LOCUS       NM_001359548            9153 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus CDC42 binding protein kinase alpha (Cdc42bpa),
            transcript variant 11, mRNA.
ACCESSION   NM_001359548 XM_017320142
VERSION     NM_001359548.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9153)
  AUTHORS   Bourdais,A., Dehapiot,B. and Halet,G.
  TITLE     MRCK activates mouse oocyte myosin II for spindle rotation and male
            pronucleus centration
  JOURNAL   J Cell Biol 222 (11) (2023)
   PUBMED   37651121
  REMARK    GeneRIF: MRCK activates mouse oocyte myosin II for spindle rotation
            and male pronucleus centration.
REFERENCE   2  (bases 1 to 9153)
  AUTHORS   Richard,C., Viret,S., Cantero Aguilar,L., Lefevre,C., Leduc,M.,
            Faouzi,E.H., Azar,N., Lavazec,C., Mayeux,P. and Verdier,F.
  TITLE     Myotonic dystrophy kinase-related CDC42-binding kinase alpha, a new
            transferrin receptor type 2-binding partner, is a regulator of
            erythropoiesis
  JOURNAL   Am J Hematol 96 (4), 480-492 (2021)
   PUBMED   33476437
  REMARK    GeneRIF: Myotonic dystrophy kinase-related CDC42-binding kinase
            alpha, a new transferrin receptor type 2-binding partner, is a
            regulator of erythropoiesis.
REFERENCE   3  (bases 1 to 9153)
  AUTHORS   Nakano,Y., Wiechert,S. and Banfi,B.
  TITLE     Overlapping Activities of Two Neuronal Splicing Factors Switch the
            GABA Effect from Excitatory to Inhibitory by Regulating REST
  JOURNAL   Cell Rep 27 (3), 860-871 (2019)
   PUBMED   30995482
REFERENCE   4  (bases 1 to 9153)
  AUTHORS   Dobrowolski,S.F., Lyons-Weiler,J., Spridik,K., Vockley,J.,
            Skvorak,K. and Biery,A.
  TITLE     DNA methylation in the pathophysiology of hyperphenylalaninemia in
            the PAH(enu2) mouse model of phenylketonuria
  JOURNAL   Mol Genet Metab 119 (1-2), 1-7 (2016)
   PUBMED   26822703
REFERENCE   5  (bases 1 to 9153)
  AUTHORS   Lee,I.C.J., Leung,T. and Tan,I.
  TITLE     Adaptor protein LRAP25 mediates myotonic dystrophy kinase-related
            Cdc42-binding kinase (MRCK) regulation of LIMK1 protein in
            lamellipodial F-actin dynamics
  JOURNAL   J Biol Chem 289 (39), 26989-27003 (2014)
   PUBMED   25107909
REFERENCE   6  (bases 1 to 9153)
  AUTHORS   Osipovich,A.B., Long,Q., Manduchi,E., Gangula,R., Hipkens,S.B.,
            Schneider,J., Okubo,T., Stoeckert,C.J. Jr., Takada,S. and
            Magnuson,M.A.
  TITLE     Insm1 promotes endocrine cell differentiation by modulating the
            expression of a network of genes that includes Neurog3 and Ripply3
  JOURNAL   Development 141 (15), 2939-2949 (2014)
   PUBMED   25053427
REFERENCE   7  (bases 1 to 9153)
  AUTHORS   Gomes,E.R., Jani,S. and Gundersen,G.G.
  TITLE     Nuclear movement regulated by Cdc42, MRCK, myosin, and actin flow
            establishes MTOC polarization in migrating cells
  JOURNAL   Cell 121 (3), 451-463 (2005)
   PUBMED   15882626
REFERENCE   8  (bases 1 to 9153)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125380.4 and AC132436.3.
