LOCUS       NM_172587               5859 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus CDC14 cell division cycle 14B (Cdc14b), transcript
            variant 1, mRNA.
ACCESSION   NM_172587
VERSION     NM_172587.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5859)
  AUTHORS   Bai,G.Y., Choe,M.H., Kim,J.S. and Oh,J.S.
  TITLE     Mis12 controls cyclin B1 stabilization via Cdc14B-mediated
            APC/CCdh1 regulation during meiotic G2/M transition in mouse
            oocytes
  JOURNAL   Development 147 (8) (2020)
   PUBMED   32341029
  REMARK    GeneRIF: Mis12 controls cyclin B1 stabilization via Cdc14B-mediated
            APC/C(Cdh1) regulation during meiotic G2/M transition in mouse
            oocytes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5859)
  AUTHORS   Imtiaz,A., Belyantseva,I.A., Beirl,A.J., Fenollar-Ferrer,C.,
            Bashir,R., Bukhari,I., Bouzid,A., Shaukat,U., Azaiez,H.,
            Booth,K.T., Kahrizi,K., Najmabadi,H., Maqsood,A., Wilson,E.A.,
            Fitzgerald,T.S., Tlili,A., Olszewski,R., Lund,M., Chaudhry,T.,
            Rehman,A.U., Starost,M.F., Waryah,A.M., Hoa,M., Dong,L.,
            Morell,R.J., Smith,R.J.H., Riazuddin,S., Masmoudi,S., Kindt,K.S.,
            Naz,S. and Friedman,T.B.
  TITLE     CDC14A phosphatase is essential for hearing and male fertility in
            mouse and human
  JOURNAL   Hum Mol Genet 27 (5), 780-798 (2018)
   PUBMED   29293958
REFERENCE   3  (bases 1 to 5859)
  AUTHORS   Lin,H., Ha,K., Lu,G., Fang,X., Cheng,R., Zuo,Q. and Zhang,P.
  TITLE     Cdc14A and Cdc14B Redundantly Regulate DNA Double-Strand Break
            Repair
  JOURNAL   Mol Cell Biol 35 (21), 3657-3668 (2015)
   PUBMED   26283732
  REMARK    GeneRIF: Cdc14B knockout (Cdc14B(-/-)) mouse embryonic fibroblasts
            showed defects in repairing ionizing radiation-induced DNA
            double-strand breaks, which occurred only at late passages when
            Cdc14A levels were low.
REFERENCE   4  (bases 1 to 5859)
  AUTHORS   Chiesa,M., Guillamot,M., Bueno,M.J. and Malumbres,M.
  TITLE     The Cdc14B phosphatase displays oncogenic activity mediated by the
            Ras-Mek signaling pathway
  JOURNAL   Cell Cycle 10 (10), 1607-1617 (2011)
   PUBMED   21502810
  REMARK    GeneRIF: Cdc14B has oncogenic activity in mammals and point to the
            Ras-MAP kinase pathway as a major effector pathway during oncogenic
            transformation.
REFERENCE   5  (bases 1 to 5859)
  AUTHORS   Wei,Z., Peddibhotla,S., Lin,H., Fang,X., Li,M., Rosen,J.M. and
            Zhang,P.
  TITLE     Early-onset aging and defective DNA damage response in
            Cdc14b-deficient mice
  JOURNAL   Mol Cell Biol 31 (7), 1470-1477 (2011)
   PUBMED   21262768
  REMARK    GeneRIF: Cdc14b is required for efficient DNA damage repair.
REFERENCE   6  (bases 1 to 5859)
  AUTHORS   Guillamot,M., Manchado,E., Chiesa,M., Gomez-Lopez,G., Pisano,D.G.,
            Sacristan,M.P. and Malumbres,M.
  TITLE     Cdc14b regulates mammalian RNA polymerase II and represses cell
            cycle transcription
  JOURNAL   Sci Rep 1, 189 (2011)
   PUBMED   22355704
  REMARK    GeneRIF: Cdc14b regulates mammalian RNA polymerase II and represses
            cell cycle transcription
REFERENCE   7  (bases 1 to 5859)
  AUTHORS   Buffone,M.G., Schindler,K. and Schultz,R.M.
