LOCUS       NM_145991               7110 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus cell division cycle 73, Paf1/RNA polymerase II complex
            component (Cdc73), mRNA.
ACCESSION   NM_145991
VERSION     NM_145991.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7110)
  AUTHORS   Saha,N., Ropa,J., Chen,L., Hu,H., Mysliwski,M., Friedman,A.,
            Maillard,I. and Muntean,A.G.
  TITLE     The PAF1c Subunit CDC73 Is Required for Mouse Hematopoietic Stem
            Cell Maintenance but Displays Leukemia-Specific Gene Regulation
  JOURNAL   Stem Cell Reports 12 (5), 1069-1083 (2019)
   PUBMED   31031188
  REMARK    GeneRIF: Cell division cycle 73 (CDC73) Is esential for embryonic
            and adult matopoiesis and Indispensable for acute myeloid leukemia
            (AML)
REFERENCE   2  (bases 1 to 7110)
  AUTHORS   Walls,G.V., Stevenson,M., Lines,K.E., Newey,P.J., Reed,A.A.C.,
            Bowl,M.R., Jeyabalan,J., Harding,B., Bradley,K.J., Manek,S.,
            Chen,J., Wang,P., Williams,B.O., Teh,B.T. and Thakker,R.V.
  TITLE     Mice deleted for cell division cycle 73 gene develop parathyroid
            and uterine tumours: model for the hyperparathyroidism-jaw tumour
            syndrome
  JOURNAL   Oncogene 36 (28), 4025-4036 (2017)
   PUBMED   28288139
  REMARK    GeneRIF: Uterine neoplasms, myometria and jaw bones of Cdc73(+/-)
            mice had increased proliferation rates that were 2-fold higher than
            in Cdc73(+/+) mice.
REFERENCE   3  (bases 1 to 7110)
  AUTHORS   Droscha,C.J., Diegel,C.R., Ethen,N.J., Burgers,T.A., McDonald,M.J.,
            Maupin,K.A., Naidu,A.S., Wang,P., Teh,B.T. and Williams,B.O.
  TITLE     Osteoblast-specific deletion of Hrpt2/Cdc73 results in high bone
            mass and increased bone turnover
  JOURNAL   Bone 98, 68-78 (2017)
   PUBMED   28384511
  REMARK    GeneRIF: These results aid in our understanding of the role
            parafibromin plays within transcriptional regulation, terminal
            differentiation, and bone homeostasis
REFERENCE   4  (bases 1 to 7110)
  AUTHORS   Osipovich,A.B., Gangula,R., Vianna,P.G. and Magnuson,M.A.
  TITLE     Setd5 is essential for mammalian development and the
            co-transcriptional regulation of histone acetylation
  JOURNAL   Development 143 (24), 4595-4607 (2016)
   PUBMED   27864380
REFERENCE   5  (bases 1 to 7110)
  AUTHORS   Strikoudis,A., Lazaris,C., Trimarchi,T., Galvao Neto,A.L., Yang,Y.,
            Ntziachristos,P., Rothbart,S., Buckley,S., Dolgalev,I.,
            Stadtfeld,M., Strahl,B.D., Dynlacht,B.D., Tsirigos,A. and
            Aifantis,I.
  TITLE     Regulation of transcriptional elongation in pluripotency and cell
            differentiation by the PHD-finger protein Phf5a
  JOURNAL   Nat Cell Biol 18 (11), 1127-1138 (2016)
   PUBMED   27749823
REFERENCE   6  (bases 1 to 7110)
  AUTHORS   Ding,L., Paszkowski-Rogacz,M., Nitzsche,A., Slabicki,M.M.,
            Heninger,A.K., de Vries,I., Kittler,R., Junqueira,M.,
            Shevchenko,A., Schulz,H., Hubner,N., Doss,M.X., Sachinidis,A.,
            Hescheler,J., Iacone,R., Anastassiadis,K., Stewart,A.F.,
            Pisabarro,M.T., Caldarelli,A., Poser,I., Theis,M. and Buchholz,F.
