LOCUS       NM_019388               2539 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus CD86 antigen (Cd86), mRNA.
ACCESSION   NM_019388
VERSION     NM_019388.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2539)
  AUTHORS   Jeon,J., Park,Y.S., Kim,S.H., Kong,E., Kim,J., Yang,J.M., Lee,J.Y.,
            Kim,Y.M., Kim,I.B. and Kim,P.
  TITLE     Deciphering perivascular macrophages and microglia in the retinal
            ganglion cell layers
  JOURNAL   Front Cell Dev Biol 12, 1368021 (2024)
   PUBMED   38596358
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2539)
  AUTHORS   Frijlink,E., Bosma,D.M., Busselaar,J., Battaglia,T.W., Staal,M.D.,
            Verbrugge,I. and Borst,J.
  TITLE     PD-1 or CTLA-4 blockade promotes CD86-driven Treg responses upon
            radiotherapy of lymphocyte-depleted cancer in mice
  JOURNAL   J Clin Invest 134 (6), e171154 (2024)
   PUBMED   38349740
  REMARK    GeneRIF: PD-1 or CTLA-4 blockade promotes CD86-driven Treg
            responses upon radiotherapy of lymphocyte-depleted cancer in mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2539)
  AUTHORS   Zhao,Y., Caron,C., Chan,Y.Y., Lee,C.K., Xu,X., Zhang,J.,
            Masubuchi,T., Wu,C., Bui,J.D. and Hui,E.
  TITLE     cis-B7:CD28 interactions at invaginated synaptic membranes provide
            CD28 co-stimulation and promote CD8+ T cell function and anti-tumor
            immunity
  JOURNAL   Immunity 56 (6), 1187-1203 (2023)
   PUBMED   37160118
REFERENCE   4  (bases 1 to 2539)
  AUTHORS   Watanabe,M., Celli,S., Alkhaleel,F.A. and Hodes,R.J.
  TITLE     Antigen-presenting T cells provide critical B7 co-stimulation for
            thymic iNKT cell development via CD28-dependent trogocytosis
  JOURNAL   Cell Rep 41 (9), 111731 (2022)
   PUBMED   36450247
REFERENCE   5  (bases 1 to 2539)
  AUTHORS   Lightman,S.M., Peresie,J.L., Carlson,L.M., Holling,G.A.,
            Honikel,M.M., Chavel,C.A., Nemeth,M.J., Olejniczak,S.H. and
            Lee,K.P.
  TITLE     Indoleamine 2,3-dioxygenase 1 is essential for sustaining durable
            antibody responses
  JOURNAL   Immunity 54 (12), 2772-2783 (2021)
   PUBMED   34788602
REFERENCE   6  (bases 1 to 2539)
  AUTHORS   Brunschwig,E.B., Levine,E., Trefzer,U. and Tykocinski,M.L.
  TITLE     Glycosylphosphatidylinositol-modified murine B7-1 and B7-2 retain
            costimulator function
  JOURNAL   J Immunol 155 (12), 5498-5505 (1995)
   PUBMED   7499830
REFERENCE   7  (bases 1 to 2539)
  AUTHORS   Borriello,F., Oliveros,J., Freeman,G.J., Nadler,L.M. and
            Sharpe,A.H.
  TITLE     Differential expression of alternate mB7-2 transcripts
  JOURNAL   J Immunol 155 (12), 5490-5497 (1995)
   PUBMED   7499829
REFERENCE   8  (bases 1 to 2539)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   9  (bases 1 to 2539)
  AUTHORS   Mbikay,M., Grant,S.G., Sirois,F., Tadros,H., Skowronski,J.,
            Lazure,C., Seidah,N.G., Hanahan,D. and Chretien,M.
  TITLE     cDNA sequence of neuroendocrine protein 7B2 expressed in beta cell
            tumors of transgenic mice
  JOURNAL   Int J Pept Protein Res 33 (1), 39-45 (1989)
   PUBMED   2542174
REFERENCE   10 (bases 1 to 2539)
  AUTHORS   Gibson,D.M., Maclean,S.J. and Cherry,M.
  TITLE     Recombination between kappa chain genetic markers and the Lyt-3
            locus
  JOURNAL   Immunogenetics 18 (2), 111-116 (1983)
   PUBMED   6411613
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK079513.1.
