LOCUS       NM_178347               4134 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus CDC23 cell division cycle 23 (Cdc23), mRNA.
ACCESSION   NM_178347
VERSION     NM_178347.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4134)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4134)
  AUTHORS   Fan,H., Zhou,Z., Zheng,W., Guan,Y., Meng,Q., Wang,W., Dong,J.,
            Wan,L., Zhu,J., Zeng,Y., Liu,R., Gu,H., Lin,G., Chen,B., Sang,Q.
            and Wang,L.
  TITLE     Homozygous variants in CDC23 cause female infertility characterized
            by oocyte maturation defects
  JOURNAL   Hum Genet 142 (11), 1621-1631 (2023)
   PUBMED   37768355
  REMARK    GeneRIF: Homozygous variants in CDC23 cause female infertility
            characterized by oocyte maturation defects.
REFERENCE   3  (bases 1 to 4134)
  AUTHORS   Ferguson,C.J., Urso,O., Bodrug,T., Gassaway,B.M., Watson,E.R.,
            Prabu,J.R., Lara-Gonzalez,P., Martinez-Chacin,R.C., Wu,D.Y.,
            Brigatti,K.W., Puffenberger,E.G., Taylor,C.M., Haas-Givler,B.,
            Jinks,R.N., Strauss,K.A., Desai,A., Gabel,H.W., Gygi,S.P.,
            Schulman,B.A., Brown,N.G. and Bonni,A.
  TITLE     APC7 mediates ubiquitin signaling in constitutive heterochromatin
            in the developing mammalian brain
  JOURNAL   Mol Cell 82 (1), 90-105 (2022)
   PUBMED   34942119
REFERENCE   4  (bases 1 to 4134)
  AUTHORS   Zhou,Q., Li,J., Yue,W., Li,A., Meng,T.G., Lei,W.L., Fan,L.H.,
            Ouyang,Y.C., Schatten,H., Wang,Z.B. and Sun,Q.Y.
  TITLE     Cell division cycle 23 is required for mouse oocyte meiotic
            maturation
  JOURNAL   FASEB J 34 (7), 8990-9002 (2020)
   PUBMED   32449168
  REMARK    GeneRIF: Cell division cycle 23 is required for mouse oocyte
            meiotic maturation.
REFERENCE   5  (bases 1 to 4134)
  AUTHORS   Tang,F., Barbacioru,C., Nordman,E., Bao,S., Lee,C., Wang,X.,
            Tuch,B.B., Heard,E., Lao,K. and Surani,M.A.
  TITLE     Deterministic and stochastic allele specific gene expression in
            single mouse blastomeres
  JOURNAL   PLoS One 6 (6), e21208 (2011)
   PUBMED   21731673
REFERENCE   6  (bases 1 to 4134)
  AUTHORS   Lelli,A., Asai,Y., Forge,A., Holt,J.R. and Geleoc,G.S.
  TITLE     Tonotopic gradient in the developmental acquisition of sensory
            transduction in outer hair cells of the mouse cochlea
  JOURNAL   J Neurophysiol 101 (6), 2961-2973 (2009)
   PUBMED   19339464
REFERENCE   7  (bases 1 to 4134)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   8  (bases 1 to 4134)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC145591.5 and
            AC074335.11.
