LOCUS       NM_001081110            3130 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus CD8 subunit alpha (Cd8a), transcript variant 1, mRNA.
ACCESSION   NM_001081110 XM_132621
VERSION     NM_001081110.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3130)
  AUTHORS   Ran,L., Yue,Z., Ran,M., Liu,Q., Su,X., Wang,L., Wen,S., Xu,L.,
            Lei,S., Ou,Z., Hu,J., Zhang,Y., Qin,C., Wang,Y., He,Q., Chen,Y.,
            Liu,W., Ye,L., Huang,Q. and Xu,L.
  TITLE     The transcription regulator ID3 maintains tumor-specific memory
            CD8+ T cells in draining lymph nodes during tumorigenesis
  JOURNAL   Cell Rep 43 (9), 114690 (2024)
   PUBMED   39216001
REFERENCE   2  (bases 1 to 3130)
  AUTHORS   Mahadevan,K.K., Dyevoich,A.M., Chen,Y., Li,B., Sugimoto,H.,
            Sockwell,A.M., McAndrews,K.M., Sthanam,L.K., Wang,H., Shalapour,S.,
            Watowich,S.S. and Kalluri,R.
  TITLE     Type I conventional dendritic cells facilitate immunotherapy in
            pancreatic cancer
  JOURNAL   Science 384 (6703), eadh4567 (2024)
   PUBMED   38935717
REFERENCE   3  (bases 1 to 3130)
  AUTHORS   Purbey,P.K., Seo,J., Paul,M.K., Iwamoto,K.S., Daly,A.E., Feng,A.C.,
            Champhekar,A.S., Langerman,J., Campbell,K.M., Schaue,D.,
            McBride,W.H., Dubinett,S.M., Ribas,A., Smale,S.T. and Scumpia,P.O.
  TITLE     Opposing tumor-cell-intrinsic and -extrinsic roles of the IRF1
            transcription factor in antitumor immunity
  JOURNAL   Cell Rep 43 (6), 114289 (2024)
   PUBMED   38833371
REFERENCE   4  (bases 1 to 3130)
  AUTHORS   Salazar,F.C., Martinez,M.S., Paira,D.A., Chocobar,Y.A., Olivera,C.,
            Godoy,G.J., Acosta-Rodriguez,E.V., Rivero,V.E. and Motrich,R.D.
  TITLE     CD8 T cells are dispensable for experimental autoimmune prostatitis
            induction and chronic pelvic pain development
  JOURNAL   Front Immunol 15, 1387142 (2024)
   PUBMED   38807587
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3130)
  AUTHORS   Xue,G., Li,X., Kalim,M., Fang,J., Jiang,Z., Zheng,N., Wang,Z.,
            Li,X., Abdelrahim,M., He,Z., Nikiforov,M., Jin,G. and Lu,Y.
  TITLE     Clinical drug screening reveals clofazimine potentiates the
            efficacy while reducing the toxicity of anti-PD-1 and CTLA-4
            immunotherapy
  JOURNAL   Cancer Cell 42 (5), 780-796 (2024)
   PUBMED   38518774
REFERENCE   6  (bases 1 to 3130)
  AUTHORS   Wallace,V.A., Fung-Leung,W.P., Timms,E., Gray,D., Kishihara,K.,
            Loh,D.Y., Penninger,J. and Mak,T.W.
  TITLE     CD45RA and CD45RBhigh expression induced by thymic selection events
  JOURNAL   J Exp Med 176 (6), 1657-1663 (1992)
   PUBMED   1460424
REFERENCE   7  (bases 1 to 3130)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   8  (bases 1 to 3130)
  AUTHORS   Mak,T.W., Rahemtulla,A., Schilham,M., Koh,D.R. and Fung-Leung,W.P.
  TITLE     Generation of mutant mice lacking surface expression of CD4 or CD8
            by gene targeting
  JOURNAL   J Autoimmun 5 Suppl A, 55-59 (1992)
   PUBMED   1503636
REFERENCE   9  (bases 1 to 3130)
  AUTHORS   Gibson,D.M., Taylor,B.A. and Cherry,M.
  TITLE     Evidence for close linkage of a mouse light chain marker with the
            Ly-2,3 locus
  JOURNAL   J Immunol 121 (4), 1585-1590 (1978)
   PUBMED   100557
REFERENCE   10 (bases 1 to 3130)
  AUTHORS   Krog,H.H., Wysocka,M., Kisielow,P. and Radzikowski,C.