  TITLE     Overexpression of CDC14B causes mitotic arrest and inhibits zygotic
            genome activation in mouse preimplantation embryos
  JOURNAL   Cell Cycle 8 (23), 3904-3913 (2009)
   PUBMED   19923902
  REMARK    GeneRIF: CDC14B is a negative regulator of the 1-to-2-cell
            transition and of zygotic genome activation in mouse embryogenesis.
REFERENCE   8  (bases 1 to 5859)
  AUTHORS   Schindler,K. and Schultz,R.M.
  TITLE     CDC14B acts through FZR1 (CDH1) to prevent meiotic maturation of
            mouse oocytes
  JOURNAL   Biol Reprod 80 (4), 795-803 (2009)
   PUBMED   19129509
  REMARK    GeneRIF: CDC14B is a negative regulator of meiotic resumption and
            may regulate meiosis I in mouse oocytes.
REFERENCE   9  (bases 1 to 5859)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 5859)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK044332.1, CN720173.1, AK041155.1 and AK036045.1.
            
            On Apr 4, 2008 this sequence version replaced NM_172587.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049794.1, SRR1660811.25714.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-469               AK044332.1         303-771
            470-995             CN720173.1         124-649
            996-3046            AK041155.1         718-2768
            3047-5859           AK036045.1         538-3350
FEATURES             Location/Qualifiers
     source          1..5859
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 33.26 cM"
     gene            1..5859
                     /gene="Cdc14b"
                     /gene_synonym="2810432N10Rik; A530086E13Rik; Cdc14B1;
                     CDC14B3"
                     /note="CDC14 cell division cycle 14B"
                     /db_xref="GeneID:218294"
                     /db_xref="MGI:MGI:2441808"
     exon            1..398
                     /gene="Cdc14b"
                     /gene_synonym="2810432N10Rik; A530086E13Rik; Cdc14B1;
                     CDC14B3"
                     /inference="alignment:Splign:2.1.0"
     exon            399..489
                     /gene="Cdc14b"
                     /gene_synonym="2810432N10Rik; A530086E13Rik; Cdc14B1;
                     CDC14B3"
                     /inference="alignment:Splign:2.1.0"
     exon            490..565
                     /gene="Cdc14b"
                     /gene_synonym="2810432N10Rik; A530086E13Rik; Cdc14B1;
                     CDC14B3"
                     /inference="alignment:Splign:2.1.0"
     exon            566..658
                     /gene="Cdc14b"
                     /gene_synonym="2810432N10Rik; A530086E13Rik; Cdc14B1;
                     CDC14B3"
                     /inference="alignment:Splign:2.1.0"
     exon            659..735
                     /gene="Cdc14b"
                     /gene_synonym="2810432N10Rik; A530086E13Rik; Cdc14B1;
                     CDC14B3"
                     /inference="alignment:Splign:2.1.0"
     exon            736..802
                     /gene="Cdc14b"
                     /gene_synonym="2810432N10Rik; A530086E13Rik; Cdc14B1;
                     CDC14B3"
                     /inference="alignment:Splign:2.1.0"
