LOCUS       NM_032465               2203 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus CD96 antigen (Cd96), mRNA.
ACCESSION   NM_032465
VERSION     NM_032465.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2203)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2203)
  AUTHORS   Feng,M., Wu,Z., Zhou,Y., Wei,Z., Tian,E., Mei,S., Zhu,Y., Liu,C.,
            He,F., Li,H., Xie,C., Jin,J., Dong,J., Yang,D., Yu,K., Qian,J.,
            Lambrechts,D., Wang,M.W. and Zhu,D.
  TITLE     BCL9 regulates CD226 and CD96 checkpoints in CD8+ T cells to
            improve PD-1 response in cancer
  JOURNAL   Signal Transduct Target Ther 6 (1), 313 (2021)
   PUBMED   34417435
  REMARK    GeneRIF: BCL9 regulates CD226 and CD96 checkpoints in CD8(+) T
            cells to improve PD-1 response in cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2203)
  AUTHORS   Chiang,E.Y., de Almeida,P.E., de Almeida Nagata,D.E., Bowles,K.H.,
            Du,X., Chitre,A.S., Banta,K.L., Kwon,Y., McKenzie,B., Mittman,S.,
            Cubas,R., Anderson,K.R., Warming,S. and Grogan,J.L.
  TITLE     CD96 functions as a co-stimulatory receptor to enhance CD8+ T cell
            activation and effector responses
  JOURNAL   Eur J Immunol 50 (6), 891-902 (2020)
   PUBMED   32043568
  REMARK    GeneRIF: CD96 functions as a co-stimulatory receptor to enhance
            CD8(+) T cell activation and effector responses.
REFERENCE   4  (bases 1 to 2203)
  AUTHORS   Mittal,D., Lepletier,A., Madore,J., Aguilera,A.R., Stannard,K.,
            Blake,S.J., Whitehall,V.L.J., Liu,C., Bettington,M.L., Takeda,K.,
            Long,G.V., Scolyer,R.A., Lan,R., Siemers,N., Korman,A.,
            Teng,M.W.L., Johnston,R.J., Dougall,W.C. and Smyth,M.J.
  TITLE     CD96 Is an Immune Checkpoint That Regulates CD8+ T-cell Antitumor
            Function
  JOURNAL   Cancer Immunol Res 7 (4), 559-571 (2019)
   PUBMED   30894377
REFERENCE   5  (bases 1 to 2203)
  AUTHORS   Stanko,K., Iwert,C., Appelt,C., Vogt,K., Schumann,J., Strunk,F.J.,
            Ahrlich,S., Schlickeiser,S., Romagnani,C., Jurchott,K., Meisel,C.,
            Willimsky,G., Kuhl,A.A. and Sawitzki,B.
  TITLE     CD96 expression determines the inflammatory potential of
            IL-9-producing Th9 cells
  JOURNAL   Proc Natl Acad Sci U S A 115 (13), E2940-E2949 (2018)
   PUBMED   29531070
  REMARK    GeneRIF: Blockade of CD96 completely restored the expansion and
            inflammatory properties of CD96(high) Th9 cells
REFERENCE   6  (bases 1 to 2203)
  AUTHORS   Martinet,L., Ferrari De Andrade,L., Guillerey,C., Lee,J.S., Liu,J.,
            Souza-Fonseca-Guimaraes,F., Hutchinson,D.S., Kolesnik,T.B.,
            Nicholson,S.E., Huntington,N.D. and Smyth,M.J.
  TITLE     DNAM-1 expression marks an alternative program of NK cell
            maturation
  JOURNAL   Cell Rep 11 (1), 85-97 (2015)
   PUBMED   25818301
REFERENCE   7  (bases 1 to 2203)
  AUTHORS   Chan,C.J., Martinet,L., Gilfillan,S., Souza-Fonseca-Guimaraes,F.,
            Chow,M.T., Town,L., Ritchie,D.S., Colonna,M., Andrews,D.M. and
            Smyth,M.J.
  TITLE     The receptors CD96 and CD226 oppose each other in the regulation of
            natural killer cell functions
  JOURNAL   Nat Immunol 15 (5), 431-438 (2014)
   PUBMED   24658051
  REMARK    GeneRIF: knock-out mice display hyperinflammatory responses to
            lipopolysaccharide and resistance to lung carcinogenesis
REFERENCE   8  (bases 1 to 2203)
  AUTHORS   Meyer,D., Seth,S., Albrecht,J., Maier,M.K., du Pasquier,L.,
            Ravens,I., Dreyer,L., Burger,R., Gramatzki,M., Schwinzer,R.,
            Kremmer,E., Foerster,R. and Bernhardt,G.
  TITLE     CD96 interaction with CD155 via its first Ig-like domain is
            modulated by alternative splicing or mutations in distal Ig-like
            domains
  JOURNAL   J Biol Chem 284 (4), 2235-2244 (2009)
   PUBMED   19056733
  REMARK    GeneRIF: CD96-driven adhesion to CD155 may be crucial in
            developmental processes
REFERENCE   9  (bases 1 to 2203)
  AUTHORS   Seth,S., Maier,M.K., Qiu,Q., Ravens,I., Kremmer,E., Forster,R. and
            Bernhardt,G.
