LOCUS       NM_025950               5312 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus cell division cycle 37-like 1 (Cdc37l1), transcript
            variant 1, mRNA.
ACCESSION   NM_025950
VERSION     NM_025950.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5312)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5312)
  AUTHORS   Cartledge,K., Elsegood,C., Roiniotis,J., Hamilton,J.A. and
            Scholz,G.M.
  TITLE     Importance of the C-terminal domain of Harc for binding to Hsp70
            and Hop as well as its response to heat shock
  JOURNAL   Biochemistry 46 (51), 15144-15152 (2007)
   PUBMED   18052042
REFERENCE   3  (bases 1 to 5312)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   4  (bases 1 to 5312)
  AUTHORS   Scholz,G.M., Cartledge,K. and Hall,N.E.
  TITLE     Identification and characterization of Harc, a novel
            Hsp90-associating relative of Cdc37
  JOURNAL   J Biol Chem 276 (33), 30971-30979 (2001)
   PUBMED   11413142
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC113961.14.
            
            On Dec 11, 2019 this sequence version replaced NM_025950.3.
            
            Summary: This gene encodes a protein related to the Hsp90
            co-chaperone Cdc37. This protein may have a role in mediating
            interactions between the Hsp90 complex and other proteins.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Oct 2014].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223969.19119.1, BC031761.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-303               AC113961.14        83790-84092         c
            304-585             AC113961.14        79137-79418         c
            586-676             AC113961.14        75108-75198         c
            677-792             AC113961.14        67372-67487         c
            793-915             AC113961.14        66764-66886         c
            916-1080            AC113961.14        62406-62570         c
            1081-5312           AC113961.14        54222-58453         c
FEATURES             Location/Qualifiers
     source          1..5312
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 23.61 cM"
     gene            1..5312
                     /gene="Cdc37l1"
                     /gene_synonym="2700033A15Rik; Cdc37l; Harc"
                     /note="cell division cycle 37-like 1"
                     /db_xref="GeneID:67072"
                     /db_xref="MGI:MGI:1914322"
     exon            1..303
                     /gene="Cdc37l1"
                     /gene_synonym="2700033A15Rik; Cdc37l; Harc"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..1179
                     /gene="Cdc37l1"
                     /gene_synonym="2700033A15Rik; Cdc37l; Harc"
                     /note="isoform 1 is encoded by transcript variant 1; hsp90
                     co-chaperone Cdc37-like 1; Hsp90-associating relative of
                     Cdc37; cell division cycle 37 homolog-like 1"
                     /codon_start=1
                     /product="hsp90 co-chaperone Cdc37-like 1 isoform 1"
                     /protein_id="NP_080226.1"
                     /db_xref="CCDS:CCDS29729.1"
                     /db_xref="GeneID:67072"