  TITLE     A genome-scale RNAi screen for Oct4 modulators defines a role of
            the Paf1 complex for embryonic stem cell identity
  JOURNAL   Cell Stem Cell 4 (5), 403-415 (2009)
   PUBMED   19345177
REFERENCE   7  (bases 1 to 7110)
  AUTHORS   Wang,P., Bowl,M.R., Bender,S., Peng,J., Farber,L., Chen,J., Ali,A.,
            Zhang,Z., Alberts,A.S., Thakker,R.V., Shilatifard,A., Williams,B.O.
            and Teh,B.T.
  TITLE     Parafibromin, a component of the human PAF complex, regulates
            growth factors and is required for embryonic development and
            survival in adult mice
  JOURNAL   Mol Cell Biol 28 (9), 2930-2940 (2008)
   PUBMED   18212049
  REMARK    GeneRIF: Expression of Hrpt2 and parafibromin is pivotal in
            mammalian development and survival in adults and that these
            functions are likely mediated by the transcriptional regulation of
            growth factors.
REFERENCE   8  (bases 1 to 7110)
  AUTHORS   Youn,M.Y., Yoo,H.S., Kim,M.J., Hwang,S.Y., Choi,Y., Desiderio,S.V.
            and Yoo,J.Y.
  TITLE     hCTR9, a component of Paf1 complex, participates in the
            transcription of interleukin 6-responsive genes through regulation
            of STAT3-DNA interactions
  JOURNAL   J Biol Chem 282 (48), 34727-34734 (2007)
   PUBMED   17911113
REFERENCE   9  (bases 1 to 7110)
  AUTHORS   Woodard,G.E., Lin,L., Zhang,J.H., Agarwal,S.K., Marx,S.J. and
            Simonds,W.F.
  TITLE     Parafibromin, product of the hyperparathyroidism-jaw tumor syndrome
            gene HRPT2, regulates cyclin D1/PRAD1 expression
  JOURNAL   Oncogene 24 (7), 1272-1276 (2005)
   PUBMED   15580289
REFERENCE   10 (bases 1 to 7110)
  AUTHORS   Yalcin,B., Willis-Owen,S.A., Fullerton,J., Meesaq,A., Deacon,R.M.,
            Rawlins,J.N., Copley,R.R., Morris,A.P., Flint,J. and Mott,R.
  TITLE     Genetic dissection of a behavioral quantitative trait locus shows
            that Rgs2 modulates anxiety in mice
  JOURNAL   Nat Genet 36 (11), 1197-1202 (2004)
   PUBMED   15489855
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL592403.6, BB645172.1, AK080861.1, AK048027.1, AK153645.1 and
            AK134896.1.
            
            On Sep 1, 2015 this sequence version replaced NM_145991.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031127.1, AK080861.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                AL592403.6         11613-11689         c
            78-269              BB645172.1         1-192
            270-2136            AK080861.1         193-2059
            2137-3215           AK048027.1         1048-2126
            3216-3777           AK048027.1         2128-2689
            3778-4715           AK153645.1         1-938
            4716-7110           AK134896.1         554-2948
FEATURES             Location/Qualifiers
     source          1..7110
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 62.52 cM"
     gene            1..7110
                     /gene="Cdc73"
                     /gene_synonym="8430414L16Rik; C130030P16Rik; Hrpt2"
                     /note="cell division cycle 73, Paf1/RNA polymerase II
                     complex component"
                     /db_xref="GeneID:214498"
                     /db_xref="MGI:MGI:2384876"
     exon            1..400
                     /gene="Cdc73"
