LOCUS       NM_001359541            9133 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus CDC42 binding protein kinase alpha (Cdc42bpa),
            transcript variant 4, mRNA.
ACCESSION   NM_001359541 XM_006496805
VERSION     NM_001359541.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 9133)
  AUTHORS   Bourdais,A., Dehapiot,B. and Halet,G.
  TITLE     MRCK activates mouse oocyte myosin II for spindle rotation and male
            pronucleus centration
  JOURNAL   J Cell Biol 222 (11) (2023)
   PUBMED   37651121
  REMARK    GeneRIF: MRCK activates mouse oocyte myosin II for spindle rotation
            and male pronucleus centration.
REFERENCE   2  (bases 1 to 9133)
  AUTHORS   Richard,C., Viret,S., Cantero Aguilar,L., Lefevre,C., Leduc,M.,
            Faouzi,E.H., Azar,N., Lavazec,C., Mayeux,P. and Verdier,F.
  TITLE     Myotonic dystrophy kinase-related CDC42-binding kinase alpha, a new
            transferrin receptor type 2-binding partner, is a regulator of
            erythropoiesis
  JOURNAL   Am J Hematol 96 (4), 480-492 (2021)
   PUBMED   33476437
  REMARK    GeneRIF: Myotonic dystrophy kinase-related CDC42-binding kinase
            alpha, a new transferrin receptor type 2-binding partner, is a
            regulator of erythropoiesis.
REFERENCE   3  (bases 1 to 9133)
  AUTHORS   Nakano,Y., Wiechert,S. and Banfi,B.
  TITLE     Overlapping Activities of Two Neuronal Splicing Factors Switch the
            GABA Effect from Excitatory to Inhibitory by Regulating REST
  JOURNAL   Cell Rep 27 (3), 860-871 (2019)
   PUBMED   30995482
REFERENCE   4  (bases 1 to 9133)
  AUTHORS   Dobrowolski,S.F., Lyons-Weiler,J., Spridik,K., Vockley,J.,
            Skvorak,K. and Biery,A.
  TITLE     DNA methylation in the pathophysiology of hyperphenylalaninemia in
            the PAH(enu2) mouse model of phenylketonuria
  JOURNAL   Mol Genet Metab 119 (1-2), 1-7 (2016)
   PUBMED   26822703
REFERENCE   5  (bases 1 to 9133)
  AUTHORS   Lee,I.C.J., Leung,T. and Tan,I.
  TITLE     Adaptor protein LRAP25 mediates myotonic dystrophy kinase-related
            Cdc42-binding kinase (MRCK) regulation of LIMK1 protein in
            lamellipodial F-actin dynamics
  JOURNAL   J Biol Chem 289 (39), 26989-27003 (2014)
   PUBMED   25107909
REFERENCE   6  (bases 1 to 9133)
  AUTHORS   Osipovich,A.B., Long,Q., Manduchi,E., Gangula,R., Hipkens,S.B.,
            Schneider,J., Okubo,T., Stoeckert,C.J. Jr., Takada,S. and
            Magnuson,M.A.
  TITLE     Insm1 promotes endocrine cell differentiation by modulating the
            expression of a network of genes that includes Neurog3 and Ripply3
  JOURNAL   Development 141 (15), 2939-2949 (2014)
   PUBMED   25053427
REFERENCE   7  (bases 1 to 9133)
  AUTHORS   Gomes,E.R., Jani,S. and Gundersen,G.G.
  TITLE     Nuclear movement regulated by Cdc42, MRCK, myosin, and actin flow
            establishes MTOC polarization in migrating cells
  JOURNAL   Cell 121 (3), 451-463 (2005)
   PUBMED   15882626
REFERENCE   8  (bases 1 to 9133)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125380.4 and AC132436.3.
