LOCUS       NM_001110162            3865 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus cell division cycle associated 2 (Cdca2), transcript
            variant 1, mRNA.
ACCESSION   NM_001110162
VERSION     NM_001110162.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3865)
  AUTHORS   Kang,H.S., Grimm,S.A., Liao,X.H. and Jetten,A.M.
  TITLE     GLIS3 expression in the thyroid gland in relation to TSH signaling
            and regulation of gene expression
  JOURNAL   Cell Mol Life Sci 81 (1), 65 (2024)
   PUBMED   38281222
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3865)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3865)
  AUTHORS   Ulmke,P.A., Sakib,M.S., Ditte,P., Sokpor,G., Kerimoglu,C., Pham,L.,
            Xie,Y., Mao,X., Rosenbusch,J., Teichmann,U., Nguyen,H.P.,
            Fischer,A., Eichele,G., Staiger,J.F. and Tuoc,T.
  TITLE     Molecular Profiling Reveals Involvement of ESCO2 in Intermediate
            Progenitor Cell Maintenance in the Developing Mouse Cortex
  JOURNAL   Stem Cell Reports 16 (4), 968-984 (2021)
   PUBMED   33798452
REFERENCE   4  (bases 1 to 3865)
  AUTHORS   Naiman,N., Fujioka,K., Fujino,M., Valerius,M.T., Potter,S.S.,
            McMahon,A.P. and Kobayashi,A.
  TITLE     Repression of Interstitial Identity in Nephron Progenitor Cells by
            Pax2 Establishes the Nephron-Interstitium Boundary during Kidney
            Development
  JOURNAL   Dev Cell 41 (4), 349-365 (2017)
   PUBMED   28535371
REFERENCE   5  (bases 1 to 3865)
  AUTHORS   Ray,J.P., Staron,M.M., Shyer,J.A., Ho,P.C., Marshall,H.D.,
            Gray,S.M., Laidlaw,B.J., Araki,K., Ahmed,R., Kaech,S.M. and
            Craft,J.
  TITLE     The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling,
            Differentiation, and Metabolism of T Helper 1 and Follicular B
            Helper T Cells
  JOURNAL   Immunity 43 (4), 690-702 (2015)
   PUBMED   26410627
REFERENCE   6  (bases 1 to 3865)
  AUTHORS   Xie,L., Hoffmann,A.D., Burnicka-Turek,O., Friedland-Little,J.M.,
            Zhang,K. and Moskowitz,I.P.
  TITLE     Tbx5-hedgehog molecular networks are essential in the second heart
            field for atrial septation
  JOURNAL   Dev Cell 23 (2), 280-291 (2012)
   PUBMED   22898775
REFERENCE   7  (bases 1 to 3865)
  AUTHORS   Wurzenberger,C., Held,M., Lampson,M.A., Poser,I., Hyman,A.A. and
            Gerlich,D.W.
  TITLE     Sds22 and Repo-Man stabilize chromosome segregation by
            counteracting Aurora B on anaphase kinetochores
  JOURNAL   J Cell Biol 198 (2), 173-183 (2012)
   PUBMED   22801782
REFERENCE   8  (bases 1 to 3865)
  AUTHORS   Sansom,S.N., Griffiths,D.S., Faedo,A., Kleinjan,D.J., Ruan,Y.,
            Smith,J., van Heyningen,V., Rubenstein,J.L. and Livesey,F.J.
  TITLE     The level of the transcription factor Pax6 is essential for
            controlling the balance between neural stem cell self-renewal and
            neurogenesis
  JOURNAL   PLoS Genet 5 (6), e1000511 (2009)
   PUBMED   19521500
REFERENCE   9  (bases 1 to 3865)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   10 (bases 1 to 3865)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD354922.1, AK160223.1, AK166952.1 and BC067009.1.