     exon            803..865
                     /gene="Cdc14b"
                     /gene_synonym="2810432N10Rik; A530086E13Rik; Cdc14B1;
                     CDC14B3"
                     /inference="alignment:Splign:2.1.0"
     exon            866..953
                     /gene="Cdc14b"
                     /gene_synonym="2810432N10Rik; A530086E13Rik; Cdc14B1;
                     CDC14B3"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1184
                     /gene="Cdc14b"
                     /gene_synonym="2810432N10Rik; A530086E13Rik; Cdc14B1;
                     CDC14B3"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1323
                     /gene="Cdc14b"
                     /gene_synonym="2810432N10Rik; A530086E13Rik; Cdc14B1;
                     CDC14B3"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1483
                     /gene="Cdc14b"
                     /gene_synonym="2810432N10Rik; A530086E13Rik; Cdc14B1;
                     CDC14B3"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1581
                     /gene="Cdc14b"
                     /gene_synonym="2810432N10Rik; A530086E13Rik; Cdc14B1;
                     CDC14B3"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1728
                     /gene="Cdc14b"
                     /gene_synonym="2810432N10Rik; A530086E13Rik; Cdc14B1;
                     CDC14B3"
                     /inference="alignment:Splign:2.1.0"
     exon            1729..5859
                     /gene="Cdc14b"
                     /gene_synonym="2810432N10Rik; A530086E13Rik; Cdc14B1;
                     CDC14B3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5840..5845
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdc14b"
                     /gene_synonym="2810432N10Rik; A530086E13Rik; Cdc14B1;
                     CDC14B3"
                     /note="hexamer: ATTAAA"
     polyA_site      5859
                     /gene="Cdc14b"
                     /gene_synonym="2810432N10Rik; A530086E13Rik; Cdc14B1;
                     CDC14B3"
                     /note="major polyA site"
ORIGIN      
        1 ggcccttctt tttgtgaatg aagctccacg gaacatccct cctgggggtc cccgggagcc
       61 gcggcccgct gagctcggac gccacggcag cagcgtccca gggagcgcgc gctttgctcc
      121 agccaccggc cagcgctgtg gggcccccgg gtcgcgggcg gcgggagacg cagcgcgagg
      181 acccgggccg ggttgccggg ccatggtcgc ggtcccctga cgggccgcga ccgcctccat
      241 gaagcgtaag agcgagcggc gctcggcttg ggccaccgcg cccccctgct cacgccgcag
      301 ctcgtcctcc tctcccggcg tgaagaagag ccgcagctcc acgccgcagg agctgcaccg
      361 cctggagcag caggacgacc tgtacctgga catcacggat cgcctttgtt ttgccattct
      421 ctacagcaga ccaaagagtg caacaaacga acattatttc agcatagata acgagctaga
      481 gtatgagaac ttctatgcgg attttggacc actcaatctg gccatggttt acagatattg
      541 ttgcaagata aataagaagc tcaagtccat tacaatgctg aggaagaaaa ttatccattt
      601 tactggcact gatcagagaa agcaagcgaa tgccgccttc cttgtcgggt gttatatggt
      661 tatatatttg gggaggacac cagaagacgc gtatagaaca ttaatcttcg gagatacagc
      721 ctatattcct ttcagagatg ctgcctatgg aagctgcagt ttctatatta cacttctcga
      781 ctgttttcac gcagtaaaga aggcaatgca gtatggcttc tttaatttca actcatttaa
