LOCUS       NM_027879               3370 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus cell division cycle 40 (Cdc40), mRNA.
ACCESSION   NM_027879 XM_001477295 XM_483893
VERSION     NM_027879.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3370)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3370)
  AUTHORS   Chai,G., Webb,A., Li,C., Antaki,D., Lee,S., Breuss,M.W., Lang,N.,
            Stanley,V., Anzenberg,P., Yang,X., Marshall,T., Gaffney,P.,
            Wierenga,K.J., Chung,B.H., Tsang,M.H., Pais,L.S., Lovgren,A.K.,
            VanNoy,G.E., Rehm,H.L., Mirzaa,G., Leon,E., Diaz,J., Neumann,A.,
            Kalverda,A.P., Manfield,I.W., Parry,D.A., Logan,C.V., Johnson,C.A.,
            Bonthron,D.T., Valleley,E.M.A., Issa,M.Y., Abdel-Ghafar,S.F.,
            Abdel-Hamid,M.S., Jennings,P., Zaki,M.S., Sheridan,E. and
            Gleeson,J.G.
  TITLE     Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause
            Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly
  JOURNAL   Neuron 109 (2), 241-256 (2021)
   PUBMED   33220177
  REMARK    GeneRIF: Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause
            Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly.
REFERENCE   3  (bases 1 to 3370)
  AUTHORS   Chen,J., Melton,C., Suh,N., Oh,J.S., Horner,K., Xie,F., Sette,C.,
            Blelloch,R. and Conti,M.
  TITLE     Genome-wide analysis of translation reveals a critical role for
            deleted in azoospermia-like (Dazl) at the oocyte-to-zygote
            transition
  JOURNAL   Genes Dev 25 (7), 755-766 (2011)
   PUBMED   21460039
REFERENCE   4  (bases 1 to 3370)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3370)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC158078.1, AK004569.1, AA163414.1 and BE691319.1.
            
            On Jul 29, 2011 this sequence version replaced NM_027879.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC147503.1, AK004569.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2094              BC158078.1         1-2094
            2095-2868           AK004569.1         2062-2835
            2869-2879           AA163414.1         234-244
            2880-3361           AK004569.1         2847-3328
            3362-3370           BE691319.1         1-9                 c
FEATURES             Location/Qualifiers
     source          1..3370
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 22.06 cM"
     gene            1..3370
                     /gene="Cdc40"
                     /gene_synonym="1200003H23Rik; EHB3; PRP17"
                     /note="cell division cycle 40"
                     /db_xref="GeneID:71713"
                     /db_xref="MGI:MGI:1918963"
     exon            1..257
                     /gene="Cdc40"
                     /gene_synonym="1200003H23Rik; EHB3; PRP17"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1808
                     /gene="Cdc40"
                     /gene_synonym="1200003H23Rik; EHB3; PRP17"
                     /note="PRP17 homolog; cell division cycle 40 homolog"
                     /codon_start=1
                     /product="pre-mRNA-processing factor 17"
                     /protein_id="NP_082155.1"
                     /db_xref="CCDS:CCDS48546.1"
                     /db_xref="GeneID:71713"
                     /db_xref="MGI:MGI:1918963"
                     /translation="MSAAIAALAASYGSGSGSESDSDSEGSRCPLPAADSLMHLTKSP
                     SAKLSLTVAVDSAPEVAVKEDLETGVHLDPAVKEVQYNPTYETMFAPEFGPENPFRTQ
                     QMAAPRNMLSGYAEPAHINDFMFEQQRRTFATYGYALDPSLDNHQVSAKYIGSVEEAE
                     KNQGLTVFETGQKKTEKRKKFKENDASNIDGFLGPWAKYVDEKDVAKPSEEEQKELDE
                     ITAKRQKKGKQEEEKPGEEKTILHVKEMYDYQGRSYLHIPQDVGVNLRSSVPPEKCYL
