LOCUS       NM_001199349            3617 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus CD99 antigen-like 2 (Cd99l2), transcript variant 1,
            mRNA.
ACCESSION   NM_001199349
VERSION     NM_001199349.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3617)
  AUTHORS   Samus,M., Seelige,R., Schafer,K., Sorokin,L. and Vestweber,D.
  TITLE     CD99L2 deficiency inhibits leukocyte entry into the central nervous
            system and ameliorates neuroinflammation
  JOURNAL   J Leukoc Biol 104 (4), 787-797 (2018)
   PUBMED   29791026
  REMARK    GeneRIF: Conditional Tie-2-Cre driven gene inactivation of CD99L2
            inhibits leukocyte entry into the CNS during active MOG35-55
            -induced experimental autoimmune encephalomyelitis and alleviates
            severity of the disease. CD99L2 participates in the development of
            EAE by supporting diapedesis of leukocytes through the endothelial
            basement membrane of blood vessels of the BBB in the CNS.
REFERENCE   2  (bases 1 to 3617)
  AUTHORS   Rutledge,N.S., Weber,E.W., Winger,R., Tourtellotte,W.G., Park,S.H.
            and Muller,W.A.
  TITLE     CD99-like 2 (CD99L2)-deficient mice are defective in the acute
            inflammatory response
  JOURNAL   Exp Mol Pathol 99 (3), 455-459 (2015)
   PUBMED   26321243
  REMARK    GeneRIF: Mice lacking CD99L2 had a defective inflammatory response
            in the thioglycollate peritonitis model
REFERENCE   3  (bases 1 to 3617)
  AUTHORS   Liu,F., Zhang,G., Liu,F., Zhou,X., Chen,X., Han,X., Wu,Z. and
            Zhao,T.
  TITLE     Effect of shRNA targeting mouse CD99L2 gene in a murine B cell
            lymphoma in vitro and in vivo
  JOURNAL   Oncol Rep 29 (4), 1405-1414 (2013)
   PUBMED   23338758
  REMARK    GeneRIF: The present study provides data for further investigation
            into the mCD99L2 gene in tumor cells.
REFERENCE   4  (bases 1 to 3617)
  AUTHORS   Seelige,R., Natsch,C., Marz,S., Jing,D., Frye,M., Butz,S. and
            Vestweber,D.
  TITLE     Cutting edge: Endothelial-specific gene ablation of CD99L2 impairs
            leukocyte extravasation in vivo
  JOURNAL   J Immunol 190 (3), 892-896 (2013)
   PUBMED   23293350
  REMARK    GeneRIF: CD99L2 is an essential endothelial Ag for leukocyte
            extravasation, which does not require homophilic interactions with
            CD99L2 on leukocytes.
REFERENCE   5  (bases 1 to 3617)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3617)
  AUTHORS   Schenkel,A.R., Dufour,E.M., Chew,T.W., Sorg,E. and Muller,W.A.
  TITLE     The murine CD99-related molecule CD99-like 2 (CD99L2) is an
            adhesion molecule involved in the inflammatory response
  JOURNAL   Cell Commun Adhes 14 (5), 227-237 (2007)
   PUBMED   18163232
  REMARK    GeneRIF: Transfection of L cell fibroblasts with CD99L2 imparted to
            them the ability to adhere to each other in a divalent
            cation-dependent, homophilic manner. Anti-CD99L2 antibody blocked
            influx of neutrophils and monocytes into a site of inflammation in
            vivo.
REFERENCE   7  (bases 1 to 3617)
  AUTHORS   Bixel,M.G., Petri,B., Khandoga,A.G., Khandoga,A.,
            Wolburg-Buchholz,K., Wolburg,H., Marz,S., Krombach,F. and
            Vestweber,D.