            
            On Jan 13, 2018 this sequence version replaced XM_017320142.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660825.192915.1,
                                           SRR1660819.152440.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-528               AC125380.4         122073-122600
            529-620             AC125380.4         160675-160766
            621-778             AC125380.4         185958-186115
            779-862             AC125380.4         192818-192901
            863-958             AC125380.4         198142-198237
            959-1107            AC125380.4         201365-201513
            1108-1201           AC132436.3         17511-17604
            1202-1402           AC132436.3         20687-20887
            1403-1651           AC132436.3         22872-23120
            1652-1731           AC132436.3         25018-25097
            1732-1898           AC132436.3         28066-28232
            1899-2021           AC132436.3         30291-30413
            2022-2155           AC132436.3         40093-40226
            2156-2398           AC132436.3         49665-49907
            2399-2509           AC132436.3         50102-50212
            2510-2757           AC132436.3         56746-56993
            2758-2863           AC132436.3         61768-61873
            2864-2988           AC132436.3         64875-64999
            2989-3094           AC132436.3         66985-67090
            3095-3243           AC132436.3         67466-67614
            3244-3335           AC132436.3         69744-69835
            3336-3412           AC132436.3         73388-73464
            3413-3460           AC132436.3         74457-74504
            3461-3544           AC132436.3         90018-90101
            3545-3650           AC132436.3         92373-92478
            3651-3787           AC132436.3         93451-93587
            3788-3927           AC132436.3         94153-94292
            3928-4009           AC132436.3         95444-95525
            4010-4226           AC132436.3         97063-97279
            4227-4289           AC132436.3         97998-98060
            4290-4883           AC132436.3         100128-100721
            4884-4981           AC132436.3         102666-102763
            4982-5066           AC132436.3         104874-104958
            5067-5190           AC132436.3         105856-105979
            5191-5308           AC132436.3         106881-106998
            5309-5426           AC132436.3         115327-115444
            5427-5584           AC132436.3         117261-117418
            5585-9153           AC132436.3         117756-121324
FEATURES             Location/Qualifiers
     source          1..9153
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 84.01 cM"
     gene            1..9153
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /note="CDC42 binding protein kinase alpha"
                     /db_xref="GeneID:226751"
                     /db_xref="MGI:MGI:2441841"
     exon            1..528
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            529..620
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            621..778
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            779..862
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     CDS             821..5716
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /EC_number="2.7.11.1"
