LOCUS       NM_001410385            3687 bp    mRNA    linear   ROD 13-MAY-2024
DEFINITION  Mus musculus cell division cycle 25A (Cdc25a), transcript variant
            2, mRNA.
ACCESSION   NM_001410385 XM_006511929
VERSION     NM_001410385.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3687)
  AUTHORS   Liu,C., Gao,Q., Dong,J. and Cai,H.
  TITLE     Usf2 Deficiency Promotes Autophagy to Alleviate Cerebral
            Ischemia-Reperfusion Injury Through Suppressing YTHDF1-m6A-Mediated
            Cdc25A Translation
  JOURNAL   Mol Neurobiol 61 (5), 2556-2568 (2024)
   PUBMED   37914905
  REMARK    GeneRIF: Usf2 Deficiency Promotes Autophagy to Alleviate Cerebral
            Ischemia-Reperfusion Injury Through Suppressing YTHDF1-m6A-Mediated
            Cdc25A Translation.
REFERENCE   2  (bases 1 to 3687)
  AUTHORS   Li,N., Cai,Y., Zou,M., Zhou,J., Zhang,L., Zhou,L., Xiang,W., Cui,Y.
            and Li,H.
  TITLE     CFIm-mediated alternative polyadenylation safeguards the
            development of mammalian pre-implantation embryos
  JOURNAL   Stem Cell Reports 18 (1), 81-96 (2023)
   PUBMED   36563685
REFERENCE   3  (bases 1 to 3687)
  AUTHORS   Kafer,G.R. and Cesare,A.J.
  TITLE     A Survey of Essential Genome Stability Genes Reveals That
            Replication Stress Mitigation Is Critical for Peri-Implantation
            Embryogenesis
  JOURNAL   Front Cell Dev Biol 8, 416 (2020)
   PUBMED   32548123
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3687)
  AUTHORS   Chen,Y., Li,X., Liao,H., Leung,X., He,J., Wang,X., Li,F., Yue,H.
            and Xu,W.
  TITLE     CFTR mutation compromises spermatogenesis by enhancing miR-15b
            maturation and suppressing its regulatory target CDC25Adagger
  JOURNAL   Biol Reprod 101 (1), 50-62 (2019)
   PUBMED   30985893
  REMARK    GeneRIF: CFTR mutation compromises spermatogenesis by enhancing
            miR-15b maturation and suppressing its regulatory target
            CDC25Adagger.
REFERENCE   5  (bases 1 to 3687)
  AUTHORS   Suzuki,T., Kikuguchi,C., Nishijima,S., Nagashima,T., Takahashi,A.,
            Okada,M. and Yamamoto,T.
  TITLE     Postnatal liver functional maturation requires Cnot
            complex-mediated decay of mRNAs encoding cell cycle and immature
            liver genes
  JOURNAL   Development 146 (4) (2019)
   PUBMED   30733279
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3687)
  AUTHORS   Hashimoto,H., Nishino,A., Shintani,N., Hagihara,N., Copeland,N.G.,
            Jenkins,N.A., Yamamoto,K., Matsuda,T., Ishihara,T., Nagata,S. and
            Baba,A.
  TITLE     Genomic organization and chromosomal location of the mouse
            vasoactive intestinal polypeptide 1 (VPAC1) receptor
  JOURNAL   Genomics 58 (1), 90-93 (1999)
   PUBMED   10331949
REFERENCE   7  (bases 1 to 3687)
  AUTHORS   Hardiman,G., Jenkins,N.A., Copeland,N.G., Gilbert,D.J.,
            Garcia,D.K., Naylor,S.L., Kastelein,R.A. and Bazan,J.F.
  TITLE     Genetic structure and chromosomal mapping of MyD88
  JOURNAL   Genomics 45 (2), 332-339 (1997)
   PUBMED   9344657
REFERENCE   8  (bases 1 to 3687)
  AUTHORS   Lock,L.F., Wickramasinghe,D., Ernst,M.K., Gilbert,D.J.,
            Copeland,N.G., Jenkins,N.A. and Donovan,P.J.
  TITLE     The Cdc25 genes map to mouse chromosomes 2, 9, and 18
  JOURNAL   Mamm Genome 7 (10), 771-772 (1996)
   PUBMED   8854867
REFERENCE   9  (bases 1 to 3687)
  AUTHORS   Wickramasinghe,D., Becker,S., Ernst,M.K., Resnick,J.L.,
            Centanni,J.M., Tessarollo,L., Grabel,L.B. and Donovan,P.J.