  TITLE     A CD99-related antigen on endothelial cells mediates neutrophil but
            not lymphocyte extravasation in vivo
  JOURNAL   Blood 109 (12), 5327-5336 (2007)
   PUBMED   17344467
  REMARK    GeneRIF: expressed on mouse leukocytes and endothelial cells and is
            involved in transendothelial migration of neutrophils in vitro and
            in the recruitment of neutrophils into inflamed peritoneum
REFERENCE   8  (bases 1 to 3617)
  AUTHORS   Shen,L.J., Fang,W.Y., Xie,S.M., He,Y., Jiang,H.Y. and Zhao,T.
  TITLE     [Expression and cloning of mCD99L2 gene from mouse B lymphoma cell
            line A20 and construction of its eukaryotic expression vector]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 26 (2), 144-149 (2006)
   PUBMED   16503515
REFERENCE   9  (bases 1 to 3617)
  AUTHORS   Suh,Y.H., Shin,Y.K., Kook,M.C., Oh,K.I., Park,W.S., Kim,S.H.,
            Lee,I.S., Park,H.J., Huh,T.L. and Park,S.H.
  TITLE     Cloning, genomic organization, alternative transcripts and
            expression analysis of CD99L2, a novel paralog of human CD99, and
            identification of evolutionary conserved motifs
  JOURNAL   Gene 307, 63-76 (2003)
   PUBMED   12706889
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY727540.1, AK080225.1 and BF147574.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and it encodes the longer protein (isoform 1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK080225.1, AK166275.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-245               BY727540.1         2-246
            246-3595            AK080225.1         2-3351
            3596-3617           BF147574.1         1-22                c
FEATURES             Location/Qualifiers
     source          1..3617
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 36.82 cM"
     gene            1..3617
                     /gene="Cd99l2"
                     /gene_synonym="Mic2l1; Xap89"
                     /note="CD99 antigen-like 2"
                     /db_xref="GeneID:171486"
                     /db_xref="MGI:MGI:2177151"
     exon            1..328
                     /gene="Cd99l2"
                     /gene_synonym="Mic2l1; Xap89"
                     /inference="alignment:Splign:2.1.0"
     CDS             262..975
                     /gene="Cd99l2"
                     /gene_synonym="Mic2l1; Xap89"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; MIC2 (monoclonal Imperial Cancer Research Fund
                     2)-like 1; CD99 antigen-like protein 2; MIC2 like-1;
                     MIC2-like protein 1"
                     /codon_start=1
                     /product="CD99 antigen-like protein 2 isoform 1 precursor"
                     /protein_id="NP_001186278.1"
                     /db_xref="CCDS:CCDS57761.1"
                     /db_xref="GeneID:171486"
                     /db_xref="MGI:MGI:2177151"
                     /translation="MVARLTAFLVCLVFSLATLVQRGYGDTDGFNLEDALKETSSVKQ
                     RWDHFSTTTRRPVTTRAPANPAERWDHVATTTTRRPGTTRAPSNPMELDGFDLEDALD
                     DRNDLDGPKKPSAGEAGGWSDKDLEDIVEGGGYKPDKNKGGGGYGSNDDPGSGISTET
                     GTIAGVASALAMALIGAVSSYISYQQKKFCFSIQQGLNADYVKGENLEAVVCEEPQVT
                     YSKQETQSAEPPPPEPPRI"
