LOCUS       NM_001271566            3137 bp    mRNA    linear   ROD 23-DEC-2022
DEFINITION  Mus musculus cell division cycle 7 (S. cerevisiae) (Cdc7),
            transcript variant 1, mRNA.
ACCESSION   NM_001271566
VERSION     NM_001271566.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3137)
  AUTHORS   Suski JM, Ratnayeke N, Braun M, Zhang T, Strmiska V, Michowski W,
            Can G, Simoneau A, Snioch K, Cup M, Sullivan CM, Wu X, Nowacka J,
            Branigan TB, Pack LR, DeCaprio JA, Geng Y, Zou L, Gygi SP, Walter
            JC, Meyer T and Sicinski P.
  TITLE     CDC7-independent G1/S transition revealed by targeted protein
            degradation
  JOURNAL   Nature 605 (7909), 357-365 (2022)
   PUBMED   35508654
  REMARK    GeneRIF: CDC7-independent G1/S transition revealed by targeted
            protein degradation.
REFERENCE   2  (bases 1 to 3137)
  AUTHORS   Akagawa R, Nabeshima YI and Kawauchi T.
  TITLE     Alternative Functions of Cell Cycle-Related and DNA Repair Proteins
            in Post-mitotic Neurons
  JOURNAL   Front Cell Dev Biol 9, 753175 (2021)
   PUBMED   34746147
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3137)
  AUTHORS   Jin L, Chen Y, Crossman DK, Datta A, Vu T, Mobley JA, Basu MK,
            Scarduzio M, Wang H, Chang C and Datta PK.
  TITLE     STRAP regulates alternative splicing fidelity during lineage
            commitment of mouse embryonic stem cells
  JOURNAL   Nat Commun 11 (1), 5941 (2020)
   PUBMED   33230114
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3137)
  AUTHORS   Farini D, Cesari E, Weatheritt RJ, La Sala G, Naro C, Pagliarini V,
            Bonvissuto D, Medici V, Guerra M, Di Pietro C, Rizzo FR, Musella A,
            Carola V, Centonze D, Blencowe BJ, Marazziti D and Sette C.
  TITLE     A Dynamic Splicing Program Ensures Proper Synaptic Connections in
            the Developing Cerebellum
  JOURNAL   Cell Rep 31 (9), 107703 (2020)
   PUBMED   32492419
REFERENCE   5  (bases 1 to 3137)
  AUTHORS   Kafer GR and Cesare AJ.
  TITLE     A Survey of Essential Genome Stability Genes Reveals That
            Replication Stress Mitigation Is Critical for Peri-Implantation
            Embryogenesis
  JOURNAL   Front Cell Dev Biol 8, 416 (2020)
   PUBMED   32548123
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3137)
  AUTHORS   Kim JM, Nakao K, Nakamura K, Saito I, Katsuki M, Arai K and Masai
            H.
  TITLE     Inactivation of Cdc7 kinase in mouse ES cells results in S-phase
            arrest and p53-dependent cell death
  JOURNAL   EMBO J 21 (9), 2168-2179 (2002)
   PUBMED   11980714
REFERENCE   7  (bases 1 to 3137)
  AUTHORS   Nakamura T, Nakamura-Kubo M, Nakamura T and Shimoda C.
  TITLE     Novel fission yeast Cdc7-Dbf4-like kinase complex required for the
            initiation and progression of meiotic second division
  JOURNAL   Mol Cell Biol 22 (1), 309-320 (2002)
   PUBMED   11739743
REFERENCE   8  (bases 1 to 3137)
  AUTHORS   Lepke M, Putter V, Staib C, Kneissl M, Berger C, Hoehn K, Nanda I,
            Schmid M and Grummt F.
  TITLE     Identification, characterization and chromosomal localization of
            the cognate human and murine DBF4 genes
  JOURNAL   Mol Gen Genet 262 (2), 220-229 (1999)
   PUBMED   10517317
REFERENCE   9  (bases 1 to 3137)
  AUTHORS   Faul T, Staib C, Nanda I, Schmid M and Grummt F.
  TITLE     Identification and characterization of mouse homologue to yeast
            Cdc7 protein and chromosomal localization of the cognate mouse gene
            Cdc7l
  JOURNAL   Chromosoma 108 (1), 26-31 (1999)
   PUBMED   10199953
REFERENCE   10 (bases 1 to 3137)
  AUTHORS   Kim JM, Sato N, Yamada M, Arai K and Masai H.
  TITLE     Growth regulation of the expression of mouse cDNA and gene encoding
            a serine/threonine kinase related to Saccharomyces cerevisiae CDC7
            essential for G1/S transition. Structure, chromosomal localization,
            and expression of mouse gene for s. cerevisiae Cdc7-related kinase
  JOURNAL   J Biol Chem 273 (36), 23248-23257 (1998)
   PUBMED   9722556
  REMARK    Erratum:[J Biol Chem 1998 Oct 16;273(42):27755]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK146009.1, AC134409.12 and AK145921.1.
