LOCUS       NM_172395               3128 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus CDC42 small effector 1 (Cdc42se1), transcript variant
            1, mRNA.
ACCESSION   NM_172395
VERSION     NM_172395.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3128)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3128)
  AUTHORS   Hasenpusch-Theil,K., Laclef,C., Colligan,M., Fitzgerald,E.,
            Howe,K., Carroll,E., Abrams,S.R., Reiter,J.F.,
            Schneider-Maunoury,S. and Theil,T.
  TITLE     A transient role of the ciliary gene Inpp5e in controlling direct
            versus indirect neurogenesis in cortical development
  JOURNAL   Elife 9, e58162 (2020)
   PUBMED   32840212
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3128)
  AUTHORS   Hasenpusch-Theil,K., Magnani,D., Amaniti,E.M., Han,L., Armstrong,D.
            and Theil,T.
  TITLE     Transcriptional analysis of Gli3 mutants identifies Wnt target
            genes in the developing hippocampus
  JOURNAL   Cereb Cortex 22 (12), 2878-2893 (2012)
   PUBMED   22235033
REFERENCE   4  (bases 1 to 3128)
  AUTHORS   Sansom,S.N., Griffiths,D.S., Faedo,A., Kleinjan,D.J., Ruan,Y.,
            Smith,J., van Heyningen,V., Rubenstein,J.L. and Livesey,F.J.
  TITLE     The level of the transcription factor Pax6 is essential for
            controlling the balance between neural stem cell self-renewal and
            neurogenesis
  JOURNAL   PLoS Genet 5 (6), e1000511 (2009)
   PUBMED   19521500
REFERENCE   5  (bases 1 to 3128)
  AUTHORS   Papanikolaou,A., Wang,Q.S., Papanikolaou,D., Whiteley,H.E. and
            Rosenberg,D.W.
  TITLE     Sequential and morphological analyses of aberrant crypt foci
            formation in mice of differing susceptibility to
            azoxymethane-induced colon carcinogenesis
  JOURNAL   Carcinogenesis 21 (8), 1567-1572 (2000)
   PUBMED   10910960
REFERENCE   6  (bases 1 to 3128)
  AUTHORS   Pirone,D.M., Fukuhara,S., Gutkind,J.S. and Burbelo,P.D.
  TITLE     SPECs, small binding proteins for Cdc42
  JOURNAL   J Biol Chem 275 (30), 22650-22656 (2000)
   PUBMED   10816584
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AV456394.1, AK004859.1 and CJ290563.1.
            
            On Nov 16, 2013 this sequence version replaced NM_172395.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004859.1, AK019052.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-356               AV456394.1         1-356
            357-3113            AK004859.1         2-2758
            3114-3128           CJ290563.1         374-388
FEATURES             Location/Qualifiers
     source          1..3128
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 40.74 cM"
     gene            1..3128
                     /gene="Cdc42se1"
                     /gene_synonym="1300002M12Rik; Cdcse1; SCIP1; Spec1"
                     /note="CDC42 small effector 1"
                     /db_xref="GeneID:57912"
                     /db_xref="MGI:MGI:1889510"
     exon            1..442
                     /gene="Cdc42se1"
                     /gene_synonym="1300002M12Rik; Cdcse1; SCIP1; Spec1"
                     /inference="alignment:Splign:2.1.0"
     exon            443..750
                     /gene="Cdc42se1"
                     /gene_synonym="1300002M12Rik; Cdcse1; SCIP1; Spec1"
                     /inference="alignment:Splign:2.1.0"
     CDS             697..939
                     /gene="Cdc42se1"
                     /gene_synonym="1300002M12Rik; Cdcse1; SCIP1; Spec1"
                     /note="small protein effector 1 of Cdc42"
                     /codon_start=1
                     /product="CDC42 small effector protein 1"
                     /protein_id="NP_765983.1"
                     /db_xref="CCDS:CCDS38545.1"
                     /db_xref="GeneID:57912"
                     /db_xref="MGI:MGI:1889510"
                     /translation="MSEFWHKLGCCVVEKPQPKKKRRRIDRTMIGEPMNFVHLTHIGS
                     GEMGAGDGLAMTGAVQEQMRSKGNHRDRPWSNSRAL"
     exon            751..861
                     /gene="Cdc42se1"
                     /gene_synonym="1300002M12Rik; Cdcse1; SCIP1; Spec1"
                     /inference="alignment:Splign:2.1.0"
     exon            862..953
                     /gene="Cdc42se1"
                     /gene_synonym="1300002M12Rik; Cdcse1; SCIP1; Spec1"
                     /inference="alignment:Splign:2.1.0"
     exon            954..3128
                     /gene="Cdc42se1"
                     /gene_synonym="1300002M12Rik; Cdcse1; SCIP1; Spec1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3098..3103