     exon            329..391
                     /gene="Cd99l2"
                     /gene_synonym="Mic2l1; Xap89"
                     /inference="alignment:Splign:2.1.0"
     exon            392..460
                     /gene="Cd99l2"
                     /gene_synonym="Mic2l1; Xap89"
                     /inference="alignment:Splign:2.1.0"
     exon            461..532
                     /gene="Cd99l2"
                     /gene_synonym="Mic2l1; Xap89"
                     /inference="alignment:Splign:2.1.0"
     exon            533..619
                     /gene="Cd99l2"
                     /gene_synonym="Mic2l1; Xap89"
                     /inference="alignment:Splign:2.1.0"
     exon            620..685
                     /gene="Cd99l2"
                     /gene_synonym="Mic2l1; Xap89"
                     /inference="alignment:Splign:2.1.0"
     exon            686..724
                     /gene="Cd99l2"
                     /gene_synonym="Mic2l1; Xap89"
                     /inference="alignment:Splign:2.1.0"
     exon            725..844
                     /gene="Cd99l2"
                     /gene_synonym="Mic2l1; Xap89"
                     /inference="alignment:Splign:2.1.0"
     exon            845..910
                     /gene="Cd99l2"
                     /gene_synonym="Mic2l1; Xap89"
                     /inference="alignment:Splign:2.1.0"
     exon            911..3600
                     /gene="Cd99l2"
                     /gene_synonym="Mic2l1; Xap89"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3573..3578
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd99l2"
                     /gene_synonym="Mic2l1; Xap89"
                     /note="hexamer: AACAAA"
     polyA_site      3590
                     /gene="Cd99l2"
                     /gene_synonym="Mic2l1; Xap89"
                     /note="major polyA site"
ORIGIN      
        1 agactgcggc caagtcccag agacagcagt gtttcccgtc tcgtgcagtg ggcccagcag
       61 agtcagcctc tcaactcccc cctctccccc cgcaggcatc taggcgcgcc tcgccaccgc
      121 cctccctggc tgagctagta gtgccagctc tgggcggggt cctgcggttg tgctaggctc
      181 ctcctccccg gctcctcccc tccccctcgg gccctcctgc gctaactgtg ctcctccggg
      241 cccctgcgcc tgctcccagc catggtggcc aggctcacgg ctttcctcgt ttgcctcgtt
      301 ttctccttgg ccacccttgt ccagagagga tatggagaca cagatggttt taatctggag
      361 gatgcactga aagaaacttc ctcagtaaag cagagatggg accacttcag caccacgact
      421 aggaggccag taacaaccag agccccagca aatccagcag agagatggga ccatgttgcc
      481 actactacaa ctagaaggcc aggaacaact agagcaccat caaatcctat ggaactagat
      541 gggtttgact tggaagatgc cttggatgat cgaaatgatc tagatggtcc caaaaagcca
      601 agtgcaggag aagcaggagg ttggtcagac aaggatcttg aagacatcgt ggaaggtggg
      661 ggatacaaac ctgacaagaa taaaggcggt ggtggttatg gcagcaacga tgaccctgga
      721 tctggcatat cgacagaaac tggcaccatt gcaggtgtgg ccagtgccct tgctatggcc
      781 ctgattggag ctgtatccag ctacatctcc taccagcaga agaagttttg cttcagcatt
      841 cagcagggcc tcaatgcaga ctacgtgaag ggggagaacc tggaagctgt tgtgtgtgag
      901 gagccccaag tgacatactc aaaacaagaa acgcagtctg cagaaccccc accacccgag
      961 ccaccccgga tttgaggcag gtacatctga aggaagccac cgcttgtgac ccagctccgg
     1021 atttcatttg ccaatccttt ccccaagttt cttcccatgc cactggctgc ttattgtagt
