LOCUS       NM_009861               2151 bp    mRNA    linear   ROD 19-DEC-2022
DEFINITION  Mus musculus cell division cycle 42 (Cdc42), transcript variant 1,
            mRNA.
ACCESSION   NM_009861 XR_104893
VERSION     NM_009861.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2151)
  AUTHORS   Jiang R, Tang X, Pan J, Li G, Yang N, Tang Y, Bi S, Cai H, Chen Q,
            Chen D, Wang H and Kong S.
  TITLE     CDC42 governs normal oviduct multiciliogenesis through activating
            AKT to ensure timely embryo transport
  JOURNAL   Cell Death Dis 13 (9), 757 (2022)
   PUBMED   36056002
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2151)
  AUTHORS   Jiang S, Xu CM, Yao S, Zhang R, Li XZ, Zhang RZ, Xie TY, Xing YQ,
            Zhang Q, Zhou XJ, Liao L and Dong JJ.
  TITLE     Cdc42 upregulation under high glucose induces podocyte apoptosis
            and impairs beta-cell insulin secretion
  JOURNAL   Front Endocrinol (Lausanne) 13, 905703 (2022)
   PUBMED   36034435
  REMARK    GeneRIF: Cdc42 upregulation under high glucose induces podocyte
            apoptosis and impairs beta-cell insulin secretion.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2151)
  AUTHORS   Huang D, Qiu H, Miao L, Guo L, Zhang X, Lin M, Li Z and Li F.
  TITLE     Cdc42 promotes thyroid cancer cell proliferation and migration and
            tumor-associated macrophage polarization through the PTEN/AKT
            pathway
  JOURNAL   J Biochem Mol Toxicol 36 (8), e23115 (2022)
   PUBMED   35822655
  REMARK    GeneRIF: Cdc42 promotes thyroid cancer cell proliferation and
            migration and tumor-associated macrophage polarization through the
            PTEN/AKT pathway.
REFERENCE   4  (bases 1 to 2151)
  AUTHORS   Wirth A, Labus J, Abdel Galil D, Schill Y, Schmidt S, Bunke T,
            Gorinski N, Yokoi N, Fukata M and Ponimaskin E.
  TITLE     Palmitoylation of the small GTPase Cdc42 by DHHC5 modulates spine
            formation and gene transcription
  JOURNAL   J Biol Chem 298 (6), 102048 (2022)
   PUBMED   35597282
  REMARK    GeneRIF: Palmitoylation of the small GTPase Cdc42 by DHHC5
            modulates spine formation and gene transcription.
REFERENCE   5  (bases 1 to 2151)
  AUTHORS   Zhang Z, Zhang F, Davis AK, Xin M, Walz G, Tian W and Zheng Y.
  TITLE     CDC42 controlled apical-basal polarity regulates intestinal stem
            cell to transit amplifying cell fate transition via YAP-EGF-mTOR
            signaling
  JOURNAL   Cell Rep 38 (2), 110009 (2022)
   PUBMED   35021092
  REMARK    GeneRIF: CDC42 controlled apical-basal polarity regulates
            intestinal stem cell to transit amplifying cell fate transition via
            YAP-EGF-mTOR signaling.
REFERENCE   6  (bases 1 to 2151)
  AUTHORS   Hall A.
  TITLE     Small GTP-binding proteins and the regulation of the actin
            cytoskeleton
  JOURNAL   Annu Rev Cell Biol 10, 31-54 (1994)
   PUBMED   7888179
  REMARK    Review article
REFERENCE   7  (bases 1 to 2151)
  AUTHORS   Warden CH, Mehrabian M, He KY, Yoon MY, Diep A, Xia YR, Wen PZ,
            Svenson KL, Sparkes RS and Lusis AJ.
  TITLE     Linkage mapping of 40 randomly isolated liver cDNA clones in the
            mouse
  JOURNAL   Genomics 18 (2), 295-307 (1993)
   PUBMED   8288233
REFERENCE   8  (bases 1 to 2151)
  AUTHORS   Miki T, Smith CL, Long JE, Eva A and Fleming TP.
  TITLE     Oncogene ect2 is related to regulators of small GTP-binding
            proteins
  JOURNAL   Nature 362 (6419), 462-465 (1993)
   PUBMED   8464478
  REMARK    Erratum:[Nature 1993 Aug 19;364(6439):737]
REFERENCE   9  (bases 1 to 2151)
  AUTHORS   Chavrier P, Simons K and Zerial M.
  TITLE     The complexity of the Rab and Rho GTP-binding protein subfamilies
            revealed by a PCR cloning approach
  JOURNAL   Gene 112 (2), 261-264 (1992)
   PUBMED   1555775
REFERENCE   10 (bases 1 to 2151)
  AUTHORS   Johnson,D.R.
  TITLE     Ultrastructural observations on stumpy (stm), a new
            chondrodystrophic mutant in the mouse
  JOURNAL   J Embryol Exp Morphol 39, 279-284 (1977)
   PUBMED   886261
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645468.11, CD551112.1, AK168758.1 and BE685696.1.
            
            [WARNING] On Apr 26, 2023 this sequence was replaced by
            NM_009861.4.