                     /note="isoform 11 is encoded by transcript variant 11;
                     myotonic dystrophy kinase-related CDC-42-binding
                     kinase-alpha; serine/threonine-protein kinase MRCK alpha"
                     /codon_start=1
                     /product="serine/threonine-protein kinase MRCK alpha
                     isoform 11"
                     /protein_id="NP_001346477.1"
                     /db_xref="GeneID:226751"
                     /db_xref="MGI:MGI:2441841"
                     /translation="MKILNKWEMLKRAETACFREERDVLVNGDSKWITTLHYAFQDDN
                     NLYLVMDYYVGGDLLTLLSKFEDRLPEEMARFYLAEMVIAIDSVHQLHYVHRDIKPDN
                     ILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECD
                     WWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLI
                     CSREHRLGQNGIEDFKKHPFFSGIDWDNIRNCEAPYIPEVSSPTDTSNFDVDDDCLKN
                     SETMPPPTHTAFSGHHLPFVGFTYTSSCVLSDRSCLRVTAGPTSLDLDVSVQRTLDNN
                     LATEAYERRIKRLEQEKLELTRKLQESTQTVQALQYSTVDGPLTASKDLEIKSLKEEI
                     EKLRKQVAEVNHLEQQLEEANSVRRELDDAFRQIKASEKQIKTLQQEREELNKELVQA
                     SERLKNQSKELKDAHCQRKLAMQEFMEINERLTELHTQKQKLARHVRDKEEEVDLVMQ
                     KAESLRQELRRAERAKKELEVHTEALIAEASKDKKLREQSEHYSKQLENELEGLKQKQ
                     ISYSPGICSIEHQQEITKLKTDLEKKSIFYEEEISKREGIHASEIKNLKKELHDSEGQ
                     QLALNKEILVLKDKLEKTRRESQSEREEFENEFKQQYEREKVLLTEENKKLTSELDKL
                     TSLYESLSLRNQHLEEEVKDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQALASK
                     MTEELEALRNSSLGTRATDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQEELNK
                     VKASNILTECKLKDSEKKNLELLSEIEQLIKDTEELRSEKGIEHQDSQHSFLAFLNTP
                     TDALDQFEDSLSSSSSSLIDFLDDIADCAPLPAHTPTLRKKGCPASTGFPPKRKTHQF
                     FVKSFTAPTKCHQCTSLMVGLIRQGCSCEVCGFSCHITCVNKAPTVCPVPPEQTKGPL
                     GIDPQKGVGTAYEGHVRIPKPAGVKKGWQRALAVVCDFKLFLYDIAEGKASQPTSVIS
                     QVIDMRDEEFSVSSVLASDVIHASRKDIPCIFRVTASQLSAPSNKCSILMLADSENER
                     SKWVGVLSELHKILKKNKFRDRSVYVPKEAYDSTLPLIKTTQAAAIIDHERIALGNEE
                     GLFVVHVTKDEIVRVGDNKKIHQIELIPSDQLVAVISGRNRHVRLFPMSALDGRETDF
                     YKLAETKGCQTIAAGKVRHGALSCLCVAMKRQVLCYELFQSKTRHRKFKEIQVPCNVQ
                     WMAIFSEHLCVGFQSGFLRYPLNGEGGPCNMLHSNDHTLSFISHQPMDALCAVEISNK
                     EYLLCFNSIGIYTDCQGRRSRQQELMWPANPSSCCYNAPYLSVYSENAVDIFDVNSME
                     WIQTLPLKKVRPLNTEGSLNLLGLETIRLIYFKNKMAEGDELVVPETSDNSRKQMVRN
                     INNKRRYSFRVPEEERMQQRREMLRDPEMRNKLISNPTNFNHIAHMGPGDGIQILKDL
                     PMNPRPQESRTVFSGSVSIPSITKSRPEPGRSMSASSGLSARSSAQNGSALKREFSGG
                     SYNTKRQPMPSPSEGSLSSGGMDQGSDAPARDYDGEDSDSPRHSTASNSSNLSSPPSP
                     ISPQKTKSLSLESTDRGSWDP"
     exon            863..958
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1107
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1201
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1402
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1651
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1731
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            1732..1898
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            1899..2021
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2155
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2398
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            2399..2509
