LOCUS       NM_001025779            4620 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus cell division cycle 6 (Cdc6), transcript variant 2,
            mRNA.
ACCESSION   NM_001025779
VERSION     NM_001025779.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4620)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4620)
  AUTHORS   Kumar,R. and Rao,G.N.
  TITLE     Novel Role of Prereplication Complex Component Cell Division Cycle
            6 in Retinal Neovascularization
  JOURNAL   Arterioscler Thromb Vasc Biol 42 (4), 407-427 (2022)
   PUBMED   35236105
  REMARK    GeneRIF: Novel Role of Prereplication Complex Component Cell
            Division Cycle 6 in Retinal Neovascularization.
REFERENCE   3  (bases 1 to 4620)
  AUTHORS   Akagawa,R., Nabeshima,Y.I. and Kawauchi,T.
  TITLE     Alternative Functions of Cell Cycle-Related and DNA Repair Proteins
            in Post-mitotic Neurons
  JOURNAL   Front Cell Dev Biol 9, 753175 (2021)
   PUBMED   34746147
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4620)
  AUTHORS   Dong,X. and Kwan,K.M.
  TITLE     Yin Yang 1 is critical for mid-hindbrain neuroepithelium
            development and involved in cerebellar agenesis
  JOURNAL   Mol Brain 13 (1), 104 (2020)
   PUBMED   32703236
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4620)
  AUTHORS   Zocchi,L., Mehta,A., Wu,S.C., Wu,J., Gu,Y., Wang,J., Suh,S.,
            Spitale,R.C. and Benavente,C.A.
  TITLE     Chromatin remodeling protein HELLS is critical for retinoblastoma
            tumor initiation and progression
  JOURNAL   Oncogenesis 9 (2), 25 (2020)
   PUBMED   32071286
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4620)
  AUTHORS   Illenye,S. and Heintz,N.H.
  TITLE     Functional analysis of bacterial artificial chromosomes in
            mammalian cells: mouse Cdc6 is associated with the mitotic spindle
            apparatus
  JOURNAL   Genomics 83 (1), 66-75 (2004)
   PUBMED   14667810
REFERENCE   7  (bases 1 to 4620)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 4620)
  AUTHORS   van Hannen,E.J., Zwart,G., van Agterveld,M.P., Gons,H.J., Ebert,J.
            and Laanbroek,H.J.
  TITLE     Changes in bacterial and eukaryotic community structure after mass
            lysis of filamentous cyanobacteria associated with viruses
  JOURNAL   Appl Environ Microbiol 65 (2), 795-801 (1999)
   PUBMED   9925618
REFERENCE   9  (bases 1 to 4620)
  AUTHORS   Berger,C., Strub,A., Staib,C., Lepke,M., Zisimopoulou,P., Hoehn,K.,
            Nanda,I., Schmid,M. and Grummt,F.
  TITLE     Identification and characterization of a mouse homolog to yeast
            Cdc6p
  JOURNAL   Cytogenet Cell Genet 86 (3-4), 307-316 (1999)
   PUBMED   10575231
REFERENCE   10 (bases 1 to 4620)
  AUTHORS   Hateboer,G., Wobst,A., Petersen,B.O., Le Cam,L., Vigo,E., Sardet,C.
            and Helin,K.
  TITLE     Cell cycle-regulated expression of mammalian CDC6 is dependent on
            E2F
  JOURNAL   Mol Cell Biol 18 (11), 6679-6697 (1998)
   PUBMED   9774682
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591067.35 and BC052434.1.
