LOCUS       NM_001080818            4511 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus CDC14 cell division cycle 14A (Cdc14a), transcript
            variant 1, mRNA.
ACCESSION   NM_001080818 XM_991537
VERSION     NM_001080818.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4511)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4511)
  AUTHORS   Villarroya-Beltri,C., Martins,A.F.B., Garcia,A., Gimenez,D.,
            Zarzuela,E., Novo,M., Del Alamo,C., Gonzalez-Martinez,J.,
            Bonel-Perez,G.C., Diaz,I., Guillamot,M., Chiesa,M., Losada,A.,
            Grana-Castro,O., Rovira,M., Munoz,J., Salazar-Roa,M. and
            Malumbres,M.
  TITLE     Mammalian CDC14 phosphatases control exit from stemness in
            pluripotent cells
  JOURNAL   EMBO J 42 (1), e111251 (2023)
   PUBMED   36326833
  REMARK    GeneRIF: Mammalian CDC14 phosphatases control exit from stemness in
            pluripotent cells.
REFERENCE   3  (bases 1 to 4511)
  AUTHORS   Wen,Z., Zhu,H., Zhang,A., Lin,J., Zhang,G., Liu,D., Xiao,Y., Ye,C.,
            Sun,D., Wu,B., Zhang,J. and Gao,J.
  TITLE     Cdc14a has a role in spermatogenesis, sperm maturation and male
            fertility
  JOURNAL   Exp Cell Res 395 (1), 112178 (2020)
   PUBMED   32679235
  REMARK    GeneRIF: Cdc14a has a role in spermatogenesis, sperm maturation and
            male fertility.
REFERENCE   4  (bases 1 to 4511)
  AUTHORS   Hu,H., Shao,D., Wang,L., He,F., Huang,X., Lu,Y., Xiang,X., Zhu,S.,
            Zhang,P., Li,J. and Chen,J.
  TITLE     Phospho-regulation of Cdc14A by polo-like kinase 1 is involved in
            beta-cell function and cell cycle regulation
  JOURNAL   Mol Med Rep 20 (5), 4277-4284 (2019)
   PUBMED   31545409
  REMARK    GeneRIF: PLK1 promoted cell proliferation and insulin secretion
            while inhibiting cellular apoptosis in betaTC3 cell lines under
            both low and high glucose conditions. In addition, the
            phosphoregulation of Cdc14A by PLK1 may be involved in betaTC3 cell
            cycle regulation and insulin secretion under high glucose
            conditions.
REFERENCE   5  (bases 1 to 4511)
  AUTHORS   Imtiaz,A., Belyantseva,I.A., Beirl,A.J., Fenollar-Ferrer,C.,
            Bashir,R., Bukhari,I., Bouzid,A., Shaukat,U., Azaiez,H.,
            Booth,K.T., Kahrizi,K., Najmabadi,H., Maqsood,A., Wilson,E.A.,
            Fitzgerald,T.S., Tlili,A., Olszewski,R., Lund,M., Chaudhry,T.,
            Rehman,A.U., Starost,M.F., Waryah,A.M., Hoa,M., Dong,L.,
            Morell,R.J., Smith,R.J.H., Riazuddin,S., Masmoudi,S., Kindt,K.S.,
            Naz,S. and Friedman,T.B.
  TITLE     CDC14A phosphatase is essential for hearing and male fertility in
            mouse and human
  JOURNAL   Hum Mol Genet 27 (5), 780-798 (2018)
   PUBMED   29293958
  REMARK    GeneRIF: CDC14A activity is necessary for hearing and male
            fertility.
REFERENCE   6  (bases 1 to 4511)
  AUTHORS   Lin,H., Ha,K., Lu,G., Fang,X., Cheng,R., Zuo,Q. and Zhang,P.
