LOCUS       NM_028176                833 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus cytidine deaminase (Cda), mRNA.
ACCESSION   NM_028176 XM_131801
VERSION     NM_028176.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 833)
  AUTHORS   Amin,W., Nishio,S., Honjo,T. and Kobayashi,M.
  TITLE     Necessity of HuR/ELAVL1 for the activation-induced cytidine
            deaminase-dependent decrease in topoisomerase 1 in antibody
            diversification
  JOURNAL   Int Immunol 35 (8), 361-375 (2023)
   PUBMED   37086201
  REMARK    GeneRIF: Necessity of HuR/ELAVL1 for the activation-induced
            cytidine deaminase-dependent decrease in topoisomerase 1 in
            antibody diversification.
REFERENCE   2  (bases 1 to 833)
  AUTHORS   Onclercq-Delic,R., Buhagiar-Labarchede,G., Leboucher,S.,
            Larcher,T., Ledevin,M., Machon,C., Guitton,J. and Amor-Gueret,M.
  TITLE     Cytidine deaminase deficiency in mice enhances genetic instability
            but limits the number of chemically induced colon tumors
  JOURNAL   Cancer Lett 555, 216030 (2023)
   PUBMED   36496104
REFERENCE   3  (bases 1 to 833)
  AUTHORS   Denkena,J., Zaisser,A., Merz,B., Klinger,B., Kuhl,D., Bluthgen,N.
            and Hermey,G.
  TITLE     Neuronal activity regulates alternative exon usage
  JOURNAL   Mol Brain 13 (1), 148 (2020)
   PUBMED   33172478
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 833)
  AUTHORS   Krassikova,L.S., Karshieva,S.S., Cheglakov,I.B. and Belyavsky,A.V.
  TITLE     Combined treatment, based on lysomustine administration with
            mesenchymal stem cells expressing cytosine deaminase therapy, leads
            to pronounced murine Lewis lung carcinoma growth inhibition
  JOURNAL   J Gene Med 18 (9), 220-233 (2016)
   PUBMED   27461566
  REMARK    GeneRIF: Data indicate that a combination cytosine deaminase
            (CDA)/uracil phosphoribosyltransferase protein (UPRT)-expressing
            adipose tissue-derived mesenchymal stem cells (AT-MSCs) with
            lysomustine has a superior antitumor effect in the lung carcinoma
            model compared to monotherapies with transfected AT-MSCs or
            lysomustine alone.
REFERENCE   5  (bases 1 to 833)
  AUTHORS   Wang,L., Tang,Y., Howell,D.N., Ruiz,P. and Spurney,R.F.
  TITLE     A novel mouse model of podocyte depletion
  JOURNAL   Nephron Exp Nephrol 121 (1-2), e10-e22 (2012)
   PUBMED   23095233
REFERENCE   6  (bases 1 to 833)
  AUTHORS   Sehayek,E., Duncan,E.M., Yu,H.J., Petukhova,L. and Breslow,J.L.
  TITLE     Loci controlling plasma non-HDL and HDL cholesterol levels in a
            C57BL /6J x CASA /Rk intercross
  JOURNAL   J Lipid Res 44 (9), 1744-1750 (2003)
   PUBMED   12810823
REFERENCE   7  (bases 1 to 833)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
REFERENCE   8  (bases 1 to 833)
  AUTHORS   Laliberte,J. and Momparler,R.L.
  TITLE     Human cytidine deaminase: purification of enzyme, cloning, and
            expression of its complementary DNA
  JOURNAL   Cancer Res 54 (20), 5401-5407 (1994)
   PUBMED   7923172
REFERENCE   9  (bases 1 to 833)
  AUTHORS   Ishii,K., Sakamoto,H., Furuyama,J. and Hanaoka,M.
  TITLE     Cytidine deaminase levels in cultured mammalian cell lines measured
            by the growth tests and enzyme assays
  JOURNAL   Cell Struct Funct 9 (2), 117-123 (1984)
   PUBMED   6498945
REFERENCE   10 (bases 1 to 833)
  AUTHORS   Tomchick,R., Saslaw,L.D. and Waravdekar,V.S.
  TITLE     Mouse kidney cytidine deaminase. Purification and properties
  JOURNAL   J Biol Chem 243 (10), 2534-2537 (1968)
   PUBMED   5651639
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC050114.1.
            
            On Jan 24, 2005 this sequence version replaced XM_131801.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050114.1, AK008793.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..833
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 70.17 cM"
     gene            1..833
                     /gene="Cda"
                     /gene_synonym="2210401N16Rik"
                     /note="cytidine deaminase"
                     /db_xref="GeneID:72269"
                     /db_xref="MGI:MGI:1919519"
     exon            1..166
                     /gene="Cda"
                     /gene_synonym="2210401N16Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..453
                     /gene="Cda"
                     /gene_synonym="2210401N16Rik"
                     /EC_number="3.5.4.5"
                     /note="cytidine aminohydrolase"
                     /codon_start=1
                     /product="cytidine deaminase"
                     /protein_id="NP_082452.1"
                     /db_xref="CCDS:CCDS18826.1"
                     /db_xref="GeneID:72269"
                     /db_xref="MGI:MGI:1919519"
                     /translation="MAQERPSCAVEPEHVQRLLLSSREAKKSAYCPYSRFPVGAALLT
                     GDGRIFSGCNIENACYPLGVCAERTAIQKAISEGYKDFRAIAISSDLQEEFISPCGAC
                     RQVMREFGTDWAVYMTKPDGTFVVRTVQELLPASFGPEDLQKIQ"
     exon            167..278
                     /gene="Cda"
                     /gene_synonym="2210401N16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            279..336
                     /gene="Cda"
                     /gene_synonym="2210401N16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            337..809
                     /gene="Cda"
                     /gene_synonym="2210401N16Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      776..781
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cda"
                     /gene_synonym="2210401N16Rik"
                     /note="hexamer: TATAAA"
     polyA_site      809
                     /gene="Cda"
                     /gene_synonym="2210401N16Rik"
                     /note="major polyA site"
ORIGIN      
        1 cctcggaccg acatggccca ggaacgcccc tcctgtgctg tggagcccga gcacgtccag
       61 cggctgctgc tgtcctctcg tgaggccaag aagtcagcct actgccccta cagccgcttc
      121 cctgtggggg ctgccctgct caccggggac gggaggatct tctctgggtg caacatagaa
      181 aacgcctgct acccactagg tgtgtgtgcc gagcggactg ccatccagaa ggccatctcc
      241 gaagggtaca aggatttcag ggctattgcc atctctagtg acttgcaaga agagttcatc
      301 tctccctgtg gagcctgccg acaagtcatg agagagtttg gcaccgactg ggccgtgtac
      361 atgaccaagc cggatggcac attcgtagtc aggacggtcc aggagctgct gccggcctcg
      421 tttggacctg aagacctgca gaagattcag tgaaggttga agaatagaat gtctgctgaa
      481 tgtgcaagcc ctacctaagg aacggctctt ggaagacttc ataatgatgc tgtctctggc
      541 tgggccttgg ggacacttgc cacatgggtc ccaaatggct gggcaagggt gaccttgatt
      601 cacacaccac agcctcccct tgagtgatgg aaggtgccac tcacctaggc caaagcccac
      661 atcctcttgg ggactcagag cactcctctc cttccactcc caaagacacg ggtattccag
      721 acccggtctg cctccctacc agccttctta ggctctgtcg tgtgactttt cagattataa
      781 atgccacagc acgtgctgtt tgagaagaaa aaaaaaaaaa aaaaaaaaaa aaa
//
