LOCUS       NM_009862               2185 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus cell division cycle 45 (Cdc45), transcript variant 1,
            mRNA.
ACCESSION   NM_009862
VERSION     NM_009862.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2185)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2185)
  AUTHORS   Evrin,C., Alvarez,V., Ainsworth,J., Fujisawa,R., Alabert,C. and
            Labib,K.P.
  TITLE     DONSON is required for CMG helicase assembly in the mammalian cell
            cycle
  JOURNAL   EMBO Rep 24 (11), e57677 (2023)
   PUBMED   37781960
  REMARK    GeneRIF: DONSON is required for CMG helicase assembly in the
            mammalian cell cycle.
REFERENCE   3  (bases 1 to 2185)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2185)
  AUTHORS   Kafer,G.R. and Cesare,A.J.
  TITLE     A Survey of Essential Genome Stability Genes Reveals That
            Replication Stress Mitigation Is Critical for Peri-Implantation
            Embryogenesis
  JOURNAL   Front Cell Dev Biol 8, 416 (2020)
   PUBMED   32548123
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2185)
  AUTHORS   Moon,S., Im,S.K., Kim,N., Youn,H., Park,U.H., Kim,J.Y., Kim,A.R.,
            An,S.J., Kim,J.H., Sun,W., Hwang,J.T., Kim,E.J. and Um,S.J.
  TITLE     Asxl1 exerts an antiproliferative effect on mouse lung maturation
            via epigenetic repression of the E2f1-Nmyc axis
  JOURNAL   Cell Death Dis 9 (11), 1118 (2018)
   PUBMED   30389914
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2185)
  AUTHORS   Lund,J., Roe,B., Chen,F., Budarf,M., Galili,N., Riblet,R.,
            Miller,R.D., Emanuel,B.S. and Reeves,R.H.
  TITLE     Sequence-ready physical map of the mouse chromosome 16 region with
            conserved synteny to the human velocardiofacial syndrome region on
            22q11.2
  JOURNAL   Mamm Genome 10 (5), 438-443 (1999)
   PUBMED   10337614
REFERENCE   7  (bases 1 to 2185)
  AUTHORS   Shaikh,T.H., Gottlieb,S., Sellinger,B., Chen,F., Roe,B.A.,
            Oakey,R.J., Emanuel,B.S. and Budarf,M.L.
  TITLE     Characterization of CDC45L: a gene in the 22q11.2 deletion region
            expressed during murine and human development
  JOURNAL   Mamm Genome 10 (3), 322-326 (1999)
   PUBMED   10051334
REFERENCE   8  (bases 1 to 2185)
  AUTHORS   Yamagishi,H., Garg,V., Matsuoka,R., Thomas,T. and Srivastava,D.
  TITLE     A molecular pathway revealing a genetic basis for human cardiac and
            craniofacial defects
  JOURNAL   Science 283 (5405), 1158-1161 (1999)
   PUBMED   10024240
REFERENCE   9  (bases 1 to 2185)
  AUTHORS   Sutherland,H.F., Kim,U.J. and Scambler,P.J.
  TITLE     Cloning and comparative mapping of the DiGeorge syndrome critical
            region in the mouse
  JOURNAL   Genomics 52 (1), 37-43 (1998)
   PUBMED   9740669
REFERENCE   10 (bases 1 to 2185)
  AUTHORS   McKie,J.M., Wadey,R.B., Sutherland,H.F., Taylor,C.L. and
            Scambler,P.J.
  TITLE     Direct selection of conserved cDNAs from the DiGeorge critical
            region: isolation of a novel CDC45-like gene
  JOURNAL   Genome Res 8 (8), 834-841 (1998)
   PUBMED   9724329
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC083895.21.
