LOCUS       NM_009858               1481 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus CD8 subunit beta 1 (Cd8b1), mRNA.
ACCESSION   NM_009858
VERSION     NM_009858.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1481)
  AUTHORS   Goodall,K.J., Nguyen,A., Andrews,D.M. and Sullivan,L.C.
  TITLE     Ribosylation of the CD8alphabeta heterodimer permits binding of the
            nonclassical major histocompatibility molecule, H2-Q10
  JOURNAL   J Biol Chem 297 (4), 101141 (2021)
   PUBMED   34478713
  REMARK    GeneRIF: Ribosylation of the CD8alphabeta heterodimer permits
            binding of the nonclassical major histocompatibility molecule,
            H2-Q10.
REFERENCE   2  (bases 1 to 1481)
  AUTHORS   Kojo,S., Ohno-Oishi,M., Wada,H., Nieke,S., Seo,W., Muroi,S. and
            Taniuchi,I.
  TITLE     Constitutive CD8 expression drives innate CD8+ T-cell
            differentiation via induction of iNKT2 cells
  JOURNAL   Life Sci Alliance 3 (2), e202000642 (2020)
   PUBMED   31980555
  REMARK    GeneRIF: Constitutive CD8 expression drives innate CD8(+) T-cell
            differentiation via induction of iNKT2 cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1481)
  AUTHORS   Liu,X., Jiao,Y., Cao,Y., Deng,N., Ma,Y., Hasty,K.A., Kang,A.,
            Chen,H., Stuart,J.M. and Gu,W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1481)
  AUTHORS   Nitta,T., Muro,R., Shimizu,Y., Nitta,S., Oda,H., Ohte,Y., Goto,M.,
            Yanobu-Takanashi,R., Narita,T., Takayanagi,H., Yasuda,H.,
            Okamura,T., Murata,S. and Suzuki,H.
  TITLE     The thymic cortical epithelium determines the TCR repertoire of
            IL-17-producing gammadeltaT cells
  JOURNAL   EMBO Rep 16 (5), 638-653 (2015)
   PUBMED   25770130
REFERENCE   5  (bases 1 to 1481)
  AUTHORS   Sakaguchi,S., Hombauer,M., Hassan,H., Tanaka,H., Yasmin,N.,
            Naoe,Y., Bilic,I., Moser,M.A., Hainberger,D., Mayer,H., Seiser,C.,
            Bergthaler,A., Taniuchi,I. and Ellmeier,W.
  TITLE     A novel Cd8-cis-regulatory element preferentially directs
            expression in CD44hiCD62L+ CD8+ T cells and in CD8alphaalpha+
            dendritic cells
  JOURNAL   J Leukoc Biol 97 (4), 635-644 (2015)
   PUBMED   25548254
  REMARK    GeneRIF: Comparing the sequences of mouse, human, rat and dog Cd8a
            and Cd8b1 gene loci identified 10 evolutionarily conserved regions
            (ECR). 6 ECRs overlapped with previously identified Cd8 enhancers.
            ECR-4 recruits transcription factors to the Cd8ab gene complex.
REFERENCE   6  (bases 1 to 1481)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   7  (bases 1 to 1481)
  AUTHORS   Wheeler,C.J., von Hoegen,P. and Parnes,J.R.
  TITLE     An immunological role for the CD8 beta-chain
  JOURNAL   Nature 357 (6375), 247-249 (1992)
   PUBMED   1534146
REFERENCE   8  (bases 1 to 1481)
  AUTHORS   Cornall,R.J., Friedman,J.M. and Todd,J.A.
  TITLE     Mouse microsatellites from a flow-sorted 4:6 Robertsonian
            chromosome
  JOURNAL   Mamm Genome 3 (11), 620-624 (1992)
   PUBMED   1450512
REFERENCE   9  (bases 1 to 1481)
  AUTHORS   Gibson,D.M., Taylor,B.A. and Cherry,M.
  TITLE     Evidence for close linkage of a mouse light chain marker with the
            Ly-2,3 locus
  JOURNAL   J Immunol 121 (4), 1585-1590 (1978)
   PUBMED   100557
REFERENCE   10 (bases 1 to 1481)
  AUTHORS   Gottlieb,P.D. and Durda,P.J.
  TITLE     The IB-peptide marker and the Ly-3 surface alloantigen: structural
            studies of a V kappa-region polymorphism and a T-cell marker
            determined by linked genes
  JOURNAL   Cold Spring Harb Symp Quant Biol 41 Pt 2, 805-815 (1977)
   PUBMED   408079
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY084951.1, AK169581.1, AK162993.1 and BF023006.1.
