LOCUS       NP_690023                802 aa            linear   ROD 17-SEP-2024
DEFINITION  cell division cycle 5-like protein [Mus musculus].
ACCESSION   NP_690023 XP_001002583
VERSION     NP_690023.1
DBSOURCE    REFSEQ: accession NM_152810.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 802)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 802)
  AUTHORS   Yao,X., Wang,C., Yu,W., Sun,L., Lv,Z., Xie,X., Tian,S., Yan,L.,
            Li,L. and Liu,J.
  TITLE     BCAS2 regulates oocyte meiotic prophase I by participating in mRNA
            alternative splicing
  JOURNAL   FASEB J 38 (1), e23361 (2024)
   PUBMED   38085152
REFERENCE   3  (residues 1 to 802)
  AUTHORS   Zhang,J., Liu,W., Li,G., Xu,C., Nie,X., Qin,D., Wang,Q., Lu,X.,
            Liu,J. and Li,L.
  TITLE     BCAS2 is involved in alternative splicing and mouse oocyte
            development
  JOURNAL   FASEB J 36 (2), e22128 (2022)
   PUBMED   34972250
REFERENCE   4  (residues 1 to 802)
  AUTHORS   Jokoji,G., Maeda,S., Oishi,K., Ijuin,T., Nakajima,M.,
            Tawaratsumida,H., Kawamura,I., Tominaga,H., Taketomi,E., Ikegawa,S.
            and Taniguchi,N.
  TITLE     CDC5L promotes early chondrocyte differentiation and proliferation
            by modulating pre-mRNA splicing of SOX9, COL2A1, and WEE1
  JOURNAL   J Biol Chem 297 (2), 100994 (2021)
   PUBMED   34298017
REFERENCE   5  (residues 1 to 802)
  AUTHORS   Rong,Y., Ji,S.Y., Zhu,Y.Z., Wu,Y.W., Shen,L. and Fan,H.Y.
  TITLE     ZAR1 and ZAR2 are required for oocyte meiotic maturation by
            regulating the maternal transcriptome and mRNA translational
            activation
  JOURNAL   Nucleic Acids Res 47 (21), 11387-11402 (2019)
   PUBMED   31598710
REFERENCE   6  (residues 1 to 802)
  AUTHORS   Shu,H., Chen,S., Bi,Q., Mumby,M. and Brekken,D.L.
  TITLE     Identification of phosphoproteins and their phosphorylation sites
            in the WEHI-231 B lymphoma cell line
  JOURNAL   Mol Cell Proteomics 3 (3), 279-286 (2004)
   PUBMED   14729942
REFERENCE   7  (residues 1 to 802)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (residues 1 to 802)
  AUTHORS   Lemon,W.J., Bernert,H., Sun,H., Wang,Y. and You,M.
  TITLE     Identification of candidate lung cancer susceptibility genes in
            mouse using oligonucleotide arrays
  JOURNAL   J Med Genet 39 (9), 644-655 (2002)
   PUBMED   12205107
REFERENCE   9  (residues 1 to 802)
  AUTHORS   Jiang,C.H., Tsien,J.Z., Schultz,P.G. and Hu,Y.
  TITLE     The effects of aging on gene expression in the hypothalamus and
            cortex of mice
  JOURNAL   Proc Natl Acad Sci U S A 98 (4), 1930-1934 (2001)
   PUBMED   11172053
REFERENCE   10 (residues 1 to 802)
  AUTHORS   Burns,C.G., Ohi,R., Krainer,A.R. and Gould,K.L.
  TITLE     Evidence that Myb-related CDC5 proteins are required for pre-mRNA
            splicing
  JOURNAL   Proc Natl Acad Sci U S A 96 (24), 13789-13794 (1999)
   PUBMED   10570151
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC163677.2 and
            AC169676.2.
            
            On May 4, 2006 this sequence version replaced XP_001002583.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031480.1, AK172950.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..802
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 22.36 cM"
     Protein         1..802
                     /product="cell division cycle 5-like protein"
                     /note="cell division cycle 5-related protein; cdc5-like
                     protein"
                     /calculated_mol_wt=92059
     Region          6..>303
                     /region_name="REB1"
                     /note="Myb superfamily proteins, including transcription
                     factors and mRNA splicing factors [Transcription / RNA
                     processing and modification / Cell division and chromosome
                     partitioning]; COG5147"
                     /db_xref="CDD:227476"
     Region          108..143
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6A068.2)"
     Region          165..271
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6A068.2)"
     Region          200..206
                     /region_name="Required for interaction with CTNNBL1.
