LOCUS       NM_023117               3106 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus cell division cycle 25B (Cdc25b), transcript variant
            1, mRNA.
ACCESSION   NM_023117 XM_988699
VERSION     NM_023117.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3106)
  AUTHORS   Han,Z., Wang,R., Chi,P., Zhang,Z., Min,L., Jiao,H., Ou,G., Zhou,D.,
            Qin,D., Xu,C., Gao,Z., Qi,Q., Li,J., Lu,Y., Wang,X., Chen,J.,
            Yu,X., Hu,H., Li,L. and Deng,D.
  TITLE     The subcortical maternal complex modulates the cell cycle during
            early mammalian embryogenesis via 14-3-3
  JOURNAL   Nat Commun 15 (1), 8887 (2024)
   PUBMED   39406751
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3106)
  AUTHORS   Park,E.J., Kim,H.S., Lee,D.H., Kim,S.M., Yoon,J.S., Lee,J.M.,
            Im,S.J., Lee,H., Lee,M.W. and Lee,C.W.
  TITLE     Ssu72 phosphatase is essential for thermogenic adaptation by
            regulating cytosolic translation
  JOURNAL   Nat Commun 14 (1), 1097 (2023)
   PUBMED   36841836
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3106)
  AUTHORS   Roussat,M., Jungas,T., Audouard,C., Omerani,S., Medevielle,F.,
            Agius,E., Davy,A., Pituello,F. and Bel-Vialar,S.
  TITLE     Control of G2 Phase Duration by CDC25B Modulates the Switch from
            Direct to Indirect Neurogenesis in the Neocortex
  JOURNAL   J Neurosci 43 (7), 1154-1165 (2023)
   PUBMED   36596698
  REMARK    GeneRIF: Control of G2 Phase Duration by CDC25B Modulates the
            Switch from Direct to Indirect Neurogenesis in the Neocortex.
REFERENCE   4  (bases 1 to 3106)
  AUTHORS   Zhang,H., Jiang,J.C., Wu,Y.W., Yu,Y.S., Wang,H.N., Ding,N.Z. and
            Fan,H.Y.
  TITLE     The RNA ligase RNA terminal phosphate cyclase B regulates mRNA
            alternative splicing and is required for mouse oocyte development
            and maintenance
  JOURNAL   Development 149 (19) (2022)
   PUBMED   36178098
REFERENCE   5  (bases 1 to 3106)
  AUTHORS   Beauchamp,M.C., Boucher,A., Dong,Y., Aber,R. and
            Jerome-Majewska,L.A.
  TITLE     Craniofacial Defects in Embryos with Homozygous Deletion of Eftud2
            in Their Neural Crest Cells Are Not Rescued by Trp53 Deletion
  JOURNAL   Int J Mol Sci 23 (16), 9033 (2022)
   PUBMED   36012294
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3106)
  AUTHORS   Lock,L.F., Wickramasinghe,D., Ernst,M.K., Gilbert,D.J.,
            Copeland,N.G., Jenkins,N.A. and Donovan,P.J.
  TITLE     The Cdc25 genes map to mouse chromosomes 2, 9, and 18
  JOURNAL   Mamm Genome 7 (10), 771-772 (1996)
   PUBMED   8854867
REFERENCE   7  (bases 1 to 3106)
  AUTHORS   Zuberi,A.R., Nguyen,H.Q., Auman,H.J., Taylor,B.A. and
            Roopenian,D.C.
  TITLE     A genetic linkage map of mouse chromosome 2 extending from
            thrombospondin to paired box gene 1, including the H3 minor
            histocompatibility complex
  JOURNAL   Genomics 33 (1), 75-84 (1996)
   PUBMED   8617512
REFERENCE   8  (bases 1 to 3106)
  AUTHORS   Wickramasinghe,D., Becker,S., Ernst,M.K., Resnick,J.L.,
            Centanni,J.M., Tessarollo,L., Grabel,L.B. and Donovan,P.J.
  TITLE     Two CDC25 homologues are differentially expressed during mouse
            development
  JOURNAL   Development 121 (7), 2047-2056 (1995)
   PUBMED   7635051
REFERENCE   9  (bases 1 to 3106)
  AUTHORS   Wu,S. and Wolgemuth,D.J.
  TITLE     The distinct and developmentally regulated patterns of expression
            of members of the mouse Cdc25 gene family suggest differential
            functions during gametogenesis
  JOURNAL   Dev Biol 170 (1), 195-206 (1995)
   PUBMED   7601309
REFERENCE   10 (bases 1 to 3106)
  AUTHORS   Kakizuka,A., Sebastian,B., Borgmeyer,U., Hermans-Borgmeyer,I.,
            Bolado,J., Hunter,T., Hoekstra,M.F. and Evans,R.M.
  TITLE     A mouse cdc25 homolog is differentially and developmentally
            expressed
  JOURNAL   Genes Dev 6 (4), 578-590 (1992)
   PUBMED   1313771
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL831736.16, BQ561430.1, W54021.1, BC057568.1 and AL808128.4.