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            2510..2757
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            2758..2863
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            2864..2988
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            2989..3094
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            3095..3243
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            3244..3335
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            3336..3412
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            3413..3460
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            3461..3544
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            3545..3650
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            3651..3787
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            3788..3927
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            3928..4009
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            4010..4226
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            4227..4289
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            4290..4883
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            4884..4981
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            4982..5066
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            5067..5190
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            5191..5308
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            5309..5426
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            5427..5584
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            5585..9153
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6113..6118
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /note="hexamer: AAGAAA"
     polyA_site      6134
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
     regulatory      9134..9139
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /note="hexamer: AATAAA"
     polyA_site      9153
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /note="major polyA site"
ORIGIN      
        1 tttttttttt tttttttaag gagtgttgac tctttagttc gttgtacttt taattattat
       61 tttatttaaa tgtacaattt aattgtatta ttctcttaaa atattaaatc tatattttat
      121 ggaaactcac cctcaagata tatatgttta tgggtgaaat tggagacgct tccgttaagt
      181 gaggtgactg gtgtattgga tgtttaattc agcaccggca ttgcatgaca gttgttgaaa
      241 taacaagtgg tttattttta aaaaccacat ctttaaactt ttaggttcag atagtaacag
      301 tagacatcgt aagggcattt aaaagaaaac cagcagaaat cgaagcaaac atgtccggag
      361 aagtgcgttt gaggcagttg gagcagttta ttttagatgg gccagctcag accaatgggc
      421 agtgcttcag tgtggagacg ctactggaca tcctcatctg tctttacgat gaatgcaata
      481 attctccatt gagaagagag aagaacattc ttgaatatct agaatgggct aaaccattta
      541 cttctaaagt gaagcaaatg cgattacata gagaagactt tgaaatatta aaggtgattg
      601 gtcgaggagc ttttggggag gaaaaccttt aacttacgcc ctgggtgtta cctgtccaca
      661 gcttcctggt ggctcaccgc ttctgcctgc tccagccttg ctccggcagc ttccaggctt
      721 ctgggcttca gagcttgttg tgaaagcttg ctgctttggc ctgctacccc tgcttcaggt
      781 tgctgtagtt aaactaaaaa atgcagataa agtattcgcc atgaaaattc tgaacaagtg
      841 ggaaatgctg aaaagagctg agacagcgtg ctttcgtgaa gagagggatg tgttggtaaa
      901 tggagacagt aagtggataa ccactctgca ctatgctttc caggatgaca ataacttata