            
            On Dec 1, 2007 this sequence version replaced NM_019388.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK079513.1, AK170054.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2539              AK079513.1         2-2540
FEATURES             Location/Qualifiers
     source          1..2539
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 25.72 cM"
     gene            1..2539
                     /gene="Cd86"
                     /gene_synonym="B7; B7-2; B7.2; B70; Cd28l2; CLS1; ETC-1;
                     Ly-58; Ly58; MB7; MB7-2; TS/A-2"
                     /note="CD86 antigen"
                     /db_xref="GeneID:12524"
                     /db_xref="MGI:MGI:101773"
     exon            1..130
                     /gene="Cd86"
                     /gene_synonym="B7; B7-2; B7.2; B70; Cd28l2; CLS1; ETC-1;
                     Ly-58; Ly58; MB7; MB7-2; TS/A-2"
                     /inference="alignment:Splign:2.1.0"
     exon            131..180
                     /gene="Cd86"
                     /gene_synonym="B7; B7-2; B7.2; B70; Cd28l2; CLS1; ETC-1;
                     Ly-58; Ly58; MB7; MB7-2; TS/A-2"
                     /inference="alignment:Splign:2.1.0"
     exon            181..516
                     /gene="Cd86"
                     /gene_synonym="B7; B7-2; B7.2; B70; Cd28l2; CLS1; ETC-1;
                     Ly-58; Ly58; MB7; MB7-2; TS/A-2"
                     /inference="alignment:Splign:2.1.0"
     exon            517..813
                     /gene="Cd86"
                     /gene_synonym="B7; B7-2; B7.2; B70; Cd28l2; CLS1; ETC-1;
                     Ly-58; Ly58; MB7; MB7-2; TS/A-2"
                     /inference="alignment:Splign:2.1.0"
     exon            814..934
                     /gene="Cd86"
                     /gene_synonym="B7; B7-2; B7.2; B70; Cd28l2; CLS1; ETC-1;
                     Ly-58; Ly58; MB7; MB7-2; TS/A-2"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1028
                     /gene="Cd86"
                     /gene_synonym="B7; B7-2; B7.2; B70; Cd28l2; CLS1; ETC-1;
                     Ly-58; Ly58; MB7; MB7-2; TS/A-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1069
                     /gene="Cd86"
                     /gene_synonym="B7; B7-2; B7.2; B70; Cd28l2; CLS1; ETC-1;
                     Ly-58; Ly58; MB7; MB7-2; TS/A-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..2539
                     /gene="Cd86"
                     /gene_synonym="B7; B7-2; B7.2; B70; Cd28l2; CLS1; ETC-1;
                     Ly-58; Ly58; MB7; MB7-2; TS/A-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1160..1165
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd86"
                     /gene_synonym="B7; B7-2; B7.2; B70; Cd28l2; CLS1; ETC-1;
                     Ly-58; Ly58; MB7; MB7-2; TS/A-2"
                     /note="hexamer: ATTAAA"
     regulatory      1172..1177
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd86"
                     /gene_synonym="B7; B7-2; B7.2; B70; Cd28l2; CLS1; ETC-1;
                     Ly-58; Ly58; MB7; MB7-2; TS/A-2"
                     /note="hexamer: AATACA"
     polyA_site      1180
                     /gene="Cd86"
                     /gene_synonym="B7; B7-2; B7.2; B70; Cd28l2; CLS1; ETC-1;
                     Ly-58; Ly58; MB7; MB7-2; TS/A-2"
                     /note="major polyA site"
     polyA_site      1196
                     /gene="Cd86"
                     /gene_synonym="B7; B7-2; B7.2; B70; Cd28l2; CLS1; ETC-1;
                     Ly-58; Ly58; MB7; MB7-2; TS/A-2"
     regulatory      2513..2518