            
            On Mar 21, 2012 this sequence version replaced NM_023117.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK153903.1, SRR1660811.228555.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-345               AL831736.16        118570-118914
            346-894             BQ561430.1         2-550
            895-1170            W54021.1           28-303              c
            1171-3092           BC057568.1         964-2885
            3093-3106           AL808128.4         3768-3781
FEATURES             Location/Qualifiers
     source          1..3106
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 63.29 cM"
     gene            1..3106
                     /gene="Cdc25b"
                     /note="cell division cycle 25B"
                     /db_xref="GeneID:12531"
                     /db_xref="MGI:MGI:99701"
     exon            1..433
                     /gene="Cdc25b"
                     /inference="alignment:Splign:2.1.0"
     CDS             234..1964
                     /gene="Cdc25b"
                     /EC_number="3.1.3.48"
                     /note="isoform a is encoded by transcript variant 1;
                     M-phase inducer phosphatase 2; dual specificity
                     phosphatase Cdc25B"
                     /codon_start=1
                     /product="M-phase inducer phosphatase 2 isoform a"
                     /protein_id="NP_075606.1"
                     /db_xref="CCDS:CCDS16758.1"
                     /db_xref="GeneID:12531"
                     /db_xref="MGI:MGI:99701"
                     /translation="MEVPLQKSAPGSALSPARVLGGIQRPRHLSVFEFESDGFLGSPE
                     PTASSSPVTTLTQTMHNLAGLGSEPPKAQVGSLSFQNRLADLSLSRRTSECSLSSESS
                     ESSDAGLCMDSPSPVDPQMAERTFEQAIQAASRVIQNEQFTIKRFRSLPVRLLEHSPV
                     LQSITNSRALDSWRKTEAGYRAAANSPGEDKENDGYIFKMPQELPHSSSAQALAEWVS
                     RRQAFTQRPSSAPDLMCLTTEWKMEVEELSPVAQSSSLTPVERASEEDDGFVDILESD
                     LKDDEKVPAGMENLISAPLVKKLDKEEEQDLIMFSKCQRLFRSPSMPCSVIRPILKRL
                     ERPQDRDVPVQSKRRKSVTPLEEQQLEEPKARVFRSKSLCHEIENILDSDHRGLIGDY
                     SKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVEKFVIVDCRYPYEYEGGHIKNA
                     VNLPLERDAETFLLQRPIMPCSLDKRIILIFHCEFSSERGPRMCRFIRERDRAANDYP
                     SLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHEAFRDELRNFRLKTRSWAGERSR
                     RELCSRLQDQ"
     exon            434..555
                     /gene="Cdc25b"
                     /inference="alignment:Splign:2.1.0"
     exon            556..607
                     /gene="Cdc25b"
                     /inference="alignment:Splign:2.1.0"
     exon            608..649
                     /gene="Cdc25b"
                     /inference="alignment:Splign:2.1.0"
     exon            650..686
                     /gene="Cdc25b"
                     /inference="alignment:Splign:2.1.0"
     exon            687..812
                     /gene="Cdc25b"
                     /inference="alignment:Splign:2.1.0"
     exon            813..935
                     /gene="Cdc25b"
                     /inference="alignment:Splign:2.1.0"
     exon            936..1067
                     /gene="Cdc25b"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1148
                     /gene="Cdc25b"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1322
                     /gene="Cdc25b"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1415
                     /gene="Cdc25b"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1478
                     /gene="Cdc25b"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1577
                     /gene="Cdc25b"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1711
                     /gene="Cdc25b"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1823
                     /gene="Cdc25b"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..3106
                     /gene="Cdc25b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3070..3075
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdc25b"
