LOCUS       NM_010740               6638 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus CD93 antigen (Cd93), mRNA.
ACCESSION   NM_010740 XM_993058
VERSION     NM_010740.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6638)
  AUTHORS   Xu,Y., Sun,Y., Zhu,Y. and Song,G.
  TITLE     Structural insight into CD93 recognition by IGFBP7
  JOURNAL   Structure 32 (3), 282-291 (2024)
   PUBMED   38218180
  REMARK    GeneRIF: Structural insight into CD93 recognition by IGFBP7.
REFERENCE   2  (bases 1 to 6638)
  AUTHORS   Vemuri,K., de Alves Pereira,B., Fuenzalida,P., Subashi,Y.,
            Barbera,S., van Hooren,L., Hedlund,M., Ponten,F., Lindskog,C.,
            Olsson,A.K., Lugano,R. and Dimberg,A.
  TITLE     CD93 maintains endothelial barrier function and limits metastatic
            dissemination
  JOURNAL   JCI Insight 9 (7), e169830 (2024)
   PUBMED   38441970
  REMARK    GeneRIF: CD93 maintains endothelial barrier function and limits
            metastatic dissemination.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6638)
  AUTHORS   Trivigno,S.M.G., Vismara,M., Canobbio,I., Rustichelli,S.,
            Galvagni,F., Orlandini,M., Torti,M. and Guidetti,G.F.
  TITLE     The C-Type Lectin Receptor CD93 Regulates Platelet Activation and
            Surface Expression of the Protease Activated Receptor 4
  JOURNAL   Thromb Haemost 124 (2), 122-134 (2024)
   PUBMED   37669782
  REMARK    GeneRIF: The C-Type Lectin Receptor CD93 Regulates Platelet
            Activation and Surface Expression of the Protease Activated
            Receptor 4.
REFERENCE   4  (bases 1 to 6638)
  AUTHORS   Lugano,R., Vemuri,K., Barbera,S., Orlandini,M., Dejana,E.,
            Claesson-Welsh,L. and Dimberg,A.
  TITLE     CD93 maintains endothelial barrier function by limiting the
            phosphorylation and turnover of VE-cadherin
  JOURNAL   FASEB J 37 (4), e22894 (2023)
   PUBMED   36961390
  REMARK    GeneRIF: CD93 maintains endothelial barrier function by limiting
            the phosphorylation and turnover of VE-cadherin.
REFERENCE   5  (bases 1 to 6638)
  AUTHORS   Sun,Y., Chen,W., Torphy,R.J., Yao,S., Zhu,G., Lin,R., Lugano,R.,
            Miller,E.N., Fujiwara,Y., Bian,L., Zheng,L., Anand,S., Gao,F.,
            Zhang,W., Ferrara,S.E., Goodspeed,A.E., Dimberg,A., Wang,X.J.,
            Edil,B.H., Barnett,C.C., Schulick,R.D., Chen,L. and Zhu,Y.
  TITLE     Blockade of the CD93 pathway normalizes tumor vasculature to
            facilitate drug delivery and immunotherapy
  JOURNAL   Sci Transl Med 13 (604) (2021)
   PUBMED   34321321
REFERENCE   6  (bases 1 to 6638)
  AUTHORS   Petrenko,O., Beavis,A., Klaine,M., Kittappa,R., Godin,I. and
            Lemischka,I.R.
  TITLE     The molecular characterization of the fetal stem cell marker AA4
  JOURNAL   Immunity 10 (6), 691-700 (1999)
   PUBMED   10403644
REFERENCE   7  (bases 1 to 6638)
  AUTHORS   Nepomuceno,R.R., Ruiz,S., Park,M. and Tenner,A.J.
  TITLE     C1qRP is a heavily O-glycosylated cell surface protein involved in
            the regulation of phagocytic activity
  JOURNAL   J Immunol 162 (6), 3583-3589 (1999)
   PUBMED   10092817
REFERENCE   8  (bases 1 to 6638)
  AUTHORS   Yoder,M.C., Hiatt,K., Dutt,P., Mukherjee,P., Bodine,D.M. and
            Orlic,D.
