LOCUS       NM_027276               2334 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus CDC16 cell division cycle 16 (Cdc16), transcript
            variant 1, mRNA.
ACCESSION   NM_027276
VERSION     NM_027276.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2334)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2334)
  AUTHORS   Ferguson,C.J., Urso,O., Bodrug,T., Gassaway,B.M., Watson,E.R.,
            Prabu,J.R., Lara-Gonzalez,P., Martinez-Chacin,R.C., Wu,D.Y.,
            Brigatti,K.W., Puffenberger,E.G., Taylor,C.M., Haas-Givler,B.,
            Jinks,R.N., Strauss,K.A., Desai,A., Gabel,H.W., Gygi,S.P.,
            Schulman,B.A., Brown,N.G. and Bonni,A.
  TITLE     APC7 mediates ubiquitin signaling in constitutive heterochromatin
            in the developing mammalian brain
  JOURNAL   Mol Cell 82 (1), 90-105 (2022)
   PUBMED   34942119
REFERENCE   3  (bases 1 to 2334)
  AUTHORS   Fan,M., Rhee,J., St-Pierre,J., Handschin,C., Puigserver,P., Lin,J.,
            Jaeger,S., Erdjument-Bromage,H., Tempst,P. and Spiegelman,B.M.
  TITLE     Suppression of mitochondrial respiration through recruitment of
            p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK
  JOURNAL   Genes Dev 18 (3), 278-289 (2004)
   PUBMED   14744933
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134623.5 and AK147938.1.
            
            On Oct 24, 2017 this sequence version replaced NM_027276.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147938.1, BC026606.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AC134623.5         28943-28962         c
            21-645              AK147938.1         2-626
            646-646             AC134623.5         23654-23654         c
            647-2334            AK147938.1         628-2315
FEATURES             Location/Qualifiers
     source          1..2334
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 6.38 cM"
     gene            1..2334
                     /gene="Cdc16"
                     /gene_synonym="2700071J12Rik; 2810431D22Rik; APC6"
                     /note="CDC16 cell division cycle 16"
                     /db_xref="GeneID:69957"
                     /db_xref="MGI:MGI:1917207"
     exon            1..199
                     /gene="Cdc16"
                     /gene_synonym="2700071J12Rik; 2810431D22Rik; APC6"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..2014
                     /gene="Cdc16"
                     /gene_synonym="2700071J12Rik; 2810431D22Rik; APC6"
                     /note="isoform 1 is encoded by transcript variant 1; cell
                     division cycle protein 16 homolog; anaphase-promoting
                     complex subunit 6; cyclosome subunit 6"
                     /codon_start=1
                     /product="cell division cycle protein 16 homolog isoform
                     1"
                     /protein_id="NP_081552.2"
                     /db_xref="CCDS:CCDS22114.1"
                     /db_xref="GeneID:69957"
                     /db_xref="MGI:MGI:1917207"
                     /translation="MNLEPLRKRVRQYLDQQQYQSALFWADKVASLSHEEPQDVYWLA
                     QCLYLTAQYHRAAHALRSRKLDKLYEACRYLAARCHYAAKEHQQALDILDMEEPINRR
                     LFEKYLKDDNGSRDPSSDWEMSQSSIKSSICLLRGKIYDALDNRTLATYSYKEALKLD
                     VYCFEAFDLLTSHHMLTAQEEKELLDSLPLNKLCAEEQELLRFVFENKLKKYNKPSET
                     VIPESVDGLQENLDVVVSLAERHYYNCDFKMCYKLTSTVMEKDPFHANCLPVHIGTLV
                     ELNKANELFYLSHKLVDLYPSNPVSWFAVGCYYLMVGHKNEHARRYLSKATTLEKTYG
