LOCUS       NM_027219               2542 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus CDC42 effector protein 1 (Cdc42ep1), mRNA.
ACCESSION   NM_027219 XM_001000925
VERSION     NM_027219.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2542)
  AUTHORS   Liu,Z., Vong,Q.P., Liu,C. and Zheng,Y.
  TITLE     Borg5 is required for angiogenesis by regulating persistent
            directional migration of the cardiac microvascular endothelial
            cells
  JOURNAL   Mol Biol Cell 25 (6), 841-851 (2014)
   PUBMED   24451259
  REMARK    GeneRIF: Borg5 is required for angiogenesis by regulating
            persistent directional migration of the cardiac microvascular
            endothelial cells.
REFERENCE   2  (bases 1 to 2542)
  AUTHORS   Vong,Q.P., Liu,Z., Yoo,J.G., Chen,R., Xie,W., Sharov,A.A.,
            Fan,C.M., Liu,C., Ko,M.S. and Zheng,Y.
  TITLE     A role for borg5 during trophectoderm differentiation
  JOURNAL   Stem Cells 28 (6), 1030-1038 (2010)
   PUBMED   20506138
  REMARK    GeneRIF: report that differentiation of embryonic stem cells toward
            trophectoderm is accompanied by enhanced actin protrusion and cell
            motility that require upregulation of Borg5.
REFERENCE   3  (bases 1 to 2542)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   4  (bases 1 to 2542)
  AUTHORS   Hirsch,D.S., Pirone,D.M. and Burbelo,P.D.
  TITLE     A new family of Cdc42 effector proteins, CEPs, function in
            fibroblast and epithelial cell shape changes
  JOURNAL   J Biol Chem 276 (2), 875-883 (2001)
   PUBMED   11035016
REFERENCE   5  (bases 1 to 2542)
  AUTHORS   Joberty,G., Perlungher,R.R. and Macara,I.G.
  TITLE     The Borgs, a new family of Cdc42 and TC10 GTPase-interacting
            proteins
  JOURNAL   Mol Cell Biol 19 (10), 6585-6597 (1999)
   PUBMED   10490598
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL592169.14.
            
            On Apr 30, 2007 this sequence version replaced NM_027219.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK007896.1, BC016250.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                AL592169.14        82261-82339         c
            80-804              AL592169.14        77167-77891         c
            805-2542            AL592169.14        74084-75821         c
FEATURES             Location/Qualifiers
     source          1..2542
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.7 cM"
     gene            1..2542
                     /gene="Cdc42ep1"
                     /gene_synonym="1810058K22Rik; Borg5; CEP1; MSE55"
                     /note="CDC42 effector protein 1"
                     /db_xref="GeneID:104445"
                     /db_xref="MGI:MGI:1929763"
     exon            1..79
                     /gene="Cdc42ep1"
                     /gene_synonym="1810058K22Rik; Borg5; CEP1; MSE55"
                     /inference="alignment:Splign:2.1.0"
     exon            80..804
                     /gene="Cdc42ep1"
                     /gene_synonym="1810058K22Rik; Borg5; CEP1; MSE55"
                     /inference="alignment:Splign:2.1.0"
     CDS             342..1571
                     /gene="Cdc42ep1"
                     /gene_synonym="1810058K22Rik; Borg5; CEP1; MSE55"
                     /note="binder of Rho GTPases 5; binder of Rho GTPase 5;
                     CDC42 effector protein (Rho GTPase binding) 1"
                     /codon_start=1
                     /product="cdc42 effector protein 1"
                     /protein_id="NP_081495.1"
                     /db_xref="CCDS:CCDS27624.1"
                     /db_xref="GeneID:104445"
                     /db_xref="MGI:MGI:1929763"
                     /translation="MPGPQGGTGAPTMSLGKLSPVGWVSSSHGKRRLTADMISPPLGD
                     FRHTMHVGRGGDVFGDTSFLSNHGGRSGNTHRSPRSFLARKLQQVRRVGVPPRRMASP
                     AAPSPAPPPISPIIKNAISLPQLNQATYDSLVMGKLSFDSTPASSTDGHSGYGLESGF
                     CTISRLPRVEKHSNRDRDRDPDHSQDREQSSFPSEPTPNPELRRSDSLLSFRFDLDLG