      841 ccttgacgaa tatgaacact atgaaaaagc agaaaatgga gatttcaact ggataatacc
      901 agagcgattt cttgccttct gtgggcccca ttcaagatcc aggctggaaa gtggttacca
      961 ccaacattct ccggagactt atattccata ttttaagaat cacaatgtaa ctaccattat
     1021 tcgtctgaat aaaaggatgt atgatgctaa gcgctttacg gatgctggat tcgatcacca
     1081 tgatcttttc tttccggatg gcagcacccc tgctgagtca attgtccaag aatttctgga
     1141 tatttgtgaa aatgtcaagg gtgccattgc tgtgcattgc aaagctggcc ttggtcgaac
     1201 aggcactctg ataggctgct acctcatgaa gcattacagg atgacagcag ctgagagcat
     1261 tgcctggctc agaatctgta gacccggctc agtaattggg ccccagcaac agtttctggt
     1321 catgaaacaa tcaagcctct ggctagaagg cgactatttc cgtcaaaagt taagagggca
     1381 ggagaatggc cccctcagag aagccttctc caaacacctt tcggatgctg atgacctgtc
     1441 cttaaatggg cttgagaatc aagacaatca agagcctgag ccgtatagtg atgatgatga
     1501 agtcagtgga atgacacaag gagacagact tcgggccctg aaaagccgga gacagccgaa
     1561 agccagcgct atccccctca catgtcccct agctgtgctg acctctgcac tgtgtagtgt
     1621 tgccatctgg tggattgtgt gtgactacat tcttcccacc ctgctgttct gtcttgatgg
     1681 cttcagaaca cagtagccat ctggaccctt tgacagatag tttgctgttc cagccatttc
     1741 aaggactaag acagtcttac gttaaagtaa aaaaacggtg accagcactc cagggaagac
     1801 taggaacaga aaacccaaaa aggatttagc caatcaatct gagaacaaag cagactctgc
     1861 aatggcctta gcttcttacc acataagaag ttcattcaat gaagaaaatg tcactggcct
     1921 ctcatccact cactgactct ggggtgtggt tgaaccattt gagggcctga ctctcccttt
     1981 tgttatctca agttggacaa aagctgctgt tgtgaactta gtctcaggtg tcaatatcct
     2041 gtcctctgcc accagagagt tgtctggtga gtgtggtaca tgtgtgtgtg tccctgtgat
     2101 ggcaatcatg tttgctgctg gcctccagaa gagttgagga tctgatggag atatcttagg
     2161 tatttatttt ttgttcaacc ttgtgaccct gactcgcagt ttataaagat gaaagagatg
     2221 aacatcccac cagtggtacc ctccatcttc aggtatgatt tggtacaatc agcttcactt
     2281 tcctcttgtt aatcctgttg tgatgttcac tgtgtgaagt acccaagctg cttgtttttc
     2341 accaaagagt gctttattaa caacctgtga acactgcatt taaacactgt tgtatgttgt
     2401 tgtggttact gaaaacctgc taggaaatgt tgagaatgtt ggaacccttt ctcagttacc
     2461 tggttcctac aaatccttcc ttgtgtcatt ttaggatgaa gatttcagag ctgggatgtt
     2521 gttgggttgc tcagccacgt tataattgtg tttacttcat tacatcaaaa ccaaacatca
     2581 accctagcat tttcctttgg gaaagcatcc taaataatgg tggctttaac aacaaaattg
     2641 tgagccttgc tgtattggcg cacgccttga atcccagcat tgggaggcag aggcaggtgg
     2701 atctccaggt ggagttccag gccagccaat gatacacaag gaaatcctgt ctcaaaaata
     2761 aaacaaagca aaacaaaaaa accaaaccca aaatcccaaa attgttaacc ctttgtagag
     2821 tctttctctg taacgctgtg gagttttttc cttgtgatcc acagtttgat tttagtgaca
     2881 atcacttgct tctggagtta ggctgtttgt gtaagagatc tcactgttgc ctttggttag
     2941 ggaatatgac tagaaactgt agtgtgcctt ttctcttcac cctgctggaa gccagcagca
     3001 cccgtgccat gaagcaattg caaaaccaga atttatctgc tgccacaaaa aaaaaaaaaa
     3061 aaaaaaagac agagcccata attagaaaat actctatagt tgtcttggtt acttccacaa
     3121 ttgaggctaa tggttttttg actctcccag tttagaaact ggagaaatgc aatattgaaa
     3181 gccattgaca gccaatgcct tcccaagaca ggtgaatgtg tcaggtgagc aggcaatccc
     3241 acttgaaaag ctgccttcct tgtagttgat attgacaggt taaagtctag ttaatgtaaa
     3301 aatattgaaa gacaataggt cccccctttc agtgtttcta tcctcaaact gcattggttg