                     /db_xref="MGI:MGI:1914322"
                     /translation="MEQPWPPPGPWSFPRTGGETEEESDLDVSPSSSHYSPVPDGGAQ
                     MYSHGIELACQKQKEFVKSSVACKWNLAEAQQKLGSLALHNSESLDQEHAKAQTAVSE
                     LRQREEEWRQKEEALVQRERMCLWNMDAISKDVFNKSFINQDKRKTEEEDKSQSFMQK
                     YEQKIRHFGMLSRWDDSQRFLSDHPHLVCEETAKYLILWCFHLEAEQKGALMEQIAHQ
                     AVVMQFIMEMAKNCNVDPRGCFRLFFQKAKAEEEGYFEAFKNELEAFKSRVRLYAQSQ
                     SLQPVTVQNHVPHSGVGCIGSLESLPQNPDSLQCCTPAPLCSVDSVVHKEDDDRMMDT
                     V"
     exon            304..585
                     /gene="Cdc37l1"
                     /gene_synonym="2700033A15Rik; Cdc37l; Harc"
                     /inference="alignment:Splign:2.1.0"
     exon            586..676
                     /gene="Cdc37l1"
                     /gene_synonym="2700033A15Rik; Cdc37l; Harc"
                     /inference="alignment:Splign:2.1.0"
     exon            677..792
                     /gene="Cdc37l1"
                     /gene_synonym="2700033A15Rik; Cdc37l; Harc"
                     /inference="alignment:Splign:2.1.0"
     exon            793..915
                     /gene="Cdc37l1"
                     /gene_synonym="2700033A15Rik; Cdc37l; Harc"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1080
                     /gene="Cdc37l1"
                     /gene_synonym="2700033A15Rik; Cdc37l; Harc"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..5312
                     /gene="Cdc37l1"
                     /gene_synonym="2700033A15Rik; Cdc37l; Harc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1656..1661
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdc37l1"
                     /gene_synonym="2700033A15Rik; Cdc37l; Harc"
                     /note="hexamer: AATAAA"
     polyA_site      1667
                     /gene="Cdc37l1"
                     /gene_synonym="2700033A15Rik; Cdc37l; Harc"
                     /note="major polyA site"
     regulatory      2625..2630
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdc37l1"
                     /gene_synonym="2700033A15Rik; Cdc37l; Harc"
                     /note="hexamer: AATAAA"
     polyA_site      2646
                     /gene="Cdc37l1"
                     /gene_synonym="2700033A15Rik; Cdc37l; Harc"
                     /note="major polyA site"
     regulatory      5291..5296
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdc37l1"
                     /gene_synonym="2700033A15Rik; Cdc37l; Harc"
                     /note="hexamer: AGTAAA"
     regulatory      5296..5301
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdc37l1"
                     /gene_synonym="2700033A15Rik; Cdc37l; Harc"
                     /note="hexamer: AATAAA"
     polyA_site      5307
                     /gene="Cdc37l1"
                     /gene_synonym="2700033A15Rik; Cdc37l; Harc"
     polyA_site      5312
                     /gene="Cdc37l1"
                     /gene_synonym="2700033A15Rik; Cdc37l; Harc"
ORIGIN      
        1 agtccgccgg cggcacagtc caggcctgct ccgggggtgc atcggcttcg ccaggggcag
       61 agggattctg ggtaacgacc gtggccggcc gggcggctgg ctccgcccag caggttccac
      121 tcacgccagg gccgttggcg ctggcggttg ccgggcccgg accagtggga catggagcag
