LOCUS       NM_026514               2269 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus CDC42 effector protein 3 (Cdc42ep3), mRNA.
ACCESSION   NM_026514
VERSION     NM_026514.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2269)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2269)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2269)
  AUTHORS   Antypa,M., Faux,C., Eichele,G., Parnavelas,J.G. and Andrews,W.D.
  TITLE     Differential gene expression in migratory streams of cortical
            interneurons
  JOURNAL   Eur J Neurosci 34 (10), 1584-1594 (2011)
   PUBMED   22103416
REFERENCE   4  (bases 1 to 2269)
  AUTHORS   Boon,A.C., deBeauchamp,J., Hollmann,A., Luke,J., Kotb,M., Rowe,S.,
            Finkelstein,D., Neale,G., Lu,L., Williams,R.W. and Webby,R.J.
  TITLE     Host genetic variation affects resistance to infection with a
            highly pathogenic H5N1 influenza A virus in mice
  JOURNAL   J Virol 83 (20), 10417-10426 (2009)
   PUBMED   19706712
REFERENCE   5  (bases 1 to 2269)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   6  (bases 1 to 2269)
  AUTHORS   Joberty,G., Perlungher,R.R. and Macara,I.G.
  TITLE     The Borgs, a new family of Cdc42 and TC10 GTPase-interacting
            proteins
  JOURNAL   Mol Cell Biol 19 (10), 6585-6597 (1999)
   PUBMED   10490598
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK014281.1, AK019447.1 and AI118540.1.
            
            On Jan 18, 2019 this sequence version replaced NM_026514.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK019447.1, AK014281.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-978               AK014281.1         3-980
            979-1966            AK019447.1         981-1968
            1967-2269           AI118540.1         10-312              c
FEATURES             Location/Qualifiers
     source          1..2269
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 50.3 cM"
     gene            1..2269
                     /gene="Cdc42ep3"
                     /gene_synonym="3200001F04Rik; Borg2; Cep3; UB1"
                     /note="CDC42 effector protein 3"
                     /db_xref="GeneID:260409"
                     /db_xref="MGI:MGI:2384718"
     exon            1..275
                     /gene="Cdc42ep3"
                     /gene_synonym="3200001F04Rik; Borg2; Cep3; UB1"
                     /inference="alignment:Splign:2.1.0"
     exon            276..2269
                     /gene="Cdc42ep3"
                     /gene_synonym="3200001F04Rik; Borg2; Cep3; UB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             503..1267
                     /gene="Cdc42ep3"
                     /gene_synonym="3200001F04Rik; Borg2; Cep3; UB1"
                     /note="binder of Rho GTPases 2; CDC42 effector protein
                     (Rho GTPase binding) 3"
                     /codon_start=1
                     /product="cdc42 effector protein 3"
                     /protein_id="NP_080790.1"
                     /db_xref="CCDS:CCDS28984.1"
                     /db_xref="GeneID:260409"
                     /db_xref="MGI:MGI:2384718"
                     /translation="MPAKTPIYLKAANNKKGKKFKLRDILSPDMISPPLGDFRHTIHI
                     GKEGQHDVFGDISFLQGNYELLPGNQEKAHSGQFPGHNDFFRANSTSDSMFTETPSPV
                     LKNAISLPTIGGSQALMLPLLSPVTFHSKQESFGRPKLPRLSCEPVMEEKVQEQSSLL
                     ENGAVHQGDTSWGSSGSGSQSSQGRDSHSSSLSEQSSDWPADDMFEHPASCELVKSKT
                     KSEESFSDLTGSLLSLQLDLGPSLLDEVLNVMDKNK"
     regulatory      2018..2023
