LOCUS       NM_009860               1945 bp    mRNA    linear   ROD 07-MAY-2024
DEFINITION  Mus musculus cell division cycle 25C (Cdc25c), mRNA.
ACCESSION   NM_009860
VERSION     NM_009860.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1945)
  AUTHORS   Zhou,X., Lu,D., Yi,W. and Xu,D.
  TITLE     Downregulation of CDC25C in NPCs Disturbed Cortical Neurogenesis
  JOURNAL   Int J Mol Sci 24 (2), 1505 (2023)
   PUBMED   36675024
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1945)
  AUTHORS   Tampakakis,E., Gangrade,H., Glavaris,S., Htet,M., Murphy,S.,
            Lin,B.L., Liu,T., Saberi,A., Miyamoto,M., Kowalski,W.,
            Mukouyama,Y.S., Lee,G., Minichiello,L. and Kwon,C.
  TITLE     Heart neurons use clock genes to control myocyte proliferation
  JOURNAL   Sci Adv 7 (49), eabh4181 (2021)
   PUBMED   34851661
REFERENCE   3  (bases 1 to 1945)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1945)
  AUTHORS   Gomez-Redondo,I., Ramos-Ibeas,P., Pericuesta,E.,
            Fernandez-Gonzalez,R., Laguna-Barraza,R. and Gutierrez-Adan,A.
  TITLE     Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for Early
            Embryo Development and 2-Cell-Like Conversion
  JOURNAL   Int J Mol Sci 21 (11), 4115 (2020)
   PUBMED   32527007
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1945)
  AUTHORS   Cheong,A., Archambault,D., Degani,R., Iverson,E., Tremblay,K.D. and
            Mager,J.
  TITLE     Nuclear-encoded mitochondrial ribosomal proteins are required to
            initiate gastrulation
  JOURNAL   Development 147 (10) (2020)
   PUBMED   32376682
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1945)
  AUTHORS   Lock,L.F., Wickramasinghe,D., Ernst,M.K., Gilbert,D.J.,
            Copeland,N.G., Jenkins,N.A. and Donovan,P.J.
  TITLE     The Cdc25 genes map to mouse chromosomes 2, 9, and 18
  JOURNAL   Mamm Genome 7 (10), 771-772 (1996)
   PUBMED   8854867
REFERENCE   7  (bases 1 to 1945)
  AUTHORS   Wu,S. and Wolgemuth,D.J.
  TITLE     The distinct and developmentally regulated patterns of expression
            of members of the mouse Cdc25 gene family suggest differential
            functions during gametogenesis
  JOURNAL   Dev Biol 170 (1), 195-206 (1995)
   PUBMED   7601309
REFERENCE   8  (bases 1 to 1945)
  AUTHORS   Nargi,J.L. and Woodford-Thomas,T.A.
  TITLE     Cloning and characterization of a cdc25 phosphatase from mouse
            lymphocytes
  JOURNAL   Immunogenetics 39 (2), 99-108 (1994)
   PUBMED   8276463
REFERENCE   9  (bases 1 to 1945)
  AUTHORS   Yokoi,H., Natsuyama,S., Iwai,M., Noda,Y., Mori,T., Mori,K.J.,
            Fujita,K., Nakayama,H. and Fujita,J.
  TITLE     Non-radioisotopic quantitative RT-PCR to detect changes in mRNA
            levels during early mouse embryo development
  JOURNAL   Biochem Biophys Res Commun 195 (2), 769-775 (1993)
   PUBMED   7690561
REFERENCE   10 (bases 1 to 1945)
  AUTHORS   Sartor,H., Ehlert,F., Grzeschik,K.H., Muller,R. and Adolph,S.
  TITLE     Assignment of two human cell cycle genes, CDC25C and CCNB1, to 5q31
            and 5q12, respectively
  JOURNAL   Genomics 13 (3), 911-912 (1992)
   PUBMED   1386342
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK141737.1 and AC145591.5.
            
            On Dec 6, 2014 this sequence version replaced NM_009860.2.