            
            On Jan 13, 2018 this sequence version replaced XM_006496805.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.66083.1,
                                           SRR1660811.15825.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-528               AC125380.4         122073-122600
            529-620             AC125380.4         160675-160766
            621-704             AC125380.4         192818-192901
            705-800             AC125380.4         198142-198237
            801-949             AC125380.4         201365-201513
            950-1043            AC132436.3         17511-17604
            1044-1244           AC132436.3         20687-20887
            1245-1493           AC132436.3         22872-23120
            1494-1573           AC132436.3         25018-25097
            1574-1740           AC132436.3         28066-28232
            1741-1863           AC132436.3         30291-30413
            1864-1997           AC132436.3         40093-40226
            1998-2240           AC132436.3         49665-49907
            2241-2351           AC132436.3         50102-50212
            2352-2599           AC132436.3         56746-56993
            2600-2705           AC132436.3         61768-61873
            2706-2830           AC132436.3         64875-64999
            2831-2936           AC132436.3         66985-67090
            2937-3085           AC132436.3         67466-67614
            3086-3177           AC132436.3         69744-69835
            3178-3254           AC132436.3         73388-73464
            3255-3338           AC132436.3         90018-90101
            3339-3444           AC132436.3         92373-92478
            3445-3581           AC132436.3         93451-93587
            3582-3721           AC132436.3         94153-94292
            3722-3803           AC132436.3         95444-95525
            3804-4020           AC132436.3         97063-97279
            4021-4083           AC132436.3         97998-98060
            4084-4677           AC132436.3         100128-100721
            4678-4775           AC132436.3         102666-102763
            4776-4860           AC132436.3         104874-104958
            4861-4984           AC132436.3         105856-105979
            4985-5102           AC132436.3         106881-106998
            5103-5288           AC132436.3         111516-111701
            5289-5406           AC132436.3         115327-115444
            5407-5564           AC132436.3         117261-117418
            5565-9133           AC132436.3         117756-121324
FEATURES             Location/Qualifiers
     source          1..9133
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 84.01 cM"
     gene            1..9133
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /note="CDC42 binding protein kinase alpha"
                     /db_xref="GeneID:226751"
                     /db_xref="MGI:MGI:2441841"
     exon            1..528
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     CDS             351..5696
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /EC_number="2.7.11.1"
                     /note="isoform 4 is encoded by transcript variant 4;
                     myotonic dystrophy kinase-related CDC-42-binding
                     kinase-alpha; serine/threonine-protein kinase MRCK alpha"
                     /codon_start=1
                     /product="serine/threonine-protein kinase MRCK alpha