  TITLE     Characterization of definitive lymphohematopoietic stem cells in
            the day 9 murine yolk sac
  JOURNAL   Immunity 7 (3), 335-344 (1997)
   PUBMED   9324354
REFERENCE   9  (bases 1 to 6638)
  AUTHORS   Nepomuceno,R.R., Henschen-Edman,A.H., Burgess,W.H. and Tenner,A.J.
  TITLE     cDNA cloning and primary structure analysis of C1qR(P), the human
            C1q/MBL/SPA receptor that mediates enhanced phagocytosis in vitro
  JOURNAL   Immunity 6 (2), 119-129 (1997)
   PUBMED   9047234
REFERENCE   10 (bases 1 to 6638)
  AUTHORS   McKearn,J.P. and Rosenberg,N.
  TITLE     Mapping cell surface antigens on mouse pre-B cell lines
  JOURNAL   Eur J Immunol 15 (3), 295-298 (1985)
   PUBMED   2579825
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK079060.1 and
            AL935149.16.
            
            On Apr 11, 2007 this sequence version replaced NM_010740.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028485.1, AK155060.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164132, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2311              AK079060.1         2-2312
            2312-6638           AL935149.16        77131-81457         c
FEATURES             Location/Qualifiers
     source          1..6638
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 73.48 cM"
     gene            1..6638
                     /gene="Cd93"
                     /gene_synonym="6030404G09Rik; AA4.1; C1qr1; C1qrp; Ly68"
                     /note="CD93 antigen"
                     /db_xref="GeneID:17064"
                     /db_xref="MGI:MGI:106664"
     exon            1..2021
                     /gene="Cd93"
                     /gene_synonym="6030404G09Rik; AA4.1; C1qr1; C1qrp; Ly68"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..2046
                     /gene="Cd93"
                     /gene_synonym="6030404G09Rik; AA4.1; C1qr1; C1qrp; Ly68"
                     /note="complement component 1, q subcomponent, receptor 1;
                     complement component C1q receptor; ly-68; C1qR(p);
                     C1q/MBL/SPA receptor; cell surface antigen AA4; lymphocyte
                     antigen 68"
                     /codon_start=1
                     /product="complement component C1q receptor precursor"
                     /protein_id="NP_034870.1"
                     /db_xref="CCDS:CCDS16839.1"
                     /db_xref="GeneID:17064"
                     /db_xref="MGI:MGI:106664"
                     /translation="MAISTGLFLLLGLLGQPWAGAAADSQAVVCEGTACYTAHWGKLS
                     AAEAQHRCNENGGNLATVKSEEEARHVQQALTQLLKTKAPLEAKMGKFWIGLQREKGN
                     CTYHDLPMRGFSWVGGGEDTAYSNWYKASKSSCIFKRCVSLILDLSLTPHPSHLPKWH
                     ESPCGTPEAPGNSIEGFLCKFNFKGMCRPLALGGPGRVTYTTPFQATTSSLEAVPFAS
                     VANVACGDEAKSETHYFLCNEKTPGIFHWGSSGPLCVSPKFGCSFNNGGCQQDCFEGG
                     DGSFRCGCRPGFRLLDDLVTCASRNPCSSNPCTGGGMCHSVPLSENYTCRCPSGYQLD
                     SSQVHCVDIDECQDSPCAQDCVNTLGSFHCECWVGYQPSGPKEEACEDVDECAAANSP
                     CAQGCINTDGSFYCSCKEGYIVSGEDSTQCEDIDECSDARGNPCDSLCFNTDGSFRCG
