LOCUS       NM_001271567            2872 bp    mRNA    linear   ROD 23-DEC-2022
DEFINITION  Mus musculus cell division cycle 7 (S. cerevisiae) (Cdc7),
            transcript variant 3, mRNA.
ACCESSION   NM_001271567
VERSION     NM_001271567.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2872)
  AUTHORS   Suski JM, Ratnayeke N, Braun M, Zhang T, Strmiska V, Michowski W,
            Can G, Simoneau A, Snioch K, Cup M, Sullivan CM, Wu X, Nowacka J,
            Branigan TB, Pack LR, DeCaprio JA, Geng Y, Zou L, Gygi SP, Walter
            JC, Meyer T and Sicinski P.
  TITLE     CDC7-independent G1/S transition revealed by targeted protein
            degradation
  JOURNAL   Nature 605 (7909), 357-365 (2022)
   PUBMED   35508654
  REMARK    GeneRIF: CDC7-independent G1/S transition revealed by targeted
            protein degradation.
REFERENCE   2  (bases 1 to 2872)
  AUTHORS   Akagawa R, Nabeshima YI and Kawauchi T.
  TITLE     Alternative Functions of Cell Cycle-Related and DNA Repair Proteins
            in Post-mitotic Neurons
  JOURNAL   Front Cell Dev Biol 9, 753175 (2021)
   PUBMED   34746147
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2872)
  AUTHORS   Jin L, Chen Y, Crossman DK, Datta A, Vu T, Mobley JA, Basu MK,
            Scarduzio M, Wang H, Chang C and Datta PK.
  TITLE     STRAP regulates alternative splicing fidelity during lineage
            commitment of mouse embryonic stem cells
  JOURNAL   Nat Commun 11 (1), 5941 (2020)
   PUBMED   33230114
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2872)
  AUTHORS   Farini D, Cesari E, Weatheritt RJ, La Sala G, Naro C, Pagliarini V,
            Bonvissuto D, Medici V, Guerra M, Di Pietro C, Rizzo FR, Musella A,
            Carola V, Centonze D, Blencowe BJ, Marazziti D and Sette C.
  TITLE     A Dynamic Splicing Program Ensures Proper Synaptic Connections in
            the Developing Cerebellum
  JOURNAL   Cell Rep 31 (9), 107703 (2020)
   PUBMED   32492419
REFERENCE   5  (bases 1 to 2872)
  AUTHORS   Kafer GR and Cesare AJ.
  TITLE     A Survey of Essential Genome Stability Genes Reveals That
            Replication Stress Mitigation Is Critical for Peri-Implantation
            Embryogenesis
  JOURNAL   Front Cell Dev Biol 8, 416 (2020)
   PUBMED   32548123
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2872)
  AUTHORS   Kim JM, Nakao K, Nakamura K, Saito I, Katsuki M, Arai K and Masai
            H.
  TITLE     Inactivation of Cdc7 kinase in mouse ES cells results in S-phase
            arrest and p53-dependent cell death
  JOURNAL   EMBO J 21 (9), 2168-2179 (2002)
   PUBMED   11980714
REFERENCE   7  (bases 1 to 2872)
  AUTHORS   Nakamura T, Nakamura-Kubo M, Nakamura T and Shimoda C.
  TITLE     Novel fission yeast Cdc7-Dbf4-like kinase complex required for the
            initiation and progression of meiotic second division
  JOURNAL   Mol Cell Biol 22 (1), 309-320 (2002)
   PUBMED   11739743
REFERENCE   8  (bases 1 to 2872)
  AUTHORS   Lepke M, Putter V, Staib C, Kneissl M, Berger C, Hoehn K, Nanda I,
            Schmid M and Grummt F.
  TITLE     Identification, characterization and chromosomal localization of
            the cognate human and murine DBF4 genes
  JOURNAL   Mol Gen Genet 262 (2), 220-229 (1999)
   PUBMED   10517317
REFERENCE   9  (bases 1 to 2872)
  AUTHORS   Faul T, Staib C, Nanda I, Schmid M and Grummt F.
  TITLE     Identification and characterization of mouse homologue to yeast
            Cdc7 protein and chromosomal localization of the cognate mouse gene
            Cdc7l
  JOURNAL   Chromosoma 108 (1), 26-31 (1999)
   PUBMED   10199953
REFERENCE   10 (bases 1 to 2872)
  AUTHORS   Kim JM, Sato N, Yamada M, Arai K and Masai H.
  TITLE     Growth regulation of the expression of mouse cDNA and gene encoding
            a serine/threonine kinase related to Saccharomyces cerevisiae CDC7
            essential for G1/S transition. Structure, chromosomal localization,
            and expression of mouse gene for s. cerevisiae Cdc7-related kinase
  JOURNAL   J Biol Chem 273 (36), 23248-23257 (1998)
   PUBMED   9722556
  REMARK    Erratum:[J Biol Chem 1998 Oct 16;273(42):27755]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134409.12.