            
            Transcript Variant: This variant (1) is the longer transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC075682.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMN00849374,
                                    SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-239               CD354922.1         1-239
            240-1550            AK160223.1         2-1312
            1551-2017           AK166952.1         1321-1787
            2018-3865           BC067009.1         1859-3706
FEATURES             Location/Qualifiers
     source          1..3865
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 34.66 cM"
     gene            1..3865
                     /gene="Cdca2"
                     /gene_synonym="2610311M19Rik"
                     /note="cell division cycle associated 2"
                     /db_xref="GeneID:108912"
                     /db_xref="MGI:MGI:1919787"
     exon            1..387
                     /gene="Cdca2"
                     /gene_synonym="2610311M19Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             388..3336
                     /gene="Cdca2"
                     /gene_synonym="2610311M19Rik"
                     /codon_start=1
                     /product="cell division cycle-associated protein 2"
                     /protein_id="NP_001103632.1"
                     /db_xref="CCDS:CCDS36962.2"
                     /db_xref="GeneID:108912"
                     /db_xref="MGI:MGI:1919787"
                     /translation="MDASSHDKPLSESKECVLNNSENDVFRLGTEPFVTPQKHVADAT
                     PNLCTPDTFKSPLDFTTVTVEQLGITPESFVKTSSGKSTSSLQKARRRSTVGVRGSPE
                     TNCLIRFIAQQRNLKKAVLSPLAREPHFEGSPRLYRNASVLRERMSAFRSAFHSIQET
                     KMASSPSAAEADGESRISDLTRKEDLLEYQQSGFPVNSSSKRRRISSQDSPDNYLSGT
                     KALADEACAGGASTDLAEKSPDIGSAQPGCMAAPLPELRETSQGLAVTDCVEGPVTPL
                     SSGTATATRSPETPMCGSSSPSAKTTATRSPATPVCGSSTPSAKTFVLRSVLKKPGKL
                     FSENGKESNLCDDGAHLISYPSNSCKEGRAGRENCKTPGCLNPRKRKRVTFGEDLSPE
                     VFDESLPANTPLCKGGTPVRPRTVKTTSPLQSPVHEQFLQPNFDDKEENLENIEPPQG
                     SFANLSLSKSSLSETPPGTNTCSSLNKDEEIICSIVRPTRTSQRRKQTLSSTGVCSSY
                     TTQAEPRKEKMSRRKSREKKHTSAALPKKKQVLKSYRKKKKGKKDVEKCFYGPRDIAS
                     KKPLLSPIPELPEVSEATPLADCTQGTSSDDFNKCGQLEEVNSFEIPTQRKRRLPQKA
                     DSPELDPAHHQSQVSDKCCYLLPLTTASERGPNASTRDTGSEGNTRAESKCQSAKEPK
                     PGTKMESGLVPRASVTQDHIVSKNPKPLGSPQSQDLFKAGQNLENPCEILIVSESMNL
                     KCEKESECLAPQGSLQGSPVSTDSKRDLNCSEDVLIQNIKEPASHSENVGRKCAGNGS
                     PGSGRERKWRRRTVCCGGQSSYLEQNGNPASSCSGENFVEISLESVQLIEELSNTIEQ
                     SFQRTSSKTKVRRSTRLQRDLENTGLVWLSPSPSTLQKPRRRMTICTLDSRGFECPSS
                     KEETISSGQNPGPLPAVSGSESQGVGSSALPRKRRSLCGSTLTDANSATQPPDCKRKP
                     SLKGESAQLP"
     exon            388..451
                     /gene="Cdca2"
                     /gene_synonym="2610311M19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            452..625
                     /gene="Cdca2"
                     /gene_synonym="2610311M19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            626..780
                     /gene="Cdca2"
                     /gene_synonym="2610311M19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            781..928
                     /gene="Cdca2"
                     /gene_synonym="2610311M19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1095