                     isoform 4"
                     /protein_id="NP_001346470.1"
                     /db_xref="GeneID:226751"
                     /db_xref="MGI:MGI:2441841"
                     /translation="MSGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNN
                     SPLRREKNILEYLEWAKPFTSKVKQMRLHREDFEILKVIGRGAFGEVAVVKLKNADKV
                     FAMKILNKWEMLKRAETACFREERDVLVNGDSKWITTLHYAFQDDNNLYLVMDYYVGG
                     DLLTLLSKFEDRLPEEMARFYLAEMVIAIDSVHQLHYVHRDIKPDNILMDMNGHIRLA
                     DFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEML
                     YGETPFYAESLVETYGKIMNHKERFQFPAQVTDVSENAKDLIRRLICSREHRLGQNGI
                     EDFKKHPFFSGIDWDNIRNCEAPYIPEVSSPTDTSNFDVDDDCLKNSETMPPPTHTAF
                     SGHHLPFVGFTYTSSCVLSDRSCLRVTAGPTSLDLDVSVQRTLDNNLATEAYERRIKR
                     LEQEKLELTRKLQESTQTVQALQYSTVDGPLTASKDLEIKSLKEEIEKLRKQVAEVNH
                     LEQQLEEANSVRRELDDAFRQIKASEKQIKTLQQEREELNKELVQASERLKNQSKELK
                     DAHCQRKLAMQEFMEINERLTELHTQKQKLARHVRDKEEEVDLVMQKAESLRQELRRA
                     ERAKKELEVHTEALIAEASKDKKLREQSEHYSKQLENELEGLKQKQISYSPGICSIEH
                     QQEITKLKTDLEKKSIFYEEEISKREGIHASEIKNLKKELHDSEGQQLALNKEILVLK
                     DKLEKTRRESQSEREEFENEFKQQYEREKVLLTEENKKLTSELDKLTSLYESLSLRNQ
                     HLEEEVKDLADKKESVAHWEAQITEIIQWVSDEKDARGYLQALASKMTEELEALRNSS
                     LGTRATDMPWKMRRFAKLDMSARLELQSALDAEIRAKQAIQEELNKVKASNILTECKL
                     KDSEKKNLELLSEIEQLIKDTEELRSEKGIEHQDSQHSFLAFLNTPTDALDQFEIADC
                     APLPAHTPTLRKKGCPASTGFPPKRKTHQFFVKSFTAPTKCHQCTSLMVGLIRQGCSC
                     EVCGFSCHITCVNKAPTVCPVPPEQTKGPLGIDPQKGVGTAYEGHVRIPKPAGVKKGW
                     QRALAVVCDFKLFLYDIAEGKASQPTSVISQVIDMRDEEFSVSSVLASDVIHASRKDI
                     PCIFRVTASQLSAPSNKCSILMLADSENERSKWVGVLSELHKILKKNKFRDRSVYVPK
                     EAYDSTLPLIKTTQAAAIIDHERIALGNEEGLFVVHVTKDEIVRVGDNKKIHQIELIP
                     SDQLVAVISGRNRHVRLFPMSALDGRETDFYKLAETKGCQTIAAGKVRHGALSCLCVA
                     MKRQVLCYELFQSKTRHRKFKEIQVPCNVQWMAIFSEHLCVGFQSGFLRYPLNGEGGP
                     CNMLHSNDHTLSFISHQPMDALCAVEISNKEYLLCFNSIGIYTDCQGRRSRQQELMWP
                     ANPSSCCYNAPYLSVYSENAVDIFDVNSMEWIQTLPLKKVRPLNTEGSLNLLGLETIR
                     LIYFKNKMAEGDELVVPETSDNSRKQMVRNINNKRRYSFRVPEEERMQQRREMLRDPE
                     MRNKLISNPTNFNHIAHMGPGDGIQILKDLPMPGFPYSPPHHHSGLISSPSNFEHIYH
                     MTVTSAEQFLSPESISPGSPPSLRSAPGTPHSVTLRNPRPQESRTVFSGSVSIPSITK
                     SRPEPGRSMSASSGLSARSSAQNGSALKREFSGGSYNTKRQPMPSPSEGSLSSGGMDQ
                     GSDAPARDYDGEDSDSPRHSTASNSSNLSSPPSPISPQKTKSLSLESTDRGSWDP"
     exon            529..620
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            621..704
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            705..800
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            801..949
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1043
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1244
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1493
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1573
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1740
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1863
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..1997
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..2240
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            2241..2351