            
            [WARNING] On May 5, 2023 this sequence was replaced by
            NM_001271567.2.
            
            Transcript Variant: This variant (3) differs in the 5' UTR and
            lacks an alternate in-frame exon in the coding region compared to
            variant 1. It encodes isoform 2, which is shorter than isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB018574.1, SRR6116558.146862.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               AC134409.12        110509-110612
            105-286             AC134409.12        111120-111301
            287-370             AC134409.12        115045-115128
            371-506             AC134409.12        115346-115481
            507-600             AC134409.12        118934-119027
            601-743             AC134409.12        119112-119254
            744-987             AC134409.12        119964-120207
            988-1163            AC134409.12        121672-121847
            1164-1246           AC134409.12        122817-122899
            1247-1396           AC134409.12        125482-125631
            1397-2872           AC134409.12        129151-130626
FEATURES             Location/Qualifiers
     source          1..2872
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5"
     gene            1..2872
                     /gene="Cdc7"
                     /gene_synonym="Cdc7l1; muCdc7"
                     /note="cell division cycle 7 (S. cerevisiae)"
                     /db_xref="GeneID:12545"
                     /db_xref="MGI:MGI:1309511"
     exon            1..104
                     /gene="Cdc7"
                     /gene_synonym="Cdc7l1; muCdc7"
                     /inference="alignment:Splign:2.1.0"
     exon            105..286
                     /gene="Cdc7"
                     /gene_synonym="Cdc7l1; muCdc7"
                     /inference="alignment:Splign:2.1.0"
     CDS             190..1788
                     /gene="Cdc7"
                     /gene_synonym="Cdc7l1; muCdc7"
                     /EC_number="2.7.11.1"
                     /note="isoform 2 is encoded by transcript variant 3; cell
                     division cycle 7-related protein kinase; CDC7-related
                     kinase; cell division cycle 7-like 1"
                     /codon_start=1
                     /product="cell division cycle 7-related protein kinase
                     isoform 2"
                     /protein_id="NP_001258496.1"
                     /db_xref="CCDS:CCDS71628.1"
                     /db_xref="GeneID:12545"
                     /db_xref="MGI:MGI:1309511"
                     /translation="MEEPMAFSSLRGSDRCPADDSLKKYEQSVKLSGIKRDIEELCEA
                     VPQLVNVFKIKDKIGEGTFSSVYLATAQLQEGHEEKIALKHLIPTSHPMRIAAELQCL
                     TVAGGQDNVMGLKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMYNLFVALK
                     RIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTRDTKIELLKFVQSEAQQEDCS
                     RNKYHGVVGHKGLLSRPAPKTVDQQCTPKTSVKRSYTQVHIKQGKDGKLIKQSKTVDI
                     ISRKLATKKTAISTKAMNSVMRETARSCPAVLTCDCYGSDRVCSVCLSRRQQVAPRAG
                     TPGFRAPEVLTKCPDQTTAIDMWSAGVIFLSLLSGRYPFYKASDDLTALAQIMTIRGS
                     RETIQAAKAFGKSVLCSKEVPAQDLRALCERLRGLDSTTPRSASGPPGNASYDPAASK
                     NTDHKASRVQAAQAQHSEDSLYKRDNDGYWSHPKDCTSNSEGWDSVPDEAYDLLDKLL
                     DLNPASRITAEAALLHAFFKDMCS"
     exon            287..370
                     /gene="Cdc7"
                     /gene_synonym="Cdc7l1; muCdc7"
                     /inference="alignment:Splign:2.1.0"
     exon            371..506
                     /gene="Cdc7"
                     /gene_synonym="Cdc7l1; muCdc7"
                     /inference="alignment:Splign:2.1.0"
     exon            507..600
                     /gene="Cdc7"
                     /gene_synonym="Cdc7l1; muCdc7"
                     /inference="alignment:Splign:2.1.0"
     exon            601..743
                     /gene="Cdc7"
                     /gene_synonym="Cdc7l1; muCdc7"
                     /inference="alignment:Splign:2.1.0"
     exon            744..987
                     /gene="Cdc7"
                     /gene_synonym="Cdc7l1; muCdc7"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1163