            
            On Apr 26, 2018 this sequence version replaced NM_001025779.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK085020.1, AK012192.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                AL591067.35        51225-51312
            89-2571             BC052434.1         1-2483
            2572-4620           AL591067.35        65318-67366
FEATURES             Location/Qualifiers
     source          1..4620
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 62.74 cM"
     gene            1..4620
                     /gene="Cdc6"
                     /gene_synonym="CDC18L; p62(cdc6)"
                     /note="cell division cycle 6"
                     /db_xref="GeneID:23834"
                     /db_xref="MGI:MGI:1345150"
     exon            1..181
                     /gene="Cdc6"
                     /gene_synonym="CDC18L; p62(cdc6)"
                     /inference="alignment:Splign:2.1.0"
     exon            182..375
                     /gene="Cdc6"
                     /gene_synonym="CDC18L; p62(cdc6)"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..1883
                     /gene="Cdc6"
                     /gene_synonym="CDC18L; p62(cdc6)"
                     /note="isoform b is encoded by transcript variant 2; cell
                     division control protein 6 homolog; CDC6-related protein;
                     cell division cycle 6 homolog"
                     /codon_start=1
                     /product="cell division control protein 6 homolog isoform
                     b"
                     /protein_id="NP_001020950.1"
                     /db_xref="CCDS:CCDS25368.1"
                     /db_xref="GeneID:23834"
                     /db_xref="MGI:MGI:1345150"
                     /translation="MPQTRSQTQATIGFPKKKLSNTLKKPNSRDCEVKLRNVQPVPTT
                     PCVDVKLLPLSPRKRLGDDNLCNTPRLSPCSPPKLGKKENGPPRSHTWKGCRLVFDDE
                     PTFKASPPKEQDRVRQHQIRSSSAQRSPESKADPEQKCPPEKESVCIRLFKQEGTCYQ
                     QAKLVLNTAVPDRLPAREQEMGVIRNFLKEHICGKKAGSLYLSGAPGTGKTACLSRIL
                     QDFKKEVKGFKSILLNCMSLRSAQAVFPAIAQEIGREELCRPAGKDLMRKLEKHLTAE
                     KGPMIVLVLDEMDQLDSKGQDVLYTLFEWPWLSNSRLVLIGIANTLDLTDRILPRLEA
                     RENCKPQLLNFPPYTRNQIAAILQDRLSQVSKDQVLDSAAIQFCARKVSAVSGDIRKA
                     LDVCRRAIEIVESDVRSQTVLKPLSECKSPSESPVPKRVGLAHISQVISEVDGNRVTL
                     SQENTQDSLPLQQKILVCSLLLLTRRLKIKEVTLGKLYEAYSSICRKQQVTAVDQSEC
                     LSLSGLLESRGLVGLKKNKESRLTKVSLKIEEKEIEHVLNGKAFTGNILAAGLP"
     exon            376..660
                     /gene="Cdc6"
                     /gene_synonym="CDC18L; p62(cdc6)"
                     /inference="alignment:Splign:2.1.0"
     exon            661..860
                     /gene="Cdc6"
                     /gene_synonym="CDC18L; p62(cdc6)"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1036
                     /gene="Cdc6"
                     /gene_synonym="CDC18L; p62(cdc6)"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1143
                     /gene="Cdc6"
                     /gene_synonym="CDC18L; p62(cdc6)"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1283
                     /gene="Cdc6"
                     /gene_synonym="CDC18L; p62(cdc6)"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1384
                     /gene="Cdc6"
                     /gene_synonym="CDC18L; p62(cdc6)"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1449
                     /gene="Cdc6"