  TITLE     Two CDC25 homologues are differentially expressed during mouse
            development
  JOURNAL   Development 121 (7), 2047-2056 (1995)
   PUBMED   7635051
REFERENCE   10 (bases 1 to 3687)
  AUTHORS   Gariboldi,M., Sturani,E., Canzian,F., De Gregorio,L., Manenti,G.,
            Dragani,T.A. and Pierotti,M.A.
  TITLE     Genetic mapping of the mouse CDC25Mm gene, a ras-specific guanine
            nucleotide-releasing factor, to chromosome 9
  JOURNAL   Genomics 21 (2), 451-453 (1994)
   PUBMED   8088844
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT573087.13.
            
            On Aug 6, 2022 this sequence version replaced XM_006511929.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422597.470767.1,
                                           SRR13422600.1068956.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-612               CT573087.13        89478-90089
            613-686             CT573087.13        91091-91164
            687-729             CT573087.13        92198-92240
            730-766             CT573087.13        93161-93197
            767-868             CT573087.13        93764-93865
            869-973             CT573087.13        95403-95507
            974-1099            CT573087.13        97419-97544
            1100-1174           CT573087.13        98049-98123
            1175-1366           CT573087.13        98249-98440
            1367-1465           CT573087.13        101178-101276
            1466-1528           CT573087.13        102804-102866
            1529-1627           CT573087.13        102962-103060
            1628-1758           CT573087.13        103641-103771
            1759-1870           CT573087.13        105675-105786
            1871-3687           CT573087.13        106009-107825
FEATURES             Location/Qualifiers
     source          1..3687
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 59.81 cM"
     gene            1..3687
                     /gene="Cdc25a"
                     /gene_synonym="D9Ertd393e"
                     /note="cell division cycle 25A"
                     /db_xref="GeneID:12530"
                     /db_xref="MGI:MGI:103198"
     exon            1..612
                     /gene="Cdc25a"
                     /gene_synonym="D9Ertd393e"
                     /inference="alignment:Splign:2.1.0"
     CDS             443..2011
                     /gene="Cdc25a"
                     /gene_synonym="D9Ertd393e"
                     /EC_number="3.1.3.48"
                     /note="isoform 2 is encoded by transcript variant 2;
                     M-phase inducer phosphatase 1; dual specificity
                     phosphatase Cdc25A"
                     /codon_start=1
                     /product="M-phase inducer phosphatase 1 isoform 2"
                     /protein_id="NP_001397314.1"
                     /db_xref="GeneID:12530"
                     /db_xref="MGI:MGI:103198"
                     /translation="MELGPEPPHRRRLFFACSPTPAPQPTGKMLFGASAAGGLSPVTN
                     LTVTMDQLEGLGSDCEKMEVRNNSSLQRMGSSESTDSGFCLDSPGPLDSKENLEISLT
                     RINSLPQKLLGCSPALKRSHSDSLDHDTFHLIDQDENKENEAFEFKKPIRPASRHIYE
                     ESKDPFTHRQNSAPARMLSSNESESGNFSPLFIPQSPVKATLSDEDDGFIDLLDGENM
                     KNDEETPSCMASLWTAPLVMRRPANLVGPVSDPKADRCGLFDSPSPCGSSTRAVLKRA
                     DRSHEEPPRGTKRRKSVPSPVKAKADVPEPAQLPSQSLSLMSSPKGTIENILDSDPRD
                     LIGDFSKGYLFNTVSGKHQDLKYISPEIMASVLNGKFAGLIKEFVIIDCRYPYEYEGG
                     HIKGAVNLHMEEEVEDFLLKNPIVPTDGKRVIVVFHCEFSSERGPRMCRYVRERDRLG