                     /gene_synonym="8430414L16Rik; C130030P16Rik; Hrpt2"
                     /inference="alignment:Splign:2.1.0"
     CDS             270..1865
                     /gene="Cdc73"
                     /gene_synonym="8430414L16Rik; C130030P16Rik; Hrpt2"
                     /note="hyperparathyroidism 2 protein homolog; cell
                     division cycle protein 73 homolog"
                     /codon_start=1
                     /product="parafibromin"
                     /protein_id="NP_666103.1"
                     /db_xref="CCDS:CCDS15341.1"
                     /db_xref="GeneID:214498"
                     /db_xref="MGI:MGI:2384876"
                     /translation="MADVLSVLRQYNIQKKEIVVKGDEVIFGEFSWPKNVKTNYVVWG
                     TGKEGQPREYYTLDSILFLLNNVHLSHPVYVRRAATENIPVVRRPDRKDLLGYLNGEA
                     STSASIDRSAPLEIGLQRSTQVKRAADEVLAEAKKPRIEDEECVRLDKERLAARLEGH
                     KEGIVQTEQIRSLSEAMSVEKIAAIKAKIMAKKRSTIKTDLDDDITALKQRSFVDAEV
                     DVTRDIVSRERVWRTRTTILQSTGKNFSKNIFAILQSVKAREEGRAPEQRPAPNAAPV
                     DPTLRTKQPIPAAYNRYDQERFKGKEETEGFKIDTMGTYHGMTLKSVTEGASARKTQT
                     PAAQPVPRPVSQARPPPNQKKGSRTPIIIIPAATTSLITMLNAKDLLQDLKFVPSDEK
                     KKQGCQRENETLIQRRKDQMQPGGTAISVTVPYRVVDQPLKLMPQDWDRVVAVFVQGP
                     AWQFKGWPWLLPDGSPVDIFAKIKAFHLKYDEVRLDPNVQKWDVTVLELSYHKRHLDR
                     PVFLRFWETLDRYMVKHKSHLRF"
     exon            401..506
                     /gene="Cdc73"
                     /gene_synonym="8430414L16Rik; C130030P16Rik; Hrpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            507..576
                     /gene="Cdc73"
                     /gene_synonym="8430414L16Rik; C130030P16Rik; Hrpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            577..639
                     /gene="Cdc73"
                     /gene_synonym="8430414L16Rik; C130030P16Rik; Hrpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            640..692
                     /gene="Cdc73"
                     /gene_synonym="8430414L16Rik; C130030P16Rik; Hrpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            693..781
                     /gene="Cdc73"
                     /gene_synonym="8430414L16Rik; C130030P16Rik; Hrpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            782..998
                     /gene="Cdc73"
                     /gene_synonym="8430414L16Rik; C130030P16Rik; Hrpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1097
                     /gene="Cdc73"
                     /gene_synonym="8430414L16Rik; C130030P16Rik; Hrpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1176
                     /gene="Cdc73"
                     /gene_synonym="8430414L16Rik; C130030P16Rik; Hrpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1241
                     /gene="Cdc73"
                     /gene_synonym="8430414L16Rik; C130030P16Rik; Hrpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1299
                     /gene="Cdc73"
                     /gene_synonym="8430414L16Rik; C130030P16Rik; Hrpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1335
                     /gene="Cdc73"
                     /gene_synonym="8430414L16Rik; C130030P16Rik; Hrpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1423
                     /gene="Cdc73"