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            2352..2599
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            2600..2705
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            2706..2830
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            2831..2936
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            2937..3085
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            3086..3177
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            3178..3254
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            3255..3338
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            3339..3444
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            3445..3581
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            3582..3721
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            3722..3803
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            3804..4020
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            4021..4083
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            4084..4677
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            4678..4775
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            4776..4860
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            4861..4984
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            4985..5102
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            5103..5288
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            5289..5406
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            5407..5564
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     exon            5565..9133
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6093..6098
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /note="hexamer: AAGAAA"
     polyA_site      6114
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
     regulatory      9114..9119
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /note="hexamer: AATAAA"
     polyA_site      9133
                     /gene="Cdc42bpa"
                     /gene_synonym="A930014J19Rik; DMPK-like"
                     /note="major polyA site"
ORIGIN      
        1 tttttttttt tttttttaag gagtgttgac tctttagttc gttgtacttt taattattat
       61 tttatttaaa tgtacaattt aattgtatta ttctcttaaa atattaaatc tatattttat
      121 ggaaactcac cctcaagata tatatgttta tgggtgaaat tggagacgct tccgttaagt
      181 gaggtgactg gtgtattgga tgtttaattc agcaccggca ttgcatgaca gttgttgaaa
      241 taacaagtgg tttattttta aaaaccacat ctttaaactt ttaggttcag atagtaacag
      301 tagacatcgt aagggcattt aaaagaaaac cagcagaaat cgaagcaaac atgtccggag
      361 aagtgcgttt gaggcagttg gagcagttta ttttagatgg gccagctcag accaatgggc
      421 agtgcttcag tgtggagacg ctactggaca tcctcatctg tctttacgat gaatgcaata
      481 attctccatt gagaagagag aagaacattc ttgaatatct agaatgggct aaaccattta
      541 cttctaaagt gaagcaaatg cgattacata gagaagactt tgaaatatta aaggtgattg
      601 gtcgaggagc ttttggggag gttgctgtag ttaaactaaa aaatgcagat aaagtattcg
      661 ccatgaaaat tctgaacaag tgggaaatgc tgaaaagagc tgagacagcg tgctttcgtg
      721 aagagaggga tgtgttggta aatggagaca gtaagtggat aaccactctg cactatgctt
      781 tccaggatga caataactta tacctggtta tggattatta tgttggtggg gatttactta
      841 ctctgctcag caaatttgaa gatagattgc ctgaagagat ggctcggttt tacttggctg
      901 agatggtgat agccattgac tcagttcacc agctccacta tgttcacaga gacatcaaac