                     /gene="Cdc7"
                     /gene_synonym="Cdc7l1; muCdc7"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1246
                     /gene="Cdc7"
                     /gene_synonym="Cdc7l1; muCdc7"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1396
                     /gene="Cdc7"
                     /gene_synonym="Cdc7l1; muCdc7"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..2872
                     /gene="Cdc7"
                     /gene_synonym="Cdc7l1; muCdc7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aattcaaagc agcgcgggaa gaatcgcgca tgcgcgcctg gcggcccggc tcagtgggac
       61 gctcctgagg gaagcgaccg cggacgtcct aacttctgtg aaccctgctg ctctcgcctg
      121 tgcacatgac cccgtagccc gctctttgca tcccagtcgt gcgtagtgga agcctctttg
      181 gggactcaga tggaggagcc aatggcgttt tcttcccttc gtggcagtga caggtgtccg
      241 gctgatgact ctttaaaaaa atatgagcag agtgttaaac tttcaggtat taaaagagat
      301 attgaggagc tttgtgaagc tgtaccacaa ctagtcaatg tgttcaaaat taaggacaaa
      361 attggagaag gcaccttcag ctctgtttat ttggccacag cacagttgca agaaggacat
      421 gaagagaaaa ttgcgctgaa acacttaatt cccacaagtc atcctatgag gattgcagca
      481 gagcttcagt gtctgacagt tgcagggggg caagacaatg tcatgggact taagtactgc
      541 ttcagaaaaa atgatcatgt ggttattgct atgccgtatc tggaacatga gtcctttttg
      601 gacattttga attctctttc cttccaagaa gttcgggaat atatgtataa tctttttgta
      661 gctttgaaac ggattcatca gtttggtatt gttcaccgtg atgtgaagcc cagcaatttt
      721 ttatacaata gacgtctgaa aaagtatgcc ttggtggact tcggtttggc ccagggaacc
      781 cgtgacacaa aaatagagct gctcaagttt gtccagtctg aggctcagca ggaagattgt
      841 tcacgaaaca agtatcatgg agtcgttgga cacaagggcc tgctgagtcg cccggcacct
      901 aaaactgtgg atcagcagtg taccccaaaa acttctgtca aaagatccta cacacaagtt
      961 cacattaagc aaggaaaaga cggaaagctc atcaagcaat caaagactgt ggacataata
     1021 tcacgaaagc tagcgacaaa aaagacggcc atttctacaa aagctatgaa cagcgtgatg
     1081 agggaaactg ccaggtcctg ccctgctgtc ctcacctgcg actgctatgg atcagataga
     1141 gtctgcagcg tttgcctgtc gaggcggcag caggttgccc ctagggcagg cacaccagga
     1201 ttcagagcgc cagaggtcct gacaaagtgt cctgaccaga ccacagcgat tgacatgtgg
     1261 tctgcaggtg tcatattcct gtccttgctc agtgggcggt acccatttta caaggccagt
     1321 gatgacttaa ctgctttggc tcagatcatg acaattcgag gatccaggga aactatccag
     1381 gctgctaaag cttttggcaa atcagttctg tgtagcaaag aagtcccagc acaagacttg
     1441 agagctctct gtgagagact gcggggtcta gactctacca ctcccaggtc agccagtggt
     1501 cctccaggga atgcttccta tgaccctgct gcttccaaga acactgacca caaagcatcc
     1561 cgtgtacagg ctgctcaggc acagcactca gaggactcct tgtataaaag ggacaacgat
     1621 ggctattgga gtcatcccaa agactgcact tccaactcag aaggctggga ctcagtacct
     1681 gatgaagcct atgacctgct cgacaagctt ctggacctaa acccagcttc aaggataaca
     1741 gcagaagcag ccttattaca tgcgttcttt aaagatatgt gctcctgata cggctctcca
     1801 cttactgttg ctgctgtgtg ttgtaaggcg atgtggataa tcacaggttg tttgtgtctg
     1861 agtctagggt agaatgaata acttgtttta aagttataat atttgttctg atgtcagatt
     1921 ataaacagat taagaattct taaagaacag ggggaaccct tgacaaggtc tttgagttaa
     1981 accatcaagt agactcagat gcttagtgtc ctggttttct ctgcctcagg agcaacctta
     2041 ctgagcctga tgcatgggtt cgaggtacag gtcataaagc taacaggtat gacagggaga
     2101 aactgagaga aacactgttt ctaagcagtg tgtggtctgc actgtgtgca tgggggaact
     2161 ggctgttggt ggtgtgtgtg gaaagtgtgc aaatgaacaa atagttattg cagagatgtt
     2221 tgtcacctcc taacacagtc attgtaagtt acatggtgct tactgcagtt tctgggtgct
     2281 tcactaagtg ttacatgtat ttatatttgg agccaaataa tgttgtgtat tattgataag
     2341 acagaaatgc ttctttttct cagtattttt ttctcacata cctttgttta gttaggtaat
     2401 ggccacagga aaagtgagca tagaactgga cattactggc gatgttttct ggtttgccag
     2461 gagcatccac atttctgcat ttctgttctg aattaatctt ggtcagaggg aatgggtctt
     2521 aggtaattga gaaaaagata aggggacaaa gtagtagagg gctcgatacg gagatttgtg
     2581 cattattttg ttctaaactt ctctctgtcc gagatagcat accaggcttc caggagtcag
     2641 gatggacttg ctgaggagtt cctgcttgta tcatcacaga ctagggagct gtctctcaga
     2701 gtgtttactg ttgtgaacat ggatagatca gtgtgtctca ttgatcaatt tgccatgtgt
     2761 atataatgta tatttgtgtg tatacacact ttgtcttatg ctgtaatttt tttaaaactt
     2821 gaatgttttg ggatatgtat ttaataataa acttttagat gcttatatca ga
//
