LOCUS       NP_848124                597 aa            linear   ROD 02-MAY-2024
DEFINITION  cell division cycle protein 23 homolog [Mus musculus].
ACCESSION   NP_848124
VERSION     NP_848124.1
DBSOURCE    REFSEQ: accession NM_178347.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 597)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 597)
  AUTHORS   Fan,H., Zhou,Z., Zheng,W., Guan,Y., Meng,Q., Wang,W., Dong,J.,
            Wan,L., Zhu,J., Zeng,Y., Liu,R., Gu,H., Lin,G., Chen,B., Sang,Q.
            and Wang,L.
  TITLE     Homozygous variants in CDC23 cause female infertility characterized
            by oocyte maturation defects
  JOURNAL   Hum Genet 142 (11), 1621-1631 (2023)
   PUBMED   37768355
  REMARK    GeneRIF: Homozygous variants in CDC23 cause female infertility
            characterized by oocyte maturation defects.
REFERENCE   3  (residues 1 to 597)
  AUTHORS   Ferguson,C.J., Urso,O., Bodrug,T., Gassaway,B.M., Watson,E.R.,
            Prabu,J.R., Lara-Gonzalez,P., Martinez-Chacin,R.C., Wu,D.Y.,
            Brigatti,K.W., Puffenberger,E.G., Taylor,C.M., Haas-Givler,B.,
            Jinks,R.N., Strauss,K.A., Desai,A., Gabel,H.W., Gygi,S.P.,
            Schulman,B.A., Brown,N.G. and Bonni,A.
  TITLE     APC7 mediates ubiquitin signaling in constitutive heterochromatin
            in the developing mammalian brain
  JOURNAL   Mol Cell 82 (1), 90-105 (2022)
   PUBMED   34942119
REFERENCE   4  (residues 1 to 597)
  AUTHORS   Zhou,Q., Li,J., Yue,W., Li,A., Meng,T.G., Lei,W.L., Fan,L.H.,
            Ouyang,Y.C., Schatten,H., Wang,Z.B. and Sun,Q.Y.
  TITLE     Cell division cycle 23 is required for mouse oocyte meiotic
            maturation
  JOURNAL   FASEB J 34 (7), 8990-9002 (2020)
   PUBMED   32449168
  REMARK    GeneRIF: Cell division cycle 23 is required for mouse oocyte
            meiotic maturation.
REFERENCE   5  (residues 1 to 597)
  AUTHORS   Tang,F., Barbacioru,C., Nordman,E., Bao,S., Lee,C., Wang,X.,
            Tuch,B.B., Heard,E., Lao,K. and Surani,M.A.
  TITLE     Deterministic and stochastic allele specific gene expression in
            single mouse blastomeres
  JOURNAL   PLoS One 6 (6), e21208 (2011)
   PUBMED   21731673
REFERENCE   6  (residues 1 to 597)
  AUTHORS   Lelli,A., Asai,Y., Forge,A., Holt,J.R. and Geleoc,G.S.
  TITLE     Tonotopic gradient in the developmental acquisition of sensory
            transduction in outer hair cells of the mouse cochlea
  JOURNAL   J Neurophysiol 101 (6), 2961-2973 (2009)
   PUBMED   19339464
REFERENCE   7  (residues 1 to 597)
  AUTHORS   Ballif,B.A., Villen,J., Beausoleil,S.A., Schwartz,D. and Gygi,S.P.