  TITLE     The murine pan T cell marker CD96 is an adhesion receptor for CD155
            and nectin-1
  JOURNAL   Biochem Biophys Res Commun 364 (4), 959-965 (2007)
   PUBMED   17971293
  REMARK    GeneRIF: These results suggest a function of the
            CD96/CD155-adhesion system in T cell biology.
REFERENCE   10 (bases 1 to 2203)
  AUTHORS   Kaname,T., Yanagi,K., Chinen,Y., Makita,Y., Okamoto,N., Maehara,H.,
            Owan,I., Kanaya,F., Kubota,Y., Oike,Y., Yamamoto,T., Kurosawa,K.,
            Fukushima,Y., Bohring,A., Opitz,J.M., Yoshiura,K., Niikawa,N. and
            Naritomi,K.
  TITLE     Mutations in CD96, a member of the immunoglobulin superfamily,
            cause a form of the C (Opitz trigonocephaly) syndrome
  JOURNAL   Am J Hum Genet 81 (4), 835-841 (2007)
   PUBMED   17847009
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK040539.1 and BC052865.1.
            
            On Nov 15, 2007 this sequence version replaced NM_032465.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156470.1, BC052865.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-253               AK040539.1         5-257
            254-1759            BC052865.1         151-1656
            1760-2102           AK040539.1         1764-2106
            2103-2203           BC052865.1         2000-2100
FEATURES             Location/Qualifiers
     source          1..2203
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 30.45 cM"
     gene            1..2203
                     /gene="Cd96"
                     /gene_synonym="1700109I12Rik; Tactile"
                     /note="CD96 antigen"
                     /db_xref="GeneID:84544"
                     /db_xref="MGI:MGI:1934368"
     exon            1..217
                     /gene="Cd96"
                     /gene_synonym="1700109I12Rik; Tactile"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..1965
                     /gene="Cd96"
                     /gene_synonym="1700109I12Rik; Tactile"
                     /note="T-cell surface protein tactile; cell surface
                     antigen CD96; t cell-activated increased late expression
                     protein; T cell activation, increased late expression"
                     /codon_start=1
                     /product="T-cell surface protein tactile precursor"
                     /protein_id="NP_115854.2"
                     /db_xref="CCDS:CCDS37348.1"
                     /db_xref="GeneID:84544"
                     /db_xref="MGI:MGI:1934368"
                     /translation="MGRKWTYCVVYTIIQIQFFRGVWEELFNVGDDVYALPGSDINLT
                     CQTKEKNFLVQMQWSKVTDKNDMIALYHPQYGLYCGQEHACESQVAATETEKGVTNWT
                     LYLRNISSALGGKYECIFTLYPEGIKTTVYNLIVEPYTQDEHNYTIEIETNRTLEIPC
                     FQNTSSEIPPRFTFSWLVEKDGVEEVLFTHHHHVNNSTSFKGRIRLGGDYRLHLSPVQ
                     IQDDGRTFSCHLTVNPLKAWKMSTTVKVFAKPEILMTVENSTMDVLGERVFTCLLKNV
                     FPKANITWFIDGRFLQGNEEGIYITNEEKNCSSGFWELKSVLTRMHSGPSQSNNMTAW
                     CMALSPGPRNKMWNTSSQPITVSFDSVIAPTKHLPTVTGSTLGTQPFSDAGVSPTGYL
                     ATPSVTIVDENGLTPDATPQTSNSSMTTKDGNYLEASSGTDAKNSSRAAASSKSGSWP
                     FPFTSPPEWHSLPGTSTGPQEPDSPVSWIPSEVHTSAPLDASLAPHDTIISTTTEFPN
                     VLTTANGTTKIDHGPITSIIVNQPSDGMSWPVLVAALLFFCTLLFGLGVRKWYRYQNE
                     IMERPPPFKPPPPPIKYTYIQEPIGCDLCCHEMEVL"
     exon            218..571
                     /gene="Cd96"
                     /gene_synonym="1700109I12Rik; Tactile"
                     /inference="alignment:Splign:2.1.0"
     exon            572..690
                     /gene="Cd96"
                     /gene_synonym="1700109I12Rik; Tactile"
                     /inference="alignment:Splign:2.1.0"
     exon            691..898
                     /gene="Cd96"
                     /gene_synonym="1700109I12Rik; Tactile"
                     /inference="alignment:Splign:2.1.0"
     exon            899..954
                     /gene="Cd96"
                     /gene_synonym="1700109I12Rik; Tactile"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1045
                     /gene="Cd96"
                     /gene_synonym="1700109I12Rik; Tactile"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1231
                     /gene="Cd96"
                     /gene_synonym="1700109I12Rik; Tactile"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1324