                     NEYPKLHYPELYVLKGGYKEFFLKCQSHCEPPSYRPMHHEDFKEDLKKFRTKSRTWAG
                     EKSKREMYSRLKKL"
     exon            613..686
                     /gene="Cdc25a"
                     /gene_synonym="D9Ertd393e"
                     /inference="alignment:Splign:2.1.0"
     exon            687..729
                     /gene="Cdc25a"
                     /gene_synonym="D9Ertd393e"
                     /inference="alignment:Splign:2.1.0"
     exon            730..766
                     /gene="Cdc25a"
                     /gene_synonym="D9Ertd393e"
                     /inference="alignment:Splign:2.1.0"
     exon            767..868
                     /gene="Cdc25a"
                     /gene_synonym="D9Ertd393e"
                     /inference="alignment:Splign:2.1.0"
     exon            869..973
                     /gene="Cdc25a"
                     /gene_synonym="D9Ertd393e"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1099
                     /gene="Cdc25a"
                     /gene_synonym="D9Ertd393e"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1174
                     /gene="Cdc25a"
                     /gene_synonym="D9Ertd393e"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1366
                     /gene="Cdc25a"
                     /gene_synonym="D9Ertd393e"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1465
                     /gene="Cdc25a"
                     /gene_synonym="D9Ertd393e"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1528
                     /gene="Cdc25a"
                     /gene_synonym="D9Ertd393e"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1627
                     /gene="Cdc25a"
                     /gene_synonym="D9Ertd393e"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1758
                     /gene="Cdc25a"
                     /gene_synonym="D9Ertd393e"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1870
                     /gene="Cdc25a"
                     /gene_synonym="D9Ertd393e"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..3687
                     /gene="Cdc25a"
                     /gene_synonym="D9Ertd393e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3665..3670
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdc25a"
                     /gene_synonym="D9Ertd393e"
                     /note="hexamer: AATAAA"
     polyA_site      3687
                     /gene="Cdc25a"
                     /gene_synonym="D9Ertd393e"
                     /note="major polyA site"
ORIGIN      
        1 atcctgagtg tgcagcaatt aacgctaagg ccactttggt ggtgagggaa gtgaaggttc
       61 cttctctgcg agccggctac ggagcaagga gggagaaaaa aagtgaggcg agttagtcgg
      121 agcggtggtc tcaagactct tcctccacgg agtttgtttg gatttaatct tgaggttgca
      181 ggcgcccgcc cgcctgcggg cctcgcggga cagagaggga agcaccggtg cttgtgcctg
      241 gcgcctgccg agtcccctac gctcgccggt ccgcgccgct gcccgtggcg gccgcgtctc
      301 tgaaccgcgg ggtcgtgttt gtgtttgacc cgcgggcgct ggtggcgtgg cacgcggctg
      361 aagccggtgc cagcggggcg gggcccggcg cagcggaggc ggaggaagac ggagcgggag
      421 tccgggcagg cccggcggcg ccatggaact gggcccggag cccccccacc gccgccgcct
      481 gttcttcgct tgcagcccca cgcctgcgcc gcagcccacg gggaagatgc tgtttggcgc
      541 gtcagctgct ggcggactgt cccctgtcac caacctgacg gtcaccatgg accagctgga
      601 aggactgggc agtgactgtg agaaaatgga agtgagaaat aacagcagtc tacagagaat
      661 gggctcctca gaatcgaccg attcaggttt ctgtctagat tctcctgggc ccttggacag
      721 taaagaaaac cttgaaattt ccctgacgag aataaattcc ctacctcaga agctcctggg
      781 atgtagccca gccctgaaga ggagccactc tgattctcta gaccacgaca cctttcacct