            
            Summary: This gene encodes a dual specificity phosphatase that
            dephosphorylates cyclin B-bound Cdk1 to trigger entry into mitosis.
            [provided by RefSeq, Dec 2014].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK141737.1, AK168287.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1941              AK141737.1         1-1941
            1942-1945           AC145591.5         44250-44253
FEATURES             Location/Qualifiers
     source          1..1945
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 18.71 cM"
     gene            1..1945
                     /gene="Cdc25c"
                     /gene_synonym="Cdc25"
                     /note="cell division cycle 25C"
                     /db_xref="GeneID:12532"
                     /db_xref="MGI:MGI:88350"
     exon            1..220
                     /gene="Cdc25c"
                     /gene_synonym="Cdc25"
                     /inference="alignment:Splign:2.1.0"
     exon            221..318
                     /gene="Cdc25c"
                     /gene_synonym="Cdc25"
                     /inference="alignment:Splign:2.1.0"
     exon            319..544
                     /gene="Cdc25c"
                     /gene_synonym="Cdc25"
                     /inference="alignment:Splign:2.1.0"
     CDS             354..1697
                     /gene="Cdc25c"
                     /gene_synonym="Cdc25"
                     /EC_number="3.1.3.48"
                     /note="cell cycle phosphatase CDC25C; dual specificity
                     phosphatase Cdc25C; cell division cycle control protein
                     25C"
                     /codon_start=1
                     /product="M-phase inducer phosphatase 3"
                     /protein_id="NP_033990.2"
                     /db_xref="CCDS:CCDS37759.1"
                     /db_xref="GeneID:12532"
                     /db_xref="MGI:MGI:88350"
                     /translation="MSTGPIPPASEEGSFVSAPSFRSKQRKILHLLLERNTSFTIRSD
                     FPESPKDKLHDSANLSILSGGTPKCCLDLSNLSSGEMSASPLTTSADLEDNGSLDSSG
                     PLDRQLTGKDFHQDLMKGIPVQLLCSTPNAMNHGHRKKIAKRSTSAHKENINTSLKAL
                     EWEAPRTPRFRKMPGGPLTSPLCELEMKHLGSPITTVPKLSQNVKLEDQERISEDPME
                     CSLGDQDAKGLSLRKMVPLCDMNAIQMEEEESGSELLIGDFSKVCVLPTVPGKHPDLK
                     YISPDTVAALLSGKFQSVIERFYIIDCRYPYEYLGGHILGALNLHSQKELHEFFLRKP
                     VVPLDIQKRVIIVFLCEFSSERGPRMCRSLREKDRALNQYPALYYPELYILKGGYRDF
                     FPEYMELCDPQSYCPMLHQDHQAELLSWRSQSKAQEGERQLQGQIALLVKGASPQ"
     exon            545..639
                     /gene="Cdc25c"
                     /gene_synonym="Cdc25"
                     /inference="alignment:Splign:2.1.0"
     exon            640..685
                     /gene="Cdc25c"
                     /gene_synonym="Cdc25"
                     /inference="alignment:Splign:2.1.0"
     exon            686..719
                     /gene="Cdc25c"
                     /gene_synonym="Cdc25"
                     /inference="alignment:Splign:2.1.0"
     exon            720..809
                     /gene="Cdc25c"
                     /gene_synonym="Cdc25"
                     /inference="alignment:Splign:2.1.0"
     exon            810..908
                     /gene="Cdc25c"
                     /gene_synonym="Cdc25"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1034
                     /gene="Cdc25c"
                     /gene_synonym="Cdc25"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1136
                     /gene="Cdc25c"
