LOCUS       NM_001378796            1741 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus cell division cycle 37 (Cdc37), transcript variant 1,
            mRNA.
ACCESSION   NM_001378796 XM_006509967
VERSION     NM_001378796.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1741)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1741)
  AUTHORS   McKenzie,M.G., Cobbs,L.V., Dummer,P.D., Petros,T.J., Halford,M.M.,
            Stacker,S.A., Zou,Y., Fishell,G.J. and Au,E.
  TITLE     Non-canonical Wnt Signaling through Ryk Regulates the Generation of
            Somatostatin- and Parvalbumin-Expressing Cortical Interneurons
  JOURNAL   Neuron 103 (5), 853-864 (2019)
   PUBMED   31257105
REFERENCE   3  (bases 1 to 1741)
  AUTHORS   Chen,B., Wei,W., Ma,L., Yang,B., Gill,R.M., Chua,M.S., Butte,A.J.
            and So,S.
  TITLE     Computational Discovery of Niclosamide Ethanolamine, a Repurposed
            Drug Candidate That Reduces Growth of Hepatocellular Carcinoma
            Cells In Vitro and in Mice by Inhibiting Cell Division Cycle 37
            Signaling
  JOURNAL   Gastroenterology 152 (8), 2022-2036 (2017)
   PUBMED   28284560
  REMARK    GeneRIF: Niclosamide ethanolamine disrupted the interaction between
            cell division cycle 37 and heat shock protein 90 in hepatocellular
            carcinoma, reducing tumor growth.
REFERENCE   4  (bases 1 to 1741)
  AUTHORS   Xu,Y., Liu,F., Liu,J., Wang,D., Yan,Y., Ji,S., Zan,J. and Zhou,J.
  TITLE     The co-chaperone Cdc37 regulates the rabies virus phosphoprotein
            stability by targeting to Hsp90AA1 machinery
  JOURNAL   Sci Rep 6, 27123 (2016)
   PUBMED   27251758
  REMARK    GeneRIF: Results showed that Cdc37 acts as a bridge to direct Hsp90
            to the transcription factor viral P proteins of all lyssaviruses.
            Although Cdc37 can load P proteins onto Hsp90, with or without
            binding to Hsp90, the interaction between Cdc37 and Hsp90 appears
            to provide additional allosterical regulation of its chaperone
            activity. Notably, both phosphorylated and non-P Cdc37 could
            facilitate Hsp90-mediated protein maturation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1741)
  AUTHORS   Erazo,T., Moreno,A., Ruiz-Babot,G., Rodriguez-Asiain,A.,
            Morrice,N.A., Espadamala,J., Bayascas,J.R., Gomez,N. and
            Lizcano,J.M.
  TITLE     Canonical and kinase activity-independent mechanisms for
            extracellular signal-regulated kinase 5 (ERK5) nuclear
            translocation require dissociation of Hsp90 from the ERK5-Cdc37
            complex
  JOURNAL   Mol Cell Biol 33 (8), 1671-1686 (2013)
   PUBMED   23428871
REFERENCE   6  (bases 1 to 1741)
  AUTHORS   Wang,H., Goode,T., Iakova,P., Albrecht,J.H. and Timchenko,N.A.
  TITLE     C/EBPalpha triggers proteasome-dependent degradation of cdk4 during
            growth arrest
  JOURNAL   EMBO J 21 (5), 930-941 (2002)
   PUBMED   11867521
REFERENCE   7  (bases 1 to 1741)
  AUTHORS   Scholz,G.M., Cartledge,K. and Hall,N.E.
  TITLE     Identification and characterization of Harc, a novel
            Hsp90-associating relative of Cdc37
  JOURNAL   J Biol Chem 276 (33), 30971-30979 (2001)
   PUBMED   11413142
REFERENCE   8  (bases 1 to 1741)
  AUTHORS   Stepanova,L., Finegold,M., DeMayo,F., Schmidt,E.V. and Harper,J.W.
  TITLE     The oncoprotein kinase chaperone CDC37 functions as an oncogene in
            mice and collaborates with both c-myc and cyclin D1 in
            transformation of multiple tissues
  JOURNAL   Mol Cell Biol 20 (12), 4462-4473 (2000)
   PUBMED   10825210
REFERENCE   9  (bases 1 to 1741)
  AUTHORS   Perdew,G.H., Wiegand,H., Vanden Heuvel,J.P., Mitchell,C. and
            Singh,S.S.
  TITLE     A 50 kilodalton protein associated with raf and pp60(v-src) protein
            kinases is a mammalian homolog of the cell cycle control protein
            cdc37
  JOURNAL   Biochemistry 36 (12), 3600-3607 (1997)
   PUBMED   9132011
REFERENCE   10 (bases 1 to 1741)
  AUTHORS   Stepanova,L., Leng,X., Parker,S.B. and Harper,J.W.
  TITLE     Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90
            that binds and stabilizes Cdk4
  JOURNAL   Genes Dev 10 (12), 1491-1502 (1996)
   PUBMED   8666233
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163637.4.