     3361 gccttggatt ggaggcatga ggattcaatg taaatccaca caaagagccc cccttcctag
     3421 gcagcacgta gctttcaaac aacgggaaaa aacagttaag gtaaagtttg ttatctctgg
     3481 atatgaattg gattggatct aggtaggagg gcaaacgttt catttaccaa tcatgctcaa
     3541 tcaaactgcc taagtctaaa atagaacctt cctgggtggt tcttccttcc ctgaacaagc
     3601 taggccaggc accaggagac agaaggagac tccattccat ctgaactaag ctagatttgt
     3661 tcgcatggat cagaatgagt tggtcagggc ctgcccacac tggctcgtgg tctgcaagtt
     3721 tgggaggaaa ccacctgggc ttcagagatg accacagtgc tttttaaaag gcactttttt
     3781 gtgtttgcag ctccattcat ctagaagtgc tgccactgtg gctcttccct gcatttaact
     3841 cccttgctaa agttacttag gaaacgtgag ttggtgagga cacattcatt tctaggaaaa
     3901 gctacttgat gttgtctggg caggactgct tagcaactga ccaccagtga catcaggacc
     3961 caggaagtct ttgatcagac taatggaaag tccttcctgt tgggaattag tggacaacct
     4021 ctccccaaac tacaactacc cagaaacttc tgggatagaa gaccctgtag ctataaagca
     4081 tgactcagta gatatgggat ggaggggccc ctttaactta agaactttaa atgcctttgt
     4141 aagtgcatca aagcttcttc cagcagaatg aaaattagaa aagtatattt ataggtgccc
     4201 ttgacgcttt tggggaacgc atactatcca gagtctaaga gaagaatgtc tgcattagct
     4261 gagctgaggg cttatagaca gattgtctta gggtttctat tcctgcacaa acatcatgac
     4321 caagaagcaa attggggagg aaagggttta ttcggcttgc gcttccatgc tgctgttcat
     4381 caccaaagga agtcaggact ggaactcaaa caggtcaggg agcaggagct gatgcagagg
     4441 ccatggtggg atgttcctta ctggcttgct cagcttgctc ttttatagaa cccaagacta
     4501 ccagcccagg gatggttcca cctacaagga gcctttcatc cttgatcact aattgagaaa
     4561 atgccttaca gttggatctc atggaggcat ttccttaact gaagctcctt tctctgtgat
     4621 aactccaggt gagtcaagtt gaaacaaaac taggcagtac acagattaat acaattctga
     4681 ggcccagcta taactcttga tttgaggcaa gaaggacgga ccctgagtag tgccacaatc
     4741 aagggtagca gtatttgtcg aaactaacat ggccacatgc tgctcttcct cattaactcc
     4801 ccagctttaa ttggtcccca aaacctagtt ctatccattg ccctgccctg ccctactgcc
     4861 cccctgtcgg gtggcttcta cctcttggct tgggccctga caggtcacag gggcttccaa
     4921 gcgttctcct gaggctcttt gagcacaatc aggtctgtcg acctttccag ctttctgggt
     4981 ctggaattcc tcaggccttt gttagcttga atagctgtct gtgacaagtg agtatgtgtt
     5041 ctagaaacat cagctgtttt tcctcacata ttttttttaa aagttcttac ttgcattttg
     5101 gaaagcagtt ggtcagaaac cttaaaacct attttttttt tttaagctgg gcaattgtag
     5161 caggcagatc tcttgtgagt tcaagaccta cctggtcttc aaagtgagtt ccagtatagt
     5221 tagagctaca cagagaatcc ctgtctcaaa caaaacaaag caaaacaaac aaacaaacaa
     5281 acaaaacaga taatacaaac tatattttaa gatttctctc ccactgaagt gacctcttga
     5341 gaatagccac tgttcttgca tttcttcata aatctgagtg ttccccatct cactgagtgg
     5401 aaatactaca gatacattta aaagatcgcc tatactgtgt aagaaattac ctcctgatga
     5461 tccagtagaa ctcactgtgg atagacacgt ctgtcagatt acggtactgc agttttacat
     5521 ccattgtttg aagactttat tgtacactca tgtgcagatg aagttttaaa atgttactga
     5581 cgagtcacca tttgatcagt cattgtcttg atattttatt aaattgtata tttctaataa
     5641 tattttttaa agttgagaga actggttgga tgtttattct cctgaaggta tttttaagat
     5701 aaagcttcac catagcctgt aaacttggca cataagtagt ttttgatact ttttgttgca
     5761 tttgaaaaat cttgtgtatt gtaaaatggt tttatacaaa atactaaata gtagaaattg
     5821 tataatttac aatcgtataa ttaaaaatat taaacagtc
//