                     /gene_synonym="Cdc25"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1199
                     /gene="Cdc25c"
                     /gene_synonym="Cdc25"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1298
                     /gene="Cdc25c"
                     /gene_synonym="Cdc25"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1432
                     /gene="Cdc25c"
                     /gene_synonym="Cdc25"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1544
                     /gene="Cdc25c"
                     /gene_synonym="Cdc25"
                     /inference="alignment:Splign:2.1.0"
     exon            1545..1945
                     /gene="Cdc25c"
                     /gene_synonym="Cdc25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1934..1939
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdc25c"
                     /gene_synonym="Cdc25"
                     /note="hexamer: ATTAAA"
     polyA_site      1945
                     /gene="Cdc25c"
                     /gene_synonym="Cdc25"
                     /note="major polyA site"
ORIGIN      
        1 ggctttgcct tcaggccatc tccggagaga agaagcaaag ctgaacctcg ggccacgtag
       61 atgcaatttt aacccgaaga atcgcttctg ttcctcagat cccttgtcat tctgtggagt
      121 cttcgcttac gtccagtcct gcaggaggtt ttttgttttt tttttgtttt ttttttgttt
      181 ttttaatctc acaaaattca agtcggcctt taaacttaag atcggtttct tctggtcaag
      241 agtgtgaaac tgcgtggtcc ggatcaagcc agtgttctct tcgttccacc tttgaagtcc
      301 tgagcttgcc tgacgtctat agccccacct ccctcggtga agactctgaa gtcatgtcta
      361 caggacctat cccacctgca agtgaagagg gaagttttgt ttcagcaccc agttttaggt
      421 ccaaacaaag gaagatatta cacctacttt tggagagaaa cacttctttt accatccgtt
      481 cagatttccc tgaatctccg aaagacaaac tccacgactc ggcaaaccta agcattctgt
      541 cgggaggaac cccaaaatgt tgccttgacc tttcgaatct tagcagtgga gagatgtctg
      601 cctctccgct tactacttct gctgaccttg aggacaatgg ttccttggat tcatctggac
      661 ctctggatag acagttaact ggcaaggatt ttcaccagga ccttatgaaa ggtatcccag
      721 tacagcttct ttgtagtact ccgaatgcta tgaatcatgg ccacagaaag aagattgcaa
      781 agcgtagcac atctgcacat aaagaaaata taaacaccag tttaaaggca ttggaatggg
      841 aggcacctag gaccccaagg tttcgaaaaa tgcctggagg tcctctgact tctcctctgt
      901 gtgagctgga aatgaagcat ctgggcagtc ccattactac ggttcctaag ctgagtcaaa
      961 atgtaaagct agaagaccaa gaaaggattt cagaagaccc aatggagtgt tccctgggag
     1021 accaggacgc caagggctta agtctaagga agatggtccc actctgtgac atgaacgcca
     1081 ttcagatgga ggaggaagag tctggctcag agcttctgat tggtgatttc tcaaaggtgt
     1141 gtgtgctgcc aacggtgcca gggaaacacc cggatctgaa gtatatcagc ccagacacag
     1201 tggctgcttt gctgtctgga aagttccaga gtgtgatcga gaggttttat atcattgatt
     1261 gccgctatcc gtatgagtac ctgggaggcc acatcctggg agccttaaac ctgcacagtc
     1321 agaaggaact gcatgagttc tttctgagga agcctgttgt tcctctggat atccagaaaa
     1381 gagtcatcat tgtgttcctc tgtgaattct cctccgagag aggccctcga atgtgccgtt
     1441 ctctgagaga aaaagacagg gctctgaacc agtatccggc attatattac cctgagctat
     1501 atatcctcaa agggggctac agagatttct ttccagagta tatggagctg tgtgacccac
     1561 agagctactg tcccatgctt caccaggacc accaggctga gctgctgagc tggcgaagcc
     1621 agagcaaggc ccaggaaggg gagcggcagc tgcagggaca gattgccctc ctggtgaagg
     1681 gtgcgagccc acaatagtga ctatgacggt ggcagtgaag acactacaga ccctggacag
     1741 aaggagtcat cttccatgtc gctaatcccg tgattatgtc tgcaaacatg ggcagagcca
     1801 ggcaggctgt aaataaatgc ctttcgtcct agcactaagg aggcaaaggc aggaggatct
     1861 ttgagtttga ggccagcctg gtctacatgt gaccttgtct caaaaacaaa acaaacaaaa
     1921 taaaacaaaa cccattaaac caaaa
//