      961 ctgacaatat attgatggat atgaatggac atattcgttt agcagatttt ggttcttgtc
     1021 tgaagctgat ggaagatgga acggtccagt cctcggtggc agttggaact ccagattata
     1081 tttctccgga aatccttcag gctatggaag acggaaaagg cagatatgga ccagagtgtg
     1141 actggtggtc cttgggggtc tgtatgtatg agatgcttta cggagaaaca ccattctatg
     1201 cagagtctct ggtggagaca tatggaaaaa ttatgaatca caaagagcgg tttcagtttc
     1261 cagcccaagt gacagacgtg tccgaaaatg ctaaagatct tattcgaaga ctcatttgta
     1321 gtagagaaca tcgacttggc caaaatggaa tagaagactt taagaagcat ccattcttca
     1381 gtggaattga ttgggataac attcggaatt gtgaagcacc ttacatccca gaagttagta
     1441 gcccgacaga tacgtcaaat tttgatgtgg atgacgactg tttaaaaaat tctgaaacaa
     1501 tgcccccacc aacacatact gcattttctg gccatcatct accatttgtt ggttttacat
     1561 atactagtag ctgtgttctt tctgatcgga gctgtttaag agtcacagca ggccccacct
     1621 cattggacct tgatgtcagt gtccagagga ctctagacaa taacttagca actgaggctt
     1681 atgaaaggag aattaagcgg cttgagcagg aaaagcttga actgactaga aaacttcaag
     1741 agtcaacaca gactgttcaa gctctgcaat attcaactgt tgatggtcca ctaacggcaa
     1801 gcaaagattt agaaattaaa agtctgaaag aagagattga aaaactaagg aaacaagtag
     1861 cagaagtgaa tcatttggaa caacaacttg aagaagctaa ttctgtgaga cgagaactag
     1921 atgatgcttt caggcaaatc aaagcttctg aaaaacaaat caaaactttg cagcaggaaa
     1981 gagaagaact aaataaggaa ctagtccagg ctagtgagcg attaaaaaac caatccaaag
     2041 agctgaaaga tgcacactgt cagaggaaac tggccatgca ggaattcatg gagatcaatg
     2101 agcgactaac agaattgcac acccaaaagc agaaacttgc tcgccatgtc cgagataagg
     2161 aagaagaggt ggacctggtg atgcaaaaag ctgagagctt aaggcaggag ctgcgcagag
     2221 cagaaagagc caagaaagag ctggaagttc acaccgaagc tctaattgct gaagcatcaa
     2281 aggacaagaa gctccgagag cagagcgaac attattctaa gcaactggaa aacgagttgg
     2341 agggcctgaa gcaaaaacaa attagttact caccaggaat atgcagcata gaacatcagc
     2401 aagagataac taaactgaaa actgacttgg aaaagaaaag tatcttttat gaagaagaaa
     2461 tttctaaaag agaaggaatt cacgcaagtg agattaaaaa cctgaagaag gagctgcatg
     2521 actcagaagg ccagcagctt gctctcaaca aagagattct ggttttaaaa gacaaattgg
     2581 aaaaaaccag gagagaaagt caaagtgaaa gggaagaatt tgaaaatgag ttcaaacaac
     2641 aatatgaacg ggaaaaagta ttattaactg aagagaataa aaagttaacg agtgaactcg
     2701 ataagctgac ttcactgtat gagagcttaa gtttgcgcaa ccagcactta gaagaagaag
     2761 tcaaagatct agcagataag aaggaatcag ttgcccactg ggaagcccaa atcacagaga
     2821 taattcagtg ggtgagcgat gagaaggatg cacgaggcta tcttcaggcc ttagcttcta
     2881 aaatgactga agagttggaa gcattaagaa attccagctt ggggacacga gcaacagata
     2941 tgccctggaa aatgcgtcgt tttgcaaaac tggacatgtc ggctagacta gagttgcagt
     3001 ctgctctgga tgcagaaata agagctaagc aggccatcca ggaagagctg aataaagtca
     3061 aagcatctaa catcttaaca gaatgtaaac tgaaagattc agagaagaag aacttggaac
     3121 tgttgtccga aatcgagcag ctgataaagg acactgaaga gcttagatct gaaaagggta
     3181 tagagcacca agactcacag cattctttct tggcattttt gaatacgcct accgatgctc
     3241 tggaccaatt tgaaattgca gactgtgctc cacttccagc tcacacacca accttaagga
     3301 aaaagggatg cccggcttca actggctttc cacctaagcg caagactcat caatttttcg
     3361 tgaagtcttt cactgcccct accaagtgtc accagtgcac ctccttgatg gtcggtttga
     3421 taagacaggg ctgttcctgt gaagtctgtg ggttctcatg tcatataact tgtgtgaaca
     3481 aagccccgac ggtttgccca gttcctcctg agcaaactaa aggtccactg ggcatagacc
     3541 cccagaaggg agttgggacg gcgtatgagg gtcatgtcag gatccctaag ccggcgggag
     3601 tgaagaaagg gtggcagaga gcactggctg tggtctgcga cttcaaactg tttctttatg
