttctcagatg tggacagctc ctactatgac
      781 ctggacacag tgctaacagg aatgatgagt gggaccaagt ccagtctctg caatggcctt
      841 gagggctttg ctgcagccac ccctcctccc agttccactt gcaagtctga cctggctgag
      901 ctggaccatg tggtagagat tctggtggag acctgagagg ccaccccagt gggctaaggg
      961 tgaggccacc agtccccatg gagctcacgt gtgttgtgac ccagagacag ataagcactt
     1021 gtcctaagag gggctctggc tcttgagctc attatccttt tgtgtgacat tggactcact
     1081 gtggaggatg gtgtgtcaca gctatgtcta gtctattttc aattagatag gtgaactttc
     1141 taaaattaag ttttatatgt ttttgggcaa tattttgtct taagatatat tttttaaact
     1201 ttttatactt tagatttttt tcagctattt tcttaaaagt atattttttc tacaaacatc
     1261 ctctgctgct acattagaaa catttataac ctaaatacga ttggtgtgtc attttaaagg
     1321 tttaaataga aaacttcttt tgttactgag tctctacact cccaaggcaa ctgtaaatgt
     1381 agccggccgg gtgtttacat gagaggctcc agtatggtct acattctagt agagcttgaa
     1441 aagaaccatg cacagctcca ctgccccctc actgggtctg ctctggcgga tcggagctct
     1501 cttcctagcc ccgtgtgcag gatggcttta tttatgccta tttatatgta aatgccactg
     1561 aaagctaagg tcttactcct ggaaatccca acaccagttc ttcagggact gctgtgaggc
     1621 agtgccttat gcaggtcttg tccttggcca tcactgtctg gttcccagcc cagcacatgt
     1681 gacatgagga catgacatgc ccgaaccacc cagcaccaca tgctccatgt caagtgtgta
     1741 cgtggagacc actggctccc aggcctgtgc tcagagaggg tgtgcagtcc tacgtgtgct
     1801 gggggggacg acggtgacct gtgcttgctt gcttttaaaa tggtgcttgg acgttttaag
     1861 gttaaaaaca atccgactcc atatgattta gggctcctcc accctggggt ggcccctatg
     1921 ctgtctgctt ggatctcaaa gtcttggtac tcggcactgt cagactccac cccatgtatc
     1981 ctttttgttt ctcttgtgct ttttttggac ttcccaacct gagcctaagg ttttatttta
     2041 tatgtgcttc aatatcaaca atgtaaacct cactttatta aaagtatcca gcaaatggaa
     2101 aaaaaaaaaa aaaa
//