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdc42ep3"
                     /gene_synonym="3200001F04Rik; Borg2; Cep3; UB1"
                     /note="hexamer: AATACA"
     polyA_site      2021
                     /gene="Cdc42ep3"
                     /gene_synonym="3200001F04Rik; Borg2; Cep3; UB1"
     regulatory      2249..2254
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdc42ep3"
                     /gene_synonym="3200001F04Rik; Borg2; Cep3; UB1"
                     /note="hexamer: AATAAA"
     polyA_site      2269
                     /gene="Cdc42ep3"
                     /gene_synonym="3200001F04Rik; Borg2; Cep3; UB1"
                     /note="major polyA site"
ORIGIN      
        1 aggttgaggc ccggcgtccg gcagccgcgc gcacagtgtc gcgggcgctt ccaactgccg
       61 ctgggagcac agcagcggga cgctcaccga caacccagtt ccgcagcggc tgcctcccgg
      121 gagacgccgc gcgcagtccc ggagcagatt ctgcggtgaa ccgttgccgc ccctctggtt
      181 ctgcgcgcac cagcgaggac tgttgcgccc tcgggaggcg acccgggccg acgcccggcc
      241 ctccgggcag aagctaggag ccttagagac tgctggtttc tctgagctgt ggaagggact
      301 cgataatgta actggctctc cggaaagacc cgcgtggccc tgcgctgagc aagatctcca
      361 agaccctgtc tcgtttttag agccacttga gaagaaatga tgtgacaatt cttatgaaaa
      421 aggacgtttt ggaagtgtag gatacccgtg cagaaggtca ctctttccct ggtctgtgaa
      481 atagacattc tcaaattcca aaatgcctgc caagacccca atttacctga aagcggctaa
      541 caacaagaag ggaaagaaat ttaaactgag ggacattctg tcccctgata tgatcagtcc
      601 tcccctgggg gactttcgtc acactataca catcggcaaa gagggccagc atgacgtctt
      661 tggggatatt tcctttcttc aagggaatta tgagctcttg ccgggaaacc aagagaaggc
      721 acactctggc cagttcccgg ggcataacga cttcttccgg gccaacagca cctcggactc
      781 aatgttcaca gaaacaccct ccccggtgct caaaaatgcc atctccctcc ccaccattgg
      841 gggatcccag gctctgatgc tgcccttatt gtccccagtg acatttcatt ccaaacagga
      901 gtcctttggg cgtcctaagt tgccaaggct cagctgtgag cctgtcatgg aagagaaagt
      961 tcaggagcaa agtagtctgt tagagaatgg ggcagtccac cagggagaca cctcgtgggg
     1021 ctccagtggt tccgggtctc agtccagcca gggccgcgac agccactcct ccagcctgtc
     1081 ggaacagtcc tccgactggc ccgcggacga catgtttgag catcctgcct cctgtgagct
     1141 tgtgaagtca aagactaaat cagaagagtc cttctctgac ctgaccggct ccctgctctc
     1201 cctgcagttg gatcttgggc cttcactttt ggatgaagtc ctgaatgtca tggataaaaa
     1261 taagtagcca ggagtcagct ctttttcttg ggagtaagag gtaccaaaat aagcagaaaa
     1321 caaaaaaatc aactaaccac agctgatgga aagagctgct ctgactgttt ttatttgcag
     1381 ccatgtgatg cattttctaa aataacgctc ctgttcctac aaaatatttt tttaaccatc
     1441 atgccctgtt tgcaaaaatt ttgaaaacaa taatttttaa aaattaaaaa aaacaaaaca
     1501 aaacaaaaaa acctgttctg gcaaaaaaga aaaaaaaaga aaagaaaaag gaggaagtga
     1561 gtcagagctc attttcaaca ggcattgctg atgctcatac atgctcagtt ttgtttgtag
     1621 acatgcagaa atccaggctg tctaagaggg ctgggtccat gggtctctcc aaggcaattc
     1681 attgcatgtt atgagaagga aacttactta tttggcacct acgccttttt ttcctagcct
     1741 tttttgtata ttgtatcttt tgggttcacc acagcgaagt ctccagcgtt atgattttac
     1801 tctttgcata ttcgagcaac cttacaggat ttgggatttt ttttccttgt ggtttttata
     1861 tatccctgta tattatttcc atgttgcaaa agtttgactg tcagctacat gttggttaaa
     1921 aacaagcaag gtattactgt aactaagtta tttttaaagt tgaaatatat ttttatgtgc
     1981 ctttggcttt ttattgcaaa gtctacattt tatacataat acatcaagtg ttatttgtcg
     2041 tgtttccatt cgggcttcct tgcaagctac gcgtgtgtat ttgaaaacaa aaccagccca
     2101 accctatgcg ttatcagcct gaccctgttg ctcgggtgtt acctcctccc agtaggaggc
     2161 acagggtgat gcttctgtgg agactggagg tgaggtaggt atttaaggac agctcatgtt
     2221 cacattactt gggtacatca taccacgcaa taaagagtaa atgctaaaa
//