            
            On May 2, 2007 this sequence version replaced NM_178347.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK081461.1, AK038523.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-190               AC145591.5         125510-125699
            191-263             AC145591.5         125784-125856
            264-401             AC074335.11        200834-200971       c
            402-444             AC074335.11        198998-199040       c
            445-550             AC074335.11        197957-198062       c
            551-683             AC074335.11        197731-197863       c
            684-861             AC074335.11        195405-195582       c
            862-959             AC074335.11        195227-195324       c
            960-1041            AC074335.11        195028-195109       c
            1042-1195           AC074335.11        191252-191405       c
            1196-1315           AC074335.11        190991-191110       c
            1316-1391           AC074335.11        190635-190710       c
            1392-1453           AC074335.11        190218-190279       c
            1454-1532           AC074335.11        188520-188598       c
            1533-1652           AC074335.11        188325-188444       c
            1653-4134           AC074335.11        185615-188096       c
FEATURES             Location/Qualifiers
     source          1..4134
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 18.69 cM"
     gene            1..4134
                     /gene="Cdc23"
                     /gene_synonym="6030435O18; D18Ertd243e"
                     /note="CDC23 cell division cycle 23"
                     /db_xref="GeneID:52563"
                     /db_xref="MGI:MGI:1098815"
     exon            1..190
                     /gene="Cdc23"
                     /gene_synonym="6030435O18; D18Ertd243e"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..1823
                     /gene="Cdc23"
                     /gene_synonym="6030435O18; D18Ertd243e"
                     /note="APC8; cyclosome subunit 8; anaphase-promoting
                     complex subunit 8; CDC23 (cell division cycle 23, yeast,
                     homolog)"
                     /codon_start=1
                     /product="cell division cycle protein 23 homolog"
                     /protein_id="NP_848124.1"
                     /db_xref="CCDS:CCDS29132.1"
                     /db_xref="GeneID:52563"
                     /db_xref="MGI:MGI:1098815"
                     /translation="MAANSSVVSVAAAATAVPGVSTVADFSDLQEIKKQLLLIAGLTR
                     ERGLLHSSKWSAELAFSLPALPLSELQPPPPLTEEDAQDVDAYTLAKAYFDVKEYDRA
                     AHFLHGCNSKKAYFLYMYSRYLSGEKKKDDETVDSLGPLEKGQVKNEALRELRVELSR
                     KHQARGLDGFGLYLYGVVLRKLDLVKEAIDVFVEATHVLPLHWGAWLELCNLITDKEM
                     LKFLSLPDTWMKEFFLAHIYTELQLIEEALQKYQHLIDVGFSKSSYIVSQIAVAYHNI
                     RDIDKALSIFNELRKQDPYRIENMDTFSNLLYVRSMKSELSYLAHNLCEIDKYRVETC
                     CVIGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAI
                     EVNKRDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKLNQLV
                     EAKKCYWRAYAVGDVEKMALVKLAKLHEQLTESEQAAQCYIKYIQDIYSCGETVEHLE
                     ESTAFRYLAQYYFKCKLWDEASTCAQKCCAFNDTREEGKALLRQILQLRNQGETPTSD
                     TPGTFFLPASLSANNTPTRRVSPLNLSSVTP"
     exon            191..263
                     /gene="Cdc23"
                     /gene_synonym="6030435O18; D18Ertd243e"
                     /inference="alignment:Splign:2.1.0"
     exon            264..401
                     /gene="Cdc23"
                     /gene_synonym="6030435O18; D18Ertd243e"
                     /inference="alignment:Splign:2.1.0"
     exon            402..444
                     /gene="Cdc23"
                     /gene_synonym="6030435O18; D18Ertd243e"
                     /inference="alignment:Splign:2.1.0"
     exon            445..550
                     /gene="Cdc23"
                     /gene_synonym="6030435O18; D18Ertd243e"
                     /inference="alignment:Splign:2.1.0"
     exon            551..683
                     /gene="Cdc23"
                     /gene_synonym="6030435O18; D18Ertd243e"
