LOCUS       NM_133837               1840 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus cell division cycle 123 (Cdc123), transcript variant
            1, mRNA.
ACCESSION   NM_133837
VERSION     NM_133837.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1840)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1840)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   3  (bases 1 to 1840)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928924.12 and AK159208.1.
            
            On Oct 7, 2017 this sequence version replaced NM_133837.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK090122.1, AK159208.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-196               AL928924.12        58928-59123         c
            197-1463            AK159208.1         1-1267
            1464-1840           AL928924.12        8240-8616           c
FEATURES             Location/Qualifiers
     source          1..1840
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 3.62 cM"
     gene            1..1840
                     /gene="Cdc123"
                     /gene_synonym="G431001I09Rik"
                     /note="cell division cycle 123"
                     /db_xref="GeneID:98828"
                     /db_xref="MGI:MGI:2138811"
     exon            1..343
                     /gene="Cdc123"
                     /gene_synonym="G431001I09Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             270..1280
                     /gene="Cdc123"
                     /gene_synonym="G431001I09Rik"
                     /note="isoform 1 is encoded by transcript variant 1; cell
                     division cycle protein 123 homolog; cell division cycle
                     123 homolog; translation initiation factor eIF2 assembly
                     protein"
                     /codon_start=1
                     /product="translation initiation factor eIF2 assembly
                     protein isoform 1"
                     /protein_id="NP_598598.1"
                     /db_xref="CCDS:CCDS15666.1"
                     /db_xref="GeneID:98828"
                     /db_xref="MGI:MGI:2138811"
                     /translation="MKKEHVSHCQFSAWYPLFRSLTIKSVILPLPQNVKDYLLDDGTL
                     VVSGREDPPTCSQSDSGNEAEETQWSDDESTATLTAPEFPEFNTQVQEAINSLGGSVF
                     PKLNWSAPRDAYWIAMNSSLKCKTLSDIFLLFKSSDFITHDFTQPFIHCTDDSPDPCI
                     EYELVLRKWCELIPGAEFRCFVKENKLIGISQRDYTQYYDHISKQKEEICRCIQDFFK
                     EHLQYKFLDEDFVFDIYRDSRGKVWLIDFNPFGEVTDSLLFTWEELTSENNLRGEVTE
                     GDAQEQDSPAFRCTNSEVTVQPSPYLSFGLPKDFVDLSTGEDAHKLIDFLKLKRNEQE
                     DD"
     exon            344..415
                     /gene="Cdc123"
                     /gene_synonym="G431001I09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            416..473
                     /gene="Cdc123"
                     /gene_synonym="G431001I09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            474..506
                     /gene="Cdc123"
                     /gene_synonym="G431001I09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            507..602
                     /gene="Cdc123"
                     /gene_synonym="G431001I09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            603..709
                     /gene="Cdc123"
                     /gene_synonym="G431001I09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            710..758
                     /gene="Cdc123"
                     /gene_synonym="G431001I09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            759..834
                     /gene="Cdc123"
                     /gene_synonym="G431001I09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            835..957
                     /gene="Cdc123"
                     /gene_synonym="G431001I09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            958..986
                     /gene="Cdc123"
                     /gene_synonym="G431001I09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1115
                     /gene="Cdc123"
                     /gene_synonym="G431001I09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1253
                     /gene="Cdc123"
                     /gene_synonym="G431001I09Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1840
                     /gene="Cdc123"
                     /gene_synonym="G431001I09Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1454..1459
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cdc123"
                     /gene_synonym="G431001I09Rik"
                     /note="hexamer: AATAGA"
     polyA_site      1471
                     /gene="Cdc123"
                     /gene_synonym="G431001I09Rik"
                     /note="major polyA site"
ORIGIN      
        1 acgaaagcgg agatgtaagc ttcctaaaaa tctacgcttt cgtgcctctt ctctgcggac
       61 tcagatctct gtgtgtcttg cgcgtctgtg tgggcacgct aagcatacag tctaccatgg
      121 ctctagagtc tagcgccagc ggacttttac ggaccggaag agtcctttct ttaagacggc
      181 tcggtcggca cttccggaag tgctgcgcag ggttccggga gagggctggc gggagaggga
      241 aaggcggcta ttgacgcggc agctggagaa tgaagaagga gcatgttagt cactgtcagt
      301 tctccgcgtg gtacccactt ttccgaagcc ttaccatcaa gagtgtcatc ctcccgcttc
      361 ctcagaatgt gaaagactat ctacttgatg atgggactct ggtggtctca ggaagggaag
      421 atccgccaac atgctcccag tcagacagtg gtaacgaagc agaggaaaca cagtggtccg
      481 atgatgagag cacagccaca cttacggcac cagagtttcc tgagttcaac actcaagtcc
      541 aagaagctat caattcgctg gggggtagtg tcttccctaa gcttaactgg agtgccccaa
      601 gggatgcgta ctggatagcg atgaacagtt ccctgaagtg taaaactctc agtgatatct
      661 tcctgctttt caagagttct gatttcatca cccatgactt cacacagccg tttattcatt
      721 gcactgatga ctctccagac ccttgtatag agtacgagct tgttctccga aaatggtgtg
      781 aattaattcc tggggctgaa ttccgatgtt ttgtcaaaga aaataagctt attggtattt
      841 ctcagaggga ttacacacaa tactatgatc atatttctaa gcaaaaagaa gaaatttgca
      901 gatgcattca agactttttc aaggaacacc tacagtataa attcttagat gaagactttg
      961 tgttcgatat atacagggac agtaggggga aggtgtggct cattgacttt aatccatttg
     1021 gggaggtcac agactcactg ttgtttactt gggaagagct aacatctgag aacaacctac
     1081 gtggtgaggt cactgaagga gatgctcagg agcaggattc tccagccttc cgttgcacaa
     1141 acagtgaagt cacagtgcag cccagcccct atctgagctt cgggctgccc aaggactttg
     1201 tagacctttc caccggggag gatgctcaca agctcatcga tttccttaag ctgaaaagaa
     1261 atgagcaaga ggacgactga gtgctgcttg gagaacaggc caagagggaa gcagctctgg
     1321 cagaggcctc gcctagaaca cagcgagggg caggtggtgg gcagggtgca aaatcattgg
     1381 cttttatatt catgtgtatt tacctggaaa aagagggagg gcctttggta cttgtaaaaa
     1441 aaataacata ataaatagat cttaaacata aggaagccta ctgtgatggt ttgtatatgc
     1501 ttgggccggg gagtggcgct attaggaagc gtggcctttt tggactaggt gtgtcactgt
     1561 ggctgtgggg tatagcaccc tcaccctagc tgcctggaag ccagtatcct gcgagcagcc
     1621 ttcagatgaa gatgcagaac tctcaccttc tcctgcacca tgcctgcctg gatgctgcca
     1681 tgctcccacc ttgatgataa tggactgaac ctctgaacct gcaagccagc cccaattaaa
     1741 tgttgtcctt ataagagttg ccttggtcac ggtgtctgtt cacagcagta aaaacttaac
     1801 taagacacat actgctctga aaataaaata actttctatg
//