            
            On or before Aug 27, 2011 this sequence version replaced
            XR_104893.1, NM_009861.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK168758.1, AK153564.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AL645468.11        104258-104270       c
            14-48               CD551112.1         1-35
            49-2139             AK168758.1         2-2092
            2140-2151           BE685696.1         1-12                c
FEATURES             Location/Qualifiers
     source          1..2151
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 69.83 cM"
     gene            1..2151
                     /gene="Cdc42"
                     /note="cell division cycle 42"
                     /db_xref="GeneID:12540"
                     /db_xref="MGI:MGI:106211"
     exon            1..114
                     /gene="Cdc42"
                     /inference="alignment:Splign:2.1.0"
     exon            115..269
                     /gene="Cdc42"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..740
                     /gene="Cdc42"
                     /EC_number="3.6.5.2"
                     /note="isoform 1 is encoded by transcript variant 1; cell
                     division control protein 42 homolog; G25K GTP-binding
                     protein; cell division cycle 42 homolog"
                     /codon_start=1
                     /product="cell division control protein 42 homolog isoform
                     1"
                     /protein_id="NP_033991.1"
                     /db_xref="CCDS:CCDS18816.1"
                     /db_xref="GeneID:12540"
                     /db_xref="MGI:MGI:106211"
                     /translation="MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTV
                     MIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEIT
                     HHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSAL
                     TQKGLKNVFDEAILAALEPPEPKKSRRCVLL"
     exon            270..342
                     /gene="Cdc42"
                     /inference="alignment:Splign:2.1.0"
     exon            343..452
                     /gene="Cdc42"
                     /inference="alignment:Splign:2.1.0"
     exon            453..650
                     /gene="Cdc42"
                     /inference="alignment:Splign:2.1.0"
     exon            651..2147
                     /gene="Cdc42"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttccgcgggc acccaaccat gcgtcccctg cgtgctgacg tcaggcgcgt gcccctgtcc
       61 ggcagccgag gaggccccgc gcagtgctgc caacgccccg gcggagaagc tgaggacaag
      121 atctaatttg aaatattaaa agtggataca aaactgtttc cgaaatgcag acaattaagt
      181 gtgttgttgt tggtgatggt gctgttggta aaacatgtct cctgatatcc tacacaacaa
      241 acaaattccc atcggaatat gtaccaactg tttttgacaa ctatgcagtc acagttatga
      301 ttggtggaga gccatacact cttggacttt ttgatactgc agggcaagag gattatgaca
      361 gactacgacc gctaagttat ccacagacag atgtttttct agtatgtttc tcagtggtct
      421 ctccatcctc atttgaaaat gtgaaagaaa agtgggtgcc tgagataact caccactgtc
      481 caaagactcc tttcttgctt gttgggaccc aaattgatct cagagatgac ccctctacta
      541 ttgagaaact tgccaagaac aaacagaagc ctattactcc agagactgct gaaaagctgg
      601 cgcgggatct gaaggctgtc aagtatgtgg agtgctctgc cctcacacag aaaggcctaa
      661 agaatgtgtt tgatgaagca atattggctg ccctggagcc tccagaaccg aagaagagcc
      721 gcaggtgtgt gctgctatga acgcatctcc agagcccttt ctgcacagct ggtgttgtcg
      781 tcatactaaa agcaatgttt aaatcaaact aaagattaaa aattaaaatt tgtttctgca
      841 ataatgacaa acgccctgca cctacccaca tgcactcatg tgagacaagg cccattagta
      901 tggcccctcc ttgcccttcc agtaatagtt aattttgaat aattatgtat tgtctgaaaa
      961 gcaatgagtg ctagtttttg ttttctttgt ttaaaaaaaa aaacaaaaat ccccacaaac
     1021 gtttgttgtt tttttgttta aaagcaagca tgcttgtatt gactgtaaca gactaattca
     1081 gattgtcaaa gctgctccct ggttccattt tggagagtaa tctggggcat cttcgtgtct
     1141 tctgttttgt tttgttttgt ttttcctcaa cccttctctc cttttggggt gtgtatgggg
     1201 ttgtttctta gacttgtatt ttaaaatttg ttaaccatag gacagcctgt ggggaggagg
     1261 acagagtatt tccacattcc actccctagg tctagtttag caaacgtgtc cccacctggt
     1321 gctcttagga aggagtatag aaacgcctcg attaacaacg tattccttct tgaaagttgc
     1381 cttttctctc cacctctgag tgggtccagt ctgtgatgga actcatgaag gtgggtggac
     1441 gctgtctcgc ccctctttct aggatgcact ctatatgtga ctgtgacttt caagggtatt
     1501 tgtttgccat ttcctgattt agggagggga ataatttcta acttctttca ttgataaatg
     1561 aaaagtattg cacctttgaa atacaccaaa tggattgagt tcctaattaa aaaaagttct
     1621 tttgcccctg tcagtcattt tcttacatgc ttagcacaga ttcacaactc actgtgtagt
     1681 gttcctagat tcagctgaag acctggtacc tagggttcct aacgggatgg tgttaggaaa
     1741 cacatcatgg ctgatgattg ccatctcctt tcaggtgatg aggtcacagg cctgcttcct
     1801 taagaagcta tgagcatggg gtggggagca tacttttaac caacatgggg accagtcagg
     1861 gctatcccct tttttcttcc atgcctatga ggaacctttg aacaactggc tgaagctttc
     1921 gcaagaaaaa tggcgagagc ctcatgattc tttataagtg ttaatagaga ctttatcaga
     1981 ttattttgtt tgcaggttcc agtttttaaa aaatgtttag ataatctcct tccccagtcc
     2041 tgatcttgtg gattcgttag tgccgaacca atgctttctt gtgtctcaac tctttgtata
     2101 tgaattcttt tcagatgtat taaacaaaca aaacccttca caagtgaaaa a
//
