LOCUS       NM_177613               1295 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus cell division cycle 34 (Cdc34), transcript variant 1,
            mRNA.
ACCESSION   NM_177613 XM_913571 XM_922791 XM_922795 XM_922801 XM_922808
            XM_922814 XM_922817
VERSION     NM_177613.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1295)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1295)
  AUTHORS   Gray,S., Santiago,E.R., Chappie,J.S. and Cohen,P.E.
  TITLE     Cyclin N-Terminal Domain-Containing-1 Coordinates Meiotic Crossover
            Formation with Cell-Cycle Progression in a Cyclin-Independent
            Manner
  JOURNAL   Cell Rep 32 (1), 107858 (2020)
   PUBMED   32640224
REFERENCE   3  (bases 1 to 1295)
  AUTHORS   Cao,Y., Li,M., Liu,F., Ni,X., Wang,S., Zhang,H., Sui,X. and Huo,R.
  TITLE     Deletion of maternal UHRF1 severely reduces mouse oocyte quality
            and causes developmental defects in preimplantation embryos
  JOURNAL   FASEB J 33 (7), 8294-8305 (2019)
   PUBMED   30995416
REFERENCE   4  (bases 1 to 1295)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 1295)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 1295)
  AUTHORS   Campbell,P.K., Waymire,K.G., Heier,R.L., Sharer,C., Day,D.E.,
            Reimann,H., Jaje,J.M., Friedrich,G.A., Burmeister,M.,
            Bartness,T.J., Russell,L.D., Young,L.J., Zimmer,M., Jenne,D.E. and
            MacGregor,G.R.
  TITLE     Mutation of a novel gene results in abnormal development of
            spermatid flagella, loss of intermale aggression and reduced body
            fat in mice
  JOURNAL   Genetics 162 (1), 307-320 (2002)
   PUBMED   12242242
REFERENCE   7  (bases 1 to 1295)
  AUTHORS   Dave,V., Zhao,C., Yang,F., Tung,C.S. and Ma,J.
  TITLE     Reprogrammable recognition codes in bicoid homeodomain-DNA
            interaction
  JOURNAL   Mol Cell Biol 20 (20), 7673-7684 (2000)
   PUBMED   11003663
REFERENCE   8  (bases 1 to 1295)
  AUTHORS   Puttagunta,R., Gordon,L.A., Meyer,G.E., Kapfhamer,D.,
            Lamerdin,J.E., Kantheti,P., Portman,K.M., Chung,W.K., Jenne,D.E.,
            Olsen,A.S. and Burmeister,M.
  TITLE     Comparative maps of human 19p13.3 and mouse chromosome 10 allow
            identification of sequences at evolutionary breakpoints
  JOURNAL   Genome Res 10 (9), 1369-1380 (2000)
   PUBMED   10984455
REFERENCE   9  (bases 1 to 1295)
  AUTHORS   Ohta,T., Michel,J.J., Schottelius,A.J. and Xiong,Y.
  TITLE     ROC1, a homolog of APC11, represents a family of cullin partners
            with an associated ubiquitin ligase activity
  JOURNAL   Mol Cell 3 (4), 535-541 (1999)
   PUBMED   10230407
REFERENCE   10 (bases 1 to 1295)
  AUTHORS   Plon,S.E., Leppig,K.A., Do,H.N. and Groudine,M.
  TITLE     Cloning of the human homolog of the CDC34 cell cycle gene by
            complementation in yeast
  JOURNAL   Proc Natl Acad Sci U S A 90 (22), 10484-10488 (1993)
   PUBMED   8248134
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC039160.1.