                     PSLLSELLGVMSLSEAPAAETPVPTANPPAPAANPAPTAKPPAHAITTLDAVTSLPAS
                     AVTSLPAPAVASSPSRGHFPNGVTSVLGPAAEAKPSPVGEGPQVPSNMAFDRHGASWG
                     ASRASWGASRASRHYTEMDARRELAGVLPQVHGSWESLNEDWSAPPASVRAPVPTSVQ
                     VNAFEFADAEEDDEVKV"
     exon            805..2542
                     /gene="Cdc42ep1"
                     /gene_synonym="1810058K22Rik; Borg5; CEP1; MSE55"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2513..2518
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdc42ep1"
                     /gene_synonym="1810058K22Rik; Borg5; CEP1; MSE55"
                     /note="hexamer: AATAAA"
     polyA_site      2537
                     /gene="Cdc42ep1"
                     /gene_synonym="1810058K22Rik; Borg5; CEP1; MSE55"
                     /note="major polyA site"
ORIGIN      
        1 ggcccagcga ctctcgggta gcgctgggac gcgccgccgc cgcgcccgcc cctggacccc
       61 ccgggctcga cgacacgagg tctccactcc agggtaggga tccttttaag gcccttctcc
      121 tgccaccttt gatcagcctc actaggacca gaagcagaga gagaacccac agactccctc
      181 agcctcagca ctggggacag cgccttagta aagtcaaggg tcgccttgtg ctccgccatc
      241 ttcattgaga ggaaggggct gagaaggatc cctgagtcca gcctgccatc ttccctggcc
      301 ccaaggtggc atggactagc agttgtaagc aatcaaagct gatgcccggt ccccaggggg
      361 gcacaggagc ccccaccatg agcctgggca agctgtctcc tgtgggatgg gtgtccagtt
      421 cccatggaaa gagacgcctg acagcagaca tgatcagccc cccacttggg gacttccgcc
      481 acaccatgca cgtaggccgt ggtggggatg tcttcggaga tacgtccttc ctcagcaacc
      541 acggaggccg ctctggaaac acccaccgct caccccgaag tttcctggcc aggaagctcc
      601 aacaggttcg cagagtcggg gtgccacctc gaaggatggc ttccccggct gcaccatcac
      661 ctgctccgcc tcccatctcg cccatcatca agaacgccat ctccctgcct cagctcaacc
      721 aggccaccta tgacagtctg gtgatgggca agcttagttt tgacagcacg ccggctagct
      781 ccacagatgg ccactctggt tacggcctgg agtctggctt ctgcaccatc tcacgcctgc
      841 cacgcgtgga aaagcacagc aaccgtgacc gtgaccgtga cccggaccat tctcaagacc
      901 gagagcaaag ttctttcccc tctgagccta cccctaaccc tgagctccga cgctctgact
      961 ctctcttgtc cttccgtttt gaccttgacc ttgggccctc actcctcagt gagctgctag
     1021 gggtcatgag cctttcagaa gctccagctg ctgaaactcc agtccctact gccaaccccc
     1081 ctgctcctgc agcaaaccct gcccctactg caaaaccccc agcccatgcg ataaccactc
     1141 tagatgctgt gacaagcctt ccagcctctg ctgtgacaag ccttccagcc cctgcggtgg
     1201 caagctcccc atcccgtgga catttcccca atggggtaac ttctgtgttg ggccctgcgg
     1261 ctgaggcaaa gcccagtcct gtgggagagg gtccccaggt accctccaac atggcctttg
     1321 acaggcatgg agccagctgg ggggccagcc gggccagctg gggggccagc cgggccagcc
     1381 gccactacac tgagatggat gcccggcggg agctggcagg ggtgttaccc caagttcatg
     1441 gctcctggga gagtctgaat gaagactgga gcgcgcctcc agccagtgtc agggctcctg
     1501 tgcccacctc ggtgcaggtc aatgcctttg agtttgctga tgctgaggaa gatgacgagg
     1561 tcaaggtgta agggactggc catgggctcc aggtcctgtc agcctcgggg ctcacagaac
     1621 agaggggctg agttcatttg cctaacagct acaagatgtg gtcaacggga gttgccccag
     1681 atccttcctg gtctatgcaa ggcaggcatg ggtccccgct gacctgaccc agctccctcc
     1741 actgtcccta ggcccactag cccttcagtt ataacctacg ccaccccctg tggtctgaca
     1801 gtatggtctt tgtgccccag gacacttccc tagtggggtg ggggttgggg caaggaccac
     1861 atagggccat tgtctgtgag tgggactggc tgcccctact cattgagagc taccgcagaa
     1921 ggcctccact gtgttctcag tagcgcggtt ccaggctcct cctcagttcc cagagaaagg
     1981 tcaggcgtga cacaggagca aatcttctgt gtaccccaga cctgcctccc atacctgatt
     2041 gttaaagctt ctctgttaag atctgcctgc ccaaggaggc aggcccggcc acggctgacc
     2101 tgtgctttct cctcctgaga gtttggaaag ttgaggaccc ccttctggcg cccccccctc
     2161 tagctaggag agaagggggg ccagacgagc taatgagtaa ccagcctgga atgttcaacg
     2221 ataagaagcc caggtgggac ccttatctgc agttcctgga acaccctggc cccaggtgcc
     2281 aggaaccagt atctgcccca taatcccatg gggctgcttg gcaggtgctc agatcaccgg
     2341 gagggagaca ggtccccatg cagagggtgg ctcaggagca cctcccatcc tctcttctca
     2401 gcagtactat accccgtgcc tcagtttcct gccccccccc ccggtaccaa agccggggtg
     2461 ggggggagca ttaacatgcg tggaaaatgc taacagttct tgctgtggaa ataataaatg
     2521 tggattcttt tatttgacct tg
//
