LOCUS       NM_013489               3265 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus CD84 antigen (Cd84), transcript variant 1, mRNA.
ACCESSION   NM_013489
VERSION     NM_013489.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3265)
  AUTHORS   Rabani,S., Gunes,E.G., Gunes,M., Pellegrino,B., Lampert,B.,
            David,K., Pillai,R., Li,A., Becker-Herman,S., Rosen,S.T. and
            Shachar,I.
  TITLE     CD84 as a therapeutic target for breaking immune tolerance in
            triple-negative breast cancer
  JOURNAL   Cell Rep 43 (11), 114920 (2024)
   PUBMED   39466774
REFERENCE   2  (bases 1 to 3265)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3265)
  AUTHORS   Zheng,N., Fleming,J., Hu,P., Jiao,J., Zhang,G., Yang,R., Li,C.,
            Liu,Y., Bi,L. and Zhang,H.
  TITLE     CD84 is a Suppressor of T and B Cell Activation during
            Mycobacterium tuberculosis Pathogenesis
  JOURNAL   Microbiol Spectr 10 (1), e0155721 (2022)
   PUBMED   35196822
  REMARK    GeneRIF: CD84 is a Suppressor of T and B Cell Activation during
            Mycobacterium tuberculosis Pathogenesis.
REFERENCE   4  (bases 1 to 3265)
  AUTHORS   Tong,D., Zhao,Y., Tang,Y., Ma,J., Wang,Z. and Li,C.
  TITLE     Circ-Usp10 promotes microglial activation and induces neuronal
            death by targeting miRNA-152-5p/CD84
  JOURNAL   Bioengineered 12 (2), 10812-10822 (2021)
   PUBMED   34753388
  REMARK    GeneRIF: Circ-Usp10 promotes microglial activation and induces
            neuronal death by targeting miRNA-152-5p/CD84.
REFERENCE   5  (bases 1 to 3265)
  AUTHORS   Radomir,L., Kramer,M.P., Perpinial,M., Schottlender,N., Rabani,S.,
            David,K., Wiener,A., Lewinsky,H., Becker-Herman,S., Aharoni,R.,
            Milo,R., Mauri,C. and Shachar,I.
  TITLE     The survival and function of IL-10-producing regulatory B cells are
            negatively controlled by SLAMF5
  JOURNAL   Nat Commun 12 (1), 1893 (2021)
   PUBMED   33767202
  REMARK    GeneRIF: The survival and function of IL-10-producing regulatory B
            cells are negatively controlled by SLAMF5.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3265)
  AUTHORS   Kibar,Z., Vogan,K.J., Groulx,N., Justice,M.J., Underhill,D.A. and
            Gros,P.
  TITLE     Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is
            altered in the mouse neural tube mutant Loop-tail
  JOURNAL   Nat Genet 28 (3), 251-255 (2001)
   PUBMED   11431695
REFERENCE   7  (bases 1 to 3265)
  AUTHORS   Doudney,K., Murdoch,J.N., Paternotte,C., Bentley,L., Gregory,S.,
            Copp,A.J. and Stanier,P.
  TITLE     Comparative physical and transcript maps of approximately 1 Mb
            around loop-tail, a gene for severe neural tube defects on distal
            mouse chromosome 1 and human chromosome 1q22-q23
  JOURNAL   Genomics 72 (2), 180-192 (2001)
   PUBMED   11401431
REFERENCE   8  (bases 1 to 3265)
  AUTHORS   Peck,S.R. and Ruley,H.E.
  TITLE     Ly108: a new member of the mouse CD2 family of cell surface
            proteins
  JOURNAL   Immunogenetics 52 (1-2), 63-72 (2000)
   PUBMED   11132158
REFERENCE   9  (bases 1 to 3265)
  AUTHORS   de la Fuente,M.A., Tovar,V., Pizcueta,P., Nadal,M., Bosch,J. and
            Engel,P.
  TITLE     Molecular cloning, characterization, and chromosomal localization
            of the mouse homologue of CD84, a member of the CD2 family of cell
            surface molecules
  JOURNAL   Immunogenetics 49 (4), 249-255 (1999)
   PUBMED   10079287
REFERENCE   10 (bases 1 to 3265)
  AUTHORS   Rathbun,G.A., Otani,F., Milner,E.C., Capra,J.D. and Tucker,P.W.
  TITLE     Molecular characterization of the A/J J558 family of heavy chain
            variable region gene segments
  JOURNAL   J Mol Biol 202 (3), 383-395 (1988)
   PUBMED   3139886
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            LXEJ02005087.1 and AC091523.23.