            
            On Feb 14, 2023 this sequence version replaced NM_009862.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Both variants 1 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF081536.1, SRR13862062.101282.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-216               AC083895.21        22756-22971
            217-411             AC083895.21        23066-23260
            412-471             AC083895.21        23411-23470
            472-564             AC083895.21        24294-24386
            565-702             AC083895.21        25906-26043
            703-846             AC083895.21        27352-27495
            847-902             AC083895.21        29338-29393
            903-951             AC083895.21        32926-32974
            952-1013            AC083895.21        36038-36099
            1014-1064           AC083895.21        37376-37426
            1065-1184           AC083895.21        38831-38950
            1185-1316           AC083895.21        39549-39680
            1317-1415           AC083895.21        39915-40013
            1416-1577           AC083895.21        41436-41597
            1578-1716           AC083895.21        47707-47845
            1717-1800           AC083895.21        47923-48006
            1801-1919           AC083895.21        49584-49702
            1920-1996           AC083895.21        49893-49969
            1997-2063           AC083895.21        52813-52879
            2064-2185           AC083895.21        54202-54323
FEATURES             Location/Qualifiers
     source          1..2185
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 11.63 cM"
     gene            1..2185
                     /gene="Cdc45"
                     /gene_synonym="Cdc45l"
                     /note="cell division cycle 45"
                     /db_xref="GeneID:12544"
                     /db_xref="MGI:MGI:1338073"
     exon            1..216
                     /gene="Cdc45"
                     /gene_synonym="Cdc45l"
                     /inference="alignment:Splign:2.1.0"
     exon            217..411
                     /gene="Cdc45"
                     /gene_synonym="Cdc45l"
                     /inference="alignment:Splign:2.1.0"
     CDS             361..2061
                     /gene="Cdc45"
                     /gene_synonym="Cdc45l"
                     /note="isoform 1 is encoded by transcript variant 1;
                     CDC45-related protein; cell division cycle 45 homolog;
                     cell division control protein 45 homolog; PORC-PI-1"
                     /codon_start=1
                     /product="cell division control protein 45 homolog isoform
                     1"
                     /protein_id="NP_033992.2"
                     /db_xref="CCDS:CCDS28027.1"
                     /db_xref="GeneID:12544"
                     /db_xref="MGI:MGI:1338073"
                     /translation="MFVTDFRKEFYETVHNQRVLLFVASDVDALCACKILQALFQCDH
                     VQYTLVPVSGWQELETAYLEHKEQFSYFILINCGANVDLLDILQPDEDSIFFVCDTHR
                     PVNVVNVYNDTQIKLLIKQEDDLEVPAYDDIFRDEAEDEDLSDSDGDGSEPSEKRTRL
                     EEEIVERNRKRRQRREWEARRKDILFDYEQYEYYGTSSAMVMFDLAWMMSKDLNDMLW
                     WAIVGLTDQWVHDKITQMKYVTDVGILQRHVSRHNHRNEAEENMLSVDCTRISFEYDL
                     CLVLYQHWSLHESLYNTSYTAARFKLWSVHGQKRLQEFLADMGLPLKQVKQKFQSMDV
                     SLKGNLREMIEESANKFGMKDMRVQTFSIQFGFKHKFLASDVVFATMSLMESPEKDGS
                     GTDHFIQALDSLSRSNLDKLYLGLELAKKHLQATQQTIASCLCTNLVTSQGPFLYCSL
                     MEGTPDVTLFSKPASLSLLSRHLLKSFVYSTKNRRCKLLPLVMAAPLSVEQGTVTVVG
                     IPPETDSSDRKNFFGRAFEKAAESTSSRTLHNYFDLSVIELKAEDRSKFLDALVSLLS
                     "
     exon            412..471
                     /gene="Cdc45"
                     /gene_synonym="Cdc45l"
                     /inference="alignment:Splign:2.1.0"
     exon            472..564
                     /gene="Cdc45"
                     /gene_synonym="Cdc45l"
                     /inference="alignment:Splign:2.1.0"
     exon            565..702
                     /gene="Cdc45"
                     /gene_synonym="Cdc45l"
                     /inference="alignment:Splign:2.1.0"
     exon            703..846
                     /gene="Cdc45"
                     /gene_synonym="Cdc45l"
                     /inference="alignment:Splign:2.1.0"
     exon            847..902
                     /gene="Cdc45"
                     /gene_synonym="Cdc45l"
                     /inference="alignment:Splign:2.1.0"
     exon            903..951
                     /gene="Cdc45"
                     /gene_synonym="Cdc45l"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1013