                     PKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGDRRCLRTFIGHSKA
                     VRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFV
                     AGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIP
                     VDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVA
                     GYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKV
                     ITCGWDGLIKLWD"
     exon            258..344
                     /gene="Cdc40"
                     /gene_synonym="1200003H23Rik; EHB3; PRP17"
                     /inference="alignment:Splign:2.1.0"
     exon            345..474
                     /gene="Cdc40"
                     /gene_synonym="1200003H23Rik; EHB3; PRP17"
                     /inference="alignment:Splign:2.1.0"
     exon            475..558
                     /gene="Cdc40"
                     /gene_synonym="1200003H23Rik; EHB3; PRP17"
                     /inference="alignment:Splign:2.1.0"
     exon            559..698
                     /gene="Cdc40"
                     /gene_synonym="1200003H23Rik; EHB3; PRP17"
                     /inference="alignment:Splign:2.1.0"
     exon            699..795
                     /gene="Cdc40"
                     /gene_synonym="1200003H23Rik; EHB3; PRP17"
                     /inference="alignment:Splign:2.1.0"
     exon            796..935
                     /gene="Cdc40"
                     /gene_synonym="1200003H23Rik; EHB3; PRP17"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1010
                     /gene="Cdc40"
                     /gene_synonym="1200003H23Rik; EHB3; PRP17"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1056
                     /gene="Cdc40"
                     /gene_synonym="1200003H23Rik; EHB3; PRP17"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1158
                     /gene="Cdc40"
                     /gene_synonym="1200003H23Rik; EHB3; PRP17"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1274
                     /gene="Cdc40"
                     /gene_synonym="1200003H23Rik; EHB3; PRP17"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1408
                     /gene="Cdc40"
                     /gene_synonym="1200003H23Rik; EHB3; PRP17"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1485
                     /gene="Cdc40"
                     /gene_synonym="1200003H23Rik; EHB3; PRP17"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1630
                     /gene="Cdc40"
                     /gene_synonym="1200003H23Rik; EHB3; PRP17"
                     /inference="alignment:Splign:2.1.0"
     exon            1631..3366
                     /gene="Cdc40"
                     /gene_synonym="1200003H23Rik; EHB3; PRP17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3343..3348
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdc40"
                     /gene_synonym="1200003H23Rik; EHB3; PRP17"
                     /note="hexamer: AATAAA"
     polyA_site      3366
                     /gene="Cdc40"
                     /gene_synonym="1200003H23Rik; EHB3; PRP17"
                     /note="major polyA site"
ORIGIN      
        1 gacaggacct gggagacgct gcttcttccg ccttggcctg gccttagcag agagtatctg
       61 ttgcagtcat gtcggctgcg attgcagctc tagctgcttc gtatggctcg ggctcggggt
      121 ccgaatcgga ttcggacagt gagggcagtc ggtgtccgct gccagccgcg gactctctca
      181 tgcacttgac caaatcgcct tcagccaagc tctctctgac cgtggcggtg gactcggctc
      241 cggaggtggc agttaaggaa gatctggaga ctggagttca ccttgaccct gctgtcaaag
      301 aagttcagta taatcccacc tatgagacca tgttcgctcc tgagtttgga ccagaaaatc
      361 cctttcgaac acagcaaatg gctgccccta gaaatatgct ttctgggtat gcagagccag