     3661 atatcgcaga gggaaaagca tcgcagccca cctccgtcat tagtcaagtg attgacatga
     3721 gagatgaaga attttctgtg agttcagtct tagcttctga tgttattcac gcaagtcgaa
     3781 aagatatccc ctgtatattc agggtcacag cttcccagct ctcagcacct agtaacaaat
     3841 gttccatcct gatgctagca gacagcgaga atgagaggag taagtgggtg ggagtgctga
     3901 gtgaactcca caagattctg aagaaaaaca agttcagaga ccgctcagtg tatgtcccca
     3961 aggaggcgta cgacagcacg ctacccctca ttaagacaac gcaggccgct gcaatcatag
     4021 atcatgaacg gatagctttg ggaaatgaag aaggattatt tgttgtgcat gtcaccaaag
     4081 atgagattgt tagagttggt gataataaga aaatccatca gatcgaactc attccaagtg
     4141 accagcttgt cgctgtgatc tcaggccgaa atcgccacgt ccgacttttt cctatgtcag
     4201 ccttggatgg gcgagagacg gatttttata aactggcaga gactaaaggg tgtcagacca
     4261 tagctgctgg gaaagtgcgc cacggagctc tgtcctgcct gtgtgtggcc atgaagagac
     4321 aggtcctctg ctatgaactg ttccaaagca agaccaggca caggaagttt aaggagattc
     4381 aagtcccatg taatgtccag tggatggcca tcttcagtga gcatctctgt gtgggattcc
     4441 agtcaggatt tctcagatac cccctgaatg gagaaggagg tccatgcaat atgctccatt
     4501 caaatgacca tacactgtca ttcatttcac accaaccaat ggacgctctc tgtgcagttg
     4561 agatctccaa caaagagtac ttgctgtgtt ttaacagcat tgggatatac acagactgcc
     4621 agggccgaag atccagacag caggaactga tgtggccagc aaatccttcc tcctgttgtt
     4681 acaatgctcc atatctctcc gtgtatagtg aaaacgcagt tgatatcttt gatgtaaact
     4741 ccatggaatg gatacagact cttcctctca aaaaggtccg acctttaaac actgaaggat
     4801 cattaaatct cttaggattg gagaccatta gattaatata tttcaaaaat aagatggcag
     4861 aaggggatga acttgtggtt cctgaaacat cagataatag tcggaaacaa atggttagaa
     4921 atatcaacaa caaacggcgt tactccttcc gagtccctga agaagagagg atgcaacaga
     4981 ggagggagat gctacgagat ccagaaatga gaaataaatt aatttctaac ccaactaatt
     5041 ttaaccacat agcacacatg ggtcctggag atggaataca gatcctaaaa gacctgccca
     5101 tgccaggttt cccttattca ccccctcatc accactccgg cctgatctcc tctccgagca
     5161 actttgagca catctatcac atgactgtca cttctgctga acagtttctc tctcctgagt
     5221 ccataagccc tgggtccccc ccgtccctgc gctctgcccc tggcacacca cactctgtga
     5281 ctctgaggaa cccacggcct caggaaagcc ggacagtatt cagtggctcc gtcagtattc
     5341 cctccatcac caagtcccgc cctgagccag gccgctccat gagtgccagc agcggcctgt
     5401 ctgcacggtc gtcagcccag aatggcagtg cactaaagag ggaattctct ggaggaagct
     5461 ataacacaaa gcgacagccc atgccctctc cctcggaggg ctctttgtca tcaggaggca
     5521 tggaccaagg aagtgacgcc cctgcgaggg actatgatgg agaggactct gattctccaa
     5581 ggcattccac agcttccaac agctctaacc tgagcagccc cccaagtccc atttcacccc
     5641 aaaagaccaa gagcctctcc ctggagagca cagaccgcgg gagctgggat ccatgagccc
     5701 aggaccggtg actgcaggca gggactctgc actcccactc cgacaacgtg cctggcagca
     5761 gccttgcctt ccgcactgct gcaatgggga ttcctccgca gccaggcccg cttcaccctc
     5821 ccctcaaccc ccaggtagct tctgtagaca gactgcgcag acgcagcgct aagagtagac
     5881 cggttgtgtt ctcaccgtag ccctcacgta gcgcccagca gcctccatga gcgtcagcca
     5941 actgttgcca ggaagtaaac cctcacgaat taaaacaatg catattttac tacaatacag
     6001 agtttaaata aatacataga tgtagaagtt aaatactgaa tgtaaatagt caaagaagca
     6061 tcttgtgttt gatgaaagat ggatgcgtat ataagaaaga tcatttaatt taaagaaatg
     6121 tgttgtttct tgtctgtttc ccagctatgt catatacagg gtagaaaggc ctcaagtgac
     6181 actgtaaaga gatcagaagt caggtcccca tggtgtctct tctcaagcct aggcaggctg
     6241 aggtcacagg gaaatctaag gaatgtttgg agattagtgc cattggtggg atgtgacctg
     6301 aacaccaccg ggggtggtga agccactcca gaggctcact tgctctgagg catcttgcct
     6361 ctggttctca gaccatgtcc cccacttaca atattttggt atctcgcaca gatgaatgtg