                     /gene_synonym="CDC18L; p62(cdc6)"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1652
                     /gene="Cdc6"
                     /gene_synonym="CDC18L; p62(cdc6)"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..1793
                     /gene="Cdc6"
                     /gene_synonym="CDC18L; p62(cdc6)"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..4620
                     /gene="Cdc6"
                     /gene_synonym="CDC18L; p62(cdc6)"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2550..2555
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdc6"
                     /gene_synonym="CDC18L; p62(cdc6)"
                     /note="hexamer: AATATA"
     polyA_site      2570
                     /gene="Cdc6"
                     /gene_synonym="CDC18L; p62(cdc6)"
                     /note="major polyA site"
     regulatory      4592..4597
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdc6"
                     /gene_synonym="CDC18L; p62(cdc6)"
                     /note="hexamer: AATAAA"
     polyA_site      4620
                     /gene="Cdc6"
                     /gene_synonym="CDC18L; p62(cdc6)"
ORIGIN      
        1 tggactttgg cgggagacga gaaggctgaa gtagagcggc tttggcgcga gttgactttg
       61 cagctgctgt agaatttgtg gcgggagagt ttttacggtg gtgatcgaga cgcgaggagt
      121 gtgcactgag cgacacggcc ctgaagagtg caaagctccg cgaggtctgg tgtccagaga
      181 gttgtgtggc catcatgcct caaaccagat cccagacaca agctaccatc ggttttccga
      241 aaaagaagct atctaatacc ctgaagaaac ccaattcccg ggattgtgaa gtaaaactta
      301 gaaacgtcca gcctgtaccc accactccgt gtgtggacgt aaaacttctg cctctcagtc
      361 cccgaaaacg tctgggcgat gacaacctgt gcaacactcc ccggttatct ccctgttctc
      421 caccaaagct gggcaagaaa gaaaacggac cccctcgctc acatacgtgg aaggggtgca
      481 gattagtatt cgatgatgag ccgacattta aggcttcccc cccaaaagaa caagacagag
      541 ttcgccaaca ccagatacgt tcctcctccg ctcaaagaag tccagagagc aaagcagatc
      601 ctgagcagaa atgtccgccg gagaaggagt ctgtgtgtat aagactgttc aagcaagaag
      661 gcacttgcta tcagcaagcc aagctcgtcc tgaatacagc tgtcccggat cggctgcctg
      721 ccagagagca ggagatgggt gtcatcagga attttctgaa ggagcacatc tgtgggaaga
      781 aagctggcag tctctacctt tctggcgctc ctgggactgg aaaaactgcc tgtttaagcc
      841 ggattctgca agacttcaag aaggaagtaa aaggctttaa atccatcctg ctgaattgca
      901 tgtccctgag gagtgcccag gctgtgttcc cagctattgc tcaggagatt ggtcgggagg
      961 agctgtgcag accagctggg aaggacttga tgagaaaact ggaaaagcac ttgacagcag
     1021 agaaaggccc catgatcgtg ttggtgttgg acgagatgga tcagctggac agcaaagggc
     1081 aggatgtatt atacacactg tttgagtggc cgtggctaag caactcccga ttggtgctca
     1141 ttggtattgc taatacccta gatctcacgg acagaattct gccgagactt gaagctagag
     1201 aaaactgtaa gccgcagtta ttgaacttcc caccttatac caggaatcag atagctgcca
     1261 tcttgcagga tcgacttagt caggtgtcaa aagaccaggt tctggacagt gctgcgatcc
     1321 agttctgtgc ccgcaaagtg tctgctgttt caggagacat ccgtaaagcg ctggatgttt
     1381 gcaggcgagc tatagaaatt gtggagtcgg atgtcaggag ccagacagtc ctcaaaccac
     1441 tctccgaatg taaatcaccc agcgagtcgc cggtccccaa gcgcgttggt cttgctcaca
     1501 tatcccaagt catttcggaa gttgatggga acagggtgac tttgagccaa gaaaacacac
     1561 aggattccct tcctctccag cagaagatcc tggtttgctc tttgctgctt ttgacccggc
     1621 ggctgaaaat caaagaggtc accctgggga agttatatga agcctacagt agcatctgtc
     1681 gcaaacagca ggtgacggcc gtagaccagt ctgagtgttt gtccctttca ggactcctgg
     1741 agtccagggg ccttgtggga ttaaagaaaa ataaggagag ccgcctcacc aaggtgtctc
     1801 tgaagattga agaaaaggaa atagagcatg tcctgaacgg caaagctttc accgggaaca