  TITLE     Cdc14A and Cdc14B Redundantly Regulate DNA Double-Strand Break
            Repair
  JOURNAL   Mol Cell Biol 35 (21), 3657-3668 (2015)
   PUBMED   26283732
  REMARK    GeneRIF: Cdc14B knockout (Cdc14B(-/-)) mouse embryonic fibroblasts
            showed defects in repairing ionizing radiation-induced DNA
            double-strand breaks, which occurred only at late passages when
            Cdc14A levels were low.
REFERENCE   7  (bases 1 to 4511)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 4511)
  AUTHORS   Mocciaro,A. and Schiebel,E.
  TITLE     Cdc14: a highly conserved family of phosphatases with non-conserved
            functions?
  JOURNAL   J Cell Sci 123 (Pt 17), 2867-2876 (2010)
   PUBMED   20720150
  REMARK    Review article
REFERENCE   9  (bases 1 to 4511)
  AUTHORS   Schindler,K. and Schultz,R.M.
  TITLE     The CDC14A phosphatase regulates oocyte maturation in mouse
  JOURNAL   Cell Cycle 8 (7), 1090-1098 (2009)
   PUBMED   19270517
  REMARK    GeneRIF: CDC14A regulates oocyte maturation and functions to
            promote the meiosis I-to-meiosis II transition as its homolog does
            in budding yeast.
REFERENCE   10 (bases 1 to 4511)
  AUTHORS   Clifford,D.M., Chen,C.T., Roberts,R.H., Feoktistova,A., Wolfe,B.A.,
            Chen,J.S., McCollum,D. and Gould,K.L.
  TITLE     The role of Cdc14 phosphatases in the control of cell division
  JOURNAL   Biochem Soc Trans 36 (Pt 3), 436-438 (2008)
   PUBMED   18481975
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK142294.1, AK052560.1 and BC072644.1.
            
            On Mar 17, 2010 this sequence version replaced NM_001080818.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK142294.1, AK043956.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1777              AK142294.1         1-1777
            1778-3193           AK052560.1         1768-3183
            3194-4484           AK142294.1         3197-4487
            4485-4511           BC072644.1         4293-4319
FEATURES             Location/Qualifiers
     source          1..4511
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 50.24 cM"
     gene            1..4511
                     /gene="Cdc14a"
                     /gene_synonym="A830059A17Rik; Cdc14; CDC14a1; CDC14A2"
                     /note="CDC14 cell division cycle 14A"
                     /db_xref="GeneID:229776"
                     /db_xref="MGI:MGI:2442676"
     exon            1..596
                     /gene="Cdc14a"
                     /gene_synonym="A830059A17Rik; Cdc14; CDC14a1; CDC14A2"
                     /inference="alignment:Splign:2.1.0"
     CDS             548..2359
                     /gene="Cdc14a"
                     /gene_synonym="A830059A17Rik; Cdc14; CDC14a1; CDC14A2"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 is encoded by transcript variant 1; dual
                     specificity protein phosphatase CDC14A; CDC14 cell
                     division cycle 14 homolog A"
                     /codon_start=1
                     /product="dual specificity protein phosphatase CDC14A
                     isoform 1"
                     /protein_id="NP_001074287.1"
                     /db_xref="CCDS:CCDS38611.1"
                     /db_xref="GeneID:229776"