  TITLE     Genetic characterization of important mouse strains used in cancer
            research
  JOURNAL   Hereditas 87 (2), 201-204 (1977)
   PUBMED   75870
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160090.4.
            
            On Mar 8, 2007 this sequence version replaced NM_001081110.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M12052.1, AK137937.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-571               AC160090.4         21779-22349         c
            572-676             AC160090.4         21169-21273         c
            677-787             AC160090.4         20907-21017         c
            788-818             AC160090.4         19858-19888         c
            819-3130            AC160090.4         16605-18916         c
FEATURES             Location/Qualifiers
     source          1..3130
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 32.14 cM"
     gene            1..3130
                     /gene="Cd8a"
                     /gene_synonym="Ly-2; Ly-35; Ly-B; Lyt-2"
                     /note="CD8 subunit alpha"
                     /db_xref="GeneID:12525"
                     /db_xref="MGI:MGI:88346"
     exon            1..571
                     /gene="Cd8a"
                     /gene_synonym="Ly-2; Ly-35; Ly-B; Lyt-2"
                     /inference="alignment:Splign:2.1.0"
     exon            572..676
                     /gene="Cd8a"
                     /gene_synonym="Ly-2; Ly-35; Ly-B; Lyt-2"
                     /inference="alignment:Splign:2.1.0"
     exon            677..787
                     /gene="Cd8a"
                     /gene_synonym="Ly-2; Ly-35; Ly-B; Lyt-2"
                     /inference="alignment:Splign:2.1.0"
     exon            788..818
                     /gene="Cd8a"
                     /gene_synonym="Ly-2; Ly-35; Ly-B; Lyt-2"
                     /inference="alignment:Splign:2.1.0"
     exon            819..3130
                     /gene="Cd8a"
                     /gene_synonym="Ly-2; Ly-35; Ly-B; Lyt-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1549..1554
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd8a"
                     /gene_synonym="Ly-2; Ly-35; Ly-B; Lyt-2"
                     /note="hexamer: ATTAAA"
     polyA_site      1568
                     /gene="Cd8a"
                     /gene_synonym="Ly-2; Ly-35; Ly-B; Lyt-2"
                     /note="major polyA site"
     regulatory      3018..3023
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd8a"
                     /gene_synonym="Ly-2; Ly-35; Ly-B; Lyt-2"
                     /note="hexamer: AATAAA"
     polyA_site      3050
                     /gene="Cd8a"
                     /gene_synonym="Ly-2; Ly-35; Ly-B; Lyt-2"
ORIGIN      
        1 gctggctaaa ggagcagttt ccccgaccct acacgcctcc cccaccgcac ctcctccgcc
       61 ctgttcctgg gcccctcccc tagagcccta gcttgaccta agctgcttgc tggtggagag
      121 cacaccatgg cctcaccgtt gacccgcttt ctgtcgctga acctgctgct gctgggtgag
      181 tcgattatcc tggggagtgg agaagctaag ccacaggcac ccgaactccg aatctttcca
      241 aagaaaatgg acgccgaact tggtcagaag gtggacctgg tatgtgaagt gttggggtcc
      301 gtttcgcaag gatgctcttg gctcttccag aactccagct ccaaactccc ccagcccacc
      361 ttcgttgtct atatggcttc atcccacaac aagataacgt gggacgagaa gctgaattcg
      421 tcgaaactgt tttctgccat gagggacacg aataataagt acgttctcac cctgaacaag