                     /inference="alignment:Splign:2.1.0"
     exon            684..861
                     /gene="Cdc23"
                     /gene_synonym="6030435O18; D18Ertd243e"
                     /inference="alignment:Splign:2.1.0"
     exon            862..959
                     /gene="Cdc23"
                     /gene_synonym="6030435O18; D18Ertd243e"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1041
                     /gene="Cdc23"
                     /gene_synonym="6030435O18; D18Ertd243e"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1195
                     /gene="Cdc23"
                     /gene_synonym="6030435O18; D18Ertd243e"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1315
                     /gene="Cdc23"
                     /gene_synonym="6030435O18; D18Ertd243e"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1391
                     /gene="Cdc23"
                     /gene_synonym="6030435O18; D18Ertd243e"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1453
                     /gene="Cdc23"
                     /gene_synonym="6030435O18; D18Ertd243e"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1532
                     /gene="Cdc23"
                     /gene_synonym="6030435O18; D18Ertd243e"
                     /inference="alignment:Splign:2.1.0"
     exon            1533..1652
                     /gene="Cdc23"
                     /gene_synonym="6030435O18; D18Ertd243e"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..4134
                     /gene="Cdc23"
                     /gene_synonym="6030435O18; D18Ertd243e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3010..3015
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdc23"
                     /gene_synonym="6030435O18; D18Ertd243e"
                     /note="hexamer: AATAAA"
     regulatory      3018..3023
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdc23"
                     /gene_synonym="6030435O18; D18Ertd243e"
                     /note="hexamer: CATAAA"
     polyA_site      3028
                     /gene="Cdc23"
                     /gene_synonym="6030435O18; D18Ertd243e"
                     /note="major polyA site"
     polyA_site      3044
                     /gene="Cdc23"
                     /gene_synonym="6030435O18; D18Ertd243e"
     regulatory      3088..3093
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdc23"
                     /gene_synonym="6030435O18; D18Ertd243e"
                     /note="hexamer: AATACA"
     polyA_site      3108
                     /gene="Cdc23"
                     /gene_synonym="6030435O18; D18Ertd243e"
     regulatory      4089..4094
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdc23"
                     /gene_synonym="6030435O18; D18Ertd243e"
                     /note="hexamer: AATAAA"
     regulatory      4093..4098
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdc23"
                     /gene_synonym="6030435O18; D18Ertd243e"
                     /note="hexamer: AATAAA"
     polyA_site      4107
                     /gene="Cdc23"
                     /gene_synonym="6030435O18; D18Ertd243e"
     polyA_site      4133
                     /gene="Cdc23"
                     /gene_synonym="6030435O18; D18Ertd243e"
ORIGIN      
        1 tggttggctg gagcggccga gggaggaaaa tggctgcgaa ttcttcggta gtctcggtgg
       61 cagcggccgc cacggcggtg ccgggcgtat ccactgtcgc ggatttttca gacttgcagg
      121 aaattaaaaa gcagctgctg ctcatcgcgg gcctcactcg ggagcggggc ctgctgcata
      181 gcagcaaatg gtctgcggag ttggccttct ctctgcccgc cttgcctttg tcggagctgc
      241 agccgccgcc gcctctgaca gaggaggacg cgcaggatgt ggatgcttac accctggcca
      301 aggcctactt tgatgttaaa gagtatgacc gggcggcaca tttccttcac ggctgcaata
      361 gcaagaaagc ctatttcctg tacatgtatt ccagatacct gtctggagag aagaagaagg
      421 atgacgaaac agttgatagc ctaggacccc tagagaaggg acaagtcaaa aacgaggctc
      481 tcagagaact gagagtggaa ctcagccgga agcaccaggc tcggggactt gatggattcg
      541 gcctttacct gtatggggtg gtgcttcgga aactggactt agtgaaagag gccattgatg
      601 tgtttgtgga ggctactcat gttttgcctt tgcactgggg agcctggtta gagctgtgta
      661 acctgatcac agacaaagag atgctgaagt tcctgtcttt gcctgacacc tggatgaaag
      721 agttcttctt ggctcacata tacacagaac tgcagctgat agaggaggcc ctgcagaagt