            
            On Mar 11, 2020 this sequence version replaced XM_006509967.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219382.36458.1,
                                           SRR11927937.4832930.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-179               AC163637.4         117241-117419
            180-458             AC163637.4         123950-124228
            459-714             AC163637.4         124498-124753
            715-830             AC163637.4         124847-124962
            831-953             AC163637.4         125042-125164
            954-1136            AC163637.4         126040-126222
            1137-1208           AC163637.4         126346-126417
            1209-1741           AC163637.4         127212-127744
FEATURES             Location/Qualifiers
     source          1..1741
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 7.72 cM"
     gene            1..1741
                     /gene="Cdc37"
                     /gene_synonym="p50; p50Cdc37"
                     /note="cell division cycle 37"
                     /db_xref="GeneID:12539"
                     /db_xref="MGI:MGI:109531"
     exon            1..179
                     /gene="Cdc37"
                     /gene_synonym="p50; p50Cdc37"
                     /inference="alignment:Splign:2.1.0"
     exon            180..458
                     /gene="Cdc37"
                     /gene_synonym="p50; p50Cdc37"
                     /inference="alignment:Splign:2.1.0"
     exon            459..714
                     /gene="Cdc37"
                     /gene_synonym="p50; p50Cdc37"
                     /inference="alignment:Splign:2.1.0"
     exon            715..830
                     /gene="Cdc37"
                     /gene_synonym="p50; p50Cdc37"
                     /inference="alignment:Splign:2.1.0"
     exon            831..953
                     /gene="Cdc37"
                     /gene_synonym="p50; p50Cdc37"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1136
                     /gene="Cdc37"
                     /gene_synonym="p50; p50Cdc37"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1208
                     /gene="Cdc37"
                     /gene_synonym="p50; p50Cdc37"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1741
                     /gene="Cdc37"
                     /gene_synonym="p50; p50Cdc37"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1719..1724
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdc37"
                     /gene_synonym="p50; p50Cdc37"
                     /note="hexamer: AATAAA"
     polyA_site      1741
                     /gene="Cdc37"
                     /gene_synonym="p50; p50Cdc37"
                     /note="major polyA site"
ORIGIN      
        1 ctctagccct tgtgggtccc tgttcagcgc ccggccgtgt ggagccccgg gagccagtcc
       61 gggcctccga agcgaagatg gtggactaca gcgtttggga tcacatcgag gtgtcggacg
      121 atgaggacga gacgcacccc aacatagaca ctgccagcct cttccgctgg cggcaccagg
      181 cccgggtgga acgcatggag cagtttcaga aggagaaaga ggaactggac cggggctgcc
      241 gggagtgcaa gcgcaaggta gccgagtgcc agcgcaagct gaaggagctg gaagtggctg
      301 agagcgatgg ccaggtggag cttgagcggc tgagagctga ggcacagcaa ctgcgcaagg
      361 aggagcggag ctgggagcag aagctggaag acatgcgcaa aaaggagaag aacatgccct
      421 ggaatgtgga cacgctcagc aaagatggct ttagcaaggc ccgcggccat gcctccgcca
      481 ccttgatgca cttagcgacg ccaccgcctc cgatgtggac aggatgggcg cggcggccac
      541 ggcccccaaa ccccaggcgc acccctgcct tgccccagcc cacttgccct ctcaccctgt
      601 cacagagcat ggtcaatacc aagcctgaga aggcagagga ggactcagag gaggcaaggg
      661 agcagaaaca caagaccttc gttgaaaaat atgagaaaca gatcaagcat ttcggcatgc
      721 tccaccgctg ggatgacagc cagaaatacc tgtcggacaa cgtccacctg gtgtgtgagg
      781 aaacggccaa ctacctggtt atctggtgca ttgacctgga ggtagaggag aaatgtgcac
      841 tgatggagca ggtagctcac cagaccatgg tgatgcagtt tattctggag ctggccaaga
      901 gtctgaaggt cgacccccga gcctgcttcc ggcagttttt caccaagatc aagaccgctg
      961 accaccagta catggagggc ttcaagtatg aactggaagc ctttaaggag cgagtgcggg
     1021 gccgcgccaa gctgcgaata gagaaggcca tgaaggaata tgaagaggag gagcgcaaga
     1081 agaggctagg ccctggtggc ctggaccccg tggaggtcta cgaatccctg cctgaggagc
     1141 tgcagaagtg ctttgatgtg aaggatgtac agatgctgca agacgccatc agcaaaatgg
     1201 atcccactga tgccaagtat cacatgcagc gttgcatcga ttctggcctc tgggtcccca
     1261 actccaagtc tggtgaggcc aaggaggggg aggaggcggg ccccggggac ccattgctgg
     1321 aagccgtccc caaagcgggc aacgagaaag acgtcagtgc gtgacccttc tccggaaaag
     1381 gaaacttagc caccatgtcc ctagctccca acttcttcac ttgtgctgct cctcacatcc
     1441 tggcccatgg cctgccccgt gtcccctctc ctcccacctg tccccagcgc tcatcagact
     1501 ctctgcttcg ggttgagggg ctctgctgtc tgcagcctcc tacccccatc agcgttatgc
     1561 caaagtcctg ggggcctggg gaggggcagc agttgccagg ttggtccacc gggttgggga
     1621 tacaaatgtc cccatctagg caaggtctgt ccctatgggt ctatggtcac tgtttttctt
     1681 ctgtctagct tcctgtcctg caactggcaa caatgtccaa taaacagttc caggtgctgg
     1741 a
//