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd86"
                     /gene_synonym="B7; B7-2; B7.2; B70; Cd28l2; CLS1; ETC-1;
                     Ly-58; Ly58; MB7; MB7-2; TS/A-2"
                     /note="hexamer: AATAAA"
     polyA_site      2538
                     /gene="Cd86"
                     /gene_synonym="B7; B7-2; B7.2; B70; Cd28l2; CLS1; ETC-1;
                     Ly-58; Ly58; MB7; MB7-2; TS/A-2"
ORIGIN      
        1 attgctgagg aagaaagagg agcaagcaga cgcgtaagag tggctcctgt aggcagcacg
       61 gacttgaaca accagactcc tgtagacgtg ttccagaact tacggaagca cccacgatgg
      121 accccagatg caccatgggc ttggcaatcc ttatctttgt gacagtcttg ctgatctcag
      181 atgctgtttc cgtggagacg caagcttatt tcaatgggac tgcatatctg ccgtgcccat
      241 ttacaaaggc tcaaaacata agcctgagtg agctggtagt attttggcag gaccagcaaa
      301 agttggttct gtacgagcac tatttgggca cagagaaact tgatagtgtg aatgccaagt
      361 acctgggccg cacgagcttt gacaggaaca actggactct acgacttcac aatgttcaga
      421 tcaaggacat gggctcgtat gattgtttta tacaaaaaaa gccacccaca ggatcaatta
      481 tcctccaaca gacattaaca gaactgtcag tgatcgccaa cttcagtgaa cctgaaataa
      541 aactggctca gaatgtaaca ggaaattctg gcataaattt gacctgcacg tctaagcaag
      601 gtcacccgaa acctaagaag atgtattttc tgataactaa ttcaactaat gagtatggtg
      661 ataacatgca gatatcacaa gataatgtca cagaactgtt cagtatctcc aacagcctct
      721 ctctttcatt cccggatggt gtgtggcata tgaccgttgt gtgtgttctg gaaacggagt
      781 caatgaagat ttcctccaaa cctctcaatt tcactcaaga gtttccatct cctcaaacgt
      841 attggaagga gattacagct tcagttactg tggccctcct ccttgtgatg ctgctcatca
      901 ttgtatgtca caagaagccg aatcagccta gcaggcccag caacacagcc tctaagttag
      961 agcgggatag taacgctgac agagagacta tcaacctgaa ggaacttgaa ccccaaattg
     1021 cttcagcaaa accaaatgca gagtgaaggc agtgagagcc tgaggaaaga gttaaaaatt
     1081 gctttgcctg aaataagaag tgcagagttt ctcagaattc aaaaatgttc tcagctgatt
     1141 ggaattctac agttgaataa ttaaagaaca aaatacacaa cagtgtccat attttatcct
     1201 gtttcctttc caagtttttg ggcaatgtca attgtgtccc ctatgccagg agcagacatc
     1261 tattttgtct tgctttgttt aactcagtgc acactcatag gccaagagca ctgaaatggc
     1321 ttctttccca ggaataacat tttggatcaa tctctcctac ttgagatcag attcttcttc
     1381 taattttgca tagtgtgttt ttatatggaa ctccttgttg taggaatact ggcttttatc
     1441 tgtcttgcac acttgcatac ttatatactt atacctggac agctacctct tcagtcagga
     1501 tgggagtggt atatttggtg atgttatttg atgtgttcgt gttgctatct taaaacagca
     1561 aagagcatat actatagtag ctcaactaca atgatctaga gaaagaccca gcacttataa
     1621 gaaacactgt ccctccatca gggtcaataa tgaatacaat gacctaagta atatacaggt
     1681 gacagcaaca gcacagagtt ctcagtgctg gcaaatcaag aaacacaaat atggaaccat
     1741 ctctagatcc aagagccact cctacctggg ctgccacaga tactggaaga atccacctgc
     1801 ctggccagca agtcacaact tagcaggcag cactgaagaa agcaagatgt actgtatgcc
     1861 cttttaagaa aatgcctgga aaggtctgga gaatgctgtg caaggataag acagccaagc
     1921 actcaaaacc aggagacatc actagaatcc aaccaacaaa tgtttatgga aggactgatc
     1981 tgcccagtcc attgaaaagt caagaggtca gagatagacc agtgtgtgtc tcaatggatg
     2041 tagatatcag ccacctcggt gctcaacagg tattttatga tctccttgtt tcaaattcat
     2101 ctagatgtag aactagggag agagcagtca cattgatgaa aggctaggac tctttcagct
     2161 catggcttgt gtggaaggag ggaaagcaga aatcacaaca ctctgagact actgtagtct
     2221 gcagatacct gagtgggtgt ggcttggcct ttcaaaggac aaagagcaac taatgctgaa
     2281 agcacatagt gtatctatac ggcatggaat agtcatcacc cagacttaaa gagaactttg
     2341 gcaggtctga gcagcaaaat attgttgttt ccattttaca taaagggccc tggagggcta
     2401 tagactattc cgctggcagg gctcatgctt gtaatgtgtc catcttgatt caccctgtgc
     2461 agactcttaa gatctggcca gttaccaaca tgttctgtac agagtggatt tcaataaagt
     2521 tttcttgaat tttttcaag
//