                     /gene="Cdc45"
                     /gene_synonym="Cdc45l"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1064
                     /gene="Cdc45"
                     /gene_synonym="Cdc45l"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1184
                     /gene="Cdc45"
                     /gene_synonym="Cdc45l"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1316
                     /gene="Cdc45"
                     /gene_synonym="Cdc45l"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1415
                     /gene="Cdc45"
                     /gene_synonym="Cdc45l"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1577
                     /gene="Cdc45"
                     /gene_synonym="Cdc45l"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1716
                     /gene="Cdc45"
                     /gene_synonym="Cdc45l"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1800
                     /gene="Cdc45"
                     /gene_synonym="Cdc45l"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..1919
                     /gene="Cdc45"
                     /gene_synonym="Cdc45l"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..1996
                     /gene="Cdc45"
                     /gene_synonym="Cdc45l"
                     /inference="alignment:Splign:2.1.0"
     exon            1997..2063
                     /gene="Cdc45"
                     /gene_synonym="Cdc45l"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2185
                     /gene="Cdc45"
                     /gene_synonym="Cdc45l"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2165..2170
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdc45"
                     /gene_synonym="Cdc45l"
                     /note="hexamer: AATAAA"
     polyA_site      2185
                     /gene="Cdc45"
                     /gene_synonym="Cdc45l"
                     /note="major polyA site"
ORIGIN      
        1 aatctatagc tcactctaat tcgacgaacc gtgtattgga aacttattgg aaacacattc
       61 aaataatgtg tgactgaatt tactttatgt ctaagagtat attgttttct aagtatgcca
      121 gggtcagata atagaccttc cttcccgaag taaagatgtc tgccaaacat aggtggtttt
      181 gggtgactgg acgttagcgt caacaccggc aacaaggaac caatcagaaa ggaggaaagg
      241 ctaagaatta ttggctgctg gcgtggacca atcagaagag ctgtgatttg gcgggagtct
      301 tgacgacctc cggggctgtc cgtgtctcag cgccagttct aggtatccgc cgctgtggct
      361 atgttcgtga ccgatttccg caaggagttc tacgagacgg tccacaacca gagggtcctt
      421 ctctttgtgg cctcggacgt ggatgccttg tgtgcttgca agatcctcca ggccctgttt
      481 cagtgtgacc acgtccagta tacgctggtt ccggtttctg ggtggcaaga acttgaaact
      541 gcatatcttg aacataaaga gcagttctcc tatttcatcc tcataaactg tggagccaac
      601 gtggacctgt tggatatcct tcagcctgat gaagacagta tattttttgt gtgtgatacc
      661 cacaggccag tgaacgttgt gaatgtgtac aatgacactc agatcaaatt gcttattaaa
      721 caagaggatg accttgaggt tcctgcctac gacgacatct ttagagatga agcagaggat
      781 gaagatcttt cagacagtga cggtgatggg tcagagcctt cagagaagcg cacacggtta
      841 gaagaggaga tagtggagcg aaacaggaag aggaggcagc gcagggagtg ggaggcccga
      901 aggaaagaca tcctctttga ctacgagcag tatgaatatt atgggacatc gtcggccatg
      961 gtgatgtttg acctggcgtg gatgatgtcc aaggacctga atgacatgct gtggtgggcc
     1021 attgttggac tgacagacca gtgggtgcat gacaagatca ctcaaatgaa gtacgtgact
     1081 gatgttggca tcctgcagcg tcatgtgtcc cgtcataacc accgaaacga ggcggaggag
     1141 aacatgctct ctgtagactg cacccggatc tccttcgagt atgacctctg cctggtactg
     1201 tatcagcact ggtccctcca tgaaagcctg tacaacacca gctacacagc agccaggttt
     1261 aagctctggt ctgtgcatgg gcagaaacga ctccaggagt tccttgcaga catggggctt
     1321 cccctgaagc aagtcaagca gaaatttcag tccatggacg tttccttgaa ggggaatctg
     1381 cgagaaatga ttgaagaatc tgcaaataaa tttgggatga aggacatgcg tgtacagact
     1441 ttcagcattc agtttgggtt caagcataaa ttcctggcca gtgatgtcgt ctttgccacc
     1501 atgtctctaa tggagagtcc tgagaaggat ggctcaggga cagaccactt catccaggct
     1561 ctcgatagcc tctccaggag taacctggac aagctatacc ttggtctaga gctcgccaag
     1621 aagcacctcc aagccacaca acagaccatc gccagctgtc tctgtaccaa cctcgtcact
     1681 tcccagggcc cttttctcta ctgctcactc atggagggca ctccagatgt caccctgttt
     1741 tccaagccag catccttgag tctgctcagc agacatctgc tcaagtcctt tgtgtactcg
     1801 acaaagaatc gacgatgcaa gctgctgccc ctggtgatgg ctgccccgct gagcgtggaa
     1861 cagggcacag tgaccgtggt gggcatcccc ccagagactg atagctcgga tagaaagaac
     1921 ttttttggtc gggcttttga gaaggcagca gaaagcacca gctctcggac tctacacaat
     1981 tactttgacc tctcagtaat tgagctgaag gctgaggacc ggagcaagtt cctggacgct
     2041 cttgtgtcac tgctgtcctg aggaattcaa cttctccaga agtgacctcc ttttccttat
     2101 ttatatttcc tggccactat tcagttgtaa gataacattt gaaatgtgag actatatggt
     2161 ttttaataaa atgtttgatg tttta
//
