LOCUS       NP_075712                499 aa            linear   ROD 06-DEC-2024
DEFINITION  cell division cycle protein 20 homolog [Mus musculus].
ACCESSION   NP_075712
VERSION     NP_075712.2
DBSOURCE    REFSEQ: accession NM_023223.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 499)
  AUTHORS   Zhou,B., Feng,C., Sun,S., Chen,X., Zhuansun,D., Wang,D., Yu,X.,
            Meng,X., Xiao,J., Wu,L., Wang,J., Wang,J., Chen,K., Li,Z., You,J.,
            Mao,H., Yang,S., Zhang,J., Jiao,C., Li,Z., Yu,D., Wu,X., Zhu,T.,
            Yang,J., Xiang,L., Liu,J., Chai,T., Shen,J., Mao,C.X., Hu,J.,
            Hao,X., Xiong,B., Zheng,S., Liu,Z. and Feng,J.
  TITLE     Identification of signaling pathways that specify a subset of
            migrating enteric neural crest cells at the wavefront in mouse
            embryos
  JOURNAL   Dev Cell 59 (13), 1689-1706 (2024)
   PUBMED   38636517
REFERENCE   2  (residues 1 to 499)
  AUTHORS   Kolesova,H., Hrabalova,P., Bohuslavova,R., Abaffy,P.,
            Fabriciova,V., Sedmera,D. and Pavlinkova,G.
  TITLE     Reprogramming of the developing heart by Hif1a-deficient
            sympathetic system and maternal diabetes exposure
  JOURNAL   Front Endocrinol (Lausanne) 15, 1344074 (2024)
   PUBMED   38505753
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 499)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 499)
  AUTHORS   Iyyappan,R., Aleshkina,D., Ming,H., Dvoran,M., Kakavand,K.,
            Jansova,D., Del Llano,E., Gahurova,L., Bruce,A.W., Masek,T.,
            Pospisek,M., Horvat,F., Kubelka,M., Jiang,Z. and Susor,A.
  TITLE     The translational oscillation in oocyte and early embryo
            development
  JOURNAL   Nucleic Acids Res 51 (22), 12076-12091 (2023)
   PUBMED   37950888
REFERENCE   5  (residues 1 to 499)
  AUTHORS   Ledvin,L., Gassaway,B.M., Tawil,J., Urso,O., Pizzo,D., Welsh,K.A.,
            Bolhuis,D.L., Fisher,D., Bonni,A., Gygi,S.P., Brown,N.G. and
            Ferguson,C.J.
  TITLE     The anaphase-promoting complex controls a
            ubiquitination-phosphoprotein axis in chromatin during
            neurodevelopment
  JOURNAL   Dev Cell 58 (23), 2666-2683 (2023)
   PUBMED   37875116
REFERENCE   6  (residues 1 to 499)
  AUTHORS   Asadi,A., Jorgensen,J. and Jacobsson,A.
  TITLE     Elovl1 and p55Cdc genes are localized in a tail-to-tail array and
            are co-expressed in proliferating cells
  JOURNAL   J Biol Chem 277 (21), 18494-18500 (2002)
   PUBMED   11891222
REFERENCE   7  (residues 1 to 499)
  AUTHORS   Sudakin,V., Chan,G.K. and Yen,T.J.
  TITLE     Checkpoint inhibition of the APC/C in HeLa cells is mediated by a
            complex of BUBR1, BUB3, CDC20, and MAD2
  JOURNAL   J Cell Biol 154 (5), 925-936 (2001)
   PUBMED   11535616
REFERENCE   8  (residues 1 to 499)
  AUTHORS   Zhang,Y. and Lees,E.
  TITLE     Identification of an overlapping binding domain on Cdc20 for Mad2
            and anaphase-promoting complex: model for spindle checkpoint
            regulation
  JOURNAL   Mol Cell Biol 21 (15), 5190-5199 (2001)
   PUBMED   11438673
REFERENCE   9  (residues 1 to 499)
  AUTHORS   Yao,J., Liu,Y., Lo,R., Tretjakoff,I., Peterson,A. and Stifani,S.
