LOCUS       NM_007656               1833 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus CD82 antigen (Cd82), transcript variant 1, mRNA.
ACCESSION   NM_007656
VERSION     NM_007656.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1833)
  AUTHORS   Kim,J.S., Kim,H.K., Lee,J., Jang,S., Cho,E., Mun,S.J., Yoon,S. and
            Yang,C.S.
  TITLE     Inhibition of CD82 improves colitis by increasing NLRP3
            deubiquitination by BRCC3
  JOURNAL   Cell Mol Immunol 20 (2), 189-200 (2023)
   PUBMED   36600050
  REMARK    GeneRIF: Inhibition of CD82 improves colitis by increasing NLRP3
            deubiquitination by BRCC3.
REFERENCE   2  (bases 1 to 1833)
  AUTHORS   McGowan,E.N.S., Wong,O., Jones,E., Nguyen,J., Wee,J., Demaria,M.C.,
            Deliyanti,D., Johnson,C.J., Hickey,M.J., McConville,M.J.,
            Wilkinson-Berka,J.L., Wright,M.D. and Binger,K.J.
  TITLE     Tetraspanin CD82 restrains phagocyte migration but supports
            macrophage activation
  JOURNAL   iScience 25 (7), 104520 (2022)
   PUBMED   35754722
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1833)
  AUTHORS   Saito-Reis,C.A., Balise,V.D., Pascetti,E.M., Jiminez,M. and
            Gillette,J.M.
  TITLE     Tetraspanin CD82 regulates S1PR1-mediated hematopoietic stem and
            progenitor cell mobilization
  JOURNAL   Stem Cell Reports 16 (10), 2422-2431 (2021)
   PUBMED   34534447
  REMARK    GeneRIF: Tetraspanin CD82 regulates S1PR1-mediated hematopoietic
            stem and progenitor cell mobilization.
REFERENCE   4  (bases 1 to 1833)
  AUTHORS   Lee,J.W., Hur,J., Kwon,Y.W., Chae,C.W., Choi,J.I., Hwang,I.,
            Yun,J.Y., Kang,J.A., Choi,Y.E., Kim,Y.H., Lee,S.E., Lee,C.,
            Jo,D.H., Seok,H., Cho,B.S., Baek,S.H. and Kim,H.S.
  TITLE     KAI1(CD82) is a key molecule to control angiogenesis and switch
            angiogenic milieu to quiescent state
  JOURNAL   J Hematol Oncol 14 (1), 148 (2021)
   PUBMED   34530889
  REMARK    GeneRIF: KAI1(CD82) is a key molecule to control angiogenesis and
            switch angiogenic milieu to quiescent state.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1833)
  AUTHORS   Hall,A., Fontelonga,T., Wright,A., Bugda Gwilt,K., Widrick,J.,
            Pasut,A., Villa,F., Miranti,C.K., Gibbs,D., Jiang,E., Meng,H.,
            Lawlor,M.W. and Gussoni,E.
  TITLE     Tetraspanin CD82 is necessary for muscle stem cell activation and
            supports dystrophic muscle function
  JOURNAL   Skelet Muscle 10 (1), 34 (2020)
   PUBMED   33243288
  REMARK    GeneRIF: Tetraspanin CD82 is necessary for muscle stem cell
            activation and supports dystrophic muscle function.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1833)
  AUTHORS   Higashiyama,S. and Nanba,D.
  TITLE     ADAM-mediated ectodomain shedding of HB-EGF in receptor cross-talk
  JOURNAL   Biochim Biophys Acta 1751 (1), 110-117 (2005)
   PUBMED   16054021
  REMARK    Review article
REFERENCE   7  (bases 1 to 1833)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (bases 1 to 1833)
  AUTHORS   Matsui,M., Araki,Y., Karasawa,H., Matsubara,N., Taketo,M.M. and
            Seldin,M.F.
  TITLE     Mapping of five subtype genes for muscarinic acetylcholine receptor
            to mouse chromosomes
  JOURNAL   Genes Genet Syst 74 (1), 15-21 (1999)
   PUBMED   10549128
REFERENCE   9  (bases 1 to 1833)
  AUTHORS   Seldin,M.F., Rochelle,J.M., Tomlinson,M.G. and Wright,M.D.