      781 atcagcatct cattgatgtg ggcttttcca agagctcgta cattgtttcc caaattgcag
      841 ttgcctatca caatatcaga gatatcgaca aagccctttc tattttcaat gagctgagga
      901 aacaagatcc ttacaggatt gaaaatatgg acacattctc caaccttctc tatgtcagga
      961 gcatgaagtc tgaattgagt tacctggcgc ataacctctg tgaaattgat aaataccgag
     1021 tagaaacatg ctgtgtaatt ggcaattatt acagcttacg ctcccagcat gagaaagcag
     1081 ctttgtattt ccagagagcc ctaaagttga atcctaggta ccttggggcc tggacactga
     1141 tggggcacga gtacatggag atgaagaaca cgtctgcagc tattcaggct taccgacatg
     1201 ccattgaggt caacaagaga gactacagag cttggtatgg ccttgggcag acttacgaaa
     1261 tccttaaaat gccattttat tgcctttatt attatagacg ggcccaccag cttcgtccca
     1321 atgattctcg catgctggtt gccttaggag aatgttatga gaaactcaat caactagtgg
     1381 aagccaaaaa gtgttattgg agagcatatg ccgtgggaga cgtggagaaa atggctcttg
     1441 tgaagctggc caagcttcat gaacagttga ctgagtcaga gcaggctgcc cagtgttaca
     1501 tcaaatacat ccaagatatc tattcctgtg gggagaccgt ggagcacttg gaggagagca
     1561 cagccttccg atacctggcc cagtactatt ttaagtgcaa gctgtgggat gaagcttcaa
     1621 cttgtgccca aaaatgttgt gcattcaatg atacccggga agaaggtaag gccttgctcc
     1681 gccagatcct acagctgagg aaccaagggg agacacccac ctctgacacg ccgggtacct
     1741 ttttcctccc tgcctcactg tctgcaaaca acactcctac acgcagagtt tctccactca
     1801 acctgtcttc agtcacacca tagtcgacta ccctcacgtc agcacattgc tagaccaata
     1861 tcaaacctta cctgcagtaa agagcagtca cgtctgtttt cccaaggacc tagacagaaa
     1921 cagcctgagg gacagcctat ggaaccacct tcagaggcag gcagaaatat ggtgggggaa
     1981 agatggtctt ctgcagccag ctagcagtgc tcccttctat tcagagtggc aggtcttggc
     2041 ctttctagcc actcccccaa ccccccaagg aatccctttt acaacactta accagcagtg
     2101 atgccacaga agcaaggttt cggcgctgct gagaggggta gacaagaacg gagcgaagct
     2161 caccatgctt ggtgcctgtc ctctgcatgc agggagctca gctgtgactt tctttttaaa
     2221 gacagggttt ctgtgtatcc tagcctgtgg cctttctgcc tcagcctccc taatgatagc
     2281 attacaggcg aatgctgagt gaggcctaac tagaacgacc tttatgttac tgagtgtact
     2341 gttcggataa gagattaggt ttagagtgga gctatccata tgatcttgtg tagttttcca
     2401 aagcagcctt ctaaaatctt ccaagtgagt cagtgagtat ggactgtggc tcacatgagg
     2461 gccagatggc cgctgtggcc atgctaacta tatatatatg tgatgaagca acacaagaag
     2521 agaacttcgt ggacattatg gaagcttttt tacttcggat tttaaagtct ccaatttggt
     2581 tttcaacctt atctacaagg ttgaagaatt cactgtgttt ttctaggttt cagagccact
     2641 tgatgtctgc tacaatgagc ttgtgcagta ggtgctatag atcattctgt ggttaggagc
     2701 tagccttcct tctcttgtac tcagaacatt ttactcccca tttaatggaa ggaacactaa
     2761 ctgggtgcca tgtggtggtg catgtcttta atcccatttg gagacaggca ggtgggtgtt
     2821 ttgacatagc aacttcctgg ccagacaaag ctacccaagc ctcttgggta tcatttaaaa
     2881 ttgtactcat ttcctagtgt gcattaggct ggttcccact gctgttcctg tccaagggtc
     2941 taacaggcca gatggtattt atatcaattt tctgtccccc tttttatatt tttctaaatt
     3001 tggaatccaa ataaaagcat aaacaatgtc tttattccat ataatatttg tgcatgaaaa
     3061 aaaaaacaag attacatagg tgattataat acaataattc tgaatacagt tctgggtgta
     3121 tgctgaagct taaaagagac ttatcagcta agcagctgac caacctcagg gcaacaacca
     3181 tgcatcttca tccccacaac tttagtattt tttgccaaag ggagatttga gtaaaggaga
     3241 gtgccgtgag cgcaagatcc gcgcataagg gctgctgtct gttgagcttt ggcaggtagg
     3301 tgttcgggga agtaagtttc gcaggaatgg tttctttcct gggggttgat gatttggttg
     3361 ctggttttcc tggtttgctc ccagccgctt tttggcagag gcttggcctt ggagctttag
     3421 cacagtgtga tactgctcag caatgcaggc tgcctttttc tgaaggtcca gtttcactag
     3481 caccatgtta ttctgcagct cagccagggt ctggttctaa gaacattaaa agttagagaa
     3541 aacataatta ttgggtatgc catgtttagt ttaaaacata catttatcat ttaagagatc
     3601 aggtaccatt agcaatgaga aatgccatag cttagtggta gagtgcctgc ctgcttagca
     3661 tacagaaagc cctgggcttt atatgacatt agctttattt tttcactggt tcttctctcc
     3721 ctctcacgta cacactggct aggctgccct cacctgcttg attaagatgt catcacagtt
     3781 ggttaatgct tgacgaagtt ttcctgctcc ggtgctgtgg caacaggctc tttctgctga
     3841 ctgcagagac tgtcctagtt tctggagctc tgtccgtagc agtcttatat tctgaaagag
     3901 tagaaatcag attgtggcca aaatcaatca acagccattt gaagacagac ttaaggaagc
     3961 cggaggctgg tgagctggct tagctggtga gggcacttag cacccaacct cgacaatctg
     4021 agttacatct aggacccaca tggtgggaag agagaaccgt tcttctggct tccacatcac
     4081 tacatacaaa taaataaatg taaagcagaa ggctttcatt cctcagaccc ttgc
//