      841 catcgaccag gatgaaaata aagaaaatga agcatttgaa tttaaaaagc caatacgacc
      901 tgcatctcgt cacatctacg aggagagtaa agatcccttt acacacaggc agaattcagc
      961 cccagctcgg atgctatctt caaatgaaag tgaatcagga aatttcagtc ctctttttat
     1021 accccagtca cctgtaaaag ccactttgtc cgatgaggat gatggcttca tagaccttct
     1081 ggatggcgag aatatgaaga atgatgagga gaccccatca tgcatggcaa gcctctggac
     1141 agctcccctt gtcatgagga gacctgcaaa ccttgttgga cctgtctctg accctaaggc
     1201 cgatcgttgc gggctgtttg actccccttc cccgtgcggc tccagcactc gggcggtgtt
     1261 gaagagagca gaccggtctc acgaggagcc tcctcggggt acaaagagga ggaagagtgt
     1321 gcccagccct gtgaaggcga aggcggatgt tccggagccc gcccagcttc catcccagtc
     1381 tctatccctg atgtcttccc ccaaaggaac cattgagaac attttggaca gtgacccaag
     1441 agaccttata ggagatttct ccaagggtta tctctttaat acagtctctg ggaagcatca
     1501 ggatttgaaa tatatttctc cagaaattat ggcatctgtt ttgaatggca agtttgccgg
     1561 tctcattaaa gagtttgtta tcattgactg ccgataccca tatgagtatg aaggaggtca
     1621 catcaagggt gccgtgaatc tgcacatgga agaagaggtt gaagacttct tacttaagaa
     1681 ccctattgtg cctactgatg gcaagcgtgt cattgtcgtg ttccactgtg agttttcctc
     1741 tgaaagaggc cctcgaatgt gccgatatgt gagagagaga gataggctcg gcaatgagta
     1801 ccccaagctc cactaccctg agctgtatgt cctgaagggg ggatacaagg agttcttttt
     1861 gaagtgccag tctcactgtg aaccccccag ctaccggcca atgcaccatg aagactttaa
     1921 agaagaccta aagaagttcc gcaccaagag ccggacctgg gcaggagaaa agagcaaaag
     1981 agagatgtac agtcgcctga agaagctctg aagccaaatg gtagcagcct gagcttccct
     2041 ctgccccgtc ccttttccct ttgctgcaga gcagtaagca aaggggccag ctgtacggta
     2101 cctggagaaa gacctgggcc ttccattcct tggacctgtc tcctacactc ccaggttgga
     2161 gcctagggca ccctgccgtt acactcttct gttctgtaag agtccttccc tgtcaggact
     2221 gtctgccaaa gctggacaag cacagcacag actggagtct gcaacaccgt gttaggctgc
     2281 tctcactgag catcccatga agaaggcctt attgggtaga ccctggcctg tcacgaggag
     2341 agaaaagccg cccaagtgct gctggccaaa taccaaagat aggctggaag ggaggagagg
     2401 gcctcgtgga tgactcttaa ctttaattta ttcagcttca tcaattattt tattattgtt
     2461 ttaattcaag acttttactt ttctgcttca ttaagtcaaa atactgccat tctaggtaga
     2521 gttttatcat cctaggagct acctctactt ttaatttaaa aaaaaaaaaa aatggggcag
     2581 ggataagaaa aaggcaaact tgttaagttg tgaacagcgc aaggagctca gtcaccccta
     2641 ggaggcgctg cagaccagta ttgctgctac tcaaagtcaa ggactgagat gctggtaaga
     2701 gcctgcacca gatccaggct tggctacagg acataagcta accttcccag acctacttct
     2761 gcattttgca gtgttcctcg gggaaagtct tgtctccact cctcacccca cgtccccatg
     2821 acagtggctg gtgtaggagt cacaggaagg cactttaggc agcttccatc aggccagtac
     2881 tggaatgctg tagtgtgccc caaggtggaa gagggggggc atgaaagagt ggagtccaca
     2941 gagtgaggga ggagcatgcc cactgaatgt ccttttaaaa aaaaaaaagt cattttatga
     3001 gtcggaatat ccaatcagtg ttgggtgggc acccaagggt gagcaggggg gcgggaagcc
     3061 caggctgtta tgtatcctgg cctacagaca actgtggaat ttctcaggag ggcgtagtaa
     3121 attttgaagt caaaggttca gagtttatca tgttttaatt tgagggtcag agagtggtga
     3181 atcacatcag ttacccccta atctaatccc atggaagtga ggctctcgga aacacctctc
     3241 gtctgagggg ccaggctgct ttgattctgc acagcctgtt ttggtgcctg cctgttgata
     3301 tccttggaca ccagcctctc tgctatcttt gctccattgg ggtctagcca ggtttttctt
     3361 aggaagagtc tcccctcttc cctctgcttt ctattctggg ggcggggagg gaatcagtga
     3421 tattgaagat ggctagttgc tttgttatgg gtttgagttg catttggcta ttaaacaaat
     3481 cttgtttgaa aatatgtgga gagcaaggga atgagcagcc ccttccctgg cgtgttgaag
     3541 tatgtcccag ttggtccctg gtctggtttg tagagattct gttagctgaa tgctttccag
     3601 gagaatggct tgcagattgt accagcatag ctagcattgt taaccaacag ttgcaggctc
     3661 tgcaaataaa agtgatcttg aaccctt
//