            
            [WARNING] On May 5, 2023 this sequence was replaced by
            NM_001271566.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1). Both variants 1 and
            2 encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146009.1, SRR7345562.4398573.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                AK146009.1         3-34
            33-33               AC134409.12        110780-110780
            34-1307             AK146009.1         36-1309
            1308-3129           AK145921.1         1065-2886
            3130-3137           AC134409.12        130619-130626
FEATURES             Location/Qualifiers
     source          1..3137
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5"
     gene            1..3137
                     /gene="Cdc7"
                     /gene_synonym="Cdc7l1; muCdc7"
                     /note="cell division cycle 7 (S. cerevisiae)"
                     /db_xref="GeneID:12545"
                     /db_xref="MGI:MGI:1309511"
     exon            1..273
                     /gene="Cdc7"
                     /gene_synonym="Cdc7l1; muCdc7"
                     /inference="alignment:Splign:2.1.0"
     exon            274..455
                     /gene="Cdc7"
                     /gene_synonym="Cdc7l1; muCdc7"
                     /inference="alignment:Splign:2.1.0"
     CDS             359..2053
                     /gene="Cdc7"
                     /gene_synonym="Cdc7l1; muCdc7"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1; cell
                     division cycle 7-related protein kinase; CDC7-related
                     kinase; cell division cycle 7-like 1"
                     /codon_start=1
                     /product="cell division cycle 7-related protein kinase
                     isoform 1"
                     /protein_id="NP_001258495.1"
                     /db_xref="CCDS:CCDS19498.1"
                     /db_xref="GeneID:12545"
                     /db_xref="MGI:MGI:1309511"
                     /translation="MEEPMAFSSLRGSDRCPADDSLKKYEQSVKLSGIKRDIEELCEA
                     VPQLVNVFKIKDKIGEGTFSSVYLATAQLQEGHEEKIALKHLIPTSHPMRIAAELQCL
                     TVAGGQDNVMGLKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMYNLFVALK
                     RIHQFGIVHRDVKPSNFLYNRRLKKYALVDFGLAQGTRDTKIELLKFVQSEAQQEDCS
                     RNKYHGVVGHKGLLSRPAPKTVDQQCTPKTSVKRSYTQVHIKQGKDGKERSVGLSVQR
                     SVFGERNFNIHSSISHESPAEKLIKQSKTVDIISRKLATKKTAISTKAMNSVMRETAR
                     SCPAVLTCDCYGSDRVCSVCLSRRQQVAPRAGTPGFRAPEVLTKCPDQTTAIDMWSAG
                     VIFLSLLSGRYPFYKASDDLTALAQIMTIRGSRETIQAAKAFGKSVLCSKEVPAQDLR
                     ALCERLRGLDSTTPRSASGPPGNASYDPAASKNTDHKASRVQAAQAQHSEDSLYKRDN
                     DGYWSHPKDCTSNSEGWDSVPDEAYDLLDKLLDLNPASRITAEAALLHAFFKDMCS"
     exon            456..539
                     /gene="Cdc7"
                     /gene_synonym="Cdc7l1; muCdc7"
                     /inference="alignment:Splign:2.1.0"
     exon            540..675
                     /gene="Cdc7"
                     /gene_synonym="Cdc7l1; muCdc7"
                     /inference="alignment:Splign:2.1.0"
     exon            676..769
                     /gene="Cdc7"
                     /gene_synonym="Cdc7l1; muCdc7"
                     /inference="alignment:Splign:2.1.0"
     exon            770..912
                     /gene="Cdc7"
                     /gene_synonym="Cdc7l1; muCdc7"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1156
                     /gene="Cdc7"
                     /gene_synonym="Cdc7l1; muCdc7"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1252
                     /gene="Cdc7"
                     /gene_synonym="Cdc7l1; muCdc7"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1428
                     /gene="Cdc7"
                     /gene_synonym="Cdc7l1; muCdc7"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1511
                     /gene="Cdc7"
                     /gene_synonym="Cdc7l1; muCdc7"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1661
                     /gene="Cdc7"