      481 ttcagcaagg aaaacgaagg ctactatttc tgctcagtca tcagcaactc ggtgatgtac
      541 ttcagttctg tcgtgccagt ccttcagaaa gtgaactcta ctactaccaa gccagtgctg
      601 cgaactccct cacctgtgca ccctaccggg acatctcagc cccagagacc agaagattgt
      661 cggccccgtg gctcagtgaa ggggaccgga ttggacttcg cctgtgatat ttacatctgg
      721 gcacccttgg ccggaatctg cgtggccctt ctgctgtcct tgatcatcac tctcatctgc
      781 taccacagga gccgaaagcg tgtttgcaaa tgtcccaggc cgctagtcag acaggaaggc
      841 aagcccagac cttcagagaa aattgtgtaa aatggcaccg ccaggaagct acaactacta
      901 catgacttca gagatctctt cttgcaagag gccaggccct cctttttcaa gtttcctgct
      961 gtcttatgta ttgccctctg tattgtttta gtaggggtgt gatggggaca gttccttttt
     1021 ctttatgaat tctctttgac acaaagcata cttgtatgca tacaatggga gtaatgagca
     1081 gactgtaaca ccagagctag ttccagtttc ggggtccatg tcgctggtgg cctcagcacc
     1141 cacttgatat aaatctcctg tctgcccatc atatagaaga agctgaagat cagaggtgga
     1201 aacagcagga tctgtagacc cggagagaac ccaagctaga ggaaccctca ctgactggtg
     1261 cagggatctc acccccatcc cctgagctct ctgtttaggt atgtgtcttt agtatagcat
     1321 gcttgtgcct caaactgcaa ggaagcaagt ggtatgaatc tgtgatctgc tcagctctgg
     1381 ctgtgagcat cagatgtaac aaatcaaagt caggagaact gcctttagcg gtgcacctgg
     1441 acatcagagc cccttgtaag aactgggaaa ttgctggcag tctagtggag cggtacggta
     1501 aatctggaaa acactcccct ctgtcactga aggctgtagt agaatccaat taaagctatt
     1561 caaaccactg ccgcagaccc tctgggtccc tgtgtctgcg tggaatgggt ctctcgagca
     1621 ggtgggcaaa gcgtaggatt aaactgacaa acagatgcac acaggagagg cgttgaatct
     1681 gaatgtaatg tcaggtcgaa cctcggactt tttataatac agaaaaaatt ccaggggcga
     1741 tatgtcacac cagacaaggt acactgaaat ttaccagata caagagaatg acttcgaaag
     1801 gaatttgcag gaactagata aatgtttaca atagagatta tcagccctgc ctaggatcat
     1861 cagcctagtg ccaggtaaga atttcacact ttagtgttaa aagcaccagg gggtaattac
     1921 tcttggcagg cctcaagaat aatgtagtgt cacggacccc taaattccta ggccttgtta
     1981 aatcttatct tgtctggaga atccccattt atcaggagag tatctcaact tgctcttggc
     2041 atggaatgta gcctgtacta aagattttta tctcagtgag attcccaggc tctttctgca
     2101 gaccagatga gctaatggcc ttgtttattg taatgcttaa ttagttactg aataggttaa
     2161 actccttgct gttatctggg atcttggaac aatgggggcg ctgggggggg gggcgggggg
     2221 gctttagcta tgtcagaatt caatcttaaa aggcacttac aatagggtaa tgcttaatag
     2281 agggcacatg gatccataca ctagactaac gcgggagtgg aaaattaatt tatggtttag
     2341 agggaacgcc agactccagg agggaatttc tgtgaaactc ttttccttgt gggcagcttc
     2401 caagcttccg cttgtcaaac tgacccaact ggagagcgtg gctttcacca gactccagga
     2461 gggagctttc gtgaaactct tcctcatgag atagcttcca agctttcgcc tgtcaagctg
     2521 actccaccag agtgcgtggc aaaccaccac tgtgaaattc ctgtagaatt atgattctct
     2581 ctgctcttgg acagcagagg gtgaggtttg acagatacga ctcaggcatc agagaagctg
     2641 caggcaggcc ctctcccatg tctaaacatg agacttggat gtgctcctgg gatcaccagc
     2701 atgctttata ctctataaac atagaatcct tggagaacat tccttagcac ccccggaagg
     2761 cagatgtaaa gaggcagact agacgtggag gaagacgctg actgtcaaaa ctgctgcccc
     2821 agagctaatt tcctctcaca gtaccatata agtaacaaat aataggcaat aaaaacctga
     2881 aggaactaag agtcacccat ggtcctctat ctattgttac tatcatttta tacctgatta
     2941 tttcctatgc atatatatgt aagaaagatt acaccctggg ttttaaaaca caacagtttt
     3001 tgtaagcaga tttagtaaat aaacatgtat attatcattt aatggttaaa tagcatttca
     3061 tagtttggtt gtatccattt agtattaaat tgtttcaaac ttccccctac tattacacta
     3121 ctaaacttgc
//