                     CPPGWELAPNGVFCSRGTVFSELPARPPQKEDNDDRKESTMPPTEMPSSPSGSKDVSN
                     RAQTTGLFVQSDIPTASVPLEIEIPSEVSDVWFELGTYLPTTSGHSKPTHEDSVSAHS
                     DTDGQNLLLFYILGTVVAISLLLVLALGILIYHKRRAKKEEIKEKKPQNAADSYSWVP
                     ERAESQAPENQYSPTPGTDC"
     exon            2022..6638
                     /gene="Cd93"
                     /gene_synonym="6030404G09Rik; AA4.1; C1qr1; C1qrp; Ly68"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6620..6625
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd93"
                     /gene_synonym="6030404G09Rik; AA4.1; C1qr1; C1qrp; Ly68"
                     /note="hexamer: AATAAA"
     polyA_site      6638
                     /gene="Cd93"
                     /gene_synonym="6030404G09Rik; AA4.1; C1qr1; C1qrp; Ly68"
                     /note="major polyA site"
ORIGIN      
        1 agtgcgcctc tgctcccttc agagcacagc ctggtgtcaa ggtccaggtt ccaccggctg
       61 ctgctgtcac cgcaggggag tctagcccct cccagaagga gacacagaag aatggccatc
      121 tcaactggtt tgttcctgct gctggggctc cttggccagc cctgggcagg ggctgctgct
      181 gattcacagg ctgtggtgtg cgaggggact gcctgctata cagcccattg gggcaagctg
      241 agtgccgctg aagcccagca tcgctgcaat gagaatggag gcaatcttgc caccgtgaag
      301 agtgaggagg aggcccggca tgttcagcaa gccctgactc agctcctgaa gaccaaggca
      361 cccttggaag caaagatggg caaattctgg atcgggctcc agcgagagaa gggcaactgt
      421 acgtaccatg atttgccaat gaggggcttc agctgggtgg gtggtggaga ggacacagct
      481 tattcaaact ggtacaaagc cagcaagagc tcctgtatct ttaaacgctg tgtgtccctc
      541 atactggacc tgtccttgac acctcacccc agccatctgc ccaagtggca tgagagtccc
      601 tgtgggaccc ccgaagctcc aggtaacagc attgaaggtt tcctgtgcaa gttcaacttc
      661 aaaggcatgt gtaggccact ggcgctgggt ggtccagggc gggtgaccta taccacccct
      721 ttccaggcca ctacctcctc tctggaggct gtgccttttg cctctgtagc caatgtagct
      781 tgtggggatg aagctaagag tgaaacccac tatttcctat gcaatgaaaa gactccagga
      841 atatttcact ggggcagctc aggcccactc tgtgtcagcc ccaagtttgg ttgcagtttc
      901 aacaacgggg gctgccagca ggattgcttc gaaggtggcg atggctcctt ccgctgcggc
      961 tgccggcctg gatttcgact gctggatgat ctagtaactt gtgcctccag gaacccctgc
     1021 agctcaaacc catgcacagg aggtggcatg tgccattctg taccactcag tgaaaactac
     1081 acttgccgtt gtcccagcgg ctaccagctg gactctagcc aagtgcactg tgtggatata
     1141 gatgagtgcc aggactcccc ctgtgcccag gattgtgtca acactctagg gagcttccac
     1201 tgtgaatgtt gggttggtta ccaacccagt ggccccaagg aagaggcctg tgaagatgtg
     1261 gatgagtgtg cagctgccaa ctcgccctgt gcccaaggct gcatcaacac tgatggctct
     1321 ttctactgct cctgtaaaga gggctatatt gtgtctgggg aagacagtac ccagtgtgag
     1381 gatatagatg agtgttcgga cgcaaggggc aatccatgtg attccctgtg cttcaacaca
     1441 gatggttcct tcaggtgtgg ctgcccgcca ggctgggagc tggctcccaa tggggtcttt
     1501 tgtagcaggg gcactgtgtt ttctgaacta ccagccaggc ctccccaaaa ggaagacaac
     1561 gatgacagaa aggagagtac tatgcctcct actgaaatgc ccagttctcc tagtggctct
     1621 aaggatgtct ccaacagagc acagacaaca ggtctcttcg tccaatcaga tattcccact
     1681 gcctctgttc cactagaaat agaaatccct agtgaagtat ctgatgtctg gttcgagttg