     6421 aaacaattct gccaccttcc agcccttccc atcctaacgg ggaattcgtg gcttctgaag
     6481 attatgggat ggtcacgcag ctacttttct gtccctgcca aaccttgccc cctctaggtt
     6541 gcaatgagga gtctctggat taagcacaac ttccctgttg gttaagggta gttttaaaca
     6601 cactgctggg gacaggtctc cttactaaat cacagaaaac ctcagaagca taggcttgaa
     6661 tggccttgac caaatatgcc ttcccacgtg aggggacggt ggggcttgtg gtgtgctggc
     6721 caccgtggac tgtgagccag cttcccctct ggatatctac tgctgcactt gtcccaggaa
     6781 gcatgaggag accacagagt cctctactca gacgtcctcc agctacgcac acaggagggg
     6841 acaggtggaa actagtgctc atgacgtaaa gaggccctgc ctctcttaat cctctcctct
     6901 tccgggatgg aaaagccacc atttctcccc actttaagcc acatctgaaa tagatctcca
     6961 agctgacctt tacacagctg ccaggccctg caggtcagac tccccaggca tgcagcttta
     7021 tgggggtgtt aagagagttg agggtgggct ggggtctttg taagcagcag ctttgacaga
     7081 cactctggag tctggagtga gcaagggttt tttggggtgg gcactgtgtc actctatatt
     7141 tatccttttg gaaacagatc atataaaaat aacttgtgta cacccaaaaa caagggtcag
     7201 atctttagtt tggccagatc cctatacatc tgcttcaact tgacactttg cttgaaagag
     7261 ctgcctcccc ttccctccgt cctttccctc ttctttctcc ttcccccagc agaaacctga
     7321 ccaggctgag acacgctgaa ctctaccctg agcctttggt ttgtagcttt gacaaccaat
     7381 tgtgaagttg cctacaggtg cttgttttta aaagaaccct tttagaatca gtctaaacct
     7441 ctacatcccc taaagtccgg ctccacacag tgacttccac cccagctctg ccccaaggag
     7501 ccctgtggat ttggtggatt tcccactgct gtcaaagaac tagccatccc aacagcagcc
     7561 ctgctggccc agagtagagg gtggggttcc aaaaatgact ctcttaccag attcatccag
     7621 ccttctgtga agagtattcc tgtcagaaac tgggaaagga tggagaaaga tgactagtcg
     7681 gtttccagga gacagaaaca aagattcctc agagcagtca ataacaaaga ttagagacaa
     7741 ggccttaggt ttaagccttt cttgagatcg ctccccctac cccatggaag gtatttgaaa
     7801 gtgtgtggca ccgggaattt atccagaaat ggaaaaaaaa atacattaag agacatttct
     7861 gatatagtgt ctatgggtta gtacttggtg ctatgtccag cctgtatgct atttaccctt
     7921 tgaattctgg ctaatctgtt atgtgagttt tgggtgggta tacaaaatat attacagggt
     7981 ttcgttttgg ttttgccaaa aacaaacgcc ttcctatcag agattgttaa gcagatcata
     8041 tatatatata tatatgattt tttaaatttg tgtacatact ccctgtgctt agccatttgt
     8101 gttctttccc agtgagcagc tttaagacag gggaataact gcaaatggcc tgttaggctt
     8161 tccactgaat tcctatagct aggcttagag aaagcatctg gaattcccgt cattcccacc
     8221 agcccttctt cagctactcc tctttcatgt taaaatcctg tcattttgtt aatttagtgg
     8281 ccgcgtttat ttccaggcaa gttcagctgc cttgtgtggg tccttgggtg tcattaaaga
     8341 gaagccagag cagaggggca gcctccgttc ccagggcagc caccacaaat ttaattctcc
     8401 cagctcagca catctagctg ccgcccaccc agcccacccc caatacaggt gcacttaaaa
     8461 tggctgacac cctgctgtag gtcctactct gccatagccc aaggccactg tccccttcca
     8521 gttccacctg gccccactgc acagcatttc cctgtaccct tggagtggct cctaccttgt
     8581 tggaaccttc agtcttcaca aacccagttc cttgcagagc cctgctacag tgagtgtgtc
     8641 tcctgctagc gccagcacca cactctcctg tcccagggac agcatcacac agagccctac
     8701 ttcagtttta ggagactgac tgtcatcagt cagccttgat gccattgaaa acaaaatgac
     8761 cttatttgat agaataacag catttatttt ataaattttt aggatttttt tctcattgta
     8821 atattattgt acagttttgc atggcctcag tgtaatcatt tttgttcaga aaattatgac
     8881 ctgtgtgtgt gtgtgtggaa gggaagatac tgctttggcc tcttagcact catttggttt
     8941 ggttttgtcc ctagatgtcc tagggaattt cctgacagta tctgctacca aactataaca
     9001 tggattcttt tgcacagaac tatttaaggt ggggtggtca aaaatgtaac aaaggatttc
     9061 tcaccaatat tttatgttgg tatcacctaa ttaaccagac tttgatgttc tgcaataaaa
     9121 taaggaactg tca
//