                     /db_xref="MGI:MGI:2442676"
                     /translation="MAAESGELIGACEFMKDRLYFATLRNRPKSTINIHYFSIDEELV
                     YENFYADFGPLNLAMVYRYCCKLNKKLKSYSLSRKKIVHYTSFDQRKRANAAFLIGAY
                     AVIYLKKTPEEAYRALLSGSNPPYLPFRDASFGNCTYNLTVLDCLQGIRKGLQHGFFD
                     FETFDAEEYEHYERVENGDFNWIVPGKFLAFSGPHPKSKIENGYPLHAPEAYFPYFKK
                     NNVTTIVRLNKKIYEAKRFTDAGFEHYDLFFIDGSTPSDNIVRRFLNICENTEGAIAV
                     HCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGSIIGPQQHFLKEKQASLWVQ
                     GDIFRSKLKNRPSSEGSITKIISTLDDMSIGANLSKLQSTERIGENNFEDEDMEIKNN
                     VTQGDKLRALKSQRHPRSSPSCAFRSDDMKGHQRAMAQTFRLSSSPQPTMSTMKTSKV
                     CLSPSVTAKKISRGSLSSGANIRSFSINSRLASSLGNLNAGTEEPETKKTTSLTKAAF
                     IASPFTSFLNGSTQTPGRNYPELNNNQYTRSSNSNSSSSSSGLGGNLNSSPVPQSAKP
                     EEHTTILRPSFPGSLSSSSVRFLSRSIPSLQSEYVHY"
     exon            597..687
                     /gene="Cdc14a"
                     /gene_synonym="A830059A17Rik; Cdc14; CDC14a1; CDC14A2"
                     /inference="alignment:Splign:2.1.0"
     exon            688..763
                     /gene="Cdc14a"
                     /gene_synonym="A830059A17Rik; Cdc14; CDC14a1; CDC14A2"
                     /inference="alignment:Splign:2.1.0"
     exon            764..856
                     /gene="Cdc14a"
                     /gene_synonym="A830059A17Rik; Cdc14; CDC14a1; CDC14A2"
                     /inference="alignment:Splign:2.1.0"
     exon            857..936
                     /gene="Cdc14a"
                     /gene_synonym="A830059A17Rik; Cdc14; CDC14a1; CDC14A2"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1003
                     /gene="Cdc14a"
                     /gene_synonym="A830059A17Rik; Cdc14; CDC14a1; CDC14A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1066
                     /gene="Cdc14a"
                     /gene_synonym="A830059A17Rik; Cdc14; CDC14a1; CDC14A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1154
                     /gene="Cdc14a"
                     /gene_synonym="A830059A17Rik; Cdc14; CDC14a1; CDC14A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1385
                     /gene="Cdc14a"
                     /gene_synonym="A830059A17Rik; Cdc14; CDC14a1; CDC14A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1524
                     /gene="Cdc14a"
                     /gene_synonym="A830059A17Rik; Cdc14; CDC14a1; CDC14A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..1684
                     /gene="Cdc14a"
                     /gene_synonym="A830059A17Rik; Cdc14; CDC14a1; CDC14A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1797
                     /gene="Cdc14a"
                     /gene_synonym="A830059A17Rik; Cdc14; CDC14a1; CDC14A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..1845
                     /gene="Cdc14a"
                     /gene_synonym="A830059A17Rik; Cdc14; CDC14a1; CDC14A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..1968
                     /gene="Cdc14a"
                     /gene_synonym="A830059A17Rik; Cdc14; CDC14a1; CDC14A2"
                     /inference="alignment:Splign:2.1.0"
