LOCUS       NM_021454                870 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus CDC42 effector protein 5 (Cdc42ep5), mRNA.
ACCESSION   NM_021454
VERSION     NM_021454.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 870)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 870)
  AUTHORS   Farrugia,A.J., Rodriguez,J., Orgaz,J.L., Lucas,M., Sanz-Moreno,V.
            and Calvo,F.
  TITLE     CDC42EP5/BORG3 modulates SEPT9 to promote actomyosin function,
            migration, and invasion
  JOURNAL   J Cell Biol 219 (9) (2020)
   PUBMED   32798219
  REMARK    GeneRIF: CDC42EP5/BORG3 modulates SEPT9 to promote actomyosin
            function, migration, and invasion.
REFERENCE   3  (bases 1 to 870)
  AUTHORS   Joberty,G., Perlungher,R.R., Sheffield,P.J., Kinoshita,M., Noda,M.,
            Haystead,T. and Macara,I.G.
  TITLE     Borg proteins control septin organization and are negatively
            regulated by Cdc42
  JOURNAL   Nat Cell Biol 3 (10), 861-866 (2001)
   PUBMED   11584266
REFERENCE   4  (bases 1 to 870)
  AUTHORS   Hirsch,D.S., Pirone,D.M. and Burbelo,P.D.
  TITLE     A new family of Cdc42 effector proteins, CEPs, function in
            fibroblast and epithelial cell shape changes
  JOURNAL   J Biol Chem 276 (2), 875-883 (2001)
   PUBMED   11035016
REFERENCE   5  (bases 1 to 870)
  AUTHORS   Joberty,G., Perlungher,R.R. and Macara,I.G.
  TITLE     The Borgs, a new family of Cdc42 and TC10 GTPase-interacting
            proteins
  JOURNAL   Mol Cell Biol 19 (10), 6585-6597 (1999)
   PUBMED   10490598
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC101941.11.
            
            On Feb 9, 2019 this sequence version replaced NM_021454.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK008154.1, BC103774.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-247               AC101941.11        108802-109048
            248-342             AC101941.11        109320-109414
            343-870             AC101941.11        121720-122247
FEATURES             Location/Qualifiers
     source          1..870
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 2.4 cM"
     gene            1..870
                     /gene="Cdc42ep5"
                     /gene_synonym="1700027J19Rik; 2010007O02Rik; Borg3; CEP5"
                     /note="CDC42 effector protein 5"
                     /db_xref="GeneID:58804"
                     /db_xref="MGI:MGI:1929745"
     exon            1..247
                     /gene="Cdc42ep5"
                     /gene_synonym="1700027J19Rik; 2010007O02Rik; Borg3; CEP5"
                     /inference="alignment:Splign:2.1.0"
     exon            248..342
                     /gene="Cdc42ep5"
                     /gene_synonym="1700027J19Rik; 2010007O02Rik; Borg3; CEP5"
                     /inference="alignment:Splign:2.1.0"
     exon            343..870
                     /gene="Cdc42ep5"
                     /gene_synonym="1700027J19Rik; 2010007O02Rik; Borg3; CEP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             343..795
                     /gene="Cdc42ep5"
                     /gene_synonym="1700027J19Rik; 2010007O02Rik; Borg3; CEP5"
                     /note="CRIB-containing BORG3 protein; binder of Rho
                     GTPases 3; binder of Rho GTPase 3; CDC42 effector protein
                     (Rho GTPase binding) 5"
                     /codon_start=1
                     /product="cdc42 effector protein 5"
                     /protein_id="NP_067429.1"
                     /db_xref="CCDS:CCDS20733.1"
                     /db_xref="GeneID:58804"
                     /db_xref="MGI:MGI:1929745"
                     /translation="MPVMKQLGPAQPKKRLDRGALSISAPLGDFRHTLHVGRGGDAFG
                     DTSFLSRHGGGPPPEPGAPPVVAPHSVAPPAAPQPPVAVPSPADPLLSFHLDLGPSML
                     DAVLGVMDAERSETTATKPDGDAHPRVQHPKTRCCSNADLQLDDVIGL"
     regulatory      844..849
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdc42ep5"
                     /gene_synonym="1700027J19Rik; 2010007O02Rik; Borg3; CEP5"
                     /note="hexamer: CATAAA"
     polyA_site      867
                     /gene="Cdc42ep5"
                     /gene_synonym="1700027J19Rik; 2010007O02Rik; Borg3; CEP5"
                     /note="major polyA site"
ORIGIN      
        1 agtcctggtt tcctcctgtc cctacaatcc cttcaaaggg cctttagctt ttctaccatc
       61 aaggctttct agtcctttaa atcctagagg caaactttta gggactaagg aaggctggga
      121 ggggcctatg gcttaaccct ctcaacccgg gacaagagac cagcttggct gactgggcgt
      181 tgactcggtg cttggttggt aggctgccat ggcccccgag aggggctgaa gcttattcct
      241 ggtgcaggtg agatctctcc tgcagaaaga aggaaaaagg cgccagagag gccaggaggg
      301 accccagctt aagtcggatc tcaattaagt ctggaccacg agatgccggt aatgaagcag
      361 ctgggccctg cacaacccaa gaagcggctg gatcgcggag cactctcgat ctcagcaccc
      421 ctcggagact tcaggcacac attgcacgtg ggacgcggtg gcgacgcctt cggggacacc
      481 tcattcctga gtcgccacgg gggcggtccg cctcccgagc ctggagcccc accggttgtg
      541 gccccacatt ctgtcgctcc acctgcagcc ccacagcccc ctgtggctgt gccttcacct
      601 gcggacccgc tgctgtcttt ccacctggac ctgggcccct ctatgctgga cgcggtgtta
      661 ggcgtcatgg acgcggagcg cagcgagaca acagccacca agcccgatgg ggatgcccac
      721 cctagagtgc agcaccccaa gacccgctgc tgctcaaatg ctgacctcca gctggacgac
      781 gtcatcggtc tgtagtgtca taattccctc aacccctccc tcccagcact ccacttttgt
      841 acacataaat ggctgaggtt tgtgccatgg
//