      181 ccgtggccgc caccgggccc ctggagcttc ccgaggactg gcggggaaac cgaggaggag
      241 agtgacttag acgtgtcccc ctcttcgtcc cactactctc cggtaccgga cggcggcgcc
      301 cagatgtata gccacgggat tgagctggct tgccaaaagc agaaagaatt tgtgaagagc
      361 tctgttgcat gtaaatggaa tcttgctgaa gcccagcaga aacttggcag cttagcactg
      421 cataactctg agtccttgga tcaggaacac gccaaagcac agaccgcggt gtcagaactg
      481 aggcagcggg aagaagagtg gcgacagaaa gaagaggctc tggtccaaag agagaggatg
      541 tgtctctgga acatggatgc cattagcaag gatgttttta ataagagttt tattaatcaa
      601 gataaaagaa aaacagaaga ggaagataaa tcacaatcat ttatgcagaa atatgagcaa
      661 aaaatcagac attttggtat gttgagtcgc tgggatgaca gtcagaggtt tttgtctgac
      721 cacccacacc tcgtatgtga agagactgct aaatatctta ttttatggtg tttccaccta
      781 gaagctgagc agaaaggcgc tctaatggaa cagatagcac accaagctgt ggtaatgcag
      841 tttattatgg aaatggccaa aaactgcaat gtggatccaa gaggctgttt tcgtttgttt
      901 ttccagaaag ccaaagcgga ggaagaaggt tattttgaag cattcaaaaa tgaacttgaa
      961 gctttcaagt caagagtaag actttacgct caatcacaaa gcttgcagcc tgtgacagtt
     1021 cagaatcatg tcccccattc tggtgttgga tgcataggct ccttagaatc cttaccacag
     1081 aatccagatt ctcttcagtg ttgtacccct gcccctctgt gcagtgtaga ctcagtggta
     1141 cacaaagaag atgatgaccg aatgatggac actgtgtgac tcagctagac tgctgagccc
     1201 aaggactagt ttgttacgag aaaggaagag cctggctatt ttcttgacac ttttatgggt
     1261 gctgcacttt atttttgttt ggttttatgg gagggaaaga gtactgaaat gttttgcaac
     1321 tttttttatg tgctgctagg gtttttgttg ttgttgtttt gtttctgaag ggaggagtgg
     1381 taaccatatg tggcaggaag tcaaactgga cagactctcc cccacccctc agttactaaa
     1441 tttgccttta actattctta tttttggaat caaagtatga aaatctgcac aacacaatgt
     1501 ttacaagact ggttgactga ggagatgtct gctacacggt ctttttctta catggatata
     1561 catgtcctac ttcgaggaag gaattcaaga taaaagtatg ctgtgtccca ctgcaaagtt
     1621 cagctgtcaa atctggtatt catcacatta aaagcaataa atccgcagtg gtgacctact
     1681 ttactaatta gtaagctggg tggcacaaat tgctatttta agacatttac gtttgtattt
     1741 tcggcaccac cagttaactc cttggctagt ataaatttga tattaaaaac attacattta
     1801 tccctaaagt agtctcaaaa ctgttcagaa gttgactttg tcctgatgac tgtttaaata
     1861 ttaagcaggc agtgagtgta gaaaatgata gttttctgtt tttccaagaa gataaaatgc
     1921 aagcttactc taatctactt gacatagtcc gggacctctc agggagtaag ttttaaaaga
     1981 atagtaacgg cctgtaagaa caaacaggaa gagtaaggtc cttgttaaat cacagccact
     2041 gtgttccatg tggtgaagcc ttgagaagtg ggagctgagc tgccagccat gcctaaggat
     2101 tgctaacagc cccttcaaag gcggtgacgg gtctcactat ctgctactcg cttctagctc
     2161 agttactaga ggatgcctct gagttttact gcttcctgtg taattcattg cagatccacc
     2221 aggatgtttg atgattcttt tatttagaat tagatgacag tgccaattat gatatcctta
     2281 ttatttgagg attaatcttc cagcatacag gagcgctagc tttggttatt tttgagtgtg
     2341 atttttggct cagtacccac ttcaatttgt agcaaatatt tggaaagtgg gtacccaggg
     2401 tttggaaatg caggtctcag tttgagttaa gaaatcatgc taaggggcca tgggggctca
     2461 gagctgtggc ctccgcctca gctgtccttt tcagccgatg gggcacctaa ccctgtggaa
     2521 atggactgga attgttgaat catacttctg taatgtcaca ctcttcctag ttcccagaat
     2581 aaaagtcttt ttgtgctttt gatataaata tatatatact ctataataaa atgtctgact
     2641 aatttatatg gcagtgctca ctggcttata agtttctttt aaatcagtga cctagtcatt
     2701 gaagttattt gttttatttt tttctctctt cctttttctt cttgtctgga gcatgctctg