     exon            1969..2329
                     /gene="Cdc14a"
                     /gene_synonym="A830059A17Rik; Cdc14; CDC14a1; CDC14A2"
                     /inference="alignment:Splign:2.1.0"
     exon            2330..4485
                     /gene="Cdc14a"
                     /gene_synonym="A830059A17Rik; Cdc14; CDC14a1; CDC14A2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4464..4469
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdc14a"
                     /gene_synonym="A830059A17Rik; Cdc14; CDC14a1; CDC14A2"
                     /note="hexamer: AATAAA"
     polyA_site      4485
                     /gene="Cdc14a"
                     /gene_synonym="A830059A17Rik; Cdc14; CDC14a1; CDC14A2"
                     /note="major polyA site"
ORIGIN      
        1 ggaggaggag agggaggaag agttgctgct gaaaggaggt ggcgaaggag gagtctgagc
       61 agctgctact agccccgcgg acacctccgg agtcctgccc gctgccgcac gagtggccac
      121 gggcgcgatc cgggccaaac gtcttgtcct ccatgatcac tttgggagcc ggggaaagac
      181 tttgcccggc cttgggagct ggtgtgcgcc gtccaggttt ggtggagacg gtgcagcgcg
      241 agaaggagga gctgcagctc gagaagcagc agcagccgcc gccgccgcag agtccggatc
      301 acagcggtta cagcccgggg cgtgtgcgtc ccgcgcccag cgggttcggt tccccacgga
      361 atgtccccgg ggcgccccac gcgctgaccc tgcagctgcc tccgccttgg gcgactgcct
      421 cctccctcag gcaggctcgg tgattgggac cgcgagctcc cagctcttgg gcagtgggga
      481 agcccccggg ggcgggtgac ctcagctggc cacgacccag ccctcccccg tgcggatctc
      541 gcttaagatg gcagcggagt ctggggaact aatcggggct tgcgagttca tgaaagatcg
      601 attatatttt gctactttaa ggaatagacc aaaaagcaca ataaatatcc actatttctc
      661 catcgacgag gagctggtct atgaaaattt ctatgcagat tttggacctc tgaacttggc
      721 aatggtgtac agatactgct gtaagctaaa caagaaacta aaatcataca gtttatcaag
      781 aaagaagata gtgcactaca cctctttcga ccagcggaaa agagcaaacg cagcattctt
      841 gataggtgct tatgccgtca tctacttaaa gaagacacca gaagaagcgt acagagctct
      901 cctgtctggc tcaaaccctc cttatcttcc attcagggat gcatcttttg gaaactgcac
      961 ttacaacctc accgtccttg actgtttaca aggaatcaga aagggattac agcatgggtt
     1021 ttttgacttt gagacgtttg atgcggaaga atatgaacat tatgagcgag ttgaaaacgg
     1081 agacttcaac tggatcgttc caggaaagtt tttagcgttc agtggaccgc atcctaaaag
     1141 caagattgag aatggttacc ctctccacgc tcccgaagcc tactttccat acttcaaaaa
     1201 gaacaacgtg accacgatcg tgagattgaa caaaaagatc tacgaggcga agcgcttcac
     1261 agacgctggc ttcgagcact atgacctgtt cttcatagac ggcagcaccc ccagcgataa
     1321 catcgtgcgg agattcctga acatctgtga gaacaccgag ggggccatcg cggtccactg
     1381 caaagctggt ctgggaagaa ccgggacatt gatagcctgt tatgtcatga aacactacag
     1441 gtttacacat gctgaaatca ttgcttggat cagaatttgc cgaccaggct ccatcatcgg
     1501 accccagcag cacttcctga aagaaaaaca agcatcattg tgggtccaag gagacatttt
     1561 tagatccaaa ctaaaaaata gaccatccag tgagggaagt attacaaaaa ttatttctac
     1621 cctggatgat atgtctattg gtgcaaattt atccaaatta caaagcacag aaaggattgg
     1681 agagaataat tttgaagacg aagatatgga aattaagaac aacgtaacgc agggagacaa
     1741 actacgtgcc ttaaaaagcc agaggcatcc ccgctcctcg ccatcctgtg catttaggtc
     1801 agatgatatg aaaggacacc aaagggcaat ggcccagact ttcagattaa gttcctcacc
     1861 gcaaccaact atgtcgacca tgaagacctc caaagtgtgt ttgtcccctt cagtgacagc
     1921 caaaaaaata agccgaggtt ctttgtcttc aggagcaaat ataagaagct tctccataaa