            
            On or before Dec 7, 2005 this sequence version replaced
            XM_922791.1, XM_922795.1, XM_922801.1, XM_922808.1, XM_922814.1,
            XM_922817.1, XM_913571.1, NM_177613.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC039160.1, CA984649.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1295
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..1295
                     /gene="Cdc34"
                     /gene_synonym="E2-CDC34; UBE2R1"
                     /note="cell division cycle 34"
                     /db_xref="GeneID:216150"
                     /db_xref="MGI:MGI:102657"
     exon            1..396
                     /gene="Cdc34"
                     /gene_synonym="E2-CDC34; UBE2R1"
                     /inference="alignment:Splign:2.1.0"
     CDS             220..927
                     /gene="Cdc34"
                     /gene_synonym="E2-CDC34; UBE2R1"
                     /EC_number="2.3.2.23"
                     /EC_number="2.3.2.24"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ubiquitin-conjugating enzyme Cdc34; ubiquitin-conjugating
                     enzyme E2 R1; ubiquitin-protein ligase R1;
                     ubiquitin-conjugating enzyme E2-32 kDa complementing;
                     ubiquitin-conjugating enzyme E2-CDC34; cell division cycle
                     34 homolog; E2 ubiquitin-conjugating enzyme R1;
                     (E3-independent) E2 ubiquitin-conjugating enzyme R1"
                     /codon_start=1
                     /product="ubiquitin-conjugating enzyme E2 R1 isoform 1"
                     /protein_id="NP_808281.1"
                     /db_xref="CCDS:CCDS23983.1"
                     /db_xref="GeneID:216150"
                     /db_xref="MGI:MGI:102657"
                     /translation="MARPLVPSSQKALLLELKGLQEEPVEGFRVTLVDEGDLYNWEVA
                     IFGPPNTYYEGGYFKARLKFPIDYPYSPPAFRFLTKMWHPNIYETGDVCISILHPPVD
                     DPQSGELPSERWNPTQNVRTILLSVISLLNEPNTFSPANVDASVMYRKWKESKGKDRE
                     YTDIIRKQVLGTKVDAERDGVKVPTTLAEYCVKTKAPAPDEGSDLFYDDYYEDGEVEE
                     ADSCFGDEEDDSGTEES"
     exon            397..483
                     /gene="Cdc34"
                     /gene_synonym="E2-CDC34; UBE2R1"
                     /inference="alignment:Splign:2.1.0"
     exon            484..581
                     /gene="Cdc34"
                     /gene_synonym="E2-CDC34; UBE2R1"
                     /inference="alignment:Splign:2.1.0"
     exon            582..716
                     /gene="Cdc34"
                     /gene_synonym="E2-CDC34; UBE2R1"
                     /inference="alignment:Splign:2.1.0"
     exon            717..1266
                     /gene="Cdc34"
                     /gene_synonym="E2-CDC34; UBE2R1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      941..946
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdc34"
                     /gene_synonym="E2-CDC34; UBE2R1"
                     /note="hexamer: AATAAA"
     polyA_site      964
                     /gene="Cdc34"
                     /gene_synonym="E2-CDC34; UBE2R1"
     regulatory      1241..1246
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdc34"
                     /gene_synonym="E2-CDC34; UBE2R1"
                     /note="hexamer: AATAAA"
     regulatory      1246..1251
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdc34"
                     /gene_synonym="E2-CDC34; UBE2R1"
                     /note="hexamer: AATAAA"
     polyA_site      1263
                     /gene="Cdc34"
                     /gene_synonym="E2-CDC34; UBE2R1"
                     /note="major polyA site"
     polyA_site      1266
                     /gene="Cdc34"
                     /gene_synonym="E2-CDC34; UBE2R1"
                     /note="major polyA site"
ORIGIN      
        1 cgcgggccgg gccgggccga agcgagcgcc gggcgggcag cggcgccaga gcgagtggag
       61 ccttcggggt ccccgggtgg cggcggcggc ggcggtgcag aggaggaagg cggcggctct
      121 ccccctgccg gcgcgcgacc cggtccgtct cgcgagctcg cgccggtccc gcggcccggc
      181 ccggccccgg gcccctccgt cgccgccgcc gccaccgcca tggcccggcc gctggtgcca
      241 agctcgcaga aggcgctgct gctggaactg aaggggctgc aggaggagcc ggtggagggc
      301 ttccgggtga cgctggtgga cgagggtgac ctgtacaact gggaggtggc catcttcggg
      361 ccccccaaca cctactatga gggcggctac ttcaaggctc gcctcaagtt ccccatcgac
      421 tacccgtatt ccccaccagc cttccggttc ctcaccaaga tgtggcaccc aaacatctat
      481 gagacagggg acgtgtgcat ctccattctc catcccccag ttgacgaccc acagagtggg
      541 gagctgccct cagagcggtg gaaccccaca cagaatgtca gaaccatcct cctgagtgta
      601 atttcgctgc tgaatgagcc caacaccttc tcgcctgcca acgtggacgc ctcggtgatg
      661 tacagaaaat ggaaggagag caaggggaag gaccgcgagt acacggacat catccggaag
      721 caggtcctgg ggaccaaggt ggacgcggag cgcgatggtg tgaaggtgcc cactacgctg
      781 gccgagtact gcgtgaagac caaggcgccg gcgcccgacg agggctcgga cctcttctac
      841 gacgactact atgaggacgg cgaagtggag gaggccgaca gctgctttgg ggatgaagag
      901 gatgactctg gcaccgaaga gtcctgaccc acgtccctga aataaactta caaattttac
      961 ctcagcagga cccgtgtggg cctcaggcga cagactacct caccgaggtt ccatgtgggc
     1021 tcccatccca tgatccttag gtcctcttac cccgtattcc ccatgggttt tcctcggctt
     1081 tggagaagag ctgtggtgca gggcaaacac cccactcagc tttcagatga tgacaagcct
     1141 gggaggctgg ggaccgactg cctggtgggg agccagagac tccagcccag cccaaggaag
     1201 gccagcacca cagtctcctc tctgcttttg gtgtgtgtga aataaaataa aatagctttc
     1261 tgagaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