                     PAWIAYGHSFAVESEHDQAMAAYFTAAQLMKGCHLPMLYIGLEYGLTNNSKLAERFFG
                     QALSIAPEDPFVIHEVGVVAFQNGEWKTAEKWFLDALEKIKAIGNEVTVDKWEPLLNN
                     LGHVCRKLKKYAEALDYHRQALVLIPQNASTYSAIGYIHSLMGNFENAVDYFHTALGL
                     RRDDTFSVTMLGHCIEMYIGDSEAYIGADIKDKLKCYDFDVHTMKTLKNIISPPWDFR
                     DFEVEKQNTEEAGLAPLQNSTKAPESRPNLEETFEIEMNESDMMLETSMSDHST"
     exon            200..254
                     /gene="Cdc16"
                     /gene_synonym="2700071J12Rik; 2810431D22Rik; APC6"
                     /inference="alignment:Splign:2.1.0"
     exon            255..352
                     /gene="Cdc16"
                     /gene_synonym="2700071J12Rik; 2810431D22Rik; APC6"
                     /inference="alignment:Splign:2.1.0"
     exon            353..391
                     /gene="Cdc16"
                     /gene_synonym="2700071J12Rik; 2810431D22Rik; APC6"
                     /inference="alignment:Splign:2.1.0"
     exon            392..532
                     /gene="Cdc16"
                     /gene_synonym="2700071J12Rik; 2810431D22Rik; APC6"
                     /inference="alignment:Splign:2.1.0"
     exon            533..692
                     /gene="Cdc16"
                     /gene_synonym="2700071J12Rik; 2810431D22Rik; APC6"
                     /inference="alignment:Splign:2.1.0"
     exon            693..784
                     /gene="Cdc16"
                     /gene_synonym="2700071J12Rik; 2810431D22Rik; APC6"
                     /inference="alignment:Splign:2.1.0"
     exon            785..918
                     /gene="Cdc16"
                     /gene_synonym="2700071J12Rik; 2810431D22Rik; APC6"
                     /inference="alignment:Splign:2.1.0"
     exon            919..998
                     /gene="Cdc16"
                     /gene_synonym="2700071J12Rik; 2810431D22Rik; APC6"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1048
                     /gene="Cdc16"
                     /gene_synonym="2700071J12Rik; 2810431D22Rik; APC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1122
                     /gene="Cdc16"
                     /gene_synonym="2700071J12Rik; 2810431D22Rik; APC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1248
                     /gene="Cdc16"
                     /gene_synonym="2700071J12Rik; 2810431D22Rik; APC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1401
                     /gene="Cdc16"
                     /gene_synonym="2700071J12Rik; 2810431D22Rik; APC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1465
                     /gene="Cdc16"
                     /gene_synonym="2700071J12Rik; 2810431D22Rik; APC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1527
                     /gene="Cdc16"
                     /gene_synonym="2700071J12Rik; 2810431D22Rik; APC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1663
                     /gene="Cdc16"
                     /gene_synonym="2700071J12Rik; 2810431D22Rik; APC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1754
                     /gene="Cdc16"
                     /gene_synonym="2700071J12Rik; 2810431D22Rik; APC6"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..2334
                     /gene="Cdc16"
                     /gene_synonym="2700071J12Rik; 2810431D22Rik; APC6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2246..2251
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdc16"
                     /gene_synonym="2700071J12Rik; 2810431D22Rik; APC6"