  TITLE     Phosphoproteomic analysis of the developing mouse brain
  JOURNAL   Mol Cell Proteomics 3 (11), 1093-1101 (2004)
   PUBMED   15345747
REFERENCE   8  (residues 1 to 597)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC145591.5 and
            AC074335.11.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK081461.1, AK038523.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..597
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 18.69 cM"
     Protein         1..597
                     /product="cell division cycle protein 23 homolog"
                     /note="APC8; cyclosome subunit 8; anaphase-promoting
                     complex subunit 8; CDC23 (cell division cycle 23, yeast,
                     homolog)"
                     /calculated_mol_wt=68434
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0000250|UniProtKB:Q9UJX2; propagated from
                     UniProtKB/Swiss-Prot (Q8BGZ4.2)"
     Region          27..63
                     /region_name="TPR 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BGZ4.2)"
     Region          45..148
                     /region_name="ANAPC8"
                     /note="Anaphase promoting complex subunit 8 / Cdc23;
                     pfam04049"
                     /db_xref="CDD:427675"
     Region          73..112
                     /region_name="TPR 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BGZ4.2)"
     Region          114..144
                     /region_name="TPR 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BGZ4.2)"
     Region          169..200
                     /region_name="TPR 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BGZ4.2)"
     Region          229..259
                     /region_name="TPR 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BGZ4.2)"
     Region          234..>405
                     /region_name="Spy"
                     /note="Predicted O-linked N-acetylglucosamine transferase,
                     SPINDLY family [Posttranslational modification, protein
                     turnover, chaperones]; COG3914"
                     /db_xref="CDD:443119"
     Region          263..293
                     /region_name="TPR 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BGZ4.2)"
     Site            273
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0000250|UniProtKB:Q9UJX2; propagated from
                     UniProtKB/Swiss-Prot (Q8BGZ4.2)"
     Region          297..327
                     /region_name="TPR 7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BGZ4.2)"
     Region          325..>495
                     /region_name="TPR"
                     /note="Tetratricopeptide (TPR) repeat [General function
                     prediction only]; COG0457"
                     /db_xref="CDD:440225"
     Region          331..361
                     /region_name="TPR 8"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BGZ4.2)"
     Region          331..359
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          366..395
                     /region_name="TPR 9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BGZ4.2)"
     Region          367..393
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            order(369..370,373..374,376,400,403..404,407..408,
                     410..411,434,437..438,441..442,445)
                     /site_type="other"
                     /note="putative protein binding surface [polypeptide
                     binding]"
                     /db_xref="CDD:276809"
     Region          398..428
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          400..432
                     /region_name="TPR 10"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BGZ4.2)"
     Region          433..466
                     /region_name="TPR 11"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BGZ4.2)"
     Region          433..461
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          467..495
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Site            467
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q9UJX2; propagated from
                     UniProtKB/Swiss-Prot (Q8BGZ4.2)"
     Region          468..500
                     /region_name="TPR 12"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BGZ4.2)"
     Region          501..536
                     /region_name="TPR repeat"
                     /note="TPR repeat [structural motif]"
                     /db_xref="CDD:276809"
     Region          504..540
                     /region_name="TPR 13"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8BGZ4.2)"
     Site            562
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9UJX2; propagated from
                     UniProtKB/Swiss-Prot (Q8BGZ4.2)"
     Site            578
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8BGZ4.2)"
     Site            582
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9UJX2; propagated from
                     UniProtKB/Swiss-Prot (Q8BGZ4.2)"
     Site            588
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8BGZ4.2)"
     Site            593
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UJX2; propagated from
                     UniProtKB/Swiss-Prot (Q8BGZ4.2)"
     Site            596
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q8BGZ4.2)"
     CDS             1..597
                     /gene="Cdc23"
                     /gene_synonym="6030435O18; D18Ertd243e"
                     /coded_by="NM_178347.4:30..1823"
                     /db_xref="CCDS:CCDS29132.1"
                     /db_xref="GeneID:52563"
                     /db_xref="MGI:MGI:1098815"
ORIGIN      
        1 maanssvvsv aaaatavpgv stvadfsdlq eikkqlllia gltrergllh sskwsaelaf
       61 slpalplsel qpppplteed aqdvdaytla kayfdvkeyd raahflhgcn skkayflymy
      121 srylsgekkk ddetvdslgp lekgqvknea lrelrvelsr khqargldgf glylygvvlr
      181 kldlvkeaid vfveathvlp lhwgawlelc nlitdkemlk flslpdtwmk efflahiyte
      241 lqlieealqk yqhlidvgfs kssyivsqia vayhnirdid kalsifnelr kqdpyrienm
      301 dtfsnllyvr smkselsyla hnlceidkyr vetccvigny yslrsqheka alyfqralkl
      361 nprylgawtl mgheymemkn tsaaiqayrh aievnkrdyr awyglgqtye ilkmpfycly
      421 yyrrahqlrp ndsrmlvalg ecyeklnqlv eakkcywray avgdvekmal vklaklheql
      481 teseqaaqcy ikyiqdiysc getvehlees tafrylaqyy fkcklwdeas tcaqkccafn
      541 dtreegkall rqilqlrnqg etptsdtpgt fflpaslsan ntptrrvspl nlssvtp
//