                     /gene_synonym="Cdc7l1; muCdc7"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..3137
                     /gene="Cdc7"
                     /gene_synonym="Cdc7l1; muCdc7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttggcactgg cggacagtcc gccctacgca ctcgcccagg gcggcccatt cattcattta
       61 tccttctgtt ggcaccctgc tgccctcggt cggctccagt cgagtggagt gtcacgccct
      121 ggcgagcgac ttcctcccgg gcaaaccgca gtccttcccc gcagcctccc ggggatccct
      181 agccggctgc agcccgctcc acctgtcccc cgcgggagtg ctcgccgcag gccagtggca
      241 gcgacgccgc tccggctggg atttggacat atgctgctgc tctcgcctgt gcacatgacc
      301 ccgtagcccg ctctttgcat cccagtcgtg cgtagtggaa gcctctttgg ggactcagat
      361 ggaggagcca atggcgtttt cttcccttcg tggcagtgac aggtgtccgg ctgatgactc
      421 tttaaaaaaa tatgagcaga gtgttaaact ttcaggtatt aaaagagata ttgaggagct
      481 ttgtgaagct gtaccacaac tagtcaatgt gttcaaaatt aaggacaaaa ttggagaagg
      541 caccttcagc tctgtttatt tggccacagc acagttgcaa gaaggacatg aagagaaaat
      601 tgcgctgaaa cacttaattc ccacaagtca tcctatgagg attgcagcag agcttcagtg
      661 tctgacagtt gcaggggggc aagacaatgt catgggactt aagtactgct tcagaaaaaa
      721 tgatcatgtg gttattgcta tgccgtatct ggaacatgag tcctttttgg acattttgaa
      781 ttctctttcc ttccaagaag ttcgggaata tatgtataat ctttttgtag ctttgaaacg
      841 gattcatcag tttggtattg ttcaccgtga tgtgaagccc agcaattttt tatacaatag
      901 acgtctgaaa aagtatgcct tggtggactt cggtttggcc cagggaaccc gtgacacaaa
      961 aatagagctg ctcaagtttg tccagtctga ggctcagcag gaagattgtt cacgaaacaa
     1021 gtatcatgga gtcgttggac acaagggcct gctgagtcgc ccggcaccta aaactgtgga
     1081 tcagcagtgt accccaaaaa cttctgtcaa aagatcctac acacaagttc acattaagca
     1141 aggaaaagac ggaaaggaga gatctgtagg cctttctgtc cagcgctctg tttttggaga
     1201 gagaaatttc aatatacaca gctccatttc acatgagagc cctgcagaga aactcatcaa
     1261 gcaatcaaag actgtggaca taatatcacg aaagctagcg acaaaaaaga cggccatttc
     1321 tacaaaagct atgaacagcg tgatgaggga aactgccagg tcctgccctg ctgtcctcac
     1381 ctgcgactgc tatggatcag atagagtctg cagcgtttgc ctgtcgaggc ggcagcaggt
     1441 tgcccctagg gcaggcacac caggattcag agcgccagag gtcctgacaa agtgtcctga
     1501 ccagaccaca gcgattgaca tgtggtctgc aggtgtcata ttcctgtcct tgctcagtgg
     1561 gcggtaccca ttttacaagg ccagtgatga cttaactgct ttggctcaga tcatgacaat
     1621 tcgaggatcc agggaaacta tccaggctgc taaagctttt ggcaaatcag ttctgtgtag
     1681 caaagaagtc ccagcacaag acttgagagc tctctgtgag agactgcggg gtctagactc
     1741 taccactccc aggtcagcca gtggtcctcc agggaatgct tcctatgacc ctgctgcttc
     1801 caagaacact gaccacaaag catcccgtgt acaggctgct caggcacagc actcagagga
     1861 ctccttgtat aaaagggaca acgatggcta ttggagtcat cccaaagact gcacttccaa
     1921 ctcagaaggc tgggactcag tacctgatga agcctatgac ctgctcgaca agcttctgga
     1981 cctaaaccca gcttcaagga taacagcaga agcagcctta ttacatgcgt tctttaaaga
     2041 tatgtgctcc tgatacggct ctccacttac tgttgctgct gtgtgttgta aggcgatgtg
     2101 gataatcaca ggttgtttgt gtctgagtct agggtagaat gaataacttg ttttaaagtt
     2161 ataatatttg ttctgatgtc agattataaa cagattaaga attcttaaag aacaggggga
     2221 acccttgaca aggtctttga gttaaaccat caagtagact cagatgctta gtgtcctggt
     2281 tttctctgcc tcaggagcaa ccttactgag cctgatgcat gggttcgagg tacaggtcat
     2341 aaagctaaca ggtatgacag ggagaaactg agagaaacac tgtttctaag cagtgtgtgg
     2401 tctgcactgt gtgcatgggg gaactggctg ttggtggtgt gtgtggaaag tgtgcaaatg
     2461 aacaaatagt tattgcagag atgtttgtca cctcctaaca cagtcattgt aagttacatg
     2521 gtgcttactg cagtttctgg gtgcttcact aagtgttaca tgtatttata tttggagcca
     2581 aataatgttg tgtattattg ataagacaga aatgcttctt tttctcagta tttttttctc
     2641 acataccttt gtttagttag gtaatggcca caggaaaagt gagcatagaa ctggacatta
     2701 ctggcgatgt tttctggttt gccaggagca tccacatttc tgcatttctg ttctgaatta
     2761 atcttggtca gagggaatgg gtcttaggta attgagaaaa agataagggg acaaagtagt
     2821 agagggctcg atacggagat ttgtgcatta ttttgttcta aacttctctc tgtccgagat
     2881 agcataccag gcttccagga gtcaggatgg acttgctgag gagttcctgc ttgtatcatc
     2941 acagactagg gagctgtctc tcagagtgtt tactgttgtg aacatggata gatcagtgtg
     3001 tctcattgat caatttgcca tgtgtatata atgtatattt gtgtgtatac acactttgtc
     3061 ttatgctgta atttttttaa aacttgaatg ttttgggata tgtatttaat aataaacttt
     3121 tagatgctta tatcaga
//