  TITLE     Mapping of the genes for four members of the transmembrane 4
            superfamily: mouse Cd9, Cd63, Cd81, and Cd82
  JOURNAL   Immunogenetics 42 (5), 422-425 (1995)
   PUBMED   7590978
REFERENCE   10 (bases 1 to 1833)
  AUTHORS   Nagira,M., Imai,T., Ishikawa,I., Uwabe,K.I. and Yoshie,O.
  TITLE     Mouse homologue of C33 antigen (CD82), a member of the
            transmembrane 4 superfamily: complementary DNA, genomic structure,
            and expression
  JOURNAL   Cell Immunol 157 (1), 144-157 (1994)
   PUBMED   8039242
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732483.8.
            
            On Oct 2, 2012 this sequence version replaced NM_007656.4.
            
            Transcript Variant: This variant (1) represents the predominant
            transcript. Variants 1, 2, 3, 4, 5, 6 and 7 encode the same
            protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK168515.1, AK153070.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-173               AL732483.8         56828-57000         c
            174-249             AL732483.8         37867-37942         c
            250-332             AL732483.8         31886-31968         c
            333-405             AL732483.8         28359-28431         c
            406-530             AL732483.8         24629-24753         c
            531-605             AL732483.8         24443-24517         c
            606-707             AL732483.8         16325-16426         c
            708-908             AL732483.8         15053-15253         c
            909-992             AL732483.8         14738-14821         c
            993-1833            AL732483.8         13600-14440         c
FEATURES             Location/Qualifiers
     source          1..1833
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 51.62 cM"
     gene            1..1833
                     /gene="Cd82"
                     /gene_synonym="C33; IA4; Kai1; Tspan27"
                     /note="CD82 antigen"
                     /db_xref="GeneID:12521"
                     /db_xref="MGI:MGI:104651"
     exon            1..173
                     /gene="Cd82"
                     /gene_synonym="C33; IA4; Kai1; Tspan27"
                     /inference="alignment:Splign:2.1.0"
     exon            174..249
                     /gene="Cd82"
                     /gene_synonym="C33; IA4; Kai1; Tspan27"
                     /inference="alignment:Splign:2.1.0"
     exon            250..332
                     /gene="Cd82"
                     /gene_synonym="C33; IA4; Kai1; Tspan27"
                     /inference="alignment:Splign:2.1.0"
     CDS             270..1070
                     /gene="Cd82"
                     /gene_synonym="C33; IA4; Kai1; Tspan27"
                     /note="kangai 1 (suppression of tumorigenicity 6,
                     prostate); C33 antigen; inducible membrane protein R2;
                     metastasis suppressor Kangai-1 homolog"
                     /codon_start=1
                     /product="CD82 antigen"
                     /protein_id="NP_031682.1"
                     /db_xref="CCDS:CCDS16454.1"
                     /db_xref="GeneID:12521"
                     /db_xref="MGI:MGI:104651"
                     /translation="MGAGCVKVTKYFLFLFNLLFFILGAVILGFGVWILADKNSFISV
                     LQTSSSSLQVGAYVFIGVGAITIVMGFLGCIGAVNEVRCLLGLYFVFLLLILIAQVTV
                     GVLFYFNADKLKKEMGNTVMDIIRNYTANATSSREEAWDYVQAQVKCCGWVSHYNWTE
                     NEELMGFTKTTYPCSCEKIKEEDNQLIVKKGFCEADNSTVSENNPEDWPVNTEGCMEK
                     AQAWLQENFGILLGVCAGVAVIELLGLFLSICLCRYIHSEDYSKVPKY"
     exon            333..405
                     /gene="Cd82"
                     /gene_synonym="C33; IA4; Kai1; Tspan27"