     2761 agtttccctc tgataccaag tggacagaat agaacacagt agatccctga tttcacagaa
     2821 gtagctcttg actgaccacc ttccacttca cttctgccca tgacttgtct atggtcaccc
     2881 aagtggccgt agctttcatt ttgtcttcta taatttaaag ctcttgatgg ccaaaacaac
     2941 aacaacaaca acaacaaaag tattagcaaa gtgagtatat aattttaaag tttattttgg
     3001 ttttgttatc taaaacaaga attaagaaaa cttttttaat actcggctgg aacttttttg
     3061 ccaaaggaat cactaacgga tgtcataatt tgcacttaag gatgggaact tgaccattag
     3121 caggacttca gtattaaggt gatctattag gctgtgtgtg gtcgtgcatg gctttaatcc
     3181 cagcgcttgg gaggcagagg ctggtttatc tttccgagtt caaggacagc cagagctaca
     3241 tagagagact gtctcaagac aaaatgacag tcttttggag tccttcgatt tccttgattt
     3301 gaaaatgtcc tcttagtatt gagctagcta tctccagaaa gaatactcct ctcttttctt
     3361 aagtaataaa gaataatact acttatcaaa tagataactc atatttcaag tgaaaaattt
     3421 ttccctaatc tatgagaaat tcaaactaat cacttaatca atgaaaaata gttgacatca
     3481 aagttattta acaaagacta ttgtgttttt tcttttaatt tttaatttac tttatttatc
     3541 tgagtatact gtagttgtct tcaaacacac cagaagaggg cattggatct cattacagat
     3601 ggttgtgagc catcaggtgg ttgctgggaa tggaacgcag gacctctgga agagcagtca
     3661 gtctcttgac tgctaagcca tctctccagc tcccaaagac tgttgtttta ttttaatgaa
     3721 atagctgagg gcttagaatg gttcagttgg tagagctctc gcctaagatt caatgagccc
     3781 ttgattgcat cctcaccacc acataaactg ggcacggtgg cacatacctg cggccttagt
     3841 gctggggatg tgaagacggg agggttagag gtgcatagtt tccctcagct acatagcaaa
     3901 tttcacagcc agccttctgc ctagatgaaa ctctgtctta gaagaagaga gacagaaaga
     3961 aatagctgta ctccatgtgt cctaagagct gttgttccat cgaatggtag tggagaacat
     4021 actgattaga attattgctc tgagattcgc ttttaattac accatctatg gttctttcaa
     4081 aattttttgc ctaagaaact tataatagcc tttaatttct cttcagaaac attaggcctt
     4141 ttttagacta gcatgcatat tattgtaaaa gcgagtaaga gcgcttgaga tggctcactt
     4201 ggtaaaggtg cttgctgcca agcctgccaa tctgtgggac ctaaatggtg ggaagagaaa
     4261 gccagcttcc tcacgcttca tccaaccttc atacatgtgc agagcataca cacacacaca
     4321 cacgagtttt atctttactt ttaaaaaatg tattaagtaa attaacatgc ttcccccgag
     4381 agcacacatc tctgttaata agtggtctcc ttatagtgga aatgccagcg aggtgttctc
     4441 agaagagtca agtgagttac tgctctcaga gggagacaca tttcagttct taagttggtg
     4501 aggagcagaa gtggtacttg tctggactgg ggtgggtttt tacttccctt tttccagcat
     4561 agcatccaca ttttagcaag aagatcctta catcctacag catcctgatt cccctctata
     4621 atgggtgtta ctgtacgatt tcatagcttg tccagaaaaa atggtctgtc tggtattagt
     4681 tggcttacag tgtcatttaa tgggaaatta caaagagaat taaattttga ctatagattg
     4741 gtgctgtata cagagaaccc catgatgttt agggagctat aaaaagtggg gctatgggtg
     4801 gagagatggc tcagtgctta aaagtggtta aaaaattctg gctgctcttc cagtggtcct
     4861 gagttcagtt cccagctacc acatgatggc tcacagccat ctacagtggg atctgacgcc
     4921 ctctgctgga gtgcaggtgc acatgcagat agagcactca tacataaaat ttataaacaa
     4981 atcttaagaa ctattaaaaa ggaaaagcca gcaggggcta gagagatggc tcattggtta
     5041 agagcacttg ctgctctggc agaggccaga gtttgatgtc cagcgcccgt ggctgatggt
     5101 tgacaagctc ctgtaactcc cattccctcc aacaccctcc catagcttct gcaggtatcc
     5161 atacatgcgc acagaagcga ataaataata aaatattttt tcaaaaaaat tgtaggggaa
     5221 tgctaaaacc ttactggctt ttactaatac tttttaaacc cagctagacg attttaattg
     5281 tttaaaataa agtaaaataa aattgaatcc aa
//