            
            On Oct 20, 2022 this sequence version replaced NM_013489.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK171188.1, SRR5189679.70699.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                LXEJ02005087.1     25797-25869         c
            74-197              AC091523.23        82927-83050
            198-530             AC091523.23        94150-94482
            531-782             AC091523.23        115044-115295
            783-917             AC091523.23        115652-115786
            918-1012            AC091523.23        126932-127026
            1013-1075           AC091523.23        127918-127980
            1076-1141           AC091523.23        128708-128773
            1142-3265           AC091523.23        130945-133068
FEATURES             Location/Qualifiers
     source          1..3265
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 79.54 cM"
     gene            1..3265
                     /gene="Cd84"
                     /gene_synonym="A130013D22Rik; CDw84; SLAMF5"
                     /note="CD84 antigen"
                     /db_xref="GeneID:12523"
                     /db_xref="MGI:MGI:1336885"
     exon            1..73
                     /gene="Cd84"
                     /gene_synonym="A130013D22Rik; CDw84; SLAMF5"
                     /inference="alignment:Splign:2.1.0"
     exon            74..197
                     /gene="Cd84"
                     /gene_synonym="A130013D22Rik; CDw84; SLAMF5"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..1141
                     /gene="Cd84"
                     /gene_synonym="A130013D22Rik; CDw84; SLAMF5"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; SLAM family member 5; leukocyte differentiation
                     antigen CD84; signaling lymphocytic activation molecule 5"
                     /codon_start=1
                     /product="SLAM family member 5 isoform 1 precursor"
                     /protein_id="NP_038517.1"
                     /db_xref="CCDS:CCDS15503.1"
                     /db_xref="GeneID:12523"
                     /db_xref="MGI:MGI:1336885"
                     /translation="MAQRHLWIWFLCLQTWSEAAGKDADPVVMNGILGESVTFLLNIQ
                     EPKKIDNIAWTSQSSVAFIKPGVNKAEVTITQGTYKGRIEIIDQKYDLVIRDLRMEDA
                     GTYKADINEENEETITKIYYLHIYRRLKTPKITQSLISSLNNTCNITLTCSVEKEEKD
                     VTYSWSPFGEKSNVLQIVHSPMDQKLTYTCTAQNPVSNSSDSVTVQQPCTDTPSFHPR
                     HAVLPGGLAVLFLLILIPMLAFLFRLYKRRRDRIVLEADDVSKKTVYAVVSRNAQPTE
                     SRIYDEIPQSKMLSCKKDPVTTIYSSVQLSEKMKETNMKDRSLPKALGNEIVV"
     exon            198..530
                     /gene="Cd84"
                     /gene_synonym="A130013D22Rik; CDw84; SLAMF5"
                     /inference="alignment:Splign:2.1.0"
     exon            531..782
                     /gene="Cd84"
                     /gene_synonym="A130013D22Rik; CDw84; SLAMF5"
                     /inference="alignment:Splign:2.1.0"
     exon            783..917
                     /gene="Cd84"
                     /gene_synonym="A130013D22Rik; CDw84; SLAMF5"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1012
                     /gene="Cd84"
                     /gene_synonym="A130013D22Rik; CDw84; SLAMF5"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1075
                     /gene="Cd84"
                     /gene_synonym="A130013D22Rik; CDw84; SLAMF5"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1141
                     /gene="Cd84"
                     /gene_synonym="A130013D22Rik; CDw84; SLAMF5"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..3265
                     /gene="Cd84"
                     /gene_synonym="A130013D22Rik; CDw84; SLAMF5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1603..1608
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd84"
                     /gene_synonym="A130013D22Rik; CDw84; SLAMF5"
                     /note="hexamer: TATAAA"
     polyA_site      1623
                     /gene="Cd84"
                     /gene_synonym="A130013D22Rik; CDw84; SLAMF5"
                     /note="major polyA site"
     regulatory      3219..3224
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd84"
                     /gene_synonym="A130013D22Rik; CDw84; SLAMF5"
                     /note="hexamer: AACAAA"
     regulatory      3246..3251
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd84"
                     /gene_synonym="A130013D22Rik; CDw84; SLAMF5"