     1081 gagttttctg gacaagcctt aggtgttcat gagtgtggtt tctgtgccct gtcctgcaga
     1141 ctacagtgac tgctctgcca tgggtcctct aaagagactt ggttctgaga cttgagaccc
     1201 acattcagca gattcctagc accagcagtg aaagtttctg ggtgatggag acagctggat
     1261 tcagccttag catgggaaaa ggaggatgcc caaggtgggg gtggcccaga ggatggttgg
     1321 ggcagcactg cagaacgttt ctggttaggc agtctctagg ttctatgaaa tcctttgcct
     1381 acatgctgta gtgggttgtt tgttgtggtg ctgaccactg agagctgtga ggagcatgct
     1441 caacgggcat ctggtgcata tggaacccat tttaagacaa atcagacagc accaagctgc
     1501 aacacacata catgtgtaca cacacacact cacacacacc ctacatgtgt gcgcacacac
     1561 acataacacc taggcacttt taaaaaatcg attgttcttc ccaacttcat gtttcatatt
     1621 ggtcagcttc cagagagctt gtccaggtga aggctcttca gtgattttag tgcaaacatg
     1681 gtctcacaat agtcttaccc caagattaga aagaaggagc atatgggagc tgtgacttgc
     1741 ggttggattc ctatcagact gtgtagggat ctccggctgg cctggttaac aggtcttgga
     1801 agtcacctac aaatgaactt tctcccaggt cagggtgggt gtttacacta ccctgtacat
     1861 gatcttattt aagtagcaag agctacagat cctgagaatg aacgtggaaa ccagaagcat
     1921 gcttgttgtt ttattagaag tggatgggga aaggggaagg taggggaagg gatactagct
     1981 tagctgcctt tgtagttgtg tagctgtcct ccctgtctgc tctgaaaagg gctctgacca
     2041 tgttcatagc ggtaaataca ggaaaccaag ggccagggcc agagctgact gctaccccta
     2101 gtttgggctg gatctgcctg cttcctggat tgtttctttg gctccagtga gcttgatagt
     2161 gaaccctgca ggtgaaagct aagctagttt ccaccccata tgaactaata gtttgccacg
     2221 tcaaacggca cttctgaaag caatgtgtgt cactgtgaag gcaagatcta cagctcctct
     2281 ggacaacatg attggcccca tatatcccat aagctgtgaa ttggctcctt cacctctgct
     2341 gagctgggaa gaggcaacac tcaccttaag aaactcccta actcttgtgc tgtctaatgc
     2401 atgccttgag tgtgtttgct gtttaaagac tattcttggt ggagggctgc tggtggtgtc
     2461 atgtttccag gcagcctgaa caccaactcc tactgtatac ctgtgggcga tgagatgccc
     2521 cctttgcttg gcctttggtc ccagacggtc caggtctgag gatccaatag ggaagctgga
     2581 gcactgggaa aatgacacta agatggaaaa aaaaaaaagc tcatggcctc aggaagcccg
     2641 ccttattctt caggaggtta ataagcaaag aaggcatcac ttgcaagatg tgtccgtttc
     2701 tagaacctct taacttgctg gtcggattgc tgtcaacatt gtcaggattg tgccttactg
     2761 acaccaagga caacaggaga tgatggtgcc accatttggc cagtgctggg ctataggtga
     2821 cttaaaggaa ggattttagt atttctggtc tgttgacatg tagctagcta gggtaatctc
     2881 aggagggttg tctaccttta tgctgaggcc tgtctgatgg caaagccctc aaaccccacg
     2941 gccatgatgt aaaataaatg ccctcttgtt aaactgtttt ctcaatagca ctggttccag
     3001 tgaaaaagag ctctaatttg ctctccctta gctacctcgg tgccttttgc ataaagccct
     3061 tctgcataaa acccatcact cagcccgcag gcgctagcta agtggctgga caggcctgag
     3121 cgggccatcg gcctcctgtt catacagttt catcccaggg gccgggctcc tccttcccac
     3181 tggcatttta tacttggtgg ggcattgtgg cctgcagaag gcttgggact ggtcctgtaa
     3241 ctgtgtcccc cctgaaggct gagttggcca acttgggtta gtcccaggtg acagaaggga
     3301 gaaaccaaat gaagcagaag agccaattgc caagatcaga tctcgatcag tgaaacttga
     3361 caggaagaac tttaaaaatg ctcaacagtc tcaagtggct tgatgtaggg gctcctaccc
     3421 tggtgtagga caggcccact gcctcagcca cttgggtcgt ggttagtacc agttctctga
     3481 ggaagacatg ttggagactg ccagaatccc tgtacatcgt tttacgtgct tgtgtccaag
     3541 tgtgaattgt aaatggtcta gtgtttgcat taaacaaagt ggactcttaa cagctcctta
     3601 aaaaaaaaaa aaaaaaa
//