                     /gene="Cdca2"
                     /gene_synonym="2610311M19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1171
                     /gene="Cdca2"
                     /gene_synonym="2610311M19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1407
                     /gene="Cdca2"
                     /gene_synonym="2610311M19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1480
                     /gene="Cdca2"
                     /gene_synonym="2610311M19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1713
                     /gene="Cdca2"
                     /gene_synonym="2610311M19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1789
                     /gene="Cdca2"
                     /gene_synonym="2610311M19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1875
                     /gene="Cdca2"
                     /gene_synonym="2610311M19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..2004
                     /gene="Cdca2"
                     /gene_synonym="2610311M19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..2173
                     /gene="Cdca2"
                     /gene_synonym="2610311M19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..3842
                     /gene="Cdca2"
                     /gene_synonym="2610311M19Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3449..3454
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdca2"
                     /gene_synonym="2610311M19Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3480
                     /gene="Cdca2"
                     /gene_synonym="2610311M19Rik"
                     /note="major polyA site"
     regulatory      3821..3826
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdca2"
                     /gene_synonym="2610311M19Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      3842
                     /gene="Cdca2"
                     /gene_synonym="2610311M19Rik"
                     /note="major polyA site"
ORIGIN      
        1 actcactggt agaccccagg acaccttttt gctgcagctc tgtctcgcca gggtcattta
       61 gggctggccg tgttttttcc gggatccacg gaggtctccc tgcgccgttc gaaagcacga
      121 gggtgaggcc cggagggagc ggtacccacg tcacacgtgg tccacggctc gtgggtatcc
      181 ctccgcgggg gcgtggccgc ggtttgaatt tgctggcggg caagtgaagc ttgaccgctt
      241 cggccggacg tggtgtgtct ggtgtgcagc ggccggcagg aggccagccc ggctcccttc
      301 cccggcctct ggtgctctct gaaacggagc ctccgcgacg cttgtcgtag tcgtccgagg
      361 gaacgcgcag ggtcctgggc gggagagatg gatgcgagtt cacacgacaa gcctctctct
      421 gaatccaagg agtgtgtcct taataattct gaaaatgacg tttttagatt gggaactgaa
      481 ccgtttgtga ctcctcagaa gcatgtagca gatgcgactc ctaatctttg cacccctgat
      541 acctttaagt cacctttgga cttcaccaca gtaaccgtag agcagttggg aattacacct
      601 gaaagctttg ttaagacctc ttccggaaag tcaacatctt cccttcagaa ggccaggcgc
      661 cgctccactg ttggtgtgcg gggctctcca gaaaccaatt gcctgatccg attcattgcc
      721 cagcagcgaa acctaaagaa ggctgtgctc tctccgttgg cacgagagcc ccacttcgag
      781 ggtagcccaa gactgtatcg aaatgccagt gttttaagag agcgaatgtc tgcttttcgg
      841 tcagcttttc actccataca ggaaactaag atggccagca gtccctcagc agcagaggca
      901 gacggagagt ctaggatatc agatttgacc agaaaagaag atcttcttga atatcagcag
      961 tctgggttcc ctgtaaactc ctcttcaaag cggaggagaa tatcctccca ggacagccct
     1021 gacaattatc tcagtggcac caaagccctt gctgacgaag cgtgtgctgg gggtgcctcc
     1081 acagatcttg ctgagaagtc acctgacatc ggttccgccc agccgggatg catggctgct