     1981 ttcccggcta gccagttctc tagggaactt gaacgccggg acagaagaac ctgagaccaa
     2041 gaagaccaca tcactcacca aggccgcttt catagccagc ccattcacca gcttcttgaa
     2101 tggcagcacc cagacacctg gcagaaacta ccctgagctc aacaacaacc agtacaccag
     2161 aagcagcaac agcaacagca gcagcagcag cagcggtctt gggggcaacc tgaacagctc
     2221 tccagtcccc cagagcgcca agcccgagga gcacaccacc atccttcgac cttccttccc
     2281 ggggtcactc tcttcctcct cagtgagatt cctgagccgt tctatacctt cccttcagtc
     2341 tgaatacgtt cattactaag gccttgccac tccagtgaag acagttccga tcttacacat
     2401 ctggatgtgc aatgcggaag gaaacagctg cttgcccgga ggatgtccct gccttcttac
     2461 cttaaagtag agagagtatt aacattgtac tgttgagaga cttgagacca gagcgctggc
     2521 taatgactac tatccatgca ctggagtgat ctttatggag ctgtccatac ttgtaaagac
     2581 agttttaatg ttaaatttgg tattttaaaa ggttattttt aatgtatttc agtgatgtat
     2641 ttgttactgc attgacatgt acagtgttac acatatatgt atcatgaact ttataaaaga
     2701 ctattttgat aattttataa atatataaaa ttatgtaaaa gctatactat attttgattt
     2761 agattttcct gctgtttgtt accaaaaaat ttgtatttta aatttgttta gctttagtat
     2821 ggttttgtct acaatgagta tgtaattctt ccttattaaa tgaaaatgag ggagcgaatt
     2881 ttgagatgtg attttaatgc tcccctatgg attcagtaga tcaggccatt ctctgctgaa
     2941 gcctgtctga actagaattc atccaaattt atctctacca agagtggggt tatttgatag
     3001 gttcgtttag gaaaaaaatt tgcccctttg ttttttttct tgagtctttt aagtaggagg
     3061 ctttaaaaaa aattgagcat ttttttaaga tcagaaataa tgggcgtttc tcctgaaagc
     3121 atgattttct ccctctgtga aacggcagaa cattccagtg cttttatttc tttccttctc
     3181 tcacgcgtgc tttaaaaaaa agaaaatgcc ttaaatcatt tattttgctt atgccttctt
     3241 gtaaatatgc aaaggaagga tacgaatttt aaggcccagg tctacggttc gaaagaacac
     3301 acccagtaaa tgtactataa tgttgttaaa gaccaaaaag cacttcaaag ggagttgata
     3361 gctcagaact gttcttggta cgaggtggtc attgccctgt gagcatgcgt ggtctgatgt
     3421 cagttttaaa gcaatgaagg aataaattga aaaaaatcgc tgctgagtag atctgtgcac
     3481 taaaggggac atttaaatgg aagcaccctc ccgatcccgg tccagaccgg atgtacacaa
     3541 cggtctgtct gcaaccggat gtgaaactgg aaggacccca cgcaccctcc cagggtaccg
     3601 cccagccctc tcatgtgtga ttctgaattt aagtttccag aagcctactg gctttttgtc
     3661 tcgttgagat tcttagatat cgattgtctt ccaggctgct tgagaatggg caaggactag
     3721 ttaaatggat tcatacaaag tgctttattc caacggttga gttatttata ctgtatttat
     3781 taggaggggg tatcttcaga ctattgtata tgcttcagga agacaccttg cttatgtttt
     3841 acccttctca gatggcattg gagtggagtt tgactcaggt ttgttaacat aagtttccag
     3901 agctgcagta ccaaataatt gcactcactt ggtggaaagt tgaattatat gttttaagaa
     3961 tcaaaaacat agaggaatta aattgtttat cttttccaaa gttgaaaaag taaaatattt
     4021 ttattatgag tcgttatttt aaaaagttgg ttcattgtat aggaagagaa tactatttct
     4081 ttcagattat cactataaag taattgaggt ggcatttgag atgtggggga aaagaaccat
     4141 actatcgttt ttagttgttc tatgaacact aatgagtgca gctactaaaa tgattgtaaa
     4201 gttgactact gtaaaatgtc cataattatg tgtgtgtata tatatatgtc atatgtatct
     4261 acatgtgtat gtcttaagct tatttataca catgtgcgta cataaggcac accaggaagg
     4321 ggatgtatat attatagaga ttatatagca cagagattct ccacttataa aaaaatggtt
     4381 tgccatgtat tttgttatga atagtttatc tttcagaaga tatttcgttc tattttgaag
     4441 tgtagaagaa tacactgcta ataaataaaa gttttatgca aattaaaaaa aaaaaaaaaa
     4501 aaaaaaaaaa a
//