      421 cacacatcaa tgacttcatg tttgaacagc aaagaaggac atttgctacg tacggctatg
      481 cactggaccc ttcgttagat aatcatcagg tgtctgctaa gtatattggc tctgtggaag
      541 aagcggagaa gaaccaaggc ttaactgtat ttgaaactgg tcagaagaaa acagaaaaga
      601 ggaaaaagtt caaagaaaat gatgcatcta atattgatgg tttcttggga ccatgggcaa
      661 aatatgtgga tgaaaaagat gtggccaaac cttcagaaga agaacaaaag gaattggatg
      721 aaatcacagc aaagaggcag aaaaaaggca aacaggaaga agagaaacct ggggaggaga
      781 agacaatctt acatgttaaa gaaatgtatg actatcaagg caggtcctac cttcacatac
      841 ctcaggatgt tggtgttaat ctacggtcat ctgtgccacc tgaaaaatgt taccttccca
      901 aaaaacaaat tcacgtgtgg tctggacaca caaagggtgt cagcgccgtc aggctctttc
      961 ctctttctgg acatttgttg ctgtcttgct ccatggactg taaaattaag ctatgggaag
     1021 tttatggaga ccggcgctgt ctgagaacat ttattggtca cagtaaagct gtgagagaca
     1081 tctgcttcaa cactgcagga acccagttcc tcagtgcggc ctacgacagg taccttaaac
     1141 tctgggacac cgagacagga cagtgtatat caagatttac aaaccgcaaa gtaccctact
     1201 gcgtcaagtt caatcccgat gaagataagc aaaatctctt tgtggctggg atgtctgata
     1261 agaagatcgt acagtgggac atccgcagtg gagagattgt tcaggaatat gatcggcatc
     1321 tgggggctgt caacacgatt gtttttgttg atgagaaccg aagattcgtg agtacatctg
     1381 atgataaaag cctacgagtt tgggaatggg atatccctgt ggattttaag tacatagcag
     1441 agcccagcat gcactcaatg cccgcagtga ctttgtctcc aaatgggaaa tggctagcat
     1501 gccagtcaat ggacaaccaa atcttaattt ttggagcaca gaacagattc agattgaata
     1561 agaagaaaat atttaagggc cacatggtag caggctacgc ttgtcaggta gacttctcac
     1621 cagacatgag ctatgtgatt tcaggagatg gaaatgggaa attaaacatc tgggactgga
     1681 agaccacaaa actctacagt cgctttaaag cccatgataa agtgtgcata ggcgcagtgt
     1741 ggcaccccca tgagacctcc aaggtcatca cgtgtggttg ggacggcctc attaagttgt
     1801 gggattaatg ggattagtcc tttcactgtc tgggatcatt tttgatccag tgtcttattt
     1861 aactatttaa ttattaaaat gtgttggatg acagtttgat ttataggtaa tcttttctta
     1921 tatggcctta tgatgttggc ctattgtttt taagagcttg gtaaatttgc ctcagagaag
     1981 ttcaatagca acttcatttt gttctttata gatgttattt atatggggaa tgacaactgg
     2041 ttatatttga caagtagtta ctgttggcag gcagttgcgt ttgtccctgt gatgtcactg
     2101 aaaggatcaa aggatcgttt tggagtgaag aaaaaaaaat gcctattgga tatgggatct
     2161 tatgggaaat gatgtagcta acgactcaga aaggtgccag gcacttaacc gacccaccca
     2221 gcagggtggc aggaatacag gcggagccac ccacagtcac ctacagtcac ctacagtcac
     2281 ctacagtcac ctacagtcac ctacagtcac ctacagtcac ctacagtcac ccacagtcac
     2341 ccacagtcac ctacagtcac ctacagtcac ctacagtcac ccacagtcac ccacagtcgc
     2401 ctacagtcac ctacagtcac ccacagtcac ccatagtcac ccacagtcac ccacagtcac
     2461 ctacagtcac ccacagtcac cgctgctgaa tcaagctctt gtcttcttcc ggttccatta
     2521 tttttatggc ctttgtattt ttacgtgtaa actagtgacc ctcattggtt gcagctttct
     2581 tctaactatt aagcaatgta aaattagaaa gcagtccgaa gttcctttct tgactctctt
     2641 cctagtcacg agagacagga ctgtgtagac ctaagcagaa agtgaggttg tctctgaagc
     2701 tggaactcaa gggaacaagc caaggctttg aatgttgctt gcaatcactg tctgtaaggc
     2761 cctggctgca cccagaaatc agggtctcag gctctgcttt gccactggat gaataataat
     2821 gagttccctc tggccagagt gtgaagacag agtccaaaat accacttgta atttctttaa
     2881 agtcacagtt ttgtccttaa aatcactctg gttttacttg tgaatataaa cagtaaaact
     2941 tttgaatgtt agaaaaaaat taaatttctt ttcagatctt tgaaaaacca ttgacattat
     3001 aagaaaatgc ctggagcccc ccagtctgaa aggccacggg gctttctctt ttttaaatca
     3061 catgctgaac attgcactgc ctagccattg ccatttctgt gtcttccagg aagggtggca
     3121 tataggagga aggaattata caaaaccatt ctgtcgtcca aaccactatt ttaacaaatg
     3181 tgaattactg gaatgtagta agagaaaaac ttcaacaaca gtattgcatg ttaacaaatc
     3241 ataatttcgt aatctcaatt tcttttattg tgtttttgac tgtttctaaa cagagtaatt
     3301 gtacataaaa gttttctctt ttttgaaaag atcctatttt tgaataaagc attcttttta
     3361 tagaaaaaaa
//