     1741 ggcacatacc tccccacgac ctccggccac agcaagccga cacatgaaga ttctgtgtct
     1801 gcacacagtg acaccgatgg gcagaacctg cttctgtttt acatcctggg gacggtggtg
     1861 gccatctcac tcttgctggt gctggcccta gggattctca tttatcataa acggagagcc
     1921 aagaaggagg agataaaaga gaagaagcct cagaatgcag ccgacagcta ttcctgggtt
     1981 ccagagcgag cagagagcca agccccggag aatcagtaca gcccaacacc agggacagac
     2041 tgctgaagac tatgtggcct tagagacagc tgccactacc ttcagagcta ccttcttaga
     2101 tgagggggaa gccacatcat tctgaatgac ttgactggac tctcagcaaa aaaattgtgc
     2161 accttccact taagaacctg gtggcttggg ataggcaggt attttcttgg tgcctttgat
     2221 atgtctgggg gtgaaagctg tgtgttggtt tgtcattgtg gggagttttg tggatattga
     2281 cagacctcac tcaaacaccc ttttcaaatc caatagcaac tggttcctct ggttcctaat
     2341 tagggggaaa ggagtcagag gggtgggaca gggtgggggg atggggcttc aaagtttttt
     2401 cttatcactt gatttatcat cgaaggagtt actggtgcta attacaatgg aaacagttcc
     2461 tttccatcac aggacagaca gcaaaccaat ttaaaactac ttaactaggt gagagtgctc
     2521 tacccttcct atagggactt tttcaggatg gctgcctttg tgtacatttg ccttctggca
     2581 tttccccttc acgtcccccc ccccccccca gcccccttgg tattgttgaa actgtcagaa
     2641 tgagaggaag ttcaaccaac tgcttaggga gtaagctggc aggaagttta gatattgtat
     2701 cccctcactc ttaactttct gatagccttg ggtttatggg caagcaaagt tacaagttgg
     2761 gaagttgctt caagtgagtg agaggtcttg gtaaaagcat aatccagagg gggaggcagg
     2821 aggggattgt tttaacagat atttgaatga aaatatcaga atgaactgat gctaacacac
     2881 acctgattat tgagaaacaa taacaaaact cctagattca tttgtctttg cgctagcaca
     2941 ggccccaact ccactgcagg gcaccctgtc tacctttata ctgtccctaa ctggaagctg
     3001 gtactgtagg ctcagaaagc cttaggaggc tttcattctg aacgtaagga aaggatgtgt
     3061 gagccaggtg atgggctcta ttttaaatgc tcccatttaa gtttacctta gtccacttca
     3121 cagttaaaag tacatctgga ggacttgagc cctatcttgt tggcgtgaca cataccaaac
     3181 caaggattag tcatgaagaa agttctctct ctctcttttt ttttcttaaa aaaaaaaaaa
     3241 aggagataga ggggaaaggg aaaggggaag agagaacagc taaaaaatgt ccagccttta
     3301 aaactgctta gagccatctt atgattgaca tgtttatttc aaagtgtcca tttacaaaag
     3361 tgtcccttaa acttgcaaaa gtgtccctta aacttgctga cggtaatgtt gtttcagctg
     3421 cacaggtctg tctggggact ggaaggcatc cctggtgagt cacttcagta tctctgggag
     3481 gcttcatctt agttgtctct gctgtttgaa aagctgagac atggaatgtg tctccatcat
     3541 gagattcaga gtctttgttc tcagactaga gaactttggt ttctaggaac aaaggcaccc
     3601 atccctcaag ttgatatcca ggaatcgaac gttaataaca agcagattca agacctttgg
     3661 aaatatctta gagaaatata ttagagaaat accttttttt ggccaattta aaatgaagat
     3721 atttttatta gtctctctct ctcctccctc tctctctctc tctcttctct ctctctctct
     3781 ctctctctct ctctctctct ctgaaaacac aaggtggaga gtaatgggaa aaagatcggg
     3841 ctcagtggga tgcctgaaat gagtgcattt aaaaatcaac tcagcatctg gctttcagtt
     3901 gaagtttggg tgtttggaac aggatccctg gcaataactg agattggcag ctaatccatt
     3961 accagcagac cagcattacc agcctttcag atcattcaga tgaatttaga gccatggtag
     4021 tatctgcata tacggacatg accctaaaag catcactttt acctccaggc cttcaactgc
     4081 tcacctttat ggctggagat gaggaagata actgaatcta ggctccccac agctgtgttt
     4141 gatctatgcc caggctgctg tgtaggactt caactgacca ggatgactta ggggatagac
