LOCUS       NM_009856               2141 bp    mRNA    linear   ROD 24-DEC-2022
DEFINITION  Mus musculus CD83 antigen (Cd83), transcript variant 1, mRNA.
ACCESSION   NM_009856
VERSION     NM_009856.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2141)
  AUTHORS   Royzman D, Andreev D, Stich L, Peckert-Maier K, Wild AB, Zinser E,
            Muhl-Zurbes P, Jones E, Adam S, Frey S, Fuchs M, Kunz M, Bauerle T,
            Nagel L, Schett G, Bozec A and Steinkasserer A.
  TITLE     The soluble CD83 protein prevents bone destruction by inhibiting
            the formation of osteoclasts and inducing resolution of
            inflammation in arthritis
  JOURNAL   Front Immunol 13, 936995 (2022)
   PUBMED   36003376
  REMARK    GeneRIF: The soluble CD83 protein prevents bone destruction by
            inhibiting the formation of osteoclasts and inducing resolution of
            inflammation in arthritis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2141)
  AUTHORS   Silveira PA, Kupresanin F, Romano A, Hsu WH, Lo TH, Ju X, Chen HT,
            Roberts H, Baker DG and Clark GJ.
  TITLE     Anti-Mouse CD83 Monoclonal Antibody Targeting Mature Dendritic
            Cells Provides Protection Against Collagen Induced Arthritis
  JOURNAL   Front Immunol 13, 784528 (2022)
   PUBMED   35222372
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2141)
  AUTHORS   Kaiser M, Wojahn I, Rudat C, Ludtke TH, Christoffels VM, Moon A,
            Kispert A and Trowe MO.
  TITLE     Regulation of otocyst patterning by Tbx2 and Tbx3 is required for
            inner ear morphogenesis in the mouse
  JOURNAL   Development 148 (8) (2021)
   PUBMED   33795231
REFERENCE   4  (bases 1 to 2141)
  AUTHORS   Yu Y, Jin QR, Mi Y, Liu JQ, Liu ZQ, Wang S, Liu ZG, Yang PC and
            Zheng PY.
  TITLE     Intestinal Epithelial Cell-Derived CD83 Contributes to Regulatory
            T-Cell Generation and Inhibition of Food Allergy
  JOURNAL   J Innate Immun 13 (5), 295-305 (2021)
   PUBMED   34182560
  REMARK    GeneRIF: Intestinal Epithelial Cell-Derived CD83 Contributes to
            Regulatory T-Cell Generation and Inhibition of Food Allergy.
REFERENCE   5  (bases 1 to 2141)
  AUTHORS   Akauliya M, Gautam A, Maharjan S, Park BK, Kim J and Kwon HJ.
  TITLE     CD83 expression regulates antibody production in response to
            influenza A virus infection
  JOURNAL   Virol J 17 (1), 194 (2020)
   PUBMED   33302987
  REMARK    GeneRIF: CD83 expression regulates antibody production in response
            to influenza A virus infection.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2141)
  AUTHORS   Wolenski M, Cramer SO, Ehrlich S, Steeg C, Grossschupff G,
            Tenner-Racz K, Racz P, Fleischer B and von Bonin A.
  TITLE     Expression of CD83 in the murine immune system
  JOURNAL   Med Microbiol Immunol 192 (4), 189-192 (2003)
   PUBMED   12687354
  REMARK    GeneRIF: murine CD83 is expressed mainly on mature dendritic cells
            and on activated T cells
REFERENCE   7  (bases 1 to 2141)
  AUTHORS   Lechmann M, Berchtold S, Hauber J and Steinkasserer A.
  TITLE     CD83 on dendritic cells: more than just a marker for maturation
  JOURNAL   Trends Immunol 23 (6), 273-275 (2002)
   PUBMED   12072358
  REMARK    GeneRIF: the soluble extracellular CD83 domain inhibits DC-mediated
            T-cell proliferation, representing the first report describing a
            functional role for CD83.
            Review article
REFERENCE   8  (bases 1 to 2141)
  AUTHORS   Fujimoto Y, Tu L, Miller AS, Bock C, Fujimoto M, Doyle C, Steeber
            DA and Tedder TF.
  TITLE     CD83 expression influences CD4+ T cell development in the thymus
  JOURNAL   Cell 108 (6), 755-767 (2002)
   PUBMED   11955430
  REMARK    GeneRIF: CD83 expression influences CD4+ T cell development in the
            thymus.
REFERENCE   9  (bases 1 to 2141)
  AUTHORS   Scholler N, Hayden-Ledbetter M, Dahlin A, Hellstrom I, Hellstrom KE
            and Ledbetter JA.
  TITLE     Cutting edge: CD83 regulates the development of cellular immunity
  JOURNAL   J Immunol 168 (6), 2599-2602 (2002)
   PUBMED   11884422
  REMARK    GeneRIF: Soluble CD83-Ig fusion protein is immunosuppressive,
            costimulatory when coimmobilized with anti-CD3, and by interacting
            with its ligand(s) is involved in regulation of immune response to
            tumor.
REFERENCE   10 (bases 1 to 2141)
  AUTHORS   Twist CJ, Beier DR, Disteche CM, Edelhoff S and Tedder TF.
  TITLE     The mouse Cd83 gene: structure, domain organization, and chromosome
            localization
  JOURNAL   Immunogenetics 48 (6), 383-393 (1998)
   PUBMED   9799334
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB840485.1, AK139410.1, BC072615.1 and AV359852.1.
            
            [WARNING] On Apr 21, 2023 this sequence was replaced by
            NM_009856.4.
