LOCUS       NM_001163346            2960 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus CDC42 effector protein 4 (Cdc42ep4), transcript
            variant 2, mRNA.
ACCESSION   NM_001163346
VERSION     NM_001163346.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2960)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   2  (bases 1 to 2960)
  AUTHORS   Hou,L., Wang,L., Zhao,Z., Xu,W., Wang,Y. and Cui,G.
  TITLE     Regulation of dendrite growth by Cdc42 effector protein-4 in
            hippocampal neurons in vitro
  JOURNAL   Mol Med Rep 25 (4) (2022)
   PUBMED   35169866
  REMARK    GeneRIF: Regulation of dendrite growth by Cdc42 effector protein4
            in hippocampal neurons in vitro.
REFERENCE   3  (bases 1 to 2960)
  AUTHORS   Kandi,R., Senger,K., Grigoryan,A., Soller,K., Sakk,V., Schuster,T.,
            Eiwen,K., Menon,M.B., Gaestel,M., Zheng,Y., Florian,M.C. and
            Geiger,H.
  TITLE     Cdc42-Borg4-Septin7 axis regulates HSC polarity and function
  JOURNAL   EMBO Rep 22 (12), e52931 (2021)
   PUBMED   34661963
REFERENCE   4  (bases 1 to 2960)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2960)
  AUTHORS   Narayanan,R., Pham,L., Kerimoglu,C., Watanabe,T., Castro
            Hernandez,R., Sokpor,G., Ulmke,P.A., Kiszka,K.A., Tonchev,A.B.,
            Rosenbusch,J., Seong,R.H., Teichmann,U., Frahm,J., Fischer,A.,
            Bonn,S., Stoykova,A., Staiger,J.F. and Tuoc,T.
  TITLE     Chromatin Remodeling BAF155 Subunit Regulates the Genesis of Basal
            Progenitors in Developing Cortex
  JOURNAL   iScience 4, 109-126 (2018)
   PUBMED   30240734
REFERENCE   6  (bases 1 to 2960)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 2960)
  AUTHORS   Hirsch,D.S., Pirone,D.M. and Burbelo,P.D.
  TITLE     A new family of Cdc42 effector proteins, CEPs, function in
            fibroblast and epithelial cell shape changes
  JOURNAL   J Biol Chem 276 (2), 875-883 (2001)
   PUBMED   11035016
REFERENCE   8  (bases 1 to 2960)
  AUTHORS   Osada,N., Kusuda,J., Suzuki,Y., Sugano,S. and Hashimoto,K.
  TITLE     Sequence analysis, gene expression, and chromosomal assignment of
            mouse Borg4 gene and its human orthologue
  JOURNAL   J Hum Genet 45 (6), 374-377 (2000)
   PUBMED   11185749
REFERENCE   9  (bases 1 to 2960)
  AUTHORS   Joberty,G., Perlungher,R.R. and Macara,I.G.
  TITLE     The Borgs, a new family of Cdc42 and TC10 GTPase-interacting
            proteins
  JOURNAL   Mol Cell Biol 19 (10), 6585-6597 (1999)
   PUBMED   10490598
REFERENCE   10 (bases 1 to 2960)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK165318.1 and AB035088.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075739.1, BC003857.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2226              AK165318.1         2-2227
            2227-2399           AB035088.1         2687-2859
            2400-2914           AK165318.1         2403-2917
            2915-2960           AB035088.1         3375-3420
FEATURES             Location/Qualifiers
     source          1..2960
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 79.22 cM"
     gene            1..2960
                     /gene="Cdc42ep4"
                     /gene_synonym="1500041M20Rik; Borg4; CEP4"
                     /note="CDC42 effector protein 4"
                     /db_xref="GeneID:56699"
                     /db_xref="MGI:MGI:1929760"
     exon            1..128
                     /gene="Cdc42ep4"
                     /gene_synonym="1500041M20Rik; Borg4; CEP4"
                     /inference="alignment:Splign:2.1.0"
     exon            129..2944
                     /gene="Cdc42ep4"
                     /gene_synonym="1500041M20Rik; Borg4; CEP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             231..1280
                     /gene="Cdc42ep4"
                     /gene_synonym="1500041M20Rik; Borg4; CEP4"
                     /note="binder of Rho GTPases 4; binder of Rho GTPase 4;
                     CDC42 effector protein (Rho GTPase binding) 4"
                     /codon_start=1
                     /product="cdc42 effector protein 4"
                     /protein_id="NP_001156818.1"
                     /db_xref="CCDS:CCDS25604.1"
                     /db_xref="GeneID:56699"
                     /db_xref="MGI:MGI:1929760"
                     /translation="MPILKQLVSSSVNSKRRSRADLTAEMISAPLGDFRHTMHVGRAG
                     DAFGDTSFLTSKAREADDESLDEQASASKLSLLSRKFRGSKRSQSVTRGDREQRDMLG