  TITLE     Disrupted development of the cerebral hemispheres in transgenic
            mice expressing the mammalian Groucho homologue
            transducin-like-enhancer of split 1 in postmitotic neurons
  JOURNAL   Mech Dev 93 (1-2), 105-115 (2000)
   PUBMED   10781944
REFERENCE   10 (residues 1 to 499)
  AUTHORS   Inbal,N., Listovsky,T. and Brandeis,M.
  TITLE     The mammalian Fizzy and Fizzy-related genes are regulated at the
            transcriptional and post-transcriptional levels
  JOURNAL   FEBS Lett 463 (3), 350-354 (1999)
   PUBMED   10606752
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY736811.1, AK168650.1 and AV499208.1.
            
            On Jan 16, 2008 this sequence version replaced NP_075712.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003215.1, AK160204.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..499
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 54.61 cM"
     Protein         1..499
                     /product="cell division cycle protein 20 homolog"
                     /note="mmCdc20; cell division cycle 20 homolog"
                     /calculated_mol_wt=54685
     Region          27..82
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JJ66.2)"
     Site            41
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12834; propagated from
                     UniProtKB/Swiss-Prot (Q9JJ66.2)"
     Site            66
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q12834; propagated from
                     UniProtKB/Swiss-Prot (Q9JJ66.2)"
     Site            70
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q12834; propagated from
                     UniProtKB/Swiss-Prot (Q9JJ66.2)"
     Site            72
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12834; propagated from
                     UniProtKB/Swiss-Prot (Q9JJ66.2)"
     Site            92
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12834; propagated from
                     UniProtKB/Swiss-Prot (Q9JJ66.2)"
     Site            106
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q12834; propagated from
                     UniProtKB/Swiss-Prot (Q9JJ66.2)"
     Site            153
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12834; propagated from
                     UniProtKB/Swiss-Prot (Q9JJ66.2)"
     Site            157
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q12834; propagated from
                     UniProtKB/Swiss-Prot (Q9JJ66.2)"
     Site            161
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q12834; propagated from
                     UniProtKB/Swiss-Prot (Q9JJ66.2)"
     Region          182..221
                     /region_name="WD 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JJ66.2)"
     Region          188..224
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          <190..471
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          224..263
                     /region_name="WD 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JJ66.2)"
     Region          229..266
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          266..303
                     /region_name="WD 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JJ66.2)"
     Region          272..307
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          307..346
                     /region_name="WD 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JJ66.2)"
     Region          312..352
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          353..395
                     /region_name="WD 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JJ66.2)"
     Region          359..397
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          397..438
                     /region_name="WD 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JJ66.2)"
     Region          402..440
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          441..480
                     /region_name="WD 7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9JJ66.2)"
     CDS             1..499
                     /gene="Cdc20"
                     /gene_synonym="2310042N09Rik; p55CDC"
                     /coded_by="NM_023223.2:223..1722"
                     /db_xref="CCDS:CCDS18551.1"
                     /db_xref="GeneID:107995"
                     /db_xref="MGI:MGI:1859866"
ORIGIN      
        1 maqfvfesdl hsllqldapi pnapvarwqr kakeatgpap spmraanrsh sagrtpgrtp
       61 gkssskvqtt pskpggdrfi pqrsasqmev asfllskenq pedrgtptkk ehqkawslnl
      121 ngfdveeaki lrlsgkpqna pegyqnrlkv lysqkatpgs srktcryips lpdrildape
      181 irndyylnlv dwssgnvlav aldnsvylwn agsgdilqll qmeqpgdyis svawikegny
      241 lavgtsnaev qlwdvqqqkr lrnmtshsar vsslswnsyi lssgsrsghi hhhdvrvaeh
      301 hvatlsghsq evcglrwapd grhlasggnd nivnvwpsgp gesgwaplqt ftqhqgavka
      361 vawcpwqsni latgggtsdr hiriwnvcsg aclsavdvhs qvcsilwsph ykelisghgf
      421 aqnqlviwky ptmakvaelk ghtarvlglt mspdgatvas aaadetlrlw rcfemdpalr
      481 rerekasvak sslihqgir
//