                     /gene="Cd96"
                     /gene_synonym="1700109I12Rik; Tactile"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1393
                     /gene="Cd96"
                     /gene_synonym="1700109I12Rik; Tactile"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1465
                     /gene="Cd96"
                     /gene_synonym="1700109I12Rik; Tactile"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1582
                     /gene="Cd96"
                     /gene_synonym="1700109I12Rik; Tactile"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1645
                     /gene="Cd96"
                     /gene_synonym="1700109I12Rik; Tactile"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1732
                     /gene="Cd96"
                     /gene_synonym="1700109I12Rik; Tactile"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1856
                     /gene="Cd96"
                     /gene_synonym="1700109I12Rik; Tactile"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..2181
                     /gene="Cd96"
                     /gene_synonym="1700109I12Rik; Tactile"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2085..2090
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd96"
                     /gene_synonym="1700109I12Rik; Tactile"
                     /note="hexamer: AATAAA"
     polyA_site      2105
                     /gene="Cd96"
                     /gene_synonym="1700109I12Rik; Tactile"
                     /note="major polyA site"
ORIGIN      
        1 tttcctgggg acttgccaag cgatcaacag ccccaaccct gtggtagagt tgaggttttt
       61 gagcacgaat agggtggcta gcgtttgctt agctagaaac agcaatcgcc tcctgtgatc
      121 attacagaaa tgctggcgtg agctcttcgg gagacaatgg ggagaaaatg gacatattgt
      181 gttgtttaca ccatcatcca gatacagttt ttcaggggag tgtgggaaga gctattcaat
      241 gttggagatg acgtgtatgc tctacctggt tctgacatca acttgacctg ccaaacaaag
      301 gagaaaaact tcttggtaca gatgcagtgg tccaaggtca cagataagaa tgacatgatt
      361 gctctttatc atccccaata tggcctctac tgtgggcagg agcatgcctg tgagtcacaa
      421 gtggctgcca cagaaactga gaagggtgta acaaattgga ctctgtactt aaggaatatc
      481 tcttctgccc tgggtggaaa gtatgagtgc atctttactc tgtatccaga aggcatcaag
      541 actacagtct acaacctcat tgtggaaccc tatacacaag atgaacacaa ctatacaata
      601 gaaatagaga caaatcggac tctggaaata ccatgctttc aaaatacctc ctcagaaatt
      661 ccacctaggt tcaccttttc atggttggtg gagaaagatg gagtggaaga agttctcttc
      721 acccaccatc accacgtcaa caattccaca tcatttaaag gcagaatcag gctgggtgga
      781 gactatagac tccacctctc cccagtccaa atccaagacg atggcaggac attctcttgc
      841 catctgactg tcaatcctct caaagcctgg aagatgtcca ccacagtcaa ggtttttgct
      901 aaaccagaaa tcctcatgac tgtggaaaac agcaccatgg atgtcttagg agagagagta
      961 tttacctgcc tactgaagaa tgtgttcccc aaggcaaata tcacctggtt tatagacgga
     1021 agatttcttc aaggcaacga agaaggaata tacattacaa atgaagagaa gaattgcagt
     1081 agcggatttt gggaactgaa gtcagtttta acaaggatgc acagtggacc atcccaatca
     1141 aacaacatga cagcttggtg tatggctctg tctccaggcc ccagaaataa aatgtggaat
     1201 acttcatcac aacccatcac ggtttccttt gattcggtga tagccccaac gaaacatcta
     1261 cccactgtga caggttctac cctgggtaca caaccttttt cagatgctgg agtatctcct
     1321 acagggtatc tagctacacc ttcagtgaca attgtagatg aaaatgggtt gacaccagat
     1381 gcaactcctc aaaccagcaa ttccagcatg actactaaag atggcaacta tttggaagcc
     1441 tccagtggga cagatgccaa gaactcctca agagctgctg cttcttctaa aagtggatct
     1501 tggccttttc ctttcacttc tcctccagaa tggcactcac tgcctggtac ctccactgga
     1561 ccccaagaac cagactcccc agtttcatgg atacccagtg aagtacacac ttcagcccct
     1621 ttggacgcca gcttagctcc tcatgatacc atcatcagta caaccacaga atttccaaat
     1681 gtcctcacaa ctgcaaatgg aactactaaa attgaccatg gacctatcac cagtatcata
     1741 gttaatcaac ccagtgatgg aatgtcctgg cctgtgcttg tcgcggcttt gctctttttc
     1801 tgcacactat tgtttgggct tggagtaaga aaatggtatc ggtatcaaaa tgaaatcatg
     1861 gagagacccc cacctttcaa gccaccacca cctcccatca agtacacgta tattcaagaa
     1921 cccattggat gcgacctgtg ttgtcatgag atggaggtcc tctaagcttt tgagccttgt
     1981 cacagcgaag cagtgctgga gtcctgtagg aagggagata ttgtacaata ttaatatcat
     2041 caccagccag gcgtgcctct gcttcagctc aaatgaatgt tggaaataaa tgacttctat
     2101 tcccagcata ctgccctctt tcatctgcaa acacctgaga tgtaaataag cattagagaa
     2161 taaagcgatg ttcacaccca gaaaaaaaaa aaaaaaaaaa aaa
//