     4201 atgaagctcc atttccaata ctcctagggg tacaggatcc actctgtggg acccacaaca
     4261 gggaagggaa tgatgaggaa catattttct caaagtgtgc tttcagcatg agccactccc
     4321 gtggagacag agctctctca tctcctgacc tgccaaagcc ttcaggagaa ccatacctca
     4381 tgtggcaaag ccaatggagc cactcactgt tcctaaatgg gtgctttatt ttcacatata
     4441 ttcttttttt tttttttttt tgagacaggg tttctctgta tagccctggc tgtcctggaa
     4501 ctcactcagt agaccaggct ggcctcgaac tcagaagtct gcctgcctct gcctcccaag
     4561 tgctgggatt aaaggtgtgc gccaccactg cccagcctca catatattct tgctgtcctc
     4621 atacttgaga ctggaaaatt ctggcttagg gcatctaaga ggcaaagcaa taaataagtg
     4681 aacttctact ggaccaaagg tgtgttaggc tatgccttct ctacccacga catcagtgag
     4741 cagagacaga acactcctct gcctgtgagg accagaggaa gtactacttg gcaacagaat
     4801 tttcttaagt ccagacctgg aaaaactgta ttttggaggg gcataccttc aggcctccag
     4861 cctacccatt actgagttgt aggtggccat cactgtcctt tgtattttat gtggttctgg
     4921 cgatggtagc cagcacatga gtatggtaga cactagcctt ccaggatccc tatactccta
     4981 gtaccttgca ttatttttgt tcattattaa agatagtcaa aaagcaatac ctcctcaccc
     5041 ccagtaattt gaggagttaa acaaacaaac aaacaaacaa actactcaga aagaagtgcc
     5101 tggagagaga gagagcccta aacactattt gcaaaggaag tctagcctca gttttccctg
     5161 gtgtctagca tggctttgat gcaaccccaa atgtatgcat tttctggctt tggagaccca
     5221 cttatcatta tcattactac catcaccacc accactacca ccaccgtcac catcactgtc
     5281 atcaccagct cagggtgcta cgcatcatca tggtgtttta ttaatgacag taactggatg
     5341 aatcccacct gtctctaact gagagcaaaa aggccagaca gaagaggagc agaaagaaga
     5401 gaagcgggct gctttccttc agcttcatac ccggggaaac cgagtaagcc tctgggaagg
     5461 tctaccctga ttccttcccc agagcactgg ataatgtgga atgaaacaca aatacttttg
     5521 agtacatgtt cacagtgcag ggcaagctgc cgagaaagaa ctctttacct cctcatcaag
     5581 ttttcctcct ctttgagttc ctaaccatga gcctcgcgtg gactgttatc accaaccaaa
     5641 ctttcaatag gtggatggga tcactaggtc attttgttct gcctctcttt tctcataaat
     5701 atttctgccc aaactaaagg aacagagatg agatttgacc aaaaaaggaa aaaaaaaaga
     5761 ttactccatt caaaataaca tattttttga aagcaaatat aggaaagcct tttcctatta
     5821 ttttttttct tcttagcttc cccattgtct gaattgggaa aacaggaaag cattgctttc
     5881 tagcacctgc aaaatggttt aatgcccctg catatttcca tgtccttcca acaatagatt
     5941 tagcatggga atctgaaata gacgccctga aaacatctgt ctcttcccca gctcctaaac
     6001 ccaggctttg attatgtatg gtttgtgaaa tctatcatcc aaaacgggga cagacacacc
     6061 tcaatcctcc atggggtcaa caactatata cccccagtga ccccttaggc aaggacttgt
     6121 tgagaactgc atcacatttt gacctgttct caacagtacc catctatttc aggtgggatc
     6181 tctggacctt tcctccttcc catcttgtct gcaatgtggc aaatggcttc tttttgcatt
     6241 tttactccgc ccccacccca agctgaagtt catttgcaga tcagcgatta agtctgaatt
     6301 gtgtggtggt cagtcttgtt tccttttgtc aggggttatt gtaaatgtta gtaatttcgc
     6361 ctcaagccct cagtaagaac ataaatattt taaaatatgt gcgtttgaaa tctgtttcat
     6421 gcatcctgga actgtgggat gctcaggcaa gagtgacttt agtctttcag tgaatgttgc
     6481 ccagaatgtg ggtagggaag gctcacaggt tactctcctc cttagagcta caacataaca
     6541 ttctgagggg agtcacaggg ttgcctttaa aaagtgggag ctatgtcatg ctttgagctt
     6601 tctgttaagc acctctccta ataaactctg aaaaaata
//