                     /inference="alignment:Splign:2.1.0"
     exon            406..530
                     /gene="Cd82"
                     /gene_synonym="C33; IA4; Kai1; Tspan27"
                     /inference="alignment:Splign:2.1.0"
     exon            531..605
                     /gene="Cd82"
                     /gene_synonym="C33; IA4; Kai1; Tspan27"
                     /inference="alignment:Splign:2.1.0"
     exon            606..707
                     /gene="Cd82"
                     /gene_synonym="C33; IA4; Kai1; Tspan27"
                     /inference="alignment:Splign:2.1.0"
     exon            708..908
                     /gene="Cd82"
                     /gene_synonym="C33; IA4; Kai1; Tspan27"
                     /inference="alignment:Splign:2.1.0"
     exon            909..992
                     /gene="Cd82"
                     /gene_synonym="C33; IA4; Kai1; Tspan27"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1833
                     /gene="Cd82"
                     /gene_synonym="C33; IA4; Kai1; Tspan27"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1803..1808
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Cd82"
                     /gene_synonym="C33; IA4; Kai1; Tspan27"
                     /note="hexamer: ATTAAA"
     polyA_site      1824
                     /gene="Cd82"
                     /gene_synonym="C33; IA4; Kai1; Tspan27"
                     /note="major polyA site"
ORIGIN      
        1 ggtcttgggg ggcgtggcgt ggcctgacaa ggccgttgag cttctggact gacttcggga
       61 gggggtggcg ggggaaaacg gagggacaga gccaagctgc gcagtcagac tcgggttggg
      121 gcgccagctg aagacgcggg acttaaagcg cgtagccaga acccaggcac cagtgtgtcc
      181 attgtccaga actcatctga aaaactgcca caggaattgc ttctctgctc caggctggtc
      241 actgaacagg ttgctccagg acctgcagaa tgggggcagg ctgtgtcaaa gtcaccaagt
      301 atttcctctt cctcttcaac ttgctgttct ttatcctggg tgctgtgatc ctgggcttcg
      361 gggtgtggat tcttgcagac aagaacagct tcatttccgt cctacaaacc tcatccagct
      421 cgctgcaggt gggggcttac gtcttcatcg gtgtgggcgc catcaccata gtgatgggct
      481 tcctgggctg tatcggtgct gtcaatgagg tccgctgctt gctgggtctg tactttgtct
      541 tccttctgct gatcctcatc gcacaggtga ccgtaggggt cctcttctac ttcaacgctg
      601 acaagctgaa gaaggagatg gggaacacag tgatggacat cattcgcaac tacactgcca
      661 atgccaccag tagccgcgag gaggcctggg actacgtgca ggcgcaggtc aagtgctgtg
      721 gctgggtcag ccactacaac tggacagaga acgaggagct catgggcttt accaagacca
      781 cttacccatg ctcctgcgag aagatcaagg aagaggacaa ccagctcatt gtgaagaaag
      841 gattctgtga ggctgataac agcactgtga gcgaaaacaa ccctgaggat tggcctgtga
      901 acactgaggg ctgcatggag aaggcgcagg cgtggcttca ggagaacttc ggcatccttc
      961 tgggcgtgtg tgctggtgtt gctgtcattg agctgctggg gttgttcctg tccatatgtt
     1021 tgtgccggta cattcattct gaagactaca gcaaggtccc caagtactga ggttgctgat
     1081 gtccccaccg tcctatttct ccaccctcag cctcccatgg ggcctctcta gctttttctc
     1141 acatgggccc tgctccatcc accactgagg cctctggccc atcctggaaa ggttgcattg
     1201 ggaactttct gggcctgggc ccttctccct gtccttctgc caccaatatg gggccctggc
     1261 tatcctgtgg cctttcttcc tactgcctgg gatattttaa cagctcgaaa tggctcccag
     1321 tattactgta cacaggatag ctgtgtctcc accctgaagt catattgtat tgtattaaaa
     1381 accagggagg gtgggtgtag cacccgtagc tgcccaggga aaggccacag gaaaggttgg
     1441 tggggttttc cccactgtca cactttcttc ataggttttc catgtttctg tgggagacag
     1501 ggtaggcaat tcttccacac acttggagca ctcccccctc cccaagctca gttcagcagg
     1561 gaactgaact gaggggcctc ctgggggact ggcccaggta gcctctggtg cgctcctctt
     1621 ggtgagggac ctgacaactt aggggtgtgg gtccctcagg tctggcacaa gaccctggat
     1681 gagaggagga tctggactgg tgtttcttgg cagctgtccc ctgtcctctg cgctaagggt
     1741 gggtgaggct gtgccttgca gggtggggga ggggttccat acactcatct ctggaatcaa
     1801 ttattaaagg agggtttata atgatccagt ctg
//