      961 cctggttatg gattattatg ttggtgggga tttacttact ctgctcagca aatttgaaga
     1021 tagattgcct gaagagatgg ctcggtttta cttggctgag atggtgatag ccattgactc
     1081 agttcaccag ctccactatg ttcacagaga catcaaacct gacaatatat tgatggatat
     1141 gaatggacat attcgtttag cagattttgg ttcttgtctg aagctgatgg aagatggaac
     1201 ggtccagtcc tcggtggcag ttggaactcc agattatatt tctccggaaa tccttcaggc
     1261 tatggaagac ggaaaaggca gatatggacc agagtgtgac tggtggtcct tgggggtctg
     1321 tatgtatgag atgctttacg gagaaacacc attctatgca gagtctctgg tggagacata
     1381 tggaaaaatt atgaatcaca aagagcggtt tcagtttcca gcccaagtga cagacgtgtc
     1441 cgaaaatgct aaagatctta ttcgaagact catttgtagt agagaacatc gacttggcca
     1501 aaatggaata gaagacttta agaagcatcc attcttcagt ggaattgatt gggataacat
     1561 tcggaattgt gaagcacctt acatcccaga agttagtagc ccgacagata cgtcaaattt
     1621 tgatgtggat gacgactgtt taaaaaattc tgaaacaatg cccccaccaa cacatactgc
     1681 attttctggc catcatctac catttgttgg ttttacatat actagtagct gtgttctttc
     1741 tgatcggagc tgtttaagag tcacagcagg ccccacctca ttggaccttg atgtcagtgt
     1801 ccagaggact ctagacaata acttagcaac tgaggcttat gaaaggagaa ttaagcggct
     1861 tgagcaggaa aagcttgaac tgactagaaa acttcaagag tcaacacaga ctgttcaagc
     1921 tctgcaatat tcaactgttg atggtccact aacggcaagc aaagatttag aaattaaaag
     1981 tctgaaagaa gagattgaaa aactaaggaa acaagtagca gaagtgaatc atttggaaca
     2041 acaacttgaa gaagctaatt ctgtgagacg agaactagat gatgctttca ggcaaatcaa
     2101 agcttctgaa aaacaaatca aaactttgca gcaggaaaga gaagaactaa ataaggaact
     2161 agtccaggct agtgagcgat taaaaaacca atccaaagag ctgaaagatg cacactgtca
     2221 gaggaaactg gccatgcagg aattcatgga gatcaatgag cgactaacag aattgcacac
     2281 ccaaaagcag aaacttgctc gccatgtccg agataaggaa gaagaggtgg acctggtgat
     2341 gcaaaaagct gagagcttaa ggcaggagct gcgcagagca gaaagagcca agaaagagct
     2401 ggaagttcac accgaagctc taattgctga agcatcaaag gacaagaagc tccgagagca
     2461 gagcgaacat tattctaagc aactggaaaa cgagttggag ggcctgaagc aaaaacaaat
     2521 tagttactca ccaggaatat gcagcataga acatcagcaa gagataacta aactgaaaac
     2581 tgacttggaa aagaaaagta tcttttatga agaagaaatt tctaaaagag aaggaattca
     2641 cgcaagtgag attaaaaacc tgaagaagga gctgcatgac tcagaaggcc agcagcttgc
     2701 tctcaacaaa gagattctgg ttttaaaaga caaattggaa aaaaccagga gagaaagtca
     2761 aagtgaaagg gaagaatttg aaaatgagtt caaacaacaa tatgaacggg aaaaagtatt
     2821 attaactgaa gagaataaaa agttaacgag tgaactcgat aagctgactt cactgtatga
     2881 gagcttaagt ttgcgcaacc agcacttaga agaagaagtc aaagatctag cagataagaa
     2941 ggaatcagtt gcccactggg aagcccaaat cacagagata attcagtggg tgagcgatga
     3001 gaaggatgca cgaggctatc ttcaggcctt agcttctaaa atgactgaag agttggaagc
     3061 attaagaaat tccagcttgg ggacacgagc aacagatatg ccctggaaaa tgcgtcgttt
     3121 tgcaaaactg gacatgtcgg ctagactaga gttgcagtct gctctggatg cagaaataag
     3181 agctaagcag gccatccagg aagagctgaa taaagtcaaa gcatctaaca tcttaacaga
     3241 atgtaaactg aaagattcag agaagaagaa cttggaactg ttgtccgaaa tcgagcagct
     3301 gataaaggac actgaagagc ttagatctga aaagggtata gagcaccaag actcacagca
     3361 ttctttcttg gcatttttga atacgcctac cgatgctctg gaccaatttg aagattccct
     3421 ttcttcttcc tcatcctcac tgattgattt tttggatgac attgcagact gtgctccact
     3481 tccagctcac acaccaacct taaggaaaaa gggatgcccg gcttcaactg gctttccacc
     3541 taagcgcaag actcatcaat ttttcgtgaa gtctttcact gcccctacca agtgtcacca
     3601 gtgcacctcc ttgatggtcg gtttgataag acagggctgt tcctgtgaag tctgtgggtt
     3661 ctcatgtcat ataacttgtg tgaacaaagc cccgacggtt tgcccagttc ctcctgagca