     1141 ccccttccag agctcaggga gacttcccag ggacttgcag tgactgactg tgtagagggc
     1201 cctgtaacac cactgagctc aggcacagcc actgccacca ggtctccaga gactcctatg
     1261 tgcgggagca gcagcccctc cgctaagacc accgccacca ggtctccagc gactcctgta
     1321 tgtggaagca gcaccccctc cgctaagacc tttgtgcttc gttctgtgtt gaagaaacct
     1381 ggtaagctgt tctcagagaa tggaaaggaa tccaacctct gtgatgacgg ggctcatctg
     1441 atctcatatc cttcaaactc ttgcaaggaa ggaagagcag gtagagaaaa ctgtaaaaca
     1501 ccaggctgtc tgaatccgag gaagaggaag agagttactt ttggagagga cttaagccct
     1561 gaagtgtttg atgagtcttt accagccaat actccattgt gcaaaggagg aacacctgtt
     1621 cgcccaagga ccgtaaaaac taccagtccc ctgcagtccc ccgttcatga gcagtttctt
     1681 cagccaaact ttgatgacaa ggaggagaac cttgaaaaca tagagccacc tcagggatca
     1741 tttgcaaatc tgagtcttag taaatcctca ctctctgaga ctcctccagg cactaacact
     1801 tgcagttctt taaataaaga tgaagaaata atctgcagta ttgttagacc tacacggacc
     1861 tctcaaagaa gaaagcagac gctgagttct acaggtgttt gcagctcata tactacacaa
     1921 gctgagcccc gtaaagagaa gatgagcagg aggaaatctc gagaaaaaaa gcacacaagc
     1981 gcggcacttc ctaaaaagaa acaggtttta aaaagttaca gaaaaaagaa aaaggggaaa
     2041 aaagatgttg aaaaatgctt ttatgggcca agagacattg catcgaagaa gccactcctg
     2101 agccctattc ctgagctgcc tgaagtctct gaagcgactc ctctggctga ctgcacgcag
     2161 gggacgagct cagatgattt caacaaatgt ggtcagctgg aagaagtgaa ctcgtttgaa
     2221 attcccacac aacggaagag acgcttacca cagaaggcag attcgcctga gctggaccca
     2281 gctcatcatc agtctcaggt ctctgacaag tgctgctacc tgttgcctct cactactgct
     2341 tctgagcgag ggccaaatgc cagtaccaga gacacaggca gtgaagggaa caccagagcg
     2401 gagagtaagt gtcaaagtgc aaaggagcca aaacccggga ccaagatgga aagcggtctt
     2461 gtgcctcggg cttctgtgac ccaagatcac atcgtgtcca agaatccaaa acctctgggc
     2521 agccctcaga gccaggacct tttcaaggct ggtcaaaatt tggaaaatcc ttgtgagatc
     2581 cttattgttt cagaaagtat gaatctaaag tgtgagaaag agagtgaatg cttagctcca
     2641 caggggagtc tgcagggcag ccctgtctct actgactcaa aaagagacct taactgttca
     2701 gaagatgtcc tcattcaaaa tataaaagaa cccgcaagcc acagtgagaa tgtgggaagg
     2761 aaatgtgcag ggaatggcag ccctggcagt gggagagaga ggaaatggag aagacgcaca
     2821 gtgtgttgtg ggggtcagag ttcatacctg gaacaaaatg ggaaccctgc gtcttcctgc
     2881 agtggggaaa actttgtgga aattagttta gaaagcgtgc agctgattga agagctgtct
     2941 aacaccatag agcaaagctt tcagagaaca agcagtaaaa ccaaggtgag acgcagcaca
     3001 aggctccaga gagacttgga aaatacaggg cttgtgtggc tgtctccaag tccttccact
     3061 ttgcagaagc ccagaaggag aatgacgatc tgcaccttag acagcagggg atttgaatgt
     3121 ccatcctcca aagaagagac catatcctca ggacaaaacc cagggccgct gcccgctgtc
     3181 tcgggcagtg agagccaggg tgttggttct tctgcgctac ctaggaagag gagaagcctt
     3241 tgtgggtcta ccctcacaga tgctaacagt gccacccagc caccagactg caagagaaaa
     3301 ccctcgctca agggagaaag cgctcagctg ccctgagggg gctgggccca ggagaacaaa
     3361 ggcaggaaca gacaatccca cctggcattg gctcttaggg aagaggaccc agcttcctgt
     3421 aggccgcttc agtgcattgc acatttctaa taaaaatcat ttgagttatg atgactttaa
     3481 gtagaaatac attaatttct ttcttctccc tctaaatata tttgtttgtc tttttgtttt
     3541 gcctttgttt tgttaaagca ttcctttcta gatccagcaa tgtgtttctg cagttttatt
     3601 ccttttacca tttaccacta aaggctttgg ctgttctgga aaaggacctt tagaatgact
     3661 tattcttttc tttgggttaa attgaccagc tttgatgact tcattgtctg tctcaaatca
     3721 gagttttcct ttgctaatta agtgacaatg aggccctgta tttgaaattt taattcattg
     3781 actggaactc tatagagaaa ctattgtaaa tgaatatgta attaaacata actgtgcagt
     3841 caaaaaaaaa aaaaaaaaaa aaaaa
//