                     /gene_synonym="8430414L16Rik; C130030P16Rik; Hrpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1585
                     /gene="Cdc73"
                     /gene_synonym="8430414L16Rik; C130030P16Rik; Hrpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1686
                     /gene="Cdc73"
                     /gene_synonym="8430414L16Rik; C130030P16Rik; Hrpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1828
                     /gene="Cdc73"
                     /gene_synonym="8430414L16Rik; C130030P16Rik; Hrpt2"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..7110
                     /gene="Cdc73"
                     /gene_synonym="8430414L16Rik; C130030P16Rik; Hrpt2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6743..6748
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdc73"
                     /gene_synonym="8430414L16Rik; C130030P16Rik; Hrpt2"
                     /note="hexamer: AATAAA"
     polyA_site      6766
                     /gene="Cdc73"
                     /gene_synonym="8430414L16Rik; C130030P16Rik; Hrpt2"
                     /note="major polyA site"
ORIGIN      
        1 gtgggtcagt caggcgttct ccgcgggcag cccgcggcgg ggccttgcct tatatagcgc
       61 ggggtcctcg gcggcctggg tggcttctgc ccgtgctgct gtcgtagacg cggccggctg
      121 ttgagtgtgg cggctgttgg ttcgcggcgg cggcggcggc ggcgggggga agagggcgag
      181 gcgacggggg aaggaggcgg caggcgcggc ggcgacggcg gggcccgggg cccgcggcgg
      241 cggcggcggc agcagcgagg ggggcgaaga tggcggacgt gctcagcgtc ctgcgacagt
      301 acaacatcca gaagaaggag atcgtggtca agggggatga agtgatcttc ggggagttct
      361 cctggcccaa gaatgtgaag accaactatg tagtttgggg gaccggaaag gaaggccaac
      421 ccagagagta ctacacattg gattctatct tatttctcct taataatgtg cacctttcgc
      481 atcctgttta tgtccggcgt gcagctactg aaaatattcc tgtggttaga agacccgacc
      541 gaaaagatct acttggatat ctcaatgggg aagcatcaac atcagcaagc atagacagga
      601 gtgccccctt ggaaataggt cttcagcggt ctactcaagt caaaagagct gcagatgaag
      661 ttttagcaga agcaaagaaa ccacggattg aggatgaaga gtgtgtgcgc cttgataaag
      721 agagattggc agctcgtttg gaaggccata aagaagggat cgtgcagact gagcagatta
      781 ggtctttgtc tgaagccatg tcagtggaaa aaattgctgc aatcaaagcc aaaattatgg
      841 ctaagaaaag atctactatc aagactgatc tagatgatga tataactgcc cttaaacaga
      901 ggagttttgt ggatgctgag gtagatgtga ccagagatat tgtcagcaga gagagagtgt
      961 ggaggacaag aacaactatt ttacagagca caggaaagaa tttttcaaag aatatttttg
     1021 caattcttca atctgtaaaa gccagagaag aaggtcgtgc ccctgaacaa cggccagctc
     1081 caaatgcagc ccccgtggat cctacattgc gtacaaaaca gcctattcca gctgcttaca
     1141 acagatatga ccaagaaaga ttcaaaggca aagaagaaac ggaaggcttt aagatcgata
     1201 ctatgggcac ctaccatggc atgacactga aatctgtaac ggaaggtgca tctgctcgta
     1261 agactcaaac tcctgcagcc cagcctgtac ctagaccagt gtctcaagcc agaccccccc
     1321 caaatcagaa gaaagggtca cggacaccca ttattattat tcctgcagct accacttctt
     1381 taataactat gcttaatgca aaagaccttc tacaggatct gaaatttgtc ccatcagatg
     1441 agaagaagaa acagggttgt caacgagaaa atgaaacact aatacagaga agaaaagacc
     1501 agatgcaacc agggggcaca gcaattagtg tcacagtacc ttacagagta gtagaccagc
     1561 ccctgaaact tatgcctcaa gactgggatc gagttgtggc tgtttttgta caaggtcctg
     1621 cttggcaatt caaaggttgg ccatggcttc tccctgatgg atcaccagtt gacatatttg
     1681 cgaaaattaa agccttccat ctcaagtatg atgaagttcg tctagatcca aatgttcaaa
     1741 agtgggatgt aacagtatta gaactcagct atcataaacg tcacttggat agaccagttt