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdc42se1"
                     /gene_synonym="1300002M12Rik; Cdcse1; SCIP1; Spec1"
                     /note="hexamer: AATAAA"
     polyA_site      3112
                     /gene="Cdc42se1"
                     /gene_synonym="1300002M12Rik; Cdcse1; SCIP1; Spec1"
     polyA_site      3117
                     /gene="Cdc42se1"
                     /gene_synonym="1300002M12Rik; Cdcse1; SCIP1; Spec1"
                     /note="major polyA site"
ORIGIN      
        1 agcgcatggc tgagcagtta attgtcctct aacttagatg tatgggttaa aaagtcttcc
       61 ggttaaacaa cagaatggcc ctcctttccc actgtaagga ctaaagggga ctttgggaga
      121 ctcagaaagg gccccagcgc atcgtcctct cagcgcctgc agcaggtgga cagactagca
      181 cagacagttg gggtgccgcg gttgtccccg agcgcggtgc ttgccgctgt ccccgcgggc
      241 cacgccgtgc gccccgaagc tgggcggagc gctgcgctcc gctctcagcc cctgggtttc
      301 gtaatcgcgt cgccggcgtt tccgccctcc gccagcccca cctctgccgg cccgccctca
      361 actccccgcc gtgccgagaa gcagccaggg gacccggagt ggcggagccc ccgcccgcag
      421 tggggacgcc ggggagccgc aggattccac atctaaagaa gacaggacct tgtgcctgcc
      481 tgcccaagcc tcttgccagt gccccaccag tcagagactc cgaccttcac cgaaaggcca
      541 cttgttggtg tctaggattt ctaccttttc ccaccccatc cggttgactg aacccagggt
      601 gttgttacac ctgcctgtga ggactggttg gttagcaaca aacacgagcc ccctggggcc
      661 tctggcagcg gcctgaagct ggaaccatca gggaacatga gcgagttttg gcacaaactg
      721 ggctgctgcg tggtcgagaa gccccagccg aagaaaaaga gaagacggat tgaccgcact
      781 atgattgggg agccaatgaa ctttgtccac ctgactcaca tcggctctgg ggagatgggg
      841 gctggagatg gacttgccat gacaggtgca gttcaggagc agatgagatc caagggaaac
      901 caccgtgaca gaccgtggag caattctagg gccttgtagc tcccatggga ctggttctgc
      961 agtcttggag ttcccattct gtgattctgt gtccagccca aaagaaatgc caccaccaga
     1021 tcccttcaac cagtgaccca agggcccccc ctctttctct ctaacaagtg cctcaaaagg
     1081 agtgggggct ggtctccctt ttctccctct ggcctctgcc cctcctggag atgggggtca
     1141 aggcagcagg actgaccaag tgactactgg tgggccagag gagctccgct gaagccctgc
     1201 acacccttga tctgagctgg gggttctctg ggaacctgga atgggttcct tgctcctgaa
     1261 tgaaggtcgg gtgctacctg tttaaacttc ttgcttttat tctctaatcg aggcaggcag
     1321 gagtgggagc cacagctgaa ccccgagttt gctaaattct tcctgcttcc ctgtactctt
     1381 tccttctgga atgaacaaca cagaggtgat ggggctaggt gaccactgcc cagtccgctc
     1441 ggaatttcag accttaaggt cacagccccg ccatgtctct ccgctggcac cagggtcttg
     1501 ctccagttag gcctctaatc ccatgcttct gtagtattaa tagcttccca gaattttttt
     1561 ttaattaaaa ttttaatttg agttctttta attaccccca tcttgctatc tctgtctttt
     1621 ccctgaccct ttaagaaact ttaggtttcc cattgagtaa gagttaaggg atggatctta
     1681 acttgaccac attccattta agacttggag tcctggcctg ccctctgtca gcccccctgc
     1741 tggcccaggt gaaaggaaga ggagggttcc agataaaaag ccaggatgta gcaaaattag
     1801 ctgtatctca gggtcaactt cctgtgaggg tggtgaggta aataggttga aagcgctctt
     1861 tggagtacag gccctcggtc ctttatggaa gcgtggcttt tcaactccaa cacttgaaaa
     1921 tagcttggac agtttgggct gcacagtgct ttgtaatggg gagggctgtt ctgcacagac
     1981 tacagcatct cttccccacc cccgaccccc tgcccagtgt ggcaaccaaa atatctccag
     2041 aaattgccaa atgtctccca gggatgaagt tacccacagc ttgagagtca aggtatgttt
     2101 tccttaagtg acttccacat ggccccccac ccccagtcgg gtgattcacc ttgagccatg
     2161 ggtaagctag cgccctcata gctcagcaga gctgcacatc cctgtttcag atgtgttgct
     2221 tgcactcccg tctctgttct tgatctctgc aagagggcct ttcacagtgc caagacggga
     2281 acggggtgtg ctgggatggg aggacaggac agttacgctg gctgtccgtc cgtacgctat
     2341 gcgcctctct gctctagtct ttgaacccgg ttaagactca gggactttgg aagatcaggt
     2401 gtcacggagt ggctttaaac gggaaagtac tgtagaaacg gagtctgtag gccttttgtt
     2461 ttctcaggtg ttgtcattct ggccctttct ttgcaggctg attagaaagg cagaacaaga
     2521 caaatgagct cctgcctgtt cctagaagag agggctgggg tctcattagc tctgtaatag
     2581 gaagcttgtt ttgtggtaat gggtcagggt tgtggaaact gatccgctcc tggcgactcc
     2641 agccatcccg ttatcccttg cctagtgact gagactttca tttgtccaaa gctctgcgct
     2701 ccgtatggca tttcaggctc taagactggt catggatgtt catttggagt ttgcctcctt
     2761 gtggttcagg cctgcctcct ttaagggagg agcttgcagg cacggaggtc ctgtgcccct
     2821 agcagcatgc tcccaggaag gccatgaatg tcaggtcaca gtggcgaaag gttgggcact
     2881 gtgtggggtt aactggagag gacacggtgt gggtgacccc tgagctccag tcttgtgtca
     2941 gtttctttga gcacagtctt ctggtggata ctctcctgca tcgagctacc ttctctgtgt
     3001 gtctgctgcc accacttaac aaggtgattg gaatgagttt gcgagtcgta atttatatta
     3061 aaaagatgat agacttttaa gatacatttt tttttccaat aaaagaatta agcaaaacgg
     3121 tttcagag
//