     3721 aactaaaggt ccactgggca tagaccccca gaagggagtt gggacggcgt atgagggtca
     3781 tgtcaggatc cctaagccgg cgggagtgaa gaaagggtgg cagagagcac tggctgtggt
     3841 ctgcgacttc aaactgtttc tttatgatat cgcagaggga aaagcatcgc agcccacctc
     3901 cgtcattagt caagtgattg acatgagaga tgaagaattt tctgtgagtt cagtcttagc
     3961 ttctgatgtt attcacgcaa gtcgaaaaga tatcccctgt atattcaggg tcacagcttc
     4021 ccagctctca gcacctagta acaaatgttc catcctgatg ctagcagaca gcgagaatga
     4081 gaggagtaag tgggtgggag tgctgagtga actccacaag attctgaaga aaaacaagtt
     4141 cagagaccgc tcagtgtatg tccccaagga ggcgtacgac agcacgctac ccctcattaa
     4201 gacaacgcag gccgctgcaa tcatagatca tgaacggata gctttgggaa atgaagaagg
     4261 attatttgtt gtgcatgtca ccaaagatga gattgttaga gttggtgata ataagaaaat
     4321 ccatcagatc gaactcattc caagtgacca gcttgtcgct gtgatctcag gccgaaatcg
     4381 ccacgtccga ctttttccta tgtcagcctt ggatgggcga gagacggatt tttataaact
     4441 ggcagagact aaagggtgtc agaccatagc tgctgggaaa gtgcgccacg gagctctgtc
     4501 ctgcctgtgt gtggccatga agagacaggt cctctgctat gaactgttcc aaagcaagac
     4561 caggcacagg aagtttaagg agattcaagt cccatgtaat gtccagtgga tggccatctt
     4621 cagtgagcat ctctgtgtgg gattccagtc aggatttctc agataccccc tgaatggaga
     4681 aggaggtcca tgcaatatgc tccattcaaa tgaccataca ctgtcattca tttcacacca
     4741 accaatggac gctctctgtg cagttgagat ctccaacaaa gagtacttgc tgtgttttaa
     4801 cagcattggg atatacacag actgccaggg ccgaagatcc agacagcagg aactgatgtg
     4861 gccagcaaat ccttcctcct gttgttacaa tgctccatat ctctccgtgt atagtgaaaa
     4921 cgcagttgat atctttgatg taaactccat ggaatggata cagactcttc ctctcaaaaa
     4981 ggtccgacct ttaaacactg aaggatcatt aaatctctta ggattggaga ccattagatt
     5041 aatatatttc aaaaataaga tggcagaagg ggatgaactt gtggttcctg aaacatcaga
     5101 taatagtcgg aaacaaatgg ttagaaatat caacaacaaa cggcgttact ccttccgagt
     5161 ccctgaagaa gagaggatgc aacagaggag ggagatgcta cgagatccag aaatgagaaa
     5221 taaattaatt tctaacccaa ctaattttaa ccacatagca cacatgggtc ctggagatgg
     5281 aatacagatc ctaaaagacc tgcccatgaa cccacggcct caggaaagcc ggacagtatt
     5341 cagtggctcc gtcagtattc cctccatcac caagtcccgc cctgagccag gccgctccat
     5401 gagtgccagc agcggcctgt ctgcacggtc gtcagcccag aatggcagtg cactaaagag
     5461 ggaattctct ggaggaagct ataacacaaa gcgacagccc atgccctctc cctcggaggg
     5521 ctctttgtca tcaggaggca tggaccaagg aagtgacgcc cctgcgaggg actatgatgg
     5581 agaggactct gattctccaa ggcattccac agcttccaac agctctaacc tgagcagccc
     5641 cccaagtccc atttcacccc aaaagaccaa gagcctctcc ctggagagca cagaccgcgg
     5701 gagctgggat ccatgagccc aggaccggtg actgcaggca gggactctgc actcccactc
     5761 cgacaacgtg cctggcagca gccttgcctt ccgcactgct gcaatgggga ttcctccgca
     5821 gccaggcccg cttcaccctc ccctcaaccc ccaggtagct tctgtagaca gactgcgcag
     5881 acgcagcgct aagagtagac cggttgtgtt ctcaccgtag ccctcacgta gcgcccagca
     5941 gcctccatga gcgtcagcca actgttgcca ggaagtaaac cctcacgaat taaaacaatg
     6001 catattttac tacaatacag agtttaaata aatacataga tgtagaagtt aaatactgaa
     6061 tgtaaatagt caaagaagca tcttgtgttt gatgaaagat ggatgcgtat ataagaaaga
     6121 tcatttaatt taaagaaatg tgttgtttct tgtctgtttc ccagctatgt catatacagg
     6181 gtagaaaggc ctcaagtgac actgtaaaga gatcagaagt caggtcccca tggtgtctct
     6241 tctcaagcct aggcaggctg aggtcacagg gaaatctaag gaatgtttgg agattagtgc
     6301 cattggtggg atgtgacctg aacaccaccg ggggtggtga agccactcca gaggctcact
     6361 tgctctgagg catcttgcct ctggttctca gaccatgtcc cccacttaca atattttggt