     1801 tcttacgttt ctgggaaaca ttggatagat acatggtaaa gcataaatcc cacttgagat
     1861 tctgaatcat ttaacccctc cttttctgaa accttggatt acgaagcatg gatacagctt
     1921 gatctacaga ctgaaagcaa gcttatgaat tcatcaagaa cttgcaaatg aagaaggaca
     1981 cagagtagtc ttttataaga ccttgtttga tgctgtgtgc ttcaaagggg caatgcctcc
     2041 catccataca agcaaacttt tttggcttac aaatattttt ttaatattag ccttctagtc
     2101 tgtaatggaa attgtatatt ttgatagaag ttttttctct attggttaaa ttagcattac
     2161 ttaaaatttg ttctttagaa ataaatacag gttataaatg tgtgtatatt taggagttat
     2221 taggctcttc aagccatctt gcttctgatt tttcattgct ctgtggttcc ttttactgga
     2281 aaatactgtc atgatggtat taaattttag actatagaac ttcaaaaccc tatcaaaggg
     2341 aagtaactat gaaatcagtt gaaagtcagc ctgtgtgtat ccgatgtcta tactaactca
     2401 tgtttaaaaa ggaataatga aaaatcaaga acaagtcttc agtttcagtt gaactgttca
     2461 gccttttcaa gatttctttt gtaaatgaat acatttaatg aatgtacatt ctctttgttg
     2521 actttgatga ttttaaactt aaagtgatat atttctatct ggaatatgtt tccacttgaa
     2581 aagaaatctt aaaaaacaaa gattaaagtg aaatagactg tagtgatttt tacttgggaa
     2641 gctacagtat gatttggggg gatgagtgtg tgtcaacata gttacagtgt aacttgaacc
     2701 tcctctaagt ctgactatga ttcttatttt atatgcgata agattttgag tcttctattt
     2761 gtacacatgt caacttggga cttcttatct tccattatcc ctaaataatg ataaattccc
     2821 aggcaccaaa gaacacattt gcttacgtgt ctgaaaatga aacaagataa aaacactggt
     2881 atttttatgt gtgtgtgttc aatgtggtat aaaatataaa acctatattt taacgtagta
     2941 agatatttta ctattcctct actttacaga gtgttgcatc cacgctacaa ttaatgacca
     3001 tattccttga gtcctggttt tgtcttttac tacttaagga atgttcattc cttgaaactg
     3061 attttatcat tagagctgtt tttgactatc caccttgtat gttgttttcc tcagtgacta
     3121 tctcttaggc tatcaaattg ggggagcaca gtaaaacact tagctctttc tttattcagg
     3181 tgaacttatt tacttagtaa tttttttttt tttttactta gtaaataagt aaatttactt
     3241 acttagcctc tttagaactt aatgctatca taaagatgag aaataattat tatttatttt
     3301 cttaacttcc aacaaaagtc cattatcagt aaaaatggga agttatttat tcagatggaa
     3361 tccggggggt tctccagaag aaaagcagct aatgttttca aaggcttcag tacttttgta
     3421 gttttagtag gttctgtcca cagtttccca ttcttgcatt cttttcttga tgattaaaga
     3481 aaactcaact ttgtttacag agtttctcag catacaaatt atccttaaat tatgtattga
     3541 ataaatttcc tccatagtga agtagtcaac aactcaaacc tgtaatattt taatgtaaaa
     3601 ttacttgtta ggactactgc aaaggacatg aactacctac cacctttcca taaagatgtt
     3661 tggtatttgt tcttaataac tgaagtttaa tttatagcgg agtttggtta aaattagtat
     3721 ctactctgtg catggtttat tttctatttt aaatttgctc tgtgtatagt caaaggcttc
     3781 tggattatac agtctttaac tccagtaaag ctaggaccgt gttttacgtg gatcttgaaa
     3841 tcagactctt tgtgtgcact aggatttctt gttttatttt taagatttaa aaacaatttt
     3901 ttcaaggtag caaggtaatg agtttcgtgg tagcattttg aggatccatg tcatcgttca
     3961 ttgttctttt cctagccccg gctctctctc tcctcttgtt ttcttcttct ttgctttcac
     4021 atgtatctat ttctttctct ttttctacct caactcttct tagtagctct tcttctccct
     4081 tctgtatcat agtctttgtt tcattaccta tacatagaca tggacataaa tttaaaaaat
     4141 ttaatctcaa cattgtgagc ccttaagtag gtttatgaaa attttaatgg ataattataa
     4201 aaataacaaa aaagggaaat gattcaaaaa aaaaaacaac acacacacaa accatctgct
     4261 ctgctctaca agtcagtcat tattcttctg tgactcagct ctacagcagc acctgaccca
     4321 gtgctttgcg cattcaggca ttcagtagct agttatatgt gtgaatggat gatatgtttt
     4381 cagcataagt ccattaacac agctttgact ttatttgatc ttacaaactg agagcacaga