            
            On Feb 16, 2018 this sequence version replaced NM_009858.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154055.1, AK087944.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                BY084951.1         2-25
            25-1129             AK169581.1         2-1106
            1130-1341           AK162993.1         1095-1306
            1342-1481           BF023006.1         219-358
FEATURES             Location/Qualifiers
     source          1..1481
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 32.14 cM"
     gene            1..1481
                     /gene="Cd8b1"
                     /gene_synonym="Cd8b; Ly-3; Ly-C; Lyt-3"
                     /note="CD8 subunit beta 1"
                     /db_xref="GeneID:12526"
                     /db_xref="MGI:MGI:88347"
     exon            1..112
                     /gene="Cd8b1"
                     /gene_synonym="Cd8b; Ly-3; Ly-C; Lyt-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..711
                     /gene="Cd8b1"
                     /gene_synonym="Cd8b; Ly-3; Ly-C; Lyt-3"
                     /note="CD8 antigen, beta chain 1; T-cell surface
                     glycoprotein CD8 beta chain; lymphocyte antigen 3; T-cell
                     membrane glycoprotein Ly-3; T-cell surface glycoprotein
                     Lyt-3"
                     /codon_start=1
                     /product="T-cell surface glycoprotein CD8 beta chain
                     precursor"
                     /protein_id="NP_033988.1"
                     /db_xref="CCDS:CCDS39506.1"
                     /db_xref="GeneID:12526"
                     /db_xref="MGI:MGI:88347"
                     /translation="MQPWLWLVFSMKLAALWSSSALIQTPSSLLVQTNHTAKMSCEVK
                     SISKLTSIYWLRERQDPKDKYFEFLASWSSSKGVLYGESVDKKRNIILESSDSRRPFL
                     SIMNVKPEDSDFYFCATVGSPKMVFGTGTKLTVVDVLPTTAPTKKTTLKMKKKKQCPF
                     PHPETQKGLTCSLTTLSLLVVCILLLLAFLGVAVYFYCVRRRARIHFMKQFHK"
     exon            113..475
                     /gene="Cd8b1"
                     /gene_synonym="Cd8b; Ly-3; Ly-C; Lyt-3"
                     /inference="alignment:Splign:2.1.0"
     exon            476..571
                     /gene="Cd8b1"
                     /gene_synonym="Cd8b; Ly-3; Ly-C; Lyt-3"
                     /inference="alignment:Splign:2.1.0"
     exon            572..661
                     /gene="Cd8b1"
                     /gene_synonym="Cd8b; Ly-3; Ly-C; Lyt-3"
                     /inference="alignment:Splign:2.1.0"
     exon            662..698
                     /gene="Cd8b1"
                     /gene_synonym="Cd8b; Ly-3; Ly-C; Lyt-3"
                     /inference="alignment:Splign:2.1.0"
     exon            699..1481
                     /gene="Cd8b1"
                     /gene_synonym="Cd8b; Ly-3; Ly-C; Lyt-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1111..1116
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd8b1"
                     /gene_synonym="Cd8b; Ly-3; Ly-C; Lyt-3"
                     /note="hexamer: AATAAA"
     polyA_site      1130
                     /gene="Cd8b1"
                     /gene_synonym="Cd8b; Ly-3; Ly-C; Lyt-3"
                     /note="major polyA site"
     regulatory      1322..1327
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd8b1"
                     /gene_synonym="Cd8b; Ly-3; Ly-C; Lyt-3"
                     /note="hexamer: AATAAA"
     polyA_site      1364
                     /gene="Cd8b1"
                     /gene_synonym="Cd8b; Ly-3; Ly-C; Lyt-3"
ORIGIN      
        1 aagctggctc ctaacctacc tttcagttga cagagcactg aggggaacag tgtccccaaa
       61 agcgccaaga tgcagccatg gctctggctg gtcttcagta tgaagctggc agctctctgg
      121 agcagctctg ccctcattca gaccccttcg tccctgctgg ttcaaaccaa ccatacggca
      181 aagatgtcct gtgaggttaa aagcatctct aagttaacaa gcatctactg gctgcgggag
      241 cgccaggacc ccaaggacaa gtactttgag ttcctggcct cctggagttc ttccaaagga
      301 gttttgtatg gtgaaagtgt ggacaagaaa agaaatataa ttcttgagtc ttcagactca
      361 agacggccct ttctcagtat catgaatgtg aagccagagg acagtgactt ctacttctgc
      421 gcgacggttg ggagccccaa gatggtcttt gggacaggga cgaagctgac tgtggttgat
      481 gtccttccta caactgcccc aaccaagaag actaccctga agatgaagaa gaagaagcaa
      541 tgcccgttcc cccacccaga gacccagaag ggcctgacat gcagccttac caccctcagc
      601 ctgctggtag tctgcatcct gcttctgctg gcattcctcg gagtggccgt ctacttttac
      661 tgtgtgcgga ggagagcccg aattcacttc atgaaacagt ttcacaaatg atcagcgccc
      721 acaacactga tagcctgcta gcaataaaag gactgtaact caatcaaagc aagatttgaa
      781 ctagtgagag acagcgcatt caagactgga gaggcccttg cccttgctca agctgcctgc
      841 tttgaactgc tgcaagctct gtgtgtggtc tggggtctca cagggaaggc cccagaaccc
      901 aagctcactc acagagtggc tgaagaacca agaactccca caccaccatg tactcttctt
      961 ggactgggcc ttggacagtg gccttccagc cactgtcttt gtcagttgct tggtatgaca
     1021 gccttattga ctctttggcc tttcatggaa aagagctagc cgggaccctg gagaagactg
     1081 caaatcctca cacagagaag ccacctcatg aataaagttt tctgcaaaca gtttcagggc
     1141 tctcagcagc catcttactc tctcaggcct tgccgtgggt ttgggaggct gttggctcag
     1201 gagacagact tctacttcat ctcctagtag gaagtttcta agcttcactt cttctctctc
     1261 gtggcttata tatttcttct ctcactctct gcccttttaa tgaaaatgtt ttggctataa
     1321 aaataaagtc ctgccgggcg tggtggtgca tgcctttaat cccagcactc gggaggcaga
     1381 ggcaggcgga tctctgagtt cgaggccagc ctggtctaca gagtgagttc caggacagcc
     1441 aaggctacac agagaaaccc tgtctcaaaa caaacaaaca a
//