                     /note="hexamer: AATAAA"
     polyA_site      3261
                     /gene="Cd84"
                     /gene_synonym="A130013D22Rik; CDw84; SLAMF5"
                     /note="major polyA site"
     polyA_site      3265
                     /gene="Cd84"
                     /gene_synonym="A130013D22Rik; CDw84; SLAMF5"
ORIGIN      
        1 acttcttcct tttctgtcta atggtgaaca cctttctgga ccagctctgg accagaatct
       61 gatttatgct ctgctccgga aacaccacac tgaagtgaaa gcagctacca caccagttat
      121 ttttcctcag aagactggag tctgactgga catggcccag cgccatctgt ggatctggtt
      181 cctttgccta caaacctggt ctgaagcagc aggaaaagat gcagacccgg tggtaatgaa
      241 tgggattctt ggggagtcag ttactttcct cttaaatatt caagaaccaa agaaaattga
      301 caacattgcc tggacttctc aatcatctgt tgcttttata aaaccaggag tcaataaagc
      361 tgaagttacc ataacccagg gcacttataa aggacgaata gaaatcatag atcagaagta
      421 tgacctggtc attagagacc tgaggatgga agatgcagga acttacaaag cagacatcaa
      481 tgaagagaat gaggaaacca tcaccaagat ctactacctt catatctacc gtcgacttaa
      541 aacaccaaaa attacacaga gtttgatatc atctttgaac aatacctgta atatcacact
      601 gacatgctct gtggaaaagg aagaaaagga tgtcacatat agctggagtc cctttggaga
      661 gaaaagcaat gtccttcaaa tcgtccactc ccccatggac caaaaactga cctacacatg
      721 tacagcccag aaccctgtca gcaacagttc tgactctgtc actgtccagc agccatgtac
      781 agacactcca agcttccatc ctcgccatgc tgtgttgcca ggaggattgg ccgtgctctt
      841 tctgcttatt ctcattccga tgttggcatt tctgttccgt ttgtataaga gaaggcgaga
      901 caggattgtc ctggaagcag atgatgtctc aaagaaaaca gtatatgctg tagtttcaag
      961 aaatgctcaa cccacagagt ccagaatcta tgatgaaatc cctcagtcca agatgctgtc
     1021 ctgtaagaaa gatccggtga ccaccattta ttcctcagtg cagctttctg agaagatgaa
     1081 ggaaaccaac atgaaggaca gaagtctgcc taaggctttg ggtaatgaaa ttgttgtcta
     1141 ggtgattctc taagaccacg aaggacacaa ggacaagtca tctatgagga ttgaatcaac
     1201 ggtttcagtc ttttggatat aacctgggcc agccaaggga tttaggaatg aagcaagctc
     1261 cgtgggtaga ggtctgatcc ccagtgtgta atgttagggg ccatgtacag gattgactct
     1321 caggcccaca gatctttacc cagagaaacc ctgacctgct cccatgctgt ttttcctggg
     1381 gaaaggaccc tagggcactc aacctttatg caatcagaca tgcctctcag agactgtcta
     1441 acagcttcca gactaatctc tgtgcagtac ttagtcttac aactctcacg ggcaacggct
     1501 tcaagttcca attttacgat gtgtctagcc tgggatgact gtttagtttc taatgtggcg
     1561 agaatgtatg ttaccatgta ggaagcacag actatggcaa tctataaatg atttgtggca
     1621 tgagactgat gtccgaattt aggggaaggg gaatggtctt acttaggcat tttatggaaa
     1681 ttgagtctct ctccccgaga agagggtgat gaagcagcat ccacgtctgc ctcttctcca
     1741 gtaacctgct tgttatcgac aatgtccagc cgatggtaat gaactgaaac aaatgcgctt
     1801 gaaagagatg aatcaatttg agatttaaca aatcgggtca atttctgaaa tgcccaagga
     1861 ccgaaggaga tcaataatag gagtcccaat aggggcccta aaagggaggg caacaaggtt
     1921 gaaagtcagg gggaggttga aaaccagttt tggtagtcta ccttccccct aggccattgt
     1981 aaatacttgt gtatgggtgt aactcagcta tctatagttc taagtatcca ctctggttcc
     2041 tctttaggtc ttaaacttcc ttcttcctag ttgatggtaa attcctgtgt aaggcagtgg
     2101 cctagctttt attcaaagtg atagtgtaat gccagaggct attctgaatg tcactgaata
     2161 ggcaacactc tccctgaatt ctaagtccat ggtctgttca agggcttttt aggacattgg
     2221 aacaccagtg aaggcttagc tatgtcagaa ttcaatctta aaatgcactt ataataagat
     2281 aatattaaaa gagagcacat ggatctatac accagactaa ctcgggaata gaatatgagt
     2341 acaaaatggg cagtatgcag ctgctgaact aaggctgtgg tagatacctt ttcaaagttt
     2401 gcattcccag atttttaaac caaggatcgt ttcctaactc taataggcag caaaacgtaa
     2461 gcaggtctct aacaaaaaca taacagtaga ttccttatct aaattaggat ctacacaatt
     2521 agttaattga caagaattac aatgaatata aaaagacttg ccaagattgg cgatcttaac
     2581 tcttaaaatt atctaacaat aagcatatag gtaaggtaca caaactttca tagctataag
     2641 gagctgacct gaaaggccaa aaacagtgtc tctgacaaaa gcatcttgta cattctctgt
     2701 accagtcttt ttgcctcatg agtcagcttt tttagttgtt tttattttaa gttggcacca
     2761 ggttggtact ccttgctgca gcccatggcg gagatacgaa gtttctttat ctgtttgtaa
     2821 gtggctgctc tctgatttct cttcttttgt atactcaaca tagctttctg gtcaccactg
     2881 tcagggcact cacaggtcac aggtcagcct gtcacattgg aagctagcat gctcttgtag
     2941 cattctgtgg aaaaaacaga aacattctcc cttttcccca tattaagtat ctgaacagga
     3001 tcatggcaag tgccaataag tggatccttt ttatctgtcc tagacatcat tatatctagt
     3061 ttgttttttt tttgtaaata aaaatgtgat tttatgtgca cagggatata attcctacct
     3121 tctttgtttt taaagaaggt atagttttta aagttttaca ataccttgtc tttgagaatt
     3181 ataaaatatc tcagtaacat gtgtaacatt aaattgttaa caaaacatct cttggaggtt
     3241 ttgaaaataa aaattttgaa gcaaa
//