     4441 attacagggc atgtgaagaa atagataatt taatgaaaat gaagtatgtg ttattaagtt
     4501 cagcttccta taagttatta gtggaagtac tcctgccagc tttacttaaa ggagggttct
     4561 ctgttattta taatctccta agttacagta agaaaaatta tatagttttt aaacagaagc
     4621 tcaccaattg gagaaatagt aataattttc aaaagttttt cagaaaaaaa gtttttttga
     4681 gaaaggggta agatccacct atttacattg ttactggaag tagtaccagc gttaaagatc
     4741 ttgttttctc ctcttttcat ctatgtatgt tttctgtgtg tatgtgtatt ttttgaggcc
     4801 actctttgca ctagaccatc tcttacattg gtgatattgg cctatatccc caaatgacaa
     4861 aatcaaatct tatttattta aggagtattt tgctgtttaa tatttaaaca acatttaata
     4921 tatttcatta ttagtattat agcttacagt ttgtttcctg tttgcttatt gctttactaa
     4981 gtatttttta gcagaggcag aacggcagct tatacaggaa taaataattc atggtgacaa
     5041 aaacctcaaa tctttttaag ttcaaggaac tattattttc tttgctgtgc agagtaggat
     5101 acaatttaat tattaaaaga aaagcatagt atgaattagt ttacacaaaa aagttttcac
     5161 ctaaggaaga ttcactaata agtattgaag agacttttac ctaaataaaa atttctgtga
     5221 ctcttaaccc aaagtgatga gagtgctctt ttttttggaa agtgggcagg gattattcat
     5281 tacactgatg agctatgcaa gattttttga cattttacag ttactgagct ggtcaaaatt
     5341 agtcatttag aacgtggctt taaattacgt tggattttgt ttgtcttact gttatttgtt
     5401 ggcttgaaaa taaacccaga gccacctcca tcctagggca agcacttcgg ccactgactt
     5461 agactctgaa ccatgagttg tgaaattatt aaagtacaga atcatagcga aactagagaa
     5521 gtttattttt gattttagtc ccctacccca gggaaagttc ttaaagaatg agtgtgagtg
     5581 atcgtatatg tacacacata caagtcaaaa gaattgccat tctgttgagt tcaaattcat
     5641 gtagaatgtt gagaaaaaaa atgagataaa atctatagaa atttgttttt aactgaaaag
     5701 ctggtggtgg ttttcaaatg aatgaaattt acattattcc ccttgaaatt actgaactgt
     5761 gttcattacc cacttgtgtt ttattttcac atggcgattc tcttcaattt tatagtaaaa
     5821 tggagaattg actaaccttg acttagagaa ttggattagg gatttaaatt aggtcctaca
     5881 ttttctggtg tattcatgcc atgttttgaa gtgtgtgttg gccctaacat aggttctgca
     5941 ctaacatgtt ggcagaaaaa ctaaagaaaa attgaagatg tacaacagtt gtatagataa
     6001 ttctttttaa taagtacaca gtaggttaat tatgatttca ggtcattgat gttttaggga
     6061 ttgtgtgtta ggaactgttc ataagagtat cttggaagtt acaaattgcc atatactgaa
     6121 atacagtaag cattctatat gaataaagtt tgtggactac aactagtttt gtgccaaaat
     6181 taaaaagatg ggattatatg tcaaaattaa ggaaactttc caagtatttt gtattctgtt
     6241 aaattttgtt tctattttaa atgtaagtaa agctacttag cctccaactt gggtcagact
     6301 tctgaatagg taaccttatt tccttccatg gtagtatcca ccgtcactgc ttgcgtgatc
     6361 attaacgagt gatgtttgtg aagcagagca gttcctgaat agagcttact ttgaagtctc
     6421 tgttttctga tgaaatgttc ccatactcat ttcattttgg gagcttttta aattgtgagc
     6481 tttattttac atacaacagt ttgcagttaa aaatcttggg aatataccta ccgcccctta
     6541 attcccccta aaagagtcca aacaaaacaa ctacagtgtg tgtgtgtgtg tgtgtgtgtg
     6601 tgtgtgtgag tgtgtgtgtg tgtgtataac atacctaatg tatacctacc aagaaggcag
     6661 aagtattgtg agtttgggat gttgttgtct ttctgtaaag tgatttaatg ggatttgtca
     6721 ggcatagtat ttctgttcag gaaataaaga tgtttacttt ttggaaccaa tgagttaaat
     6781 ccttttttca gttaataagt taatttctag aagtcttcat aaaggcagca ggttttatgg
     6841 cctactgaac ttataattga agtatgtcga atttcttgtt attgtaatag tattaaaacc
     6901 atatcccagt attttacata taaatatcct gattttaaca taaatttcaa aatcatattc
     6961 ccatatagtg aaataattaa cattgtcata ttggcaatgc cagacataat atgtgaatct
     7021 gatatgacag ttttctagtg aagaacttac tgggccatat ttaaatttaa tttttgtgtt
     7081 tttcataaat gctcaataaa tatgaacttc
//