                     /note="hexamer: AATAAA"
     polyA_site      2265
                     /gene="Cdc16"
                     /gene_synonym="2700071J12Rik; 2810431D22Rik; APC6"
                     /note="major polyA site"
     regulatory      2293..2298
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdc16"
                     /gene_synonym="2700071J12Rik; 2810431D22Rik; APC6"
                     /note="hexamer: AATAAA"
     polyA_site      2321
                     /gene="Cdc16"
                     /gene_synonym="2700071J12Rik; 2810431D22Rik; APC6"
ORIGIN      
        1 ggacttccgg ggtagggcct gtcggagcgg aagtgccgtg tggcgcgcgg ggtctggtcc
       61 gggcggtggt cggcgggctt gggtccctcg acaccccggg ggcgcgcgga ggctcgagag
      121 ggcgtcgggt gcctgccctg gcctcgcggc catgaacctg gagccgctgc gcaaacgcgt
      181 ccggcagtac ctggaccagc aacagtatca aagtgctctg ttttgggcag acaaggtagc
      241 ttcactctct catgaggagc cccaggatgt ttattggttg gctcagtgcc tttacctcac
      301 agcgcagtac caccgagcag cccatgcgct ccggtcacgc aagctggaca aattgtatga
      361 agcttgccga taccttgcag ctagatgcca ctatgctgca aaagagcacc agcaggctct
      421 ggacatcctt gacatggagg agccaattaa cagaaggctc tttgagaaat acctgaagga
      481 tgacaatggc tcgagagacc cttccagtga ctgggagatg tcacagtctt ccataaagag
      541 ctcgatttgt ctcctgagag ggaagatcta tgatgcttta gataatcgca ccctggctac
      601 ctacagttac aaagaggctc tgaaactgga tgtctactgc tttgaagcct ttgacctttt
      661 gacatcacac cacatgctga cagcacagga agaaaaagaa cttctggact ccctgcctct
      721 taacaagctc tgtgctgaag aacaagagtt gctgcgattt gtatttgaga acaaattaaa
      781 gaagtataat aagcccagtg aaacggtcat tcccgagtca gtggacggct tgcaggagaa
      841 tctggacgtg gtagtgtctt tagctgagag acactattac aactgtgatt ttaagatgtg
      901 ctacaagctt acttctacag tgatggagaa agatcctttc catgcaaact gtttacctgt
      961 gcacatagga actcttgtgg agctgaataa agcgaatgaa cttttctatc tttctcacaa
     1021 actggtggat ttatatccga gtaatcctgt gtcttggttt gcggtgggat gttactatct
     1081 catggttggt cataaaaatg agcatgccag aagatatctc agcaaagcta ccacgttgga
     1141 gaagacctac ggtcctgcct ggatagccta cgggcattcc ttcgctgtgg agagtgagca
     1201 cgaccaagca atggctgctt acttcacagc agcacagctg atgaaggggt gtcacttgcc
     1261 aatgctatat attggattag aatatggtct gaccaataac tcgaaactgg ctgagcggtt
     1321 ctttggccaa gctctgagca tcgccccaga agacccattt gtcatccatg aggttggagt
     1381 ggttgccttt cagaatggag aatggaaaac agcagaaaaa tggtttctcg atgctttgga
     1441 aaaaattaaa gcaattggaa atgaggtcac agttgacaaa tgggaacctt tgttgaacaa
     1501 cttggggcat gtctgcagaa aacttaagaa atatgctgag gctttggatt accacaggca
     1561 ggcactggtg ctaatccctc agaacgcatc cacctactct gctatagggt acatccacag
     1621 tctgatgggc aactttgaaa acgctgtgga ctatttccac acagctcttg gtctcaggcg
     1681 agacgacaca ttttctgtta caatgcttgg tcactgcatt gaaatgtaca tcggggattc
     1741 ggaagcttat atcggagcag acattaaaga caaattaaag tgctatgact tcgatgtgca
     1801 tacaatgaaa acactaaaaa acatcatttc gcctccatgg gatttcaggg actttgaagt
     1861 agaaaagcag aacacagagg aagcgggact tgcacctctg caaaactcca ctaaagctcc
     1921 agagtccaga cctaacttgg aagagacttt tgaaattgaa atgaacgaaa gtgacatgat
     1981 gctagagacg tctatgtcag accacagcac atagccacag cactgaacct gacagaggtc
     2041 cagggcccac cctcatgtgc cagagtaggt caatgctccc ctgcagcctt gctacgtcct
     2101 aagaattttc cagttcctga tgtgactcca gactacatct ctacatttag gaccagcagc
     2161 ctgcagtaac agtgggacag caggccttgg caacagatgt tttccgattt tctgaaccta
     2221 caaagtagtt agttacgtgt agcagaataa agaaggtcaa ctattcgtta tctttttcat
     2281 tgtgtctttt tcaataaatt tatatttggg aataactaga agtttccaag ctgg
//