                     /note="hexamer: AATAAA"
     polyA_site      3092
                     /gene="Cdc25b"
                     /note="major polyA site"
ORIGIN      
        1 gttatttttc gaatatataa ggaggtggag gtggcagctg cccagctcgg cgtcctcccc
       61 tcccttcctc cccacatccc tctcctcact cccaggccca ttgctcttcc tccctccctt
      121 ccctccctcc ttcccctcac cccaggctca ctctcggagc tgagccagct gggtcggcgt
      181 ctgctggccg ctgtactgtg gccctctagc tagcctttgc ccgccccgcc acgatggagg
      241 tacccctgca gaagtctgcg ccgggttcag ctctcagtcc tgcccgcgtg ctgggtggca
      301 ttcagcggcc gcgccacctc tcggtctttg agtttgagtc tgatggcttc ctggggtctc
      361 cggagcctac agcttcctcc tctccggtta ccactcttac acagaccatg cacaacctcg
      421 ctgggctcgg cagtgagcct ccaaaagctc aagtaggaag cctgtcgttc cagaacaggc
      481 tggcagacct atccctgtcc aggcgcacct ctgagtgctc cctgtcatct gagtcctcag
      541 aatcttcgga tgcaggtctg tgcatggact cccccagccc tgtggacccg cagatggcag
      601 agcgcacgtt tgaacaggcc attcaggcag ccagtcgggt cattcaaaat gagcagttta
      661 ccataaaacg cttccgatcc ttaccagtga ggctgctgga acacagtccg gtgctgcaga
      721 gcatcaccaa ctcccgagca ctggacagct ggaggaaaac tgaagcaggc taccgagccg
      781 ccgccaatag tcctggggag gacaaagaga atgatggata tatcttcaag atgccacagg
      841 agctccctca ttccagctct gcccaagctt tggcagaatg ggtcagccgc agacaggcct
      901 ttacccagag gcccagctca gcccctgact tgatgtgtct taccactgag tggaagatgg
      961 aagtagagga gctgagcccg gtggcacagt cttcttcctt gactcctgtc gaaagggctt
     1021 ctgaagaaga tgacggattt gtggacatcc tggagagtga tttaaaggat gacgagaagg
     1081 tccccgcggg catggagaac ctcattagtg ccccactggt caaaaagctg gataaggaag
     1141 aggaacagga tctcatcatg ttcagcaagt gccagaggct cttccgctcc ccatccatgc
     1201 catgcagtgt gatccgaccc atcctcaaga ggctagagcg gccccaggac cgggatgtgc
     1261 ctgtccagag caagcgcagg aaaagtgtga cacccctgga agagcagcag cttgaagaac
     1321 ctaaggcccg tgtctttcgc tcaaagtcgc tgtgtcatga gattgagaac atcctggata
     1381 gtgaccaccg tggactgatc ggagattact ctaaggcctt cctcctgcag accgtggatg
     1441 gcaaacacca agaccttaag tacatctcac cagaaactat ggtggccctg ttaacaggca
     1501 agttcagcaa catcgtggag aaatttgtca ttgtggactg cagatacccc tatgagtatg
     1561 aaggcgggca tatcaagaat gctgtgaacc tgcccctgga acgggatgct gagacctttc
     1621 tgctgcagcg tcccatcatg ccttgtagcc tggacaagag aatcatcctc attttccact
     1681 gtgaattctc gtctgagcgt ggaccacgaa tgtgccgctt catcagggaa cgggaccgtg
     1741 cagctaacga ctaccccagc ctgtactacc cggagatgta catcctcaaa ggcggctaca
     1801 aggagttctt cccacagcat ccgaactttt gtgagcccca ggactaccga cccatgaacc
     1861 acgaggcttt cagggatgag ctgaggaact ttcgccttaa gactcgcagc tgggctgggg
     1921 aacggagcag gagggaactt tgtagcaggc tgcaagacca gtgatgatga gcctgctgcc
     1981 atccttacct cgtgaggctt gggagccagt gggtcccatg ggcctgtgag gccacctacc
     2041 ttatagaggc ctcaggtgct atagggggtt gggggcatgg tgtggtgtca catctgtctg
     2101 cccctgtcct caattttcct gtctcactcc acttattttc tgtatcttgg tactggtccc
     2161 agcttaaaga gctgaacctg agggtggatg ccagctgagg agaagtctgt tgtgttcagt
     2221 gggagtcctt ttacagtctt ttttccttgt ttgtgttgac tctttgtctt cccgcttttt
     2281 ggggagagcc tcagcccgtt aggatggcac agtagcttct tgcatggcct ggatgcagga
     2341 tgctactctg ctacacaggg ctgtgtctac tctcctctcc tggccactgc atagacttat
     2401 gctctccatt ggaagcataa gtgctttctc ttctgttgta gtcttacctg tagctttcat
     2461 ttttttgtct gtctgacaca ctgaccgctg gggaggcttc cttgtacagc ttggggctag
     2521 agattcaaat atcacttact cgttaggcct ggcttttgtt agcccagaaa gggatcttgc
     2581 cctttaagac ccccagggct agagggaagg cctgactcag gagcctctgg gagccccatc
     2641 ctcactactg tgaaccccag agcctcgctg gtcagcactt gctgctgggc aatggaccag
     2701 tcaccgagct ttgctgtttg atccttctct gcccttccct gttttccttt ctatatctgg
     2761 cccagaagac ctcttgtatg tgtggttttt ctgtgttgta ctagtgactt gagtctaggc
     2821 cctttgttgc atggtcatgg atgcacagtg ccttatatac atgtatgcac acaaaccggg
     2881 tccaagtatt ttggtaagca tgatggccta tggcaggagt gtgtgtgtgc gcgtgtgaac
     2941 aaagtcatta cacttagtgt ttggaaatgt taaagaagca ttgttatggg gaggggggag
     3001 caacctctgg gttcagaatc tacatatgct ggaaggcccc aatgagtcct ctgttggggg
     3061 ccttggttca ataaagcact gagcaagttg aataatctgt ttgtta
//