     1861 tcctcgctgc tggtctgccc tgaatggctc ttactcatgg cacttgcagg tgtccctccc
     1921 actggcattt gagagccccc agaatcttca ttttagtaag gtcgtttgga aacagttacg
     1981 gcctttttta ctccgcacca gtaaatttta gtgtatggat tcatgagtgt tagcgctggc
     2041 tgatatcttt ggttcttact ggttttaccc ataaaaatga ccgagtagct gggtgtggtg
     2101 acttttatgc ctgtgatccc agcacttggg aaatagagtc aagagttaaa ggccatcctt
     2161 tgctacatag tgagcttgag ctggcctgga ctacatgaga ctctgtaaga ataaaaacag
     2221 tggccctttt taaagcaatg ttcagtactt ttcccctttc acattcctaa acacagtgcc
     2281 tacgagtata tacggacttg tgttggagag tgtgtgtatg tattacctct gtctacaaag
     2341 gatatatttt gtaaagaact ttgaagttta gaaggatgaa atggaatgat ccaggaaaat
     2401 ttacgagcct ccgtggaagg gcattgtgtt cagaggatgc ctcattcatg tgacaggtgt
     2461 tgctgccctg gactttttaa ggactgatga agaatctccc gtgctcccca ccagtatggg
     2521 ggtgacgagg agaataacta cagattgtga atatatttat tttcaagttt cgtttgtctg
     2581 ggctgcattt gttgtctctg ggttttcggg cacataggtg ttcatatccg agtcaagcag
     2641 caggagtcgc tgtttgcctt ctacggtgtg gaccgctagg actgagctcg ggccatcaaa
     2701 cttggctggc gaccagcgcc tacccttcaa gccattttat gggtttgtgt tcgtcttttt
     2761 aagcagccac actccatggt agcttaggtt ttcagaggtt aataagaaaa taccttctca
     2821 tcgggccttg gtagtacaca cccttaaatc ccagcccgca ggtgatagat agaggcaggc
     2881 gggtccctgt gtttcagaca tgttccagga cagtctggtc tacagagact ccagaaacaa
     2941 caacaacaaa attaaaaata actagcaagt ggaaatactc tctcacactt tgcctcaggg
     3001 ttagcttccc tcagacagag ccattgtttc aataggatgc agctccggat gaattttcat
     3061 ctgagcccct ctttctaggc tccctagaga agttcatctt cctggcatca agtggcagtt
     3121 tgtgacaggg acaccagagg gcaccattac aacgccgctt tgaaagtgtg gcccgggcaa
     3181 gggtggtttt gagggaaggg gcaggaaggt gcctgagtcc gacttgtttg ggaggttgct
     3241 gatgcattcg tacctggcta agtgcttggg agcaaaccat gcctgggatg aactgtctga
     3301 gtctttgctt ttctccaggc gaggctgctg ccccgatgcc tgatccggcc ccgagcttgg
     3361 gaatctgata tgggtacagg agatctgttg gccactgttt gatgcagcct gcacattatc
     3421 cttgtaaagc gatctgaacc ccacagcagg tgggatggga tgggatggga tgggatgtgc
     3481 tgggatgaga taggagggct cgctcgacgc cctctgagat gcacactgcc cactgcagaa
     3541 gactgtagag aggagattgg atgccaagca ctcactcata gaatacacat tccctctggg
     3601 gcggtgcaca agaccatact ctcccaagga gtttggagag agtctggaac tgtaagggtt
     3661 aacgagcaca actgtaaaga ttgtccgaag actgatggga agcagagacc gaatgggatt
     3721 gagaacagat gtgaggcttg atttaaatta cattttattg gatgctgcag ccttaagaga
     3781 cgtgactgct ttacagtttg tttccacact gtgggcagct gctgtctgtt ctgtgtccat
     3841 agtaggatcc tgcccaaaga ggagcggcct ccccgcctcc gatgtagttg aggcttggcg
     3901 ccttcctctt aactgcaggg cttgagtcag gaacagggtt tgactctcag tgggactggg
     3961 ctgtatcctc cctggcttct agccaagatt gcatttacag attcaaaggg gccaagttcc
     4021 ttcccctctc tctgtcttct ccccatttgg aaatagggct ttctgtggac tgttttgttt
     4081 ccttcagcac acacacacac acaccccaca cacactgtcg atttctaggt cattgctact
     4141 cttaaggctt cagcaattgg aacagggtgg gttgtgtcag tgatgcgtga agcagactta
     4201 gagtccctgc ttggcttccg ctgcccttgt gggagcagag gctgatgtat gtttgtcagc
     4261 aaagtcttaa gtgtaattca gacgccgagg cggaaaggag gagagaggcc tttccttgct
     4321 gctttttctc accgaagctg gaagctatgg gaaggtggtg ggagtttaag tggaaaggga
     4381 tgggcctgtg gttgctagtt tttgccagga tcttaggcca catggcgtag tggcaaagat
     4441 gctgacctac atttcctcct tttgaagaca ctggggtgtg tgtatcctgg tttgtcatta
     4501 ttattattgt tattattgtt gttgttgtta ttttaagaac cagattaagt ttccatagtg
     4561 tcaggtatcg ctatggaaag aacatagact caataaagtt ggtatgaatt ccaaccccaa
//