     6421 atctcgcaca gatgaatgtg aaacaattct gccaccttcc agcccttccc atcctaacgg
     6481 ggaattcgtg gcttctgaag attatgggat ggtcacgcag ctacttttct gtccctgcca
     6541 aaccttgccc cctctaggtt gcaatgagga gtctctggat taagcacaac ttccctgttg
     6601 gttaagggta gttttaaaca cactgctggg gacaggtctc cttactaaat cacagaaaac
     6661 ctcagaagca taggcttgaa tggccttgac caaatatgcc ttcccacgtg aggggacggt
     6721 ggggcttgtg gtgtgctggc caccgtggac tgtgagccag cttcccctct ggatatctac
     6781 tgctgcactt gtcccaggaa gcatgaggag accacagagt cctctactca gacgtcctcc
     6841 agctacgcac acaggagggg acaggtggaa actagtgctc atgacgtaaa gaggccctgc
     6901 ctctcttaat cctctcctct tccgggatgg aaaagccacc atttctcccc actttaagcc
     6961 acatctgaaa tagatctcca agctgacctt tacacagctg ccaggccctg caggtcagac
     7021 tccccaggca tgcagcttta tgggggtgtt aagagagttg agggtgggct ggggtctttg
     7081 taagcagcag ctttgacaga cactctggag tctggagtga gcaagggttt tttggggtgg
     7141 gcactgtgtc actctatatt tatccttttg gaaacagatc atataaaaat aacttgtgta
     7201 cacccaaaaa caagggtcag atctttagtt tggccagatc cctatacatc tgcttcaact
     7261 tgacactttg cttgaaagag ctgcctcccc ttccctccgt cctttccctc ttctttctcc
     7321 ttcccccagc agaaacctga ccaggctgag acacgctgaa ctctaccctg agcctttggt
     7381 ttgtagcttt gacaaccaat tgtgaagttg cctacaggtg cttgttttta aaagaaccct
     7441 tttagaatca gtctaaacct ctacatcccc taaagtccgg ctccacacag tgacttccac
     7501 cccagctctg ccccaaggag ccctgtggat ttggtggatt tcccactgct gtcaaagaac
     7561 tagccatccc aacagcagcc ctgctggccc agagtagagg gtggggttcc aaaaatgact
     7621 ctcttaccag attcatccag ccttctgtga agagtattcc tgtcagaaac tgggaaagga
     7681 tggagaaaga tgactagtcg gtttccagga gacagaaaca aagattcctc agagcagtca
     7741 ataacaaaga ttagagacaa ggccttaggt ttaagccttt cttgagatcg ctccccctac
     7801 cccatggaag gtatttgaaa gtgtgtggca ccgggaattt atccagaaat ggaaaaaaaa
     7861 atacattaag agacatttct gatatagtgt ctatgggtta gtacttggtg ctatgtccag
     7921 cctgtatgct atttaccctt tgaattctgg ctaatctgtt atgtgagttt tgggtgggta
     7981 tacaaaatat attacagggt ttcgttttgg ttttgccaaa aacaaacgcc ttcctatcag
     8041 agattgttaa gcagatcata tatatatata tatatgattt tttaaatttg tgtacatact
     8101 ccctgtgctt agccatttgt gttctttccc agtgagcagc tttaagacag gggaataact
     8161 gcaaatggcc tgttaggctt tccactgaat tcctatagct aggcttagag aaagcatctg
     8221 gaattcccgt cattcccacc agcccttctt cagctactcc tctttcatgt taaaatcctg
     8281 tcattttgtt aatttagtgg ccgcgtttat ttccaggcaa gttcagctgc cttgtgtggg
     8341 tccttgggtg tcattaaaga gaagccagag cagaggggca gcctccgttc ccagggcagc
     8401 caccacaaat ttaattctcc cagctcagca catctagctg ccgcccaccc agcccacccc
     8461 caatacaggt gcacttaaaa tggctgacac cctgctgtag gtcctactct gccatagccc
     8521 aaggccactg tccccttcca gttccacctg gccccactgc acagcatttc cctgtaccct
     8581 tggagtggct cctaccttgt tggaaccttc agtcttcaca aacccagttc cttgcagagc
     8641 cctgctacag tgagtgtgtc tcctgctagc gccagcacca cactctcctg tcccagggac
     8701 agcatcacac agagccctac ttcagtttta ggagactgac tgtcatcagt cagccttgat
     8761 gccattgaaa acaaaatgac cttatttgat agaataacag catttatttt ataaattttt
     8821 aggatttttt tctcattgta atattattgt acagttttgc atggcctcag tgtaatcatt
     8881 tttgttcaga aaattatgac ctgtgtgtgt gtgtgtggaa gggaagatac tgctttggcc
     8941 tcttagcact catttggttt ggttttgtcc ctagatgtcc tagggaattt cctgacagta
     9001 tctgctacca aactataaca tggattcttt tgcacagaac tatttaaggt ggggtggtca
     9061 aaaatgtaac aaaggatttc tcaccaatat tttatgttgg tatcacctaa ttaaccagac
     9121 tttgatgttc tgcaataaaa taaggaactg tca
//