            
            On Feb 8, 2014 this sequence version replaced NM_009856.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660819.182266.1, AK139410.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                BB840485.1         1-73
            74-1641             AK139410.1         2-1569
            1642-2140           BC072615.1         1551-2049
            2141-2141           AV359852.1         233-233
FEATURES             Location/Qualifiers
     source          1..2141
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 21.6 cM"
     gene            1..2141
                     /gene="Cd83"
                     /note="CD83 antigen"
                     /db_xref="GeneID:12522"
                     /db_xref="MGI:MGI:1328316"
     exon            1..139
                     /gene="Cd83"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..693
                     /gene="Cd83"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; mCD83"
                     /codon_start=1
                     /product="CD83 antigen isoform 1 precursor"
                     /protein_id="NP_033986.1"
                     /db_xref="CCDS:CCDS26481.1"
                     /db_xref="GeneID:12522"
                     /db_xref="MGI:MGI:1328316"
                     /translation="MSQGLQLLFLGCACSLAPAMAMREVTVACSETADLPCTAPWDPQ
                     LSYAVSWAKVSESGTESVELPESKQNSSFEAPRRRAYSLTIQNTTICSSGTYRCALQE
                     LGGQRNLSGTVVLKVTGCPKEATESTFRKYRAEAVLLFSLVVFYLTLIIFTCKFARLQ
                     SIFPDISKPGTEQAFLPVTSPSKHLGPVTLPKTETV"
     exon            140..261
                     /gene="Cd83"
                     /inference="alignment:Splign:2.1.0"
     exon            262..457
                     /gene="Cd83"
                     /inference="alignment:Splign:2.1.0"
     exon            458..564
                     /gene="Cd83"
                     /inference="alignment:Splign:2.1.0"
     exon            565..2141
                     /gene="Cd83"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggagtcccc ggggccggcg cgcggggaag tcccaagcgc gggtacaaga gcacggcgcg
       61 cgcccagggg gccggcccgg acagtgtcgc agcgctccag ccatgtcgca aggcctccag
      121 ctcctgtttc taggctgcgc ctgcagcctg gcacccgcga tggcgatgcg ggaggtgacg
      181 gtggcttgct ccgagaccgc cgacttgcct tgcacagcgc cctgggaccc gcagctctcc
      241 tatgcagtgt cctgggccaa ggtctccgag agtggcactg agagtgtgga gctcccggag
      301 agcaagcaaa acagctcctt cgaggccccc aggagaaggg cctattccct gacgatccaa
      361 aacactacca tctgcagctc gggcacctac aggtgtgccc tgcaggagct cggagggcag
      421 cgcaacttga gcggcaccgt ggttctgaag gtgacaggat gccccaagga agctacagag
      481 tcaactttca ggaagtacag ggcagaagct gtgttgctct tctctctggt tgttttctac
      541 ctgacactca tcattttcac ctgcaaattt gcacgactac aaagcatttt cccagatatt
      601 tctaaacctg gtacggaaca agcttttctt ccagtcacct ccccaagcaa acatttgggg
      661 ccagtgaccc ttcctaagac agaaacggta tgagtaggat ctccactggt ttttacaaag
      721 ccaagggcac atcagatcag tgtgcctgaa tgccacccgg acaagagaag aatgagctcc
      781 atcctcagat ggcaaccttt ctttgaagtc cttcacctga cagtgggctc cacactactc
      841 cctgacacag ggtcttgagc accatcatat gatcacgaag catggagtat caccgcttct
      901 ctgtggctgt cagcttaatg tttcatgtgg ctatctggtc aacctcgtga gtgcttttca
      961 gtcatctaca agctatggtg agatgcaggt gaagcagggt catgggaaat ttgaacactc
     1021 tgagctggcc ctgtgacaga ctcctgagga cagctgtcct ctcctacatc tgggatacat
     1081 ctctttgaat ttgtcctgtt tcgttgcacc agcccagatg tctcacatct ggcggaaatt
     1141 gacaggccaa gctgtgagcc agtgggaaat atttagcaaa taatttccca gtgcgaaggt
     1201 cctgctatta gtaaggagta ttatgtgtac atagaaatga gaggtcagtg aactattccc
     1261 cagcagggcc ttttcatctg gaaaagacat ccacaaaagc agcaatacag agggatgcca
     1321 catttatttt tttaatcttc atgtacttgt caaagaagaa tttttcatgt tttttcaaag
     1381 aagtgtgttt ctttcctttt ttaaaatatg aaggtctagt tacatagcat tgctagctga
     1441 caagcagcct gagagaagat ggagaatgtt cctcaaaata gggacagcaa gctagaagca
     1501 ctgtacagtg ccctgctggg aagggcagac aatggactga gaaaccagaa gtctggccac
     1561 aagattgtct gtatgattct ggacgagtca cttgtggttt tcactctctg gttagtaaac
     1621 cagatagttt agtctgggtt gaatacaatg gatgtgaagt tgcttgggga aagctgaatg
     1681 tagtgaatac attggcaact ctactgggct gttaccttgt tgatatccta gagttctgga
     1741 gctgagcgaa tgcctgtcat atctcagctt gcccatcaat ccaaacacag gaggctacaa
     1801 aaaggacatg agcatggtct tctgtgtgaa ctcctcctga gaaacgtgga gactggctca
     1861 gcgctttgcg cttgaaggac taatcacaag ttcttgaaga tatggaccta ggggagctat
     1921 tgcgccacga caggaggaag ttctcagatg ttgcattgat gtaacattgt tgcatttctt
     1981 taatgagctg ggctccttcc tcatttgctt cccaaagaga ttttgtccca ctaatggtgt
     2041 gcccatcacc cacactatga aagtaaaagg gatgctgagc agatacagcg tgcttacctc
     2101 tcagccatga ctttcatgct attaaaagaa tgcatgtgaa g
//