                     /evidence=ECO:0000250|UniProtKB:Q99459"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6A068.2)"
     Site            227
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q99459; propagated from
                     UniProtKB/Swiss-Prot (Q6A068.2)"
     Region          246..278
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6A068.2)"
     Region          260..606
                     /region_name="Interaction with PPP1R8.
                     /evidence=ECO:0000250|UniProtKB:Q99459"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6A068.2)"
     Site            303
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q99459; propagated from
                     UniProtKB/Swiss-Prot (Q6A068.2)"
     Site            358
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q99459; propagated from
                     UniProtKB/Swiss-Prot (Q6A068.2)"
     Site            377
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q99459; propagated from
                     UniProtKB/Swiss-Prot (Q6A068.2)"
     Site            385
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q99459; propagated from
                     UniProtKB/Swiss-Prot (Q6A068.2)"
     Site            396
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q99459; propagated from
                     UniProtKB/Swiss-Prot (Q6A068.2)"
     Region          404..655
                     /region_name="Myb_Cef"
                     /note="pre-mRNA splicing factor component; pfam11831"
                     /db_xref="CDD:463366"
     Site            404
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q99459; propagated from
                     UniProtKB/Swiss-Prot (Q6A068.2)"
     Region          408..460
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6A068.2)"
     Site            411
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q99459; propagated from
                     UniProtKB/Swiss-Prot (Q6A068.2)"
     Site            415
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q99459; propagated from
                     UniProtKB/Swiss-Prot (Q6A068.2)"
     Site            417
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q99459; propagated from
                     UniProtKB/Swiss-Prot (Q6A068.2)"
     Site            424
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q99459; propagated from
                     UniProtKB/Swiss-Prot (Q6A068.2)"
     Site            430
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q99459; propagated from
                     UniProtKB/Swiss-Prot (Q6A068.2)"
     Site            438
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q99459; propagated from
                     UniProtKB/Swiss-Prot (Q6A068.2)"
     Site            442
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q99459; propagated from
                     UniProtKB/Swiss-Prot (Q6A068.2)"
     Region          501..659
                     /region_name="Interaction with DAPK3.
                     /evidence=ECO:0000250|UniProtKB:O08837"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6A068.2)"
     Region          <627..>801
                     /region_name="SMC_prok_B"
                     /note="chromosome segregation protein SMC, common
                     bacterial type; TIGR02168"
                     /db_xref="CDD:274008"
     Region          706..800
                     /region_name="Interaction with PLRG1.
                     /evidence=ECO:0000250|UniProtKB:Q99459"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6A068.2)"
     CDS             1..802
                     /gene="Cdc5l"
                     /gene_synonym="1200002I02Rik; PCDC5RP"
                     /coded_by="NM_152810.2:273..2681"
                     /db_xref="CCDS:CCDS37627.1"
                     /db_xref="GeneID:71702"
                     /db_xref="MGI:MGI:1918952"
ORIGIN      
        1 mprimikggv wrntedeilk aavmkygknq wsriasllhr ksakqckarw yewldpsikk
       61 tewsreeeek llhlaklmpt qwrtiapiig rtaaqclehy eflldktaqr dneeettddp
      121 rklkpgeidp npetkparpd pidmdedele mlseararla ntqgkkakrk arekqleear
      181 rlaalqkrre lraagieiqk krkkkrgvdy naeipfekkp algfydtsee nyqaldadfr
      241 klrqqdldge lrsekegrdr kkdkqhlkrk kesdlpsail qtsgvseftk krsklvlpap
      301 qisdaelqev vkvgqaseva rqtaeesgit nsasstllse ynvtnnsial rtprtpasqd
      361 rilqeaqnlm altnvdtplk gglntplhes dfsgvtpqrq vvqtpntvls tpfrtpsnga
      421 egltprsgtt pkpvtnatpg rtplrdklni npedgmadys dpsyvkqmer esrehlrlgl
      481 lglpapkndf eivlpenaek eleereiddt yiedaadvda rkqairdaer vkemkrmhka
      541 vqkdlprpse vnetilrpln veppltdlqk seelikkemi tmlhydllhh pyepsgnkkg
      601 knvgfatnns ehitylehsp yekfskedlk kaqdalvqem evvkqgmshg elsseaynqv
      661 weecysqvly lpaqsrytra nlaskkdrie slekrleinr ghmtteakra akmekkmkil
      721 lggyqsramg lmkqlndlwd qieqahlelr tfeelkkhed saiprrlecl kedvqrqqer
      781 ekelqqryad llmeketlqa kf
//