                     SLRDSALFVKNAMSLPQLNEKEAAEKDSSKLPKSLSSSPVKKADARDGGPKSPHRNGA
                     TGPHSPDPLLDEQAFGDLMDLPIMPKVSYGLKHAESILSFHIDLGPSMLGDVLSIMDK
                     DQWGSEEEEEAGGYRDKEGPSSIVQAPPVLEVVPPLGRQESKASWDQASMLPPHAVED
                     DGWAVVAPSPSSARSVGSHTTRDSSSLSSYTSGVLEERSPAFRGPDRVAAAPPRQPDK
                     EFCFMDEEEEDEIRV"
     regulatory      2923..2928
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdc42ep4"
                     /gene_synonym="1500041M20Rik; Borg4; CEP4"
                     /note="hexamer: ATTAAA"
     polyA_site      2942
                     /gene="Cdc42ep4"
                     /gene_synonym="1500041M20Rik; Borg4; CEP4"
                     /note="major polyA site"
ORIGIN      
        1 ggagccccgg gagccagagg aaacaaacgc cggcgctgcc atgggtcgcc agccttgccg
       61 aggcgccaag cacaccgagg ggagcgtaca gccgcacctg gtccgcgctc ggggagctgg
      121 ggaccgagcc ctctgattgc cctgtctacc ctttgcattg ctggacttca gatctgaccc
      181 catacctgcc tgttgccttg ggagtgccca gctcccccgc agccagcacg atgcccattc
      241 tcaaacagct ggtgtccagc tctgtgaact cgaagcgccg ctcacgtgcg gacctcacag
      301 ccgagatgat cagtgccccg ctgggtgact tccgccacac catgcatgtg ggccgggctg
      361 gggacgcctt tggggacacg tctttcctca ctagcaaggc cagggaggca gacgacgagt
      421 ccctggatga acaggcctcg gcttccaagc tcagcctcct gtccaggaag ttccggggca
      481 gcaagcgttc acagtccgtg accagagggg accgggagca gagagacatg ctgggctccc
      541 tgcgggactc agcactgttt gtcaagaatg ccatgtccct gcctcagctc aatgagaagg
      601 aagccgcgga gaaggactcg agcaagctgc ccaagagcct gtcgtccagc cctgtgaaga
      661 aggcagacgc tagagatggt ggcccgaaga gtccccatcg gaacggggcc acaggccccc
      721 actcacctga cccactcctt gacgagcagg cctttgggga cctgatggat ctgcccatca
      781 tgcccaaagt cagctacggg ctgaagcatg cagagtcgat cctgtccttc cacatcgacc
      841 tggggccttc catgctggga gatgttctca gcatcatgga caaggaccag tggggctcag
      901 aggaggagga ggaagctggc gggtaccgtg acaaggaagg ccccagcagc attgtccagg
      961 cgccccctgt gctggaggtg gttcctcctc tagggagaca ggaaagcaag gccagctggg
     1021 accaggcctc tatgctgccc ccccacgctg tggaggatga cggatgggcg gtggtagccc
     1081 ccagccccag ctcagcacgc agtgtgggca gccacaccac tcgggacagc agctccctgt
     1141 ccagctacac ctcaggcgtc cttgaggagc gcagcccagc tttcagaggc ccagacaggg
     1201 tggcggctgc tcccccaagg cagccagaca aggaattctg cttcatggat gaggaggagg
     1261 aagatgagat ccgagtttga ggctggaccg aaagttgaaa gtcgcctcca catctctggg
     1321 ctgcatcttt tccctgctgc tgctgccgct gccaccttct ctatgacctt tgaccttact
     1381 ctgtaggtgc agctaagagc ctcgttggag tagaccctgg acctcaggga ttggggtgcc
     1441 agggaagtaa agtagcaggg gcactggtgc ctggtggcct gactctgacc taaccttcct
     1501 taccacacca gcctgggacg gatccgagcc ccagcgggaa gccattctct tccaggccct
     1561 ttgctcccag cctggcctca gatggatgcc agatgttagt ttgagttgct gccgcaatgg
     1621 cagggaagcc aggtgtgggc ttctctccaa ggtcatggac acttggctcc cttctgttca
     1681 ccttgtgtct ggagcctacc caggagatat atgcagcagg aggcaggggt gctcacgtgt
     1741 ttgagctcct ccttcttcca cctctggctc ctcactgaag cctggtattc tttggggttc
     1801 agctgaagcc aggggacggc ctcaactatt acactaaatg cagcctgtcc cagaggctgc
     1861 atcccaggac aggatggggc acagaaggaa cgaacacccc ctgcttctag cttcttgggc
     1921 tctcaagaca ctaggaacag gaaaggggcc agctctgccc atgggtgtgt ttgttccttg
     1981 ttactatgtt ttaaacctga atagagcact gccaaaatcc cctgccagga gactagtgac
     2041 cgtcttggtg gctgagtgac tgttatctca cctgaatctg gtgtacagac cctgcccagg
     2101 ttggactgtg gcggggcagc caccaccagt gtttgtcccg gaacccccac ctccatagct
     2161 gttagtggct gaaggagggc tgtgtaggaa aagttctgga atacgatgct taaatgatac
     2221 attattcccc ggggtgtgag ctacgctttg gctagttagt ggcctctcct tgggctctgg
     2281 gccaggcctc gcaaaaacac aaaacaagac gggactgtat ttgattggaa ttccagggaa
     2341 atgaaagtgg gttttttgtt tgtttgtttt tggctttttg ggatacggtc tcactctagc
     2401 ccaagccggc ctcaagctca tagcgagcct cccttaccct aggagcttcg gttgcaagtg
     2461 tgcaccactg ctcctggctg ttttgttctt ctgaaagctg ttttgctcag ctcctgtaac
     2521 tctacccaga ccgctagtag aggcaggggc ctgagccctg ggggtggtag ctcattactt
     2581 tcctgtgctg ggagcaggct gacctgctcc ctggtctagc acagccagtg ggaatctggg
     2641 gagagagcaa gctagattac aagcagagtc tggccagatg gtggccagcc atgggctgct
     2701 gtgcttccag aggccaccct cctagattca gaccctgaag tgctcactgg gcccctgaca
     2761 ggtgctccta cgcaggtagg cagtgactga gctacagagc tgtgcctctg gccagcagta
     2821 cacacacaac acacacacac ccctctccta aatctacctg gttggttcta aactctaaac
     2881 tttatatttt tttccatgac attgaaaaag cagtaagaaa acattaaaat ttcctcctaa
     2941 cactaaaaaa aaaaaaaaaa
//
